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Articles 31 - 60 of 247
Full-Text Articles in Medicine and Health Sciences
The Regression Of Endometriosis With Glycosylated Flavonoids Isolated From Melilotus Officinalis (L.) Pall. In An Endometriosis Rat Model, Mert Ilhan, Zulfiqar Ali, Ikhlas A. Khan, Hakkı Taştan, Esra Küpeli Akkol
The Regression Of Endometriosis With Glycosylated Flavonoids Isolated From Melilotus Officinalis (L.) Pall. In An Endometriosis Rat Model, Mert Ilhan, Zulfiqar Ali, Ikhlas A. Khan, Hakkı Taştan, Esra Küpeli Akkol
Faculty and Student Publications
© 2020 Objective: Melilotus officinalis (L.) Pall. is commonly used for treating bronchitis, painful menstruation, hemorrhoids, kidney stones, ulcers of the eyes, earache, and hardening and swelling of uterus. The European Medicines Agency reported the use of M. officinalis orally against stomach ache, gastric ulcer, and disorders of the liver and uterus in folk medicine. The present study aimed to appraise the activity of M. (L.) Pall. aerial parts in endometriosis rat model. Materials and methods: The endometriosis rat model was used to evaluate the potential activity of M. officinalis aerial parts based on its folkloric usage. The aerial parts …
Nanoparticle Brain Delivery: A Guide To Verification Methods, Robert A. Yokel
Nanoparticle Brain Delivery: A Guide To Verification Methods, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the brain contributing to the blood-brain and blood-cerebrospinal fluid barriers. Considering the brain as neurons, glia and their extracellular space (brain parenchyma), most studies did not show brain parenchymal NP entry. Blood-brain and blood-cerebrospinal fluid barriers anatomy and function are reviewed. Methods demonstrating brain parenchymal NP entry are presented. Results demonstrating bulk brain versus brain parenchymal entry are classified. Studies are reviewed, critiqued and classified to illustrate results demonstrating bulk brain versus parenchymal entry. Brain, blood and peripheral …
Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan
Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan
Turkish Journal of Medical Sciences
Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells, and Leydig cells in rat testicles. It was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage. Materials and methods: Group 1 (control group) was given physiological saline solution intraperitoneally (IP) throughout the experiment. Group 2 (CP group) was given a single dose of CP (7 mg/kg) IP on the day 7. Group 3 (CP + CAPE group), was given CAPE (10 μmol/kg/day) IP for 12 days and a single dose …
Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan
Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan
Turkish Journal of Medical Sciences
Background and aim: To compare the effects of bilateral proximal tubal occlusion and bilateral total salpingectomy on ovarian reserve and the cholinergic system via rat experiment. Materials and methods: Twenty-one adult female rats were randomly divided into the following three groups: G1 (n = 7), sham group; G2 (n = 7), bilateral total salpingectomy group; and G3 (n = 7), bilateral proximal tubal occlusion group. Four weeks later, the abdomen of the rats was opened. The right ovarian tissues were stored in 10% formaldehyde, whereas the left ovarian tissues were stored at ?80 °C in aluminum foil. Serum samples were …
What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga
What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of hysterectomy on rat ovaries and the possible protective role of peroxisome proliferator-activated receptor gamma (PPAR-?) agonist-rosiglitazone against ovarian reserve decrement.Materials and methods: Forty-five adult Wistar albino rats were randomly divided into three groups. Hysterectomy was performed (n = 15) in group 1 [H]; 1 mg/kg/day PPAR-? agonist/rosiglitazone was used for 50 days after hysterectomy (n = 15) in group 2 [H + R]; a sham operation was performed (n = 15) in group 3 [control, C]. Blood samples were collected for anti-Müllerian hormone (AMH) evaluation in all groups and simultaneous ovarian Doppler examination was …
