Medicine and Health Sciences Commons^™

Up-Regulation Of Interferon-A/Apobec3g Signal Pathway Potently Inactivates Hiv-1 Infectivity In Resting Cd4-T Cells, Keyang Chen, Jialing Huang, Chune Zhang, Sophia Huang, Giuseppe Nunnari, Feng-Xiang Wang, Xiangrong Tong, Ling Gao, Kristi Nikisher, Hui Zhang

Department of Medicine Faculty Papers

Poster Presentation.

The Diagnosis Of Adrenal Insufficiency In The Critically Ill Patient: Does It Really Matter?, Paul E. Marik

Division of Pulmonary and Critical Care Medicine Faculty Papers

No abstract provided.

Multiple Domains In Siz Sumo Ligases Contribute To Substrate Selectivity., Alison Reindle, Irina Belichenko, Gwendolyn R Bylebyl, Xiaole L Chen, Nishant Gandhi, Erica S Johnson

Department of Biochemistry and Molecular Biology Faculty Papers

Saccharomyces cerevisiae contains two Siz/PIAS SUMO E3 ligases, Siz1 and Siz2/Nfi1, and one other known ligase, Mms21. Although ubiquitin ligases are highly substrate-specific, the degree to which SUMO ligases target distinct sets of substrates is unknown. Here we show that although Siz1 and Siz2 each have unique substrates in vivo, sumoylation of many substrates can be stimulated by either protein. Furthermore, in the absence of both Siz proteins, many of the same substrates are still sumoylated at low levels. Some of this residual sumoylation depends on MMS21. Siz1 targets its unique substrates through at least two distinct domains. Sumoylation of …

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 2, Iss. 8, November/December 2006

Public Health Link

Vol. 2, Iss. 8 includes a faculty spotlight on Mona Sarfaty, an article on Richard Wender becoming President of the American Cancer Society and Jefferson presenters at the upcoming American Public Health Association meeting.

Patient Education In Glaucoma: What Do Patients Know About Glaucoma?, Vital Paulino Costa, George L Spaeth, Maura Smith, Cordelia Uddoh, José Paulo Cabral Vasconcellos, Newton Kara-José

Wills Eye Hospital Papers

PURPOSE: To evaluate the knowledge glaucoma patients have about their disease and its treatment.

METHODS: One hundred and eighty-three patients were interviewed at the Glaucoma Service of Wills Eye Hospital (Philadelphia, USA, Group 1) and 100 at the Glaucoma Service of University of Campinas (Campinas, Brazil, Group 2). An informal, relaxed atmosphere was created by the interviewer before asking a list of 18 open-ended questions.

RESULTS: In Group 1, 44% of the 183 patients did not have an acceptable idea about what glaucoma is, 30% did not know the purpose of the medications they were taking, 47% were not aware …

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 2, Iss. 7, October 2006

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Vol. 2, Iss. 7 includes a description of the The Albert Schweitzer Fellowship, a faculty spotlight on the Thomas Jefferson University and the Rwanda Healing Project and new course offerings for the spring.

Jefferson Alumni Bulletin – Volume 55, Number 3, Fall 2006

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 55, Number 3, Fall 2006

Dean’s Column: The Ties that Bind; Page 2

Findings: Gene Mutation Potentially Involved in Breast Cancer Initiation, New Potential Drug Targets for Metastatic Breast Cancer, “Miracle” Cancer Drug Can Be Toxic; Page 4

On Campus; Page 6

Global Initiative: Jefferson Abroad, Page 10

Into Africa: An International Health Elective; Page 16

JUREI: World Class, Right At Home; Page 17

You’re In The Military, Then…And Now; Page 18

Alumni Weekend; Page 22

Class Notes; Page 24

In Memoriam; Page 31

Giving; Page 32

By The Numbers: Jefferson in the World; Page …

Malignant Melanoma Metastacizing To The Thyroid Gland: A Case Report And Review Of The Literature, Brian Kung, Saba Aftab, Moira Wood, David Rosen

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Oral presentation 2006 AAO-H&NS Annual Meeting

Toronto, Canada September 17-20, 2006.

