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Advancing Continuous Manufacturing: The Role Of Process Analytical Technology In Process Development, Samuel R. Henson

Electronic Theses and Dissertations

The pharmaceutical industry is actively pursuing technologies which improve manufacturing processes with the goal of producing high-quality pharmaceutical products for patients, manifesting in an industry-wide investment in continuous manufacturing (CM). Process analytical technology (PAT) has been recognized for its successful monitoring of critical quality attributes during routine production and is often cited alongside CM due to its ability to make timely, in-line measurements of intermediate materials. Various PAT tools are valuable in process development, particularly as continuous wet granulation processes are developed for use within pharmaceutical manufacturing. This work applied PAT and chemometric modeling during CM process development to enhance …

Design And Investigation Of Small Molecule Drugs For Potential Treatment Of Cns Disorders, Flaviviral Infections, And Cancers, Viktoriya Mashinson

Theses & Dissertations

Chapter 1 discusses the development of antagonists against the dopamine 4 receptor (D4R) that is expressed in the motor, associative, and limbic subdivisions of the basal ganglia network and is involved in Parkinson’s disease (PD). Levodopa is the firstline drug for the management of PD symptoms but its long-term use often leads to development of levodopa-induced dyskinesia (LID). D4R antagonists have been shown to decrease the abnormal involuntary movement scores in mouse models of LID. Chapter 1 outlines the development and optimization of selective D4R antagonists for potential treatment of LID. During the investigation of our D4R antagonists we discovered …

5-Fluorouracil Induced Oxidative Stress Is Variable Across Triple Negative Breast Cancer Cell Lines, Rachel L. Walker

Departmental Honors & Graduate Capstone Projects

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with treatment limited to chemotherapy. However, not all patient tumors respond to chemotherapy. The variable cytotoxic effects of chemotherapies may be due to how cancer cells regulate reactive oxygen species (ROS). In this study, we examined two mouse breast cancer cell lines: 4T1 and EO771, vary when treated with hydrogen peroxide (H2O2) and 5-Fluorouracil (5FU), known ROS-inducing substances. In 4T1 cells H2O2 increased oxidized DNA but caused minimal cell death. While in EO771 cells that same amount of H2O2 caused complete apoptosis. Cell number, ROS, and cell death showed …

Cftr Modulator Therapy In The Treatment Of Cystic Fibrosis As Compared To Placebo, Rebecca L. Doody, Harrison James Hall

Physician Assistant Capstones, 2020-current

Objective: To assess the efficacy of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies including ivacaftor, tezacaftor/ivacaftor, and elexacaftor/tezacaftor/ivacaftor combinations in the improvement of lung function in patients aged 12 and older with Cystic Fibrosis. Design: Systematic Literature Review Methods: A search was performed in PubMed using the search terms “CFTR modulators in Cystic Fibrosis.” Further parameters set were: published in the last 10 years, Randomized Control Trials, and trials that include participants under 18. Articles were excluded if they did not compare to placebo or had a primary endpoint measurement of FEV₁. Results: The Taylor-Cousar et al study showed …

The Implementation Of Ketamine-Assisted-Psychotherapy On Healthcare Workers Suffering From Workplace-Related Ptsd Due To Covid-19, Ziluolan Zou

Nursing | Student Research Posters

During the coronavirus disease 2019 (COVID-19) pandemic, healthcare workers were exposed to a deadly disease with limited knowledge and personal protective equipment, subjected to long hours, forced to ration care due to limited critical care resources and ventilators, and isolated from their families due to fear of spreading the virus. These factors further compounded the occupational stress associated with being a healthcare worker. The literature shows that the physical, mental, and emotional challenges frontline healthcare workers faced during the COVID-19 pandemic had lasting impacts on their mental health. The prevalence of mental health illnesses, such as post-traumatic stress disorder, among …

Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don

Theses and Dissertations

In recent biomedical research, the precise control of molecular dynamics through light activation has emerged as a powerful tool, particularly in the field of neurobiology. This approach involves the use of photocleavable cages or photoprotective groups (PPGs) that are chemically tethered to biologically active molecules such as neurotransmitters or calcium chelators. These cages remain inert until exposed to specific wavelengths of light, typically in the visible range, triggering the release of the active compound with high spatiotemporal precision.

For neurotransmitter systems, such as glutamate (Glu), which plays a critical role in synaptic transmission and memory formation, researchers have developed novel …

Table B: Impacts Of Utensil Use In Preparation, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Coffee Beans, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Creamer, Non-Dairy, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Tea Infusion, Unspecified Tea Type, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Puer Tea Infusion, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Energy, Isotonic, Sports, And Nutritional Drinks, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Butter, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Sugar, Syrup And Molasses, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Oils, Fats, And Their Products, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Pepper, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Rice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Cookies And Snacks, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Barley, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Mango And Mango Juice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Cherries And Cherry Juices, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Table I: Aluminum Material Age Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Table C: Ph Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Potato, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Cauliflower, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Carrot And Parsnip, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Processed Cheese, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Jellyfish, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Seaweeds, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Plums, Prunes And Their Juices, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.