The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak
The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak
Turkish Journal of Veterinary & Animal Sciences
The main aim of the present study was to examine the neurotoxic effects of prenatal exposure to varying doses of diclofenac sodium (DS) on the rat hippocampus. Twenty-eight Wistar albino adult female rats weighing 280-300 g were initially used for pregnancy. When vaginal plaques were seen in female rats, it was accepted as the 0th day of pregnancy. Female rats were divided into five main groups; pure control, saline, low dose DS (3.6 mg/kg), moderate dose DS (9 mg/kg), and high dose DS (18 mg/kg). They were exposed to these treatments during their gestation. After birth, all newborn male rats …
Evaluation Of The Effects Of Bone Morphogenetic Protein-2 On The Healing Of Bonecalvarial Defects In Ovariectomized Rats, Ela Tules Kadi̇roğlu, Fati̇h Karayürek, Mehmet Erdem Akbalik
Evaluation Of The Effects Of Bone Morphogenetic Protein-2 On The Healing Of Bonecalvarial Defects In Ovariectomized Rats, Ela Tules Kadi̇roğlu, Fati̇h Karayürek, Mehmet Erdem Akbalik
Turkish Journal of Veterinary & Animal Sciences
Bone morphogenetic proteins (BMPs) are often used with bone grafts for bone regeneration. The aim of this study was to evaluate the effect of demineralized freeze-dried bone allografts and externally applied rhBMP-2 on bone healing in experimentally generated defects in the calvarium of ovariectomized and nonovariectomized rats via histological and immunohistochemical assays. The current study was carried out on 42 female Wistar rats. After ovariectomy was performed in half of the rats, the rats were divided into three groups: control, allograft, and allograft + BMP. An experimental defect with a diameter of 4 mm was created unilaterally in the parietal …
Evaluation Of The Early Term Healing Effects Of Resveratrol On Corneal Wounds In Rats, Hati̇ce Çi̇lem Perçi̇n, Zülfükar Kadi̇r Saritaş
Evaluation Of The Early Term Healing Effects Of Resveratrol On Corneal Wounds In Rats, Hati̇ce Çi̇lem Perçi̇n, Zülfükar Kadi̇r Saritaş
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to determine the effects of resveratrol (RES) treatment on corneal wound healing. Randomly divided into 2 groups were 26-week-old male Wistar albino rats. Group 1 was the control group (C) and group 2 was the RES group. A 2-3-mm-long vertical incision was made centrally in the right cornea of each rat to the descemet membrane using loupe magnification (2.5X) and the wounds were sutured using 10/0 nylon material. In the RES group, the rats were fed 30 mg/kg/day RES via oral gavage; the C and RES groups were provided food and water ad libitum …
A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris Niebuhr, Susan I. Jarvi, Shane R. Siers
A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris Niebuhr, Susan I. Jarvi, Shane R. Siers
USDA Wildlife Services: Staff Publications
Rat lungworm (Angiostrongylus cantonensis) is a zoonotic nematode that causes rat lungworm disease (angiostrongyliasis), a potentially debilitating form of meningitis, in humans worldwide. The definitive hosts for rat lungworm are primarily members of the genus Rattus, with gastropods as intermediate hosts. This parasite has emerged as an important public health concern in the United States, especially in Hawaii, where the number of human cases has increased in the last decade. Here we discuss the current knowledge of the rat lungworm, including information on the life cycle and host species, as well as updates on known infection levels. Three species of …
Whole Egg Consumption Impairs Insulin Sensitivity In Rat Model Of Obesity And Type 2 Diabetes, Cassondra J. Saande, Megan A. Steffes, Joseph L. Webb, Rudy J. Valentine, Matthew J. Rowling, Kevin Schalinske
