Cardiovascular System Commons^™

Posttransplant Recoarctation Of The Aorta: A Twelve Year Experience., Girish S. Shirali, C E. Cephus, M A. Kuhn, K K. Ogata, L K. Vander Dussen, R E. Chinnock, N F. Mulla, J K. Johnston, L L. Bailey, S R. Gundry, A J. Razzouk, R L. Larsen

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: This study was undertaken to investigate the incidence of posttransplant recoarctation of the aorta, delineate the mode of presentation, identify risk factors that predict recoarctation and examine the results of intervention for posttransplant recoarctation.

BACKGROUND: Patients with aortic arch hypoplasia require extended arch reconstruction at transplant, with an inherent possibility of subsequent recoarctation of the aorta.

METHODS: This was a retrospective review of all children (ageyears) who underwent cardiac transplantation over a 10-year period. Collected data included pretransplant diagnosis, details of the transplant procedure and posttransplant data including development of recoarctation of the aorta, interventions for recoarctation and the …

Dobutamine Stress Echocardiography For Assessing Coronary Artery Disease After Transplantation In Children., R L. Larsen, P M. Applegate, D A. Dyar, P A. Ribeiro, S D. Fritzsche, N F. Mulla, Girish S. Shirali, M A. Kuhn, R E. Chinnock, P M. Shah

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: The purpose of this study was to determine the feasibility, safety and diagnostic accuracy of dobutamine stress echocardiography (DSE) for evaluating posttransplant coronary artery disease (TxCAD) in children, and to determine the frequency of selected cardiac events after normal or abnormal DSE.

BACKGROUND: Posttransplant coronary artery disease is the most common cause of graft loss (late death or retransplantation) after cardiac transplantation (CTx) in children. Coronary angiography, routinely performed to screen for TxCAD, is an invasive procedure with limited sensitivity. The efficacy of DSE for detecting atherosclerotic coronary artery disease is established, but is unknown in children after CTx. …

Pressure-Induced Intracellular Signaling In Isolated Arteries, Victor A. Miriel

Theses and Dissertations in Biomedical Sciences

The ability of cells to respond to mechanical stimuli has been studied through a variety of techniques in numerous cell types. The cells of the vascular wall have adapted to specific mechanical stresses through the activation of intracellular signaling pathways which result in cell-specific responses such as hypertrophy, hyperplasia, proliferation, and migration. Vascular smooth muscle of the arteries have been shown to be sensitive to mechanical stimuli such as stretch, and pressure.

This study attempts to add to the current knowledge of mechanotransduction by utilizing the isolated artery preparation. This preparation allows for the study of vascular smooth muscle signal …

A Cytochemical Evaluation Of Blood-Brain Barrier Sodium, Potassium- And Calcium-Adenosine Triphosphatase Polarity, Panya Steve Manoonkitiwongsa

Loma Linda University Electronic Theses, Dissertations & Projects

The blood-brain barrier (BBB) is formed by cerebral vascular endothelial cells. Brain ion and fluid homeotasis essential for proper neural functioning is due to the BBB. Sodium-potassium and calcium-activated adenosine triphosphatase (Na⁺, K⁺-ATPase and Ca²⁺-ATPase) serve as one of the main mechanisms controlling brain Na⁺, K⁺, and Ca²⁺ concentrations. The present accepted concept is that both of these enzymes are localized to the abluminal plasma membrane of endothelial cells although there have been contrary results from some studies. Because of these discrepancies, further work was needed. Various cytochemical procedures …

Evaluation Of Accelerated Plethysmography As A Measure Of Health And Fitness, Angela Marie Humble

Dissertations and Theses

Plethysmography is a technique used for measuring alterations in the volume of organs or limbs. Japanese researchers have developed a relatively new application of plethysmography (accelerated plethysmography) that uses information from the pulse wave measured at the fingertip to make inferences about health and fitness status. The instrument used to collect data -- the Precaregraph (accelerated plethysmograph) -- provides an accelerated pulse waveform and APG index, a mathematical representation of the waveform. It was the purpose of this study to evaluate the validity of the Precaregraph by examining the relationship between the APG index and previously validated measures of health …

