Medicine and Health Sciences Commons^™

A Critical Review Of Telomerase Biology And Model Systems For The Study Of Telomerase, Jeremy Charles Aisenberg

Theses and Dissertations

The study of telomere and telomerase biology holds substantial promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, including 95% of all advanced malignancies. Development of effective model systems to elucidate the molecular mechanisms underlying the role of telomeres and telomerase in the processes aging and cancer is of particular importance. While inbred strains of mice have provided a wealth of information for a variety of pathways and diseases, the mouse model …

The Jefferson Oncology Group, Patricia Dugan

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

The Jefferson Familial Colorectal Cancer Registry, Deborah G. Rose, Bruce Boman

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

A Cancer Education Service (Aces) Program Of Research With Minority And Underserved Populations, Ronald E. Myers

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Improved Cancer Care Through Increased Basic Cancer Education, Patricia Rushton, Lillian Nail, Sherry Brown

Faculty Publications

Literature shows that nursing care in rural communities improves when the nurse has increased knowledge through continuing education. Specific oncology studies in areas of stress, pain assessment and documentation, and death and dying.(Hedman-1990,Camp-Sorrell-1991,Foglesong-1987,Webber-1991) demonstrate similar results. It is reasonable that continuing education in areas of the cancer process, standard therapies, and methods of symptom control would improve patient care. This project allowed nurses who had limited access to cancer education in rural areas of Utah to receive basic cancer education. The subjects of this education included: 1) the cancer process, 2) chemotherapy, 3)radiation therapy, 4) the use and care of …

The Macrobiotic Diet May Have Benefits In Cancer Prevention, Brittany Lewis

Undergraduate Honors Capstone Projects

Macrobiotics is one of the most popular alternative or complementary approaches to fighting cancer. The diet is primarily plant-based, is centered on the idea of an all encompassing "yin-yang" concept in life, mind, environment and food. The dietary components of the macrobiotic diet, along with the many lifestyle implications are shown to have beneficial effects in cancer prevention and therapy. The diet has many anti-carcinogenic compounds, as well as a decrease in foods thought to promote cancer. A cause for concern is the vitamin deficiencies that may ensue in following a strict macrobiotic diet, which typically results from an all …

Stage At Diagnosis And Cancer Survival For Indigenous Australians In The Northern Territory, John R. Condon, Tony Barnes, Bruce K. Armstrong, Sid Selva-Nayagam, J. Mark Elwood

Aboriginal Policy Research Consortium International (APRCi)

Objective: To investigate whether Indigenous Australians with cancer have more advanced disease at diagnosis than other Australians, and whether late diagnosis explains lower Indigenous cancer survival rates. Design: Retrospective cohort study.

Setting and participants: Indigenous and non-Indigenous people diagnosed with cancers of the colon and rectum, lung, breast or cervix and non-Hodgkin lymphoma in the Northern Territory of Australia in 1991–2000. Main outcome measures: SEER summary stage of cancer at diagnosis (local, regional or distant spread), cause-specific cancer survival rates and relative risk of cancer death.

Results: Diagnosis with advanced disease (regional or distant spread) was more common for Indigenous …

2004 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center, with a focus on the Ewing's sarcoma family of tumors.

Cancer Information Seeking Preferences Among Health Professionals Serving American Indians In Minnesota, North Dakota, And Wisconsin, K. Knutsen, R. Strickland, J. Matloub, P. Remington, J. Kaur

Native Health Database Full Text

This article identifies cancer information resources used by health professionals in tribal health departments or Indian Health Service clinics serving American Indian communities in Wisconsin, Minnesota and North Dakota.