Objectives: The thyroid gland is a relatively uncommon site for secondary malignancy. Even lesscommon is metastasis of malignant melanoma to the thyroid gland. We present a case of malignantmelanoma metastatic to the thyroid gland presenting as thyroid enlargement.

Study Design: This is a case report which utilizes chart review, intraoperative photographs,radiographic images, and pathology slides.

Methods: A 68 year old patient with no prior evidence of primary skin melanoma presented witha neck mass which tested positive for melanoma. A year and a half following modified radical neckdissection, the patient …

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 2, Iss. 6, September 2006

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Vol. 2, Iss. 6 of the MPH Public Health Link highlights faculty member Vic Spain, the formal announcement of national accreditation for Jefferson Master of Science Program in Public Health and new course offerings for the Spring.

Peritoneal Perfusion With Oxygenated Perfluorocarbon Augments Systemic Oxygenation., Shamus R Carr, Joshua P Cantor, Atul S Rao, Thiru V Lakshman, Joshua E Collins, Joseph S Friedberg

Department of Surgery Faculty Papers

BACKGROUND: Despite maximal ventilatory support, many patients die from hypoxia in the setting of potentially reversible pulmonary failure. There remains a pressing need for additional pulmonary supportive care measures, especially techniques that do not require systemic anticoagulation. The objective of our experiments was to determine whether systemic oxygenation could be increased in a large animal, with induced hypoxia, by perfusing the abdominal cavity with oxygenated perfluorocarbons.

METHODS: Fifteen pigs with a mean (+/- SD) weight of 45 +/- 5 kg were intubated and rendered hypoxic by ventilating them with a blend of nitrogen and oxygen to achieve subatmospheric concentrations of …

Jefferson Alumni Bulletin – Volume 55, Number 2, Summer 2006

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 55, Number 2, Summer 2006 Dean’s Column: A Complex Undertaking; Page 3 Construction Begins on Innovative Breast Care Center; Page 4 Clues to How Molecular Gatekeepers Work; Page 5 A Tie Between Obesity and Alzheimer’s Disease; Page 6 Fighting Artificial Implant Infections; Page 7 Reducing Radiation’s Side Effects; Page 8 Developing a New Vascular Bypass Graft; Page 8 On Campus: Dicker to Direct Translational Research Program; Page 9 Parents Day; Page 12 Class Notes; Page 13 Swatl Shah, MD’95 Rebuilds After Katrina; Page 19 Match Day 2006; Page 23 Special Center Section: Alumni Weekend

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link, Vol. 2, Iss.5, June 2006

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Vol. 2, Iss.5 of the MPH Public Health Link newsletter highlights recent graduate, Charbel Haber.

2006 Commencement For Jefferson College Of Health Professions And Jefferson College Of Graduate Studies

Jefferson College of Nursing Commencements

No abstract provided.

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link, Vol. 2, Iss.4, May 2006

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Vol. 2, Iss. 4 of Public Health Link newsletter includes a summary of the retreat to the Franklin Institute, SAPHE's public health week award luncheon and thesis presenters.

Download Full Pdf Issue Of Thomas Jefferson University Public Health Link, Vol. 2, Iss.3, April 2006

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Vol. 2, Iss. 3 of Public Health Link includes spotlight on Richard Wender, MD from the Department of Family and Community Medicine at Thomas Jefferson University. Also includes National Public Health Week and thesis presentations.

Voltage-Dependent Gating Rearrangements In The Intracellular T1-T1 Interface Of A K+ Channel., Guangyu Wang, Manuel Covarrubias

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The intracellular tetramerization domain (T1) of most eukaryotic voltage-gated potassium channels (Kv channels) exists as a "hanging gondola" below the transmembrane regions that directly control activation gating via the electromechanical coupling between the S4 voltage sensor and the main S6 gate. However, much less is known about the putative contribution of the T1 domain to Kv channel gating. This possibility is mechanistically intriguing because the T1-S1 linker connects the T1 domain to the voltage-sensing domain. Previously, we demonstrated that thiol-specific reagents inhibit Kv4.1 channels by reacting in a state-dependent manner with native Zn(2+) site thiolate groups in the T1-T1 interface; …

Download Full Pdf Issue Vol. 2, Iss. 2, Thomas Jefferson University-Public Health Link, March 2006

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Volume 2, Issue 2, March 2006 includes: accreditation update, poster sessions, Population Health Forum, Sigma XI Research Day and Annual APHA meeting.