Whole Egg Consumption Impairs Insulin Sensitivity In Rat Model Of Obesity And Type 2 Diabetes, Cassondra J. Saande, Megan A. Steffes, Joseph L. Webb, Rudy J. Valentine, Matthew J. Rowling, Kevin Schalinske
Rudy Valentine
Background: The literature regarding the relation between egg consumption and type 2 diabetes (T2D) is inconsistent and there is limited evidence pertaining to the impact of egg consumption on measures of insulin sensitivity. Objective: The objective of this study was to investigate the effect of dietary whole egg on metabolic biomarkers of insulin resistance in T2D rats. Downloaded from https://academic.oup.com/cdn/advance-article-abstract/doi/10.1093/cdn/nzz015/5374517 by Iowa State University user on 28 March 2019 Methods: Male Zucker diabetic fatty rats (n=12; 6 wk of age) and their lean controls (n=12; 6 wk of age) were randomly assigned to a casein- or whole egg-based diet. At …
Crf Mediates Stress-Induced Pathophysiological High-Frequency Oscillations In Traumatic Brain Injury, Chakravarthi Narla, Paul S. Jung, Francisco Bautista Cruz, Michelle Everest, Julio Martinez-Trujillo, Michael O. Poulter
Crf Mediates Stress-Induced Pathophysiological High-Frequency Oscillations In Traumatic Brain Injury, Chakravarthi Narla, Paul S. Jung, Francisco Bautista Cruz, Michelle Everest, Julio Martinez-Trujillo, Michael O. Poulter
Physiology and Pharmacology Publications
Copyright © 2019 Narla et al. It is not known why there is increased risk to have seizures with increased anxiety and stress after traumatic brain injury (TBI). Stressors cause the release of corticotropin-releasing factor (CRF) both from the hypothalamic pituitary adrenal (HPA) axis and from CNS neurons located in the central amygdala and GABAergic interneurons. We have previously shown that CRF signaling is plastic, becoming excitatory instead of inhibitory after the kindling model of epilepsy. Here, using Sprague Dawley rats we have found that CRF signaling increased excitability after TBI. Following TBI, CRF type 1 receptor (CRFR1)-mediated activity caused …
Ephrin-B3 Controls Excitatory Synapse Density Through Cell-Cell Competition For Ephbs., Nathan T. Henderson, Sylvain J. Le Marchand, Martin Hruska, Simon Hippenmeyer, Liqun Luo, Matthew B. Dalva
Ephrin-B3 Controls Excitatory Synapse Density Through Cell-Cell Competition For Ephbs., Nathan T. Henderson, Sylvain J. Le Marchand, Martin Hruska, Simon Hippenmeyer, Liqun Luo, Matthew B. Dalva
Department of Neuroscience Faculty Papers
Cortical networks are characterized by sparse connectivity, with synapses found at only a subset of axo-dendritic contacts. Yet within these networks, neurons can exhibit high connection probabilities, suggesting that cell-intrinsic factors, not proximity, determine connectivity. Here, we identify ephrin-B3 (eB3) as a factor that determines synapse density by mediating a cell-cell competition that requires ephrin-B-EphB signaling. In a microisland culture system designed to isolate cell-cell competition, we find that eB3 determines winning and losing neurons in a contest for synapses. In a Mosaic Analysis with Double Markers (MADM) genetic mouse model system in vivo the relative levels of eB3 control …
Investigation Of Treatment Efficacy Of 10% Povidone-Iodine Sclerotherapy On Ovarian Cyst Diameter: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu
Investigation Of Treatment Efficacy Of 10% Povidone-Iodine Sclerotherapy On Ovarian Cyst Diameter: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was toinvestigate the effects of 10% povidone-iodine (PI) sclerotherapyon ovarian cyst diameter through an experimental study.Materials and methods: To be able to create ovarian cysts, right unilateral salpingectomy was performed on 20 Wistar albino rats. One month after the operation, the abdomens of all rats were reopened. Sixteen rats with macroscopic ovarian cysts were divided randomly into 2 groups consisting of 8 rats. Group 1 (G1): the cyst content was only aspirated. Group 2 (G2): the ovarian cyst was aspirated and then the cystic cavity was irrigated with PI. Abdomens of all rats were …
Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats, İlker Yi̇ği̇t, Berri̇n Günaydin, Ömer Hakan Emmez, Meci̇t Orhan Uludağ, Nur Banu Bal, İsmai̇l Tuncer Deği̇m
Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats, İlker Yi̇ği̇t, Berri̇n Günaydin, Ömer Hakan Emmez, Meci̇t Orhan Uludağ, Nur Banu Bal, İsmai̇l Tuncer Deği̇m
Turkish Journal of Medical Sciences
Background/aim: Based on our previous in vitro study with multilamellar liposomal bupivacaine (MLB) versus bupivacaine alone in artificial cerebrospinal fluid, we aimed to investigate in vivo antinociceptive effect of intrathecal MLB by determining tail flick latency (TFL) time after thermal stimulation in rats. Materials and methods: After preparing MLB and high-yield drug entrapment in liposome (HYDEL) bupivacaine, 18 female Wistar rats were assigned to 3 groups as control (bupivacaine) and study groups (MLB and HYDEL bupivacaine) including 6 rats in each group to administer these drugs intrathecally. Antinociceptive activity was determined in terms of TFL time after thermal stimulation. Maximum …
Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar
Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar
Turkish Journal of Medical Sciences
Background/aim: Phenytoin is an anticonvulsant drug which causes fibroblast proliferation, collagen synthesis, and an increase in epidermal growth factor. Therefore, the aim of the present study is to evaluate the effect of phenytoin injection on the wound healing process in rats with vocal cord injury by histopathological methods. Materials and methods: The vocal cords of 10 albino Wistar rats were damaged bilaterally; the left vocal cord was kept as the control group. Phenytoin was injected in the right vocal cord. Ten rats were sacrificed. The thickness of the lamina propria and density of the fibroblast and collagen were evaluated histopathologically.Results: …
A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris N. Niebuhr, Susan I. Jarvi, Shane R. Siers
A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris N. Niebuhr, Susan I. Jarvi, Shane R. Siers
Human–Wildlife Interactions
Rat lungworm (Angiostrongylus cantonensis) is a zoonotic nematode that causes rat lungworm disease (angiostrongyliasis), a potentially debilitating form of meningitis, in humans worldwide. The definitive hosts for rat lungworm are primarily members of the genus Rattus, with gastropods as intermediate hosts. This parasite has emerged as an important public health concern in the United States, especially in Hawaii, where the number of human cases has increased in the last decade. Here we discuss the current knowledge of the rat lungworm, including information on the life cycle and host species, as well as updates on known infection levels. Three …
Chemical Profile And In Vivo Toxicity Evaluation Of Unripe Citrus Aurantifolia Essential Oil, Christian K. Adokoh, Du-Bois Asante, Desmond O. Acheampong, Yohei Kotsuchibashi, Francis A. Armah, Ignatius H. Sirikyi, Keisuke Kimura, Edward Gmakame, Sey Abdul-Rauf
Chemical Profile And In Vivo Toxicity Evaluation Of Unripe Citrus Aurantifolia Essential Oil, Christian K. Adokoh, Du-Bois Asante, Desmond O. Acheampong, Yohei Kotsuchibashi, Francis A. Armah, Ignatius H. Sirikyi, Keisuke Kimura, Edward Gmakame, Sey Abdul-Rauf
Research outputs 2014 to 2021
Citrus aurantifolia (Christm.) Swingle (syn. C. MEDICA var. ACIDA Brandis) (family: Rutaceae) essential oil is one of the cheapest oils found in local markets. Although, it is generally accepted as non-toxic to vital organs and cells, majority of people are cynical about it usage. Herein, the present study reports the chemical composition and in vivo oral toxicity study of unripe C. aurantifolia essential oil found in Ghana. The toxicity of C. aurantifolia essential oil extract was investigated via oral administration using two methods: The acute toxicity single dose study (SDS) and the repeated dose method. The oil exhibited no acute …