The Role Of Connective Tissue Growth Factor (Ctgf) In Fibrosis Associated With Intestinal Neuroendocrine Tumors, Michael David Shapiro

Yale Medicine Thesis Digital Library

Carcinoid tumors of the small bowel often present with fibrosis in the peritumoral tissues, distant in the heart or lungs, and locally in the peritoneal cavity. The mechanism of the fibroblastic lesions in patients with small bowel carcinoids is unclear and their timely diagnosis impossible. There exists no test to determine the risk of fibrosis, detect its presence, or monitor its progression once discovered. Furthermore, no current therapy protects against such fibrosis. We have proposed that CTGF, a mediator of the profibrotic activities of TGFâ1 (a known regulator of fibrosis)is directly involved in the genesis of ileal carcinoid-related fibrosis. The …

Responding To Localised Prostate Cancer : Lifeworld Reconstruction During The First Post-Diagnostic Year, David P. Wall

Theses: Doctorates and Masters

This thesis investigated the experiences of men diagnosed with localised prostate cancer, as they reconstructed their lifeworlds during the first post-diagnostic year. With the exception of health related quality of life, a review of the psychosocial research literature revealed few studies that, explored the psychosocial experience of men diagnosed with localised prostate cancer. Furthermore, the review uncovered no studies that explored the process of Iifeworld reconstruction, and only three studies that considered the role of masculinity in the responses of men to the prostate cancer experience. Such a limited understanding, about the nature and process of lifeworld reconstruction, potentially compromises …

A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay

Turkish Journal of Medical Sciences

Bioluminescent imaging (BLI) is particularly well suited for imaging small animals, and it can be readily used by scientists who are already routinely using the luciferase gene as a reporter in cell-based assays. This strategy relies on ATP and an O_2 dependent photochemical reaction between luciferin and luciferase, resulting in the release of photons from only live cells. In BLI, the intensity of the light detected by the device is proportional to the intensity of light emitted and the relationship is quantitative. This study was performed to determine the sensitivity of BLI for the imaging of lung metastasis and breast …

Treatment Patterns For Cancer In Western Australia: Does Being Indigenous Make A Difference?, Sonja E. Hall, Caroline E. Bulsara, Max K. Bulsara, Timothy G. Leahy, Margaret R. Culbong, Delia Hendrie, C D'Arcy J. Holman

Aboriginal Policy Research Consortium International (APRCi)

Objective: To examine whether hospital patients with cancer who were identified as Indigenous were as likely to receive surgery for the cancer as non-Indigenous patients. Design, setting and patients: Epidemiological survey of all Western Australian (WA) patients who had a cancer registration in the state-based WA Record Linkage Project that mentioned cancer of the breast (1982–2000) or cancer of the lung or prostate (1982–2001).

Main outcome measures: The likelihoods of receiving breast-conserving surgery or mastectomy for breast cancer, lung surgery for lung cancer, or radical or non-radical prostatectomy for prostate cancer were compared between the Indigenous and non-Indigenous populations using …

Cancer Esophagus Karachi 1995-2002:Epidemiology, Risk Factors And Trends, Y. Bhurgri, N. Faridi, L. A.G. Kazi, S. K. Ali, H. Bhurgri, A. Usman, J. Malik, A. Bhurgri, R. Ahmed, S. Muzaffar, N. Kayani, Shahid Pervez, S. H. Hasan

Department of Pathology and Laboratory Medicine

Objective: To study the trends of cancer esophagus in Karachi South during 1995-2002 and identify risk factors.

Methods: Incident esophageal cancer cases recorded at the Karachi Cancer Registry for Karachi South, during 1st January 1995 to 31st December 2003 were reviewed. For maximum completion of data, incident cases registered from 1st January 1995 to 31st December 2002 were included for final analyses.

Results: The Age Standardized Incidence Rates (ASIRs) of cancer esophagus in Karachi South for males were 6.5/100,000 (1995-1997) and 6.4/100,000 (1998-2002). In females the observed rates were 7.0/100,000 (1995-1997) and 8.6/100,000 (1998-2002).

Conclusion: In the moderately high incidence, …

Motor Neuronopathy Associated With Adenocarcinoma Of Esophagus, Bhojo A Khealani, R. Qureshi, Mohammad Wasay

Department of Medicine

Neurologic paraneoplastic syndromes (NPS) are remote neurologic effects, except metastasis, of systemic cancers. These are a rare group of disorders, commonly associated with small cell lung carcinoma (SCLC).1 Various NPS have been described, including motor neuronopathy. The motor neuronopathy has commonly been described with small cell carcinoma of lung, breast cancer and lymphoproliferative disorders.2,3 We report a case of motor neuronopathy in association with large cell adenocarcinoma of esophagus. To our knowledge this is the first reported case of motor neuronopathy associated with adenocarcinoma of the esophagus.

