Medicine and Health Sciences Commons^™

Technology Evaluation: Pro-542, Progenics Pharmaceuticals Inc., Muhammad Mukhtar, Zahida Parveen, Roger J Pomerantz

Department of Medicine Faculty Papers

Progenics's rCD4-IgG2 (PRO-542) is a recombinant fusion protein, which has been developed using the company's Universal Antiviral Binding (UnAB) technology, and is in phase I/II clinical trials for the treatment of human immunodeficiency virus type I (HIV-1) infection [273391]. At the beginning of 1997, Progenics received a Phase II Small Business Innovation Research Program (SBIR) grant from the National Institute of Allergy and Infectious diseases (NIAID) to fund the development of PRO-542 [236048]. A further grant of $2.7 million was awarded in August 1998 for the clinical evaluation of PRO-542 and other anti-HIV therapies [294200]. Progenics is collaborating with the …

Jefferson Alumni Bulletin – Volume Xlix, Number 4, September 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 4, September 2000 Next board chair is Douglas MacMaster, Esg, page 8 Tom Nasca’75 is honored with portrait – and new post, page 8 West coast transplant expert heads surgery, page 9 Alumni awards honor researchers in AIDS and pediatric immunology, page 11 The choir at 30: in perfect health, page 13 Alumni-related giving nears $10 million, page 16 Two medical schools select Jeff Alumni as their top executives, page 41 Two schools establish professorships honoring Jeffersonians, page 43

Jefferson Alumni Bulletin – Volume Xlix, Number 3, June 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 3, June 2000 Synergy of clinical skills and behavioral medicine, page 4 African-American students at Jefferson, page 8 Competency based training: a new paradigm?, page 15 An answer on acute respiratory distress syndrome, page 17 FHIT gene implicated in many types of tumors, page 17 Pinpointing genetics of hereditary colorectal cancer, page 19 Phil Marone’57: associate Dean for Alumni relations, page 25

Evaluating The Sensitivity Of The Nanostrong Ncounter® Analysis System To Determine Gene Expression Changes Associated With Chemotherapy Treatment, Katerina Dukleska, Md, Christopher W. Schultz, Bs, Mahsa Zarei, Phd, David Mckeown, Md, Charles J. Yeo, Md, Jonathan Brody, Phd, Jordan M. Winter, Md

Department of Surgery Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease with a 5-year survival of 8% for all stages combined (Siegel RL et al.). Currently, it’s the third leading cause of cancer-related deaths in the United States and by 2020 it is projected to become the second leading cause (Rahib L, et al).
• The poor prognosis in PDA is in part due to the limited therapies that are currently available.
• This highlights the importance of high-throughput technologies for gene expression analyses and drug screens.
• A recently developed NanoString Technologies nCounter® analysis system, an example of high-throughput technology, utilizes a color-coded barcode …

2000 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlix, Number 2, March 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 2, March 2000 Integrative medicine: Broadening the mainstream, page 4 Orthopaedics circa 2013, page 8 Doctoring a sickly system: medical errors, page 10 The two logos: university and health system, page 12 University expands neuroscience programs; Wills eye to construct sophisticated new building, page 14 Jeff hosts international medical students program, page 17 Rb2 gene therapy could shrink lung tumors, and may improve angioplasty, page 19 Gene repair could fix various inherited diseases, page 20 Alumni affairs: Events, notices, dates to remember, page 22

A Cultivated Taste For Yeast., C Brenner

Kimmel Cancer Center Faculty Papers

The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define protein function, to define drug targets, and to discover and characterize drugs.

Jefferson Alumni Bulletin – Volume Xlix, Number 1, December 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume , Number, December 1999 Bringing Cancer Knowledge From the Laboratory to the Bedside, Page 4 Increasing the Effectiveness of Radiotherapies, Page 6 Molecular Pathways of Apoptosis are Discovered, Page 13 Structural Approaches to New Therapies: A Jefferson Symposium, Page 14 Method to Isolate Stem Cells is Found Here, Page 18 Learning Environment May Prevent Alzheimer’s, Page 21 Jefferson Ranks in the Top Quarter of All Medical Schools in Training Grants, Page 21 Book about the Art Collection is Now Available, Page 25 JAMA Study Proves That Jefferson Brings Family Physicians to Underserved Rural America, Page …

Jefferson Alumni Bulletin – Volume Xlviii, Number 3, September 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 3, September 1999 Commencement and Reunions, Page 4 A Class Day to Remember, Page 8 Seeking a Balance among the Three Legs of the Stool, Page 9 U.S. News Ranks Jefferson One of Best in Nation, Page 14 Smullens is Named Chief Medical Officer of JHS, Page 14 Gene Repair Molecules Are Created, Page 17 Mary Monteith Honored on Her Retirement, Page 18 Bacharach Appointed Associate Dean for Alumni Relations, Page 18 Annual Giving, Page 19 Heckman, Canale in National Orthopaedics Posts, Page 53 Morrow Directs Cancer Department of ACS, Page 59 Andriole …

Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During

Department of Neurosurgery Faculty Papers

The neurogenetic prototypic disease on which we chose to test our gene therapy strategy is Canavan disease (CD). CD is an autosomal recessive leukodystrophy associated with spongiform degeneration of the brain. At present the disease is uniformly fatal in affected probands. CD is characterized by mutations in the aspartoacylase (ASPA) gene, resulting in loss of enzyme activity. In this review, recent evidence is summarized on the etiology and possible treatments for CD. In particular, we discuss two gene delivery systems representing recent advances in both viral and liposome technology: a novel cationic liposome-polymer-DNA (LPD) complex, DCChol/DOPE-protamine, as well as recombinant …

Jefferson Alumni Bulletin – Volume Xlviii, Number 2, June 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 2, June 1999 Meeting Challenges from the Start, Page 4 Developing the Curriculum, Page 5 Building a Campus, Page 6 Leaders in Their Fields: The 19th Century, Page 12 In the Nation’s Service, Page 11 Keeping Pace for the 20th Century, Page 12 A Comprehensive Medical School, Page 14 How Do We Monitor the Quality of the Education? Page 17 The Jefferson Health System, Page 20 Education in the Health System, Page 22 Teaching under Managed Care, Page 24 A Student’s Perspective, Page 26 JeffHOPE: Learning and Caring Go Hand in Hand, Page …

1999 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Radiculopathy And Myelopathy At Segments Adjacent To The Site Of A Previous Anterior Cervical Arthrodesis., Alan S. Hilibrand, Gregory D. Carlson, M A Palumbo, P K Jones, H H Bohlman

Rothman Institute Papers

BACKGROUND: We studied the incidence, prevalence, and radiographic progression of symptomatic adjacent-segment disease, which we defined as the development of new radiculopathy or myelopathy referable to a motion segment adjacent to the site of a previous anterior arthrodesis of the cervical spine.

METHODS: A consecutive series of 374 patients who had a total of 409 anterior cervical arthrodeses for the treatment of cervical spondylosis with radiculopathy or myelopathy, or both, were followed for a maximum of twenty-one years after the operation. The annual incidence of symptomatic adjacent-segment disease was defined as the percentage of patients who had been disease-free at …

Jefferson Alumni Bulletin – Volume Xlviii, Number 1, March 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 1, March 1999 Otolaryngology-Head and Neck Surgery, Page 4 Gene Therapy in a Liquid: an Easier Treatment, Page 10 Gene Repair Technique is Developed, Page 10 Moving Closer to Gene Therapy for Lung Cancer, Page 11 Frankford Hospital Joins Jefferson Health System, Page 14 Dean Gonnella Receives AAMC’s Flexner Award, Page 17

Jefferson Alumni Bulletin – Volume Xlvii, Number 4, October 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 4, October 1998

Flanagan, Gallo, and Nadel are Honored with the Alumni Achievement Awards, Page 6

Clinic Presentations Treat a Range of Fields, Page 8

Alumni are Invited to Compete for the Gratz Prize, Page 13

Annual Giving Tops Two Million Dollars, Page 26

Jefferson Alumni Bulletin – Volume Xlvii, Number 3, July 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 3, July 1998

Drug Development and Clinical Trials, Page 4

Thomas Jefferson university Hospital is Ranked One of the Top 100 in the Country, Page 8

The W.W. Smith Charitable Trust Gives $1.5 Million, Page 9

First GI Text from an Endoscopic Perspective, Page 9

Brucker Lecture on Refocusing of Managed Care, Page 10

Gene Therapy for Canavan’s Disease, Page 11

Decorin May Be a Natural Cancer Fighter in Cells, Page 13

Clue to How a Protein Works to Suppress Tumors, Page 13

Francis Elected to ACP Board of Regents, Page 23

Department Of Radiology-Annual Report-July 1, 1997 To June 30, 1998, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Executive Summary Report, July 1, 1997 to June 30, 1998. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 103 pages.

1998 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlvii, Number 2, March 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 2, March 1998

Department Restructurings Respond to the Evolution in Scientific Disciplines, Page 4

The Rb2/p130 Gene and Endometrial Cancer, Page 7

Gene Therapy Trial for Glioblastoma, Page 8

Ovarian Cancer Vaccine is Promising in First Tests, Page 9

Transgenic Mouse for Study of Photoaging, Page 10

Uric Acid Reduces MS Symptoms in Mice, Page 11

Albert Einstein Healthcare Network Will Join Jefferson Health System by July, Page 12

Proposed Amendments to Alumni Association Bylaws, Page 14

Joseph Seltzer, ’71, the Next Alumni President, Page 15

Wallace Miller ’56 Receives RSNA Gold Medal, …

Jefferson Alumni Bulletin – Volume Xlvii, Number 1, December 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 1, December 1997 Annual Giving Celebrates a Half-Century of Strengthening Jefferson, Page 4 Screening for Breast Cancer: A Continuing Dilemma, Page 8 The McClellan house: A Link to the University’s Past, Page 12 The Bulletin Reaches its 75th Year, Page 17 Landmark Breast Cancer Meeting at Jefferson, Page 21 University and SmithKline Beecham Link Clinical Research, Page 22 Missing Cancer-Suppressor Genes May Have Deadly Effects, Page 23 Goldstein is Vice President for Research at JDFI, Page 27 Brezinski Develops Noninvasive Method to Detect Early Signs of Cancer and Heart Attacks, Page 29