Understanding Water Diffusion In Experimental Spinal Cord Injury Remote From Injury Epicenter, Alice Motovylyak
Understanding Water Diffusion In Experimental Spinal Cord Injury Remote From Injury Epicenter, Alice Motovylyak
Dissertations (1934 -)
Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous preclinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion changes in the spinal cord both caudal and rostral to the injury epicenter. The aim of this dissertation was to quantify the structural changes that lead to different diffusion measures in the rat cervical spinal cord after a thoracic contusion injury in an attempt to find a biomarker of injury. Animals received a thoracic contusion injury …
Validation And Optimisation Of A Touchscreen Progressive Ratio Test Of Motivation In Male Rats, Jonathan M. Hailwood, Christopher J. Heath, Trevor W. Robbins, Lisa M. Saksida, Timothy J. Bussey
Validation And Optimisation Of A Touchscreen Progressive Ratio Test Of Motivation In Male Rats, Jonathan M. Hailwood, Christopher J. Heath, Trevor W. Robbins, Lisa M. Saksida, Timothy J. Bussey
Brain and Mind Institute Researchers' Publications
© 2018, The Author(s). Rationale: Across species, effort-related motivation can be assessed by testing behaviour under a progressive ratio (PR) schedule of reinforcement. However, to date, PR tasks for rodents have been available using traditional operant response systems only. Objectives: Touchscreen operant response systems allow the assessment of behaviour in laboratory rodents, using tasks that share high face validity with the computerised assessments used in humans. Here, we sought to optimise a rat touchscreen variant of PR and validate it by assessing the effects of a number of manipulations known to affect PR performance in non-touchscreen paradigms. Methods: Separate groups …
Map7 Regulates Axon Morphogenesis By Recruiting Kinesin-1 To Microtubules And Modulating Organelle Transport., Stephen R. Tymanskyj, Benjamin Yang, Kristen J. Verhey, Le Ma
Map7 Regulates Axon Morphogenesis By Recruiting Kinesin-1 To Microtubules And Modulating Organelle Transport., Stephen R. Tymanskyj, Benjamin Yang, Kristen J. Verhey, Le Ma
Department of Neuroscience Faculty Papers
Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood. Here, we report our study of MAP7, a unique microtubule-associated protein that interacts with both microtubules and the motor protein kinesin-1. Structure-function analysis in rat embryonic sensory neurons shows that the kinesin-1 interacting domain in MAP7 is required for axon and branch growth but not for branch formation. Also, two unique microtubule binding sites are found in MAP7 that have distinct dissociation kinetics and are both required for branch formation. Furthermore, MAP7 recruits kinesin-1 dynamically to microtubules, leading to alterations in organelle …
A Comparative Study On The Effect Of Aging On The Hippocampal Ca1 Area Of Male Albino Rat, Abeer E. El-Mehi, Fatma El-Nabawia A El-Safti, Rasha R. Selima, Wael B. El-Kholoy
A Comparative Study On The Effect Of Aging On The Hippocampal Ca1 Area Of Male Albino Rat, Abeer E. El-Mehi, Fatma El-Nabawia A El-Safti, Rasha R. Selima, Wael B. El-Kholoy
Menoufia Medical Journal
Objectives This work aimed to study the effect of aging on the structure of the hippocampus in the adult and aged male albino rats. Background Dementia is one of the most important problems nowadays. Aging is associated with learning and memory impairments. Aging is the progressive accumulation of changes with time that are associated with or responsible for the ever-increasing susceptibility to disease and death, which accompanies advancing age. The hippocampal formation is one of the most common brain areas affected by aging in both humans and other mammalian species. Materials and methods Eighteen male albino rats were divided into …
Biochemical And Biological Effects Of Irisin In A Model Of Diabetes Mellitus, Mohamed Omer Sirelkhatim Mahgoub