Cancer Among Arab Americans In The Metropolitan Detroit Area, Kendra L. Schwartz, Anahid Kulwicki, Linda K. Weiss, Haifa Fakhouri, Wael Sakr, Gregory Kau, Richard K. Severson

FMPHS Faculty Publications

Detroit is home to one of the largest populations of Arab Americans outside of the Middle East, yet little is known about the cancer distribution in this ethnic group. The authors of this study created an Arab/Chaldean surname list and matched it with the Detroit SEER Registry to identify cancer cases of probable Arabic descent. We then determined proportional incidence ratios (PIR) for specific cancer sites among metropolitan Detroit Arab Americans as compared to non-Arab Whites, and contrasted the results with Middle Eastern data. Arab/Chaldean men had greater proportions of leukemia (29%), multiple myeloma (46%), liver (64%), kidney (33%), and …

2003 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center, with a focus on AML.

Individual Telephone Support For Family Caregivers Of Seriously Ill Cancer Patients, Sandra M. Walsh, Griselle B. Estrada, Nancy S. Hogan

Nursing: School of Nursing Faculty Publications and Other Works

Medical-surgical nurses are an important source of information and guidance for family caregivers during health care crises. The concerns expressed by family caregivers to nurse interventionists during a supportive and informational telephone intervention are described in this study. An analysis of telephone call content using constant comparison methods identified major stressors of the family caregiver during the illness trajectory

The Therapeutic Effects Of Exercise On Fatigue, Davina Porock, Mei Fu

Publications and Research

No abstract provided.

European Mistletoe/Iscador® Faq , Clinic Staff

Topics in Integrative Medicine

Mistletoe (Viscum album) may be the most commonly used complementary cancer therapy in Europe today. Background information and important questions are presented.

The Effect Of Professionally-Facilitated Group Support On Psychological Well-Being Among Clients With Cancer, Joann C. Harper Phd, Ms, Rn

Dissertations

Many persons suffer from cancer, some of whom seek psychological relief through group support. Despite the widely held belief that group support helps, its efficacy has not been consistently evident in the scientific literature. The purpose of this study was to compare the effect of professionally-facilitated group support on the psychological well-being of clients with cancer between persons who participated in professionally-facilitated group support with those who did not. A comparison design measured effect by the Psychological General Well-Being (PGWB) index. Each study enrollee was diagnosed with a new or recurrent cancer within 18 months of study entry. ANCOVA was …

Synergistic Interactions Of Chlorambucil, Dha, And Trail In Jurkat And H460 Human Cancer Cells, Jennifer Ellen Bush-O'Donnell

Theses, Dissertations and Capstones

Traditional chemotherapeutic drugs are prone to toxicity and may result in secondary cancers. In recent years much attention has been garnered by alternate methods of cancer treatment with fewer side effects, including immunotherapy and administration of ω-3 fatty acids, both of which have been shown to cause apoptosis in cancer cells. Docosahexaenoic acid (DHA), a fatty acid, is a normal component of cell membranes and is safe for systemic administration. The cytokine TRAIL (tumor necrosis factorrelated apoptosis-inducing ligand) is able to induce apoptosis in cancer cells while sparing normal tissue. In this study, the alkylating agent chlorambucil (CLB) was combined …

Cancer Mortality Among American Indians And Alaska Natives: Regional Differences, 1994-1998, D.K. Espey, R.E. Paisano, N. Cobb

Native Health Database Full Text

This monograph delineates cancer mortality rates among American Indians and Alaska Native within the different regions served by the Indian Health Service (IHS). The table and charts depict broader geographic regions than in previous IHS cancer mortality monographs. The estimated IHS service population for each region and the cancer mortality rates from 1994 to 1998 are presented. Comparisons are made to the general U.S. population for the same time period. The intention of this publication is to provide detailed information about thew impact of cancer among Native American peoples, with a focus on the regional variability of cancer incidence for …