Predicting Red Blood Cell Transfusions In Very Low Birth Weight Infants Based On Clinical Risk Factors., David A. Paul, Stephen A. Pearlman, Kathleen H. Leef, John L. Stefano

Department of Pediatrics Faculty Papers

OBJECTIVE: To describe the clinical factors most predictive of red blood cell transfusion in very low birth weight (VLBW) infants.

STUDY DESIGN: Retrospective review of VLBW infants cared for at a single level III NICU during a two year period, n = 199.

RESULTS: Overall transfusion requirement was 4.6 +/- 6.2 transfusions/infant/hospital course. Length of hospital stay, days of mechanical ventilation, requirement for dopamine support, birth weight, initial hematocrit, periventricular leukomalacia and necrotizing enterocolitis all independently correlated with number of transfusions and donors. Bronchopulmonary dysplasia and patent ductus arteriosus were associated with donor but not transfusion number.

CONCLUSIONS: Our data …

Stent Placement Compared With Balloon Angioplasty For Obstructed Coronary Bypass Grafts. Saphenous Vein De Novo Trial Investigators., M P Savage, J S Douglas, D L Fischman, C J Pepine, S B King, J A Werner, S R Bailey, P A Overlie, S H Fenton, J A Brinker, M B Leon, S Goldberg

Department of Medicine Faculty Papers

BACKGROUND: Treatment of stenosis in saphenous-vein grafts after coronary-artery bypass surgery is a difficult challenge. The purpose of this study was to compare the effects of stent placement with those of balloon angioplasty on clinical and angiographic outcomes in patients with obstructive disease of saphenous-vein grafts.

METHODS: A total of 220 patients with new lesions in aortocoronary-venous bypass grafts were randomly assigned to placement of Palmaz-Schatz stents or standard balloon angioplasty. Coronary angiography was performed during the index procedure and six months later.

RESULTS: As compared with the patients assigned to angioplasty, those assigned to stenting had a higher rate …

Jefferson Alumni Bulletin – Volume Xlvi, Number 4, September 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 4, September 1997

University Awards Honorary Degree to Dr. Davis, Page 5

Luscombe, miller, and Staas Receive the Alumni Achievement Awards, Page 6

Clinic Presentations Address a Range of Fields, Page 8

Receptions Across Country Welcome College Leaders, Page 12

Landmark Diabetes Prevention Program, Page 21

Cardiology and Cardiothoracic Surgery Reception, Page 25

Annual Giving Tops $1.7 Million, Page 30

Department Of Radiology-Annual Report-July 1, 1996 To June 30, 1997, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1996 to June 30, 1997. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 108 pages.

Jefferson Alumni Bulletin – Volume Xlvi, Number 3, June 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 3, June 1997

Dermatology and Cutaneous Biology, Page 4

Mutations in Cornea-Specific Proteins Are Cause of Fragile Eye Disease, Page 8

Albert Einstein Healthcare Network Becomes a Founding Member of the Jefferson Health System, Page 9

Innovative New Journal has Jefferson Roots, Page 11

Students Publish Pharmacology Study Guide, Page 12

JeffLINE Alumni Connection Offers Lifelong Learning, Page 23

1997 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlvi, Number 2, March 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 2, March 1997

Urology, Page 4

Report from the Alumni Trustees, Page 8

Student Notebook from 1831-33 Returns to Jefferson, Page 9

Named Professorships at Jeff, Page 10

Where the Alumni Are: A Map, Page 12

Why Does Melanoma Vaccine Work? An Answer, Page 14

Jefferson’s First Combined Kidney/Pancreas Transplant, Page 15

Dr. Shaedler is Honored for 29 Years of Teaching, Page 16

Jefferson Alumni Bulletin – Volume Xlvi, Number 1, December 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 1, December 1996

Rational Drug Design, Page 4

Technology Transfer, Page 7

Clinical Trials, Page 9

World-Class Athletes and Drugs, Page 12

The Makings of the Complete Physician, Page 14

Major Alliance Links Jefferson with Mercy Health, Page 17

“Gene Repair” Corrects Mutation Leading to Disease, Page 19

Genetic Discoveries Lead to New Lung Cancer Tests, Page 20

Alumni Can Participate in JeffHOPE, Page 24

Student AMA Organizes Bone Marrow Drive, Page 25

Jefferson Alumni Bulletin – Volume Xlv, Number 4, September 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 4, September 1996

Commencement Addresses, Page 4

Clinic Presentations, Page 8

Annual Giving, Page 27

Bookstore, Page 54

Department Of Radiology-Annual Report-July 1, 1995 To June 30, 1996, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1995 to June 30, 1996. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 110 pages.