Biochemical And Biological Effects Of Irisin In A Model Of Diabetes Mellitus, Mohamed Omer Sirelkhatim Mahgoub
Dissertations
Diabetes mellitus (DM) is a highly prevalent health problem affecting more than 425 million people worldwide. It is associated with several detrimental complications such as neuropathy, nephropathy, retinopathy and cardiovascular diseases. Irisin is a novel hormone that plays a role in metabolism by stimulating the browning of white adipose tissue (WAT) into beige adipose tissue which acquires properties that are similar to those of brown adipose tissue (BAT). Several studies have attempted to characterize the roles of irisin in DM and obesity, however, contradictory results have been reported and physiological roles of irisin have been questioned by several researchers. In …
Compressed Sensing For Few-View Multi-Pinhole Spect With Applications To Preclinical Imaging, Benjamin Michael Rizzo
Compressed Sensing For Few-View Multi-Pinhole Spect With Applications To Preclinical Imaging, Benjamin Michael Rizzo
Dissertations (1934 -)
Single Photon Emission Computed Tomography (SPECT) can be used to identify and quantify changes in molecular and cellular targets involved in disease. A radiopharmaceutical that targets a specific metabolic function is administered to a subject and planar projections are formed by imaging emissions at different view angles around the subject. The reconstruction task is to determine the distribution of radioactivity within the subject from the projections. We present a reconstruction approach that utilizes only a few view angles, resulting in a highly underdetermined system, which could be used for dynamic imaging applications designed to quantify physiologic processes altered with disease. …
Immunohistochemical Expression Of Secretory Proteins In Pneumonic Rat Lungs, Enver Beytut
Immunohistochemical Expression Of Secretory Proteins In Pneumonic Rat Lungs, Enver Beytut
Turkish Journal of Veterinary & Animal Sciences
The present study evaluated the expression of secretory proteins involving surfactant proteins (SP-A, SP-B, proSP-C), Clara cell secretory protein (CCSP), and thyroid transcription factor-I (TTF-I), together with lambda light chain IgG (λ-IgG), proliferating cell nuclear antigen (PCNA), and lymphocytic phenotypes (T and B cells) in the pneumonic rat lungs. The most prominent gross lesion was severe pulmonary abscession. The lungs showed severe parenchymal destruction and necrosis encapsulated by fibrous tissue. Immunostaining for SPs displayed evident hyperplasia of type II pneumocytes. Immunoreaction to SP-A and SP-B occurred strongly on the luminal surface of type II cells, and to proSP-C in the …
The Effect Of Caffeine On Neuron Number Of Rats Exposedto 900-Mhz Electromagnetic Field, Aydin Him, Nimet Burcu Deniz, Mehmet Emi̇n Önger
The Effect Of Caffeine On Neuron Number Of Rats Exposedto 900-Mhz Electromagnetic Field, Aydin Him, Nimet Burcu Deniz, Mehmet Emi̇n Önger
Turkish Journal of Veterinary & Animal Sciences
Previous studies have shown that the electromagnetic field (EMF) emitted by cell phones decreased the number of neurons in some parts of the brain. It was also shown that caffeine protects the nerve cells. This study examines if caffeine has any effects on preventing neuron loss in rats exposed to EMF. Rats were exposed to a 900-MHz EMF for 60 min a day for 28 days. The rats that were exposed to EMF were fed 1 mg/L caffeinated water instead of tap water. The rats in the sham group were put inside the exposure chamber but were not exposed to …
Cannabinoid Receptor Type 2 Agonist Jwh-133 Deteriorates The Liver Toxicity Induced By Cypermethrin*, Hi̇dayet Tutun, Emi̇ne Baydan
Cannabinoid Receptor Type 2 Agonist Jwh-133 Deteriorates The Liver Toxicity Induced By Cypermethrin*, Hi̇dayet Tutun, Emi̇ne Baydan
Turkish Journal of Veterinary & Animal Sciences