Download Full Pdf Issue Volume 2, Issue 1 - Msph Newsletter 2006

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This is the first issue of 2006 and it highlights upcoming events and an accreditation update.

Analysis Of Epstein-Barr Virus Reservoirs In Paired Blood And Breast Cancer Primary Biopsy Specimens By Real Time Pcr., R Serene Perkins, Katherine Sahm, Cindy Marando, Diana Dickson-Witmer, Gregory R Pahnke, Mark Mitchell, Nicholas J Petrelli, Irving M Berkowitz, Patricia Soteropoulos, Virginie M Aris, Stephen P Dunn, Leslie J Krueger

Department of Surgery Faculty Papers

INTRODUCTION: Epstein-Barr virus (EBV) is present in over 90% of the world's population. This infection is considered benign, even though in limited cases EBV is associated with infectious and neoplastic conditions. Over the past decade, the EBV association with breast cancer has been constantly debated. Adding to this clinical and biological uncertainty, different techniques gave contradictory results for the presence of EBV in breast carcinoma specimens. In this study, minor groove binding (MGB)-TaqMan real time PCR was used to detect the presence of EBV DNA in both peripheral blood and tumor samples of selected patients. METHODS: Peripheral blood and breast …

Smc3 Knockdown Triggers Genomic Instability And P53-Dependent Apoptosis In Human And Zebrafish Cells., Giancarlo Ghiselli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: The structural maintenance of chromosome 3 (SMC3) protein is a constituent of a number of nuclear multimeric protein complexes that are involved in DNA recombination and repair in addition to chromosomal segregation. Overexpression of SMC3 activates a tumorigenic cascade through which mammalian cells acquire a transformed phenotype. This has led us to examine in depth how SMC3 level affects cell growth and genomic stability. In this paper the effect of SMC3 knockdown has been investigated. RESULTS: Mammalian cells that are SMC3 deficient fail to expand in a clonal population. In order to shed light on the underlying mechanism, experiments …

Classification And Risk Stratification Of Invasive Breast Carcinomas Using A Real-Time Quantitative Rt-Pcr Assay., Laurent Perreard, Cheng Fan, John F Quackenbush, Michael Mullins, Nicholas P Gauthier, Edward Nelson, Mary Mone, Heidi Hansen, Saundra S Buys, Karen Rasmussen, Alejandra Ruiz Orrico, Donna Dreher, Rhonda Walters, Joel Parker, Zhiyuan Hu, Xiaping He, Juan P Palazzo, Olufunmilayo I Olopade, Aniko Szabo, Charles M Perou, Philip S Bernard

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

INTRODUCTION: Predicting the clinical course of breast cancer is often difficult because it is a diverse disease comprised of many biological subtypes. Gene expression profiling by microarray analysis has identified breast cancer signatures that are important for prognosis and treatment. In the current article, we use microarray analysis and a real-time quantitative reverse-transcription (qRT)-PCR assay to risk-stratify breast cancers based on biological 'intrinsic' subtypes and proliferation. METHODS: Gene sets were selected from microarray data to assess proliferation and to classify breast cancers into four different molecular subtypes, designated Luminal, Normal-like, HER2+/ER-, and Basal-like. One-hundred and twenty-three breast samples (117 invasive …

Jefferson Alumni Bulletin – Volume 55, Number 1, Winter 2006

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 55, Number 1, Winter 2006

Letters; Page 2

Dean’s Column: Disparities In Care; Page 3

On Campus: Pestell Appointed Director of the Kimmel Cancer Center; Page 6

Bookshelf; Page 9

Class Notes; Page 12

Alumni Profiles; Page 16

Achievement Award Winner Jim Baglan, MD’77; Page 17

Helping In Katrina-Ravaged New Orleans; page 18

Giving; page 20