Medicine and Health Sciences Commons^™

Effects Of Chaplain Care On Coping With Cancer, Sarah Battiston, Scott L. Baughan

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical case decision report using:

Piderman KM, Radecki CR, Jenkins SM, et al. Hearing and heeding the voices of those with advanced illnesses. Journal of Palliative Care. 2020;35(4):248-255. https://doi.org/10.1177/0825859720928623

for a patient having difficulty coping with cancer

The Transmission Of Oropharyngeal Squamous Cell Carcinoma, Kunjal Patel, Aleesha Thomas

Mako: NSU Undergraduate Student Journal

The existence of Oropharyngeal Squamous Cell Carcinoma (OPSCC) has recently been found to have correlations with the Human Papillomavirus. HPV-associated OPSCC exhibits a unique method of infection and transmission and has made this branch an emerging disease in the recent decade. This systematic review of the literature was conducted to further explore research into Oropharyngeal Squamous Cell Cancer (OPSCC). Commonly referred to as “throat cancer”, this growth originates in the oropharynx. Symptoms of this condition include sore throat, lumps in the neck, and difficulty with swallowing. OPSCC has many variants but has shown a strong association with Human Papillomavirus (HPV), …

Association Between Tspan15 (Rs78707713) And Slc44a2 (Rs2288904) Genetic Polymorphisms And Venous Thromboembolism In Cancer Patients, Shaimaa El Sayed Ramadan Genena, Alshimaa Mahmoud Alhanafy, Suzan Foad Omar, Manal Monir Mansour, Mona Abdelhamid Mohammed Kora, Mohamed Abdelhafez, Marwa Mohammed Ibrahim Mohammed Khalil

Menoufia Medical Journal

Objectives: to assess the relationship between TSPAN15 and SLC44A2 polymorphisms and VTE in cancer patients was evaluated with correlation to PROTECHT scoring system and survival data. Background: Although venous thromboembolism (VTE) is common in cancer patients, the underlying mechanisms are complex and poorly understood. .Methods: This study enrolled two groups: 50 VTE-cancer patients in group I and 50 cancer patients with no VTE in group II. Full history, general examination, histopathological diagnosis, and clinical stage were recorded. Complete blood count, coagulation profile, and analysis of TSPAN15 (rs78707713) and SLC44A2 (rs2288904) SNPs by polymerase chain reaction technique were done. Radiological examinations …

Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç

Turkish Journal of Medical Sciences

Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are …

Assessment Of Adherence To National Comprehensive Cancer Network Guideline Recommended Anticoagulant Therapy In The Management Of Patients With Cancer-Associated Venous Thromboembolic Disease, Ghufran Hassoun Naeemah, Ayad Ali Hussein Ameen

Maaen Journal for Medical Sciences

Background: Venous thromboembolism (VTE), a vascular disorder, is a serious and sometimes fatal problem, ranking as the second-deadliest complication for people with cancer. VTE includes pulmonary embolism, superficial vein thrombosis, deep vein thromboembolism, and internal vein thrombosis. It is important to note that cancer patients have almost nine times higher odds of dying from this illness. Objective: The Najaf Cancer Center conducted a study to evaluate the effectiveness of oncologist strategies in the prevention and treatment of cancer-associated venous thromboembolism (VTE). The primary objective was to measure the adherence of VTE patients to anticoagulant therapy recommended by the NCCN guidelines. …

Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak

Turkish Journal of Medical Sciences

Background/aim: Multiple sclerosis (MS) patients may be protected against cancer because of increased immune surveillance. However, aberrant T/B cell functioning in MS may increase the risk of cancer. We aimed to compare the frequency of cancer among patients with MS with an appropriate control group matched by the variables such as age, gender, tobacco smoking history, body mass index (BMI), and family history of cancer. Materials and methods: The MS patients who were registered and followed up at the MS Center in Hacettepe University Hospitals and appropriately matched with controls were included. A self-administered questionnaire with links to the online …

The Journey From Provider To Patient: Lessons Learned, Jane E. Sullivan

Patient Experience Journal

The lens through which one experiences a health crisis is influenced by their personal beliefs and experiences as well as by their professional training and circumstances. Parotid (salivary) gland tumors are rare. Having more than one parotid tumor is rarer still. My experience as a clinician and researcher who was diagnosed with two parotid gland tumors was influenced by my life experiences and my professional background. This affected my reaction to the situation and the questions I asked. It also affected my expectations of my providers. This is a reflection on my six-plus-year journey and the lessons learned, both personally …

Abstracts From The 2023 Health Care Systems Research Network (Hcsrn) Annual Conference, Denver, Colorado

Journal of Patient-Centered Research and Reviews

The Health Care Systems Research Network (HCSRN) is comprised of 20 learning health systems with embedded population-based research units. The network’s annual conference serves as a forum for research teams from member institutions to disseminate project findings, explore scientific collaborations, and share insights about conducting research in real-world care delivery settings. Abstracts presented at HCSRN 2023 are published in this issue supplement of Journal of Patient-Centered Research and Reviews, the journal of record for HCSRN’s annual conference proceedings.