Cannabinoid receptor 2 (CB2) has a role in the pathology of some liver diseases. Cypermethrin (CYP) is a synthetic pyrethroid insecticide used commonly for the control of pests and vectors, and for protection of foodstuffs. In this study, the involvement of CB2 in CYP-induced liver damage in rats was investigated. CYP was applied to rats orally at a dose of 125 mg/kg bw per day for 14 days. CB2 agonist JWH-133 was administered by intraperitoneal injection at a dose of 3 mg/kg bw per day for the last 4 days of CYP toxicity. JWH-133 deteriorated the liver damage induced by …
The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan
The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effects of apoptosis-inducing Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP 3) and antiapoptotic epidermal growth factor (EGF) on the pathophysiology of experimental low-flow priapism. Materials and methods: Twenty-four adult Sprague-Dawley rats were divided into four equal groups. Group I was the control group. Ischemic priapism was induced for 4 h in Group II rats. In Group III, intraperitoneal EGF at 10 µg/kg was given for 7 days before induction of ischemic priapism for 4 h. In Group IV, intraperitoneal EGF at 20 µg/kg was given for 7 days before induction of ischemic priapism …
Demonstration Of The Effect Of Brivaracetam On An Experimental Epilepsy Model, Mustafa Çeti̇ner, Hasan Emre Aydin
Demonstration Of The Effect Of Brivaracetam On An Experimental Epilepsy Model, Mustafa Çeti̇ner, Hasan Emre Aydin
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of valproic acid (VPA) and a new-generation antiepileptic drug called brivaracetam (BRV) on the brain damage occurring after status epilepticus (SE) in rats. Materials and methods: In our study, an experimental animal model of SE, generated by stereotaxically injecting 0.4-2 μg of kainic acid into the rat hippocampus, was used. The laboratory animals were divided into 4 groups: the first group was a sham group that was subjected to anesthesia and SE was not induced; the second group was a SE group, in which SE was induced using kainic …
Effect Of Phosphodiesterase-5 Inhibition On Joint And Muscle Damage In Rats Withadjuvant Arthritis, Fai̇ze Eli̇f Bahadir, Mustafa Kutay Köroğlu, Meral Yüksel, Feri̇ha Ercan, Yaşar İnci̇ Ali̇can
Effect Of Phosphodiesterase-5 Inhibition On Joint And Muscle Damage In Rats Withadjuvant Arthritis, Fai̇ze Eli̇f Bahadir, Mustafa Kutay Köroğlu, Meral Yüksel, Feri̇ha Ercan, Yaşar İnci̇ Ali̇can
Turkish Journal of Medical Sciences
Background/aim: This study was designed to examine the effect of tadalafil, a phosphodiesterase (PDE)5 inhibitor, on the severity of joint and muscle damage in rats with adjuvant-induced arthritis (AA). Materials and methods: AA was induced by intradermal inoculation into right hind paw of male Sprague Dawley rats (300-450g) with complete Freund's adjuvant (CFA; 0.1 mL). AA rats were treated with either tadalafil (10 mg/kg; per oral) alone or along with the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 mg/kg; intraperitoneally). After decapitation on day 16, trunk blood was collected for total oxidant status (TOS) and total antioxidant capacity (TAC) assays. …
Repaglinide Inhibits Cyclosporine A-Induced Renal Tubular Toxicityby Affecting Apoptosis And Bax And Bcl-2 Expression, Jin Li, Hui Li, Qi Xiong Li, Ying Xue
Repaglinide Inhibits Cyclosporine A-Induced Renal Tubular Toxicityby Affecting Apoptosis And Bax And Bcl-2 Expression, Jin Li, Hui Li, Qi Xiong Li, Ying Xue
Turkish Journal of Medical Sciences
Background/aim: Repaglinide (RG) is a prandial glucose regulator used for the treatment of type 2 diabetes. Our recent study showed that RG plays an important role in cyclosporine A (CsA)-induced nephrotoxicity through its antioxidant properties. However, it is not known whether or not RG has any protective effect on CsA-induced renal tubular toxicity by affecting apoptosis and expression of apoptosis-associated protein. The purpose of this study was to investigate the effects of RG on CsA-induced renal tubule apoptosis and Bax and Bcl-2 protein expression in rats. Materials and methods: Forty male Sprague Dawley rats weighing 250-300 g were randomly divided …