The Optimal Fontan Connection: A Growing Extracardiac Lateral Tunnel With Pedicled Pericardium., S R. Gundry, A J. Razzouk, M J. Del Rio, Girish S. Shirali, L L. Bailey

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: The concept of a lateral tunnel for the Fontan operation is now widely accepted. Most lateral tunnels are constructed intraatrially with the use of aortic crossclamping. Construction of extracardiac lateral tunnels with the use of homografts or other nonviable tubes eliminates aortic crossclamping but lacks growth potential in length or width. The native pericardium, which is "sealed" posteriorly along the pulmonary artery, atrium, and inferior vena cava, could be turned down onto the right atrium to form a viable extracardiac lateral tunnel.

METHODS: We designed and successfully constructed extracardiac lateral tunnels using viable autologous pericardium, pedicled on its lateral …

Comparison Of Cardiovascular Disease Risk In Japanese Natives And Japanese Americans, Mayumi Takeda

Dissertations and Theses

This research examined potential differences in cardiovascular disease risk (CVR) in two groups: Japanese Natives living in Saga, Japan and Japanese Americans living in or near Portland, Oregon. It explored data gathered in an effort to build a theoretical framework for future studies. Environmental, nutritional, and lifestyle differences were also examined to compare the health status of Japanese residents in the two countries. The history of Japan from World War II to present, and the history of Japanese Americans both first and second generation, are discussed in the literature review.

Accelerated plethysmography (APG) is a technique which presumably allows the …

Effect Of Cocaine On Rabbit Renin Angiotensin System: Cocaine Detection In Adult And Fetal Tissue And Adult Plasma Using Ion Mobility Spectrometry, Barbara Belinda Guinn

Biological Sciences Theses & Dissertations

Ion mobility spectrometry (IMS) was used to detect cocaine and/or the metabolite ecgonine methyl ester (EME) in tissue and plasma samples from male, maternal, and fetal New Zealand White (NZW) rabbits. EME was consistently detected in all adult plasma samples 5 minutes after the injection of cocaine hydrochloride (cocaine•HCI, 2 mg/kg). EME was also in the liver, kidneys, testicles, and ovaries. Five minutes after the injection of cocaine•HCI, the male arterial pressure (MAP) increased from a mean control value of 79 ± 3.2 mmHg to 88 ± 4.1 mmHg, and the pCO₂ increased from a control value of28 ± …

Endothelial Nitric Oxide Synthase And Growth Factor Regulation Of Flow-Mediated Vascular Remodeling, David Anthony Tulis

Theses and Dissertations in Biomedical Sciences

This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent …

A Quasi-One-Dimensional Theory For Anisotropic Propagation Of Excitation In Cardiac Muscle, Jiashin Wu, Edward A. Johnson, J. Mailen Kootsey

Faculty Publications

It has been shown that propagation of excitation in cardiac muscle is anisotropic. Compared to propagation at right angles to the long axes of the fibers, propagation along the long axis is faster, the extracellular action potential (AP) is larger in amplitude, and the intracellular AP has a lower maximum rate of depolarization, a larger time constant of the foot, and a lower peak amplitude. These observations are contrary to the predictions of classical one-dimensional (1-D) cable theory and, thus far, no satisfactory theory for them has been reported. As an alternative description of propagation in cardiac muscle, this study …

Ventricular Remodeling Following Infant-Pediatric Cardiac Transplantation. Does Age At Transplantation Or Size Disparity Matter?, Girish S. Shirali, F Lombano, W L. Beeson, D A. Dyar, N F. Mulla, A Khan, J K. Johnston, R E. Chinnock, S R. Gundry, A J. Razzouk

Manuscripts, Articles, Book Chapters and Other Papers

Early left ventricular (LV) remodeling following pediatric cardiac transplantation has not been described. To identify patterns and determinants of change in left ventricular mass and volume posttransplant, we studied 125 consecutive children who underwent cardiac transplantation between January 1, 1989 and July 31, 1993. Two-dimensional imaging-directed M-mode echocardiograms were studied weekly until 26 weeks post-transplant. LV mass and volume (indexed to BSA1.5) were measured. LV mass index increased until 3 weeks post-transplant, and then decreased. The mean decrement in LV mass index after 8 weeks post-transplant (relative to baseline) was significantly larger in patients with donor-recipient weight ratio > 1.5 compared …

Optimization Of Cryopreservation Protocols For Cardiovascular Tissue, Jianfei Hu

Theses and Dissertations in Biomedical Sciences

The purpose of this research was to determine the effects of cryopreservation on the physical, biochemical and cellular aspects of heart valve tissue. The present study demonstrated that radiolabeled proline accumulation provides a quantitative estimate of total cellular metabolic viability. Radiolabeled inulin was demonstrated to be a useful marker for extracellular tissue space. Assessment of metabolic viability of the cellular population of leaflet tissue as a function of procurement and processing revealed that proline accumulation declined with increasing warm and cold ischemic times. Amphotericin B and streptomycin were toxic to the cells. Cefoxitin, lincomycin, polymyxin B, vancomycin and penicillin had …

A Comparison Of An Acoustic Stethoscope And An Amplified Stethoscope In White Noise And Cafeteria Noise During Cardiac Auscultation, Lynda Lynell Gigstad

Dissertations and Theses

A basic relationship between stethoscopic auscultation and background noise interference was reviewed and examined in this study. The principle experimental design of the study questioned whether hospital background noise levels are capable of masking the threshold of detection for auscultated heart sounds. Several cited studies monitoring background noise levels in various hospital locations have reported averages exceeding the U.S. Environmental Protection Agency (EPA) (1974) and World Health Organization (WHO) (1980) recommendations of "quiet", namely 35 to 40 dBA (Falk & Woods, 1973; Hilton, 1985, 1987; Shapiro & Berland, 1972; Turner, et al., 1975; Woods & Falk, 1974) by as much …

Fetal Whole-Body Fluid, Cardiovascular And Endocrine Dynamics : Computer Analysis Of Regulatory Mechanisms, Peter Stuart Gold

Loma Linda University Electronic Theses, Dissertations & Projects

The dynamics of transcapillary fluid and protein distribution and endocrine regulation of cardiovascular function were studied in chronically instrumented fetal sheep during the third trimester. Average experimental changes in vascular pressures, blood volume, plasma hormone concentrations, hematocrit and plasma protein concentration were analyzed using mathematical modeling and parameter optimization techniques in order to determine values for the major parameters which regulate fluid, protein and endocrine dynamics and to determine endocrine dose-response relationships to changes in cardiovascular function. The hormones which were considered are arginine vasopressin (AVP), angiotensin II (AII), epinephrine (EPI) and norepinephrine (NE). Vascular disturbances which were considered include …

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

Aspects Of Cardiovascular Oxygen Transport In Vertebrates, Michael Scott Hedrick

Dissertations and Theses

The hematological and rheological characteristics of blood from a number of vertebrates was compared to assess possible species differences in blood viscosity that may influence cardiovascular oxygen transport. Nucleated red blood cells (RBCs) were more viscous (measured by cone-plate viscometry) in comparison with enucleate (mammalian) RBCs at hematocrits greater than 40% when measured at equivalent temperatures. The lower viscosity of enucleate RBCs is attributed to an enhanced deformability of enucleate cells in comparison to nucleated cells.

Serial Cardiovascular Adaptations During Pregnancy, Mark Vincent Hart

Dissertations and Theses

Maternal cardiovascular adaptations appear to be essential in order to supply extra circulation to both the developing fetus and maternal system during a successful pregnancy. Since inadequate cardiovascular adjustments may produce abortions or maternal morbidity, the characterization of maternal cardiovascular changes during pregnancy and the elaboration of the underlying mechanism for these changes are essential to the understanding of how the heart enlarges during pregnancy and what significance this enlargement might have. To provide needed information regarding this time course and extent of maternal cardiac enlargement and the hormonal and hemodynamic changes which may be responsible for these changes, the …