Precision Medicine Advancements In Glioblastoma: A Systematic Review, Karan Iyer, Shubham Saini, Suman Bhadra, Sohini Kulavi, Jaya Bandyopadhyay

BioMedicine

Background. Glioblastoma multiforme, commonly known as GBM or glioblastoma is a grade IV astrocytoma. Brain tumors are difficult to treat and lead to poor prognosis and survival in patients. Gliomas are categorized into four different grades among which GBM is the worst grade primary brain tumor with a survival of less than a year. The genomic heterogeneity of the brain tumor results in different profiles for patients diagnosed with glioblastoma. Precision medicine focuses on this specific tumor type and suggests specialized treatment for better prognosis and overall survival (OS). Purpose. With the recent advancements in Genome-Wide Studies (GWS) and various …

Diagnosis And Management Of Colon Cancer Patients Presenting In Advanced Stages Of Complications, Vlad Denis Constantin, Adrian Silaghi, Dragos Epistatu, Anca Silvia Dumitriu, Stana Paunica, Daniela Gabriela Bălan, Bogdan Socea

Journal of Mind and Medical Sciences

Colorectal cancer is an important health problem with a significant impact on the individual and society. Malignancy (including colorectal cancer) is usually slightly symptomatic in its initial stages. This causes cancer to be discovered in some patients accidentally (either through screening tests in predisposed individuals or during routine investigations for other diseases), while in other patients the colorectal cancer is discovered in late stages, when the symptoms are much more intense due to complications. Unfortunately, such advanced cases of the disease have high rates of morbidity and mortality even with treatment. Current treatment methods are usually complex, interdisciplinary, causing significant …

Biomarker Metabolite Discovery For Pancreatic Cancer Using Machine Learning, Immanuelle Kezia, Linda Erlina, Aryo Tedjo, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Pancreatic cancer is one of the deadliest cancers in the world. This cancer is caused by multiple factors and mostly detected at late stadium. Biomarker is a marker that can identify some diseases very specific. For pancreatic cancer, biomarker has been recognized using blood sample known as liquid biopsy, breath, pancreatic secret, and tumor marker CA19-9. Those biomarkers are invasive, so we want to identify the disease using a very convenient method. Metabolite is product from cell metabolism. Metabolites can become a biomarker especially from difficult diseases. In this paper, we want to find biomarker from metabolite using machine learning …

The Effect Of Hydrochlorothiazide On The Recurrence Of Nonmelanoma Skin Cancer: A 7-Year Retrospective Study Comprising 300 Patients, Burak Özkan, Süleyman Savran, Kadri̇ Akinci, Abbas Albayati̇, Pinar İncel Uysal, Ahmet Çağri Uysal

Turkish Journal of Medical Sciences

Background/aim: Hydrochlorothiazide (HCTZ) possesses well-described photosensitizing properties, and a causal association with nonmelanoma skin cancer (NMSC) was recently shown. However, previous studies have not shown whether HCTZ use is associated with the risk of recurrence of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC). This study aims to investigate the association between HCTZ use and recurrence in patients with NMSC. Materials and methods: We identified cases with NMSC from our hospital archives during the period between 2013 and 2019. Patients were divided into groups according to the pathological diagnosis, HCTZ use, and recurrence. Multivariable analysis was performed to determine …

Indwelling Pleural Catheterization Maximizes Functionality And Quality Of Life In Management Of Recurrent Malignant Pleural Effusions, Avinash Ramkissoon

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Davies HE, Mishra EK, Kahan BC, et al. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: The TIME2 randomized controlled trial. J Am Med Assoc. 2012;307(22):2383-2389. https://doi.org/10.1001/jama.2012.5535

for the management of recurrent malignant pleural effusions in a patient with metastatic renal cell carcinoma.

Feasibility And Preliminary Efficacy Of Implementing A Group-Mediated Cognitive Behavioral Resistance Exercise Intervention In Head And Neck Cancer Patients Undergoing Chemoradiation Treatment, Kathryn Dispennette, Dukagjin Blakaj, Megan Kilar, Zachary Chaplow