A Review Of Polyamines And Cancer, Wayne E. Criss

Turkish Journal of Medical Sciences

of Polyamines and Cancer Wayne E. CRISS Department of Biochemistry, Faculty of Medicine and Institute of Oncology, Hacettepe University, Ankara - Turkey

Cancer Patterns In Quetta (1998-1999), Yasmin Bhurgri, Hadi Bhurgri, A. Ajam, Shahid Pervez, S. H. Hasan, A. Usman, J. A. Khan, Q. Kasi, I. Kasi, A. G. Rasool, A. Bhurgri, N. Faridi, J. Malik

Department of Pathology and Laboratory Medicine

Introduction: Quetta, the capital of Baluchistan, is located at latitude 30,25; longitude 67.00. It has a population of 759,245; 425,474 males (56%) and 333,771 females (44%); Census 1998. The majority of residents are Persian or Baluchi speaking Baluchs.

Methodology: The cancer cases from Quetta reported to the Karachi Cancer Registry were reviewed. The data included cases from the Aga Khan University Hospital (AKUH), Pathology Department (Quetta collection point) and health care facilities in Karachi. The residents of Baluchistan were ascertained and cancer cases residents of Quetta identified with the help of recorded addresses and retraceable telephone numbers.

Results: During a …

2001 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center, with a focus on Wilms' Tumor.

Developing And Testing A Pain Management Program For Family Caregivers Of Advanced Cancer Patients, Lynn Oldham

Theses: Doctorates and Masters

Increasingly, advanced cancer patients are receiving care in the community supported by families and hospice home care services. However, little or no preparation is provided to family caregivers who assume this supportive role, often 24 hours per day. Pain management is consistently identified by family caregivers as their primary concern related to care and support of a relative with cancer. This project involved a three-phase program of research to develop and test a pain management program (PMP) that would provide family caregivers of advanced cancer patients with information and skills to manage the patient's pain.

Prognostic Impact Of P53 Status, Tls-Chop Fusion Transcript Structure, And Histological Grade In Myxoid Liposarcoma: A Molecular And Clinicopathologic Study Of 82 Cases, C. R. Antonescu, S. J. Tschernyavsky, R. Decuseara, Denis H. Y. Leung, J. M. Woodruff, M. F. Brennan, J. A. Bridge, J. R. Neff, J. R. Goldblum, M. Ladanyi

Research Collection School Of Economics

Purpose: A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS). Three common forms of the TLS-CHOP fusion have been described, differing by the presence or absence of TLS exons 6-8 in the fusion product. Type 5-2 (also known as type II) consists of TLS exons 1-5 fused to CHOP exon 2; type 7-2 (also known as type I) also includes TLS exons 6 and 7 in the fusion, whereas type 8-2 (also known as type III) fuses TLS exons 1-8 to CHOP exon 2. We sought to determine the impact …

Review Of: Preventing And Controlling Cancer In North America: A Cross- Cultural Perspective (Diane Weiner, Ed.), Hunter Yancey

RISK: Health, Safety & Environment (1990-2002)

Review of the book: Preventing and Controlling Cancer in North America: A Cross-Cultural Perspective (Diane Weiner, ed., Praeger Publishers 1999). Illustrations, Introduction, Concluding Remarks, Bibliography, Index, About the Contributors. ISBN 0-275-96180-X [245 pp. $72.50 Hardbound, 88 Post Road West, Westport, CT 06881.]

Effect Of Relaxation On Neuro-Immune Responses Of Persons Undergoing Chemotherapy, Patricia K. Taylor Pothier Phd, Ms, Rn

Dissertations

Chemotherapy can be considered both a physiologic and a psychological stressor. Anxiety, nausea, emesis, and immunosuppression are commonly associated with chemotherapy, and may adversely affect the outcome or the process of treatment. Chemotherapy-related anxiety can exacerbate negative side-effects. Some psychological stressors, such as anxiety, can result in down-regulation of certain immune functions. Studies have demonstrated that behavioral interventions, such as specific relaxation strategies, can modify stress-related immune modulation. These behavioral interventions have also been shown to decrease the degree of nausea and vomiting associated with chemotherapy. The purpose of this study was to examine whether a relaxation intervention would result …