Cardiovascular System Commons^™

Background Differences In Baseline And Stimulated Mmp Levels Influence Abdominal Aortic Aneurysm Susceptibility, Matthew A. Dale, Melissa K. Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J. Swier, Devendra K. Agrawal, Timothy Greiner, Jeffrey S. Carson, B. Timothy Baxter, Wanfen Xiong

Department of Mechanical and Materials Engineering: Faculty Publications

Objective: Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are less susceptible to aneurysm formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to abdominal aortic aneurysm (AAA) will be increased in 129/SvEv mice versus C57Bl/6 mice. We tested this hypothesis by assessing differences in aneurysm size, tissue properties, immune response, and MMP expression.

Methods: Mice of C57Bl/6 or 129/SvEv background underwent AAA induction …

Congenital Anomalies Of The Heart, C. W.M. Poynter

Papers from the University Studies series (The University of Nebraska)

For a number of years I have been studying the abnormalities of the circulatory system resulting from developmental disturbances. One paper relating to the aortic arches has already appeared, Poynter (1916), and in this one I shall confine myself to the anomalies of the heart. There are few subjects which have attracted more attention among the medical profession than the irregularities in the developmen~ of the heart and great vessels, but in the case of the heart the interest is not so much from the teratological side as in the case of the arteries; its developmental defects are frequently of …

Arterial Anomalies Pertaining To The Aortic Arches And The Branches Arising From Them, Charles William Mccorkle Poynter

Papers from the University Studies series (The University of Nebraska)

For a number of years I have been interested in the arterial variations which have been encountered in my dissecting rooms. Notes have been made of these abnormalities and the literature describing similar conditions has been gradually collected. The more recent textbooks in anatomy devote little space to the subject of arterial variations and the classic works which have reviewed the field are no longer readily consulted; then, too, new facts have been added to our knowledge of arterial development since the most recent of the latter were published. In view of these facts it has seemed worth while to …