The Coronary Distribution Zone : Mathematical Modelling Of The Left Ventricular Epicardial Surface For Area Calculation, Three-Dimensional Rotaton And Display, S. Matts E. Sjölander

Loma Linda University Electronic Theses, Dissertations & Projects

A computer model of the left ventricular (LV) epicardial surface was developed from Jang’s truncated ellipsoidal model, which has a minor to major axis ratio of 6:10. The model was applied in calculating the area of a segment of the myocardium, jeopardized by an impending occlusion of its associated artery. The endangered segment of the LV muscle was also visualized in different projections by rotations in three space and graphical displays simulating the three dimensions.

The area formula for the surface of the ideal model , a truncated prolate spheroid, was derived and used in producing maps for manual calculations …

Some Physiological Effects Of The Bed Bath On The Cardiovascular System Of Acute Myocardial Infarction Patients, Arleen Canfield

Loma Linda University Electronic Theses, Dissertations & Projects

At Loma Linda University, a protocol has been in effect that specifies the kinds and amounts of activity that acute myocardial infarction patients may have. The protocol has described six activity levels with each successive level permitting more activity. The patient must have reached the fourth level of progression before he is permitted to receive a complete bed bath. The problem studied in this research: As the result of receiving a bed bath, what physiological effects will occur in the cardiovascular system of patients with acute myocardial infarction?

The theoretical framework for this study consisted of the following: recommendations for …

The Relationship Of Central Venous Pressure To Hemorrhage In Open Heart Surgery, Mable Reynolds

Loma Linda University Electronic Theses, Dissertations & Projects

The problem of this study was to review 100 open heart surgical cases in a selected hospital to determine the changes occurring in central venous pressure in relation to blood loss.

The review of literature revealed that central venous pressure is an important factor in determining immediate postoperative care of open heart surgical patients. If central venous pressure falls below the normal range of 5 to 10 centimeters of water, hemorrhage is suspected. If central venous pressure is elevated between 15 and 20 centimeters of water, cardiac tamponade is suspected.

The descriptive survey method of research was used. Medical records …

Factors Affecting The Rest Of The Hospitalized Cardiac Patient, Julia M. Bensonhaver

Loma Linda University Electronic Theses, Dissertations & Projects

A study was conducted to determine factors which can promote and prevent the rest of the hospitalized cardiac patient. Literature was reviewed in the areas of patients' opinions about their hospitalization and pertinent concepts in medical and nursing literature regarding cardiac rest. A study was not found which polled cardiac patient specifically regarding their ability to rest. Most authorities in this area strongly advocate rest for the cardiac patient, but there is disagreement of how and how long the patient should rest.

A questionnaire was sent to seventy cardiac patients who had been hospitalized in the nine months prior to …

The Circulatory Effects Of Histamine, Fred B. Moor

Medical Arts and Sciences: A Scientific Journal of the College of Medical Evangelists

No abstract provided.

Congenital Anomalies Of The Heart, C. W.M. Poynter

University Studies (University of Nebraska) (1888–1984)

For a number of years I have been studying the abnormalities of the circulatory system resulting from developmental disturbances. One paper relating to the aortic arches has already appeared, Poynter (1916), and in this one I shall confine myself to the anomalies of the heart. There are few subjects which have attracted more attention among the medical profession than the irregularities in the developmen~ of the heart and great vessels, but in the case of the heart the interest is not so much from the teratological side as in the case of the arteries; its developmental defects are frequently of …

Arterial Anomalies Pertaining To The Aortic Arches And The Branches Arising From Them, Charles William Mccorkle Poynter

University Studies (University of Nebraska) (1888–1984)

For a number of years I have been interested in the arterial variations which have been encountered in my dissecting rooms. Notes have been made of these abnormalities and the literature describing similar conditions has been gradually collected. The more recent textbooks in anatomy devote little space to the subject of arterial variations and the classic works which have reviewed the field are no longer readily consulted; then, too, new facts have been added to our knowledge of arterial development since the most recent of the latter were published. In view of these facts it has seemed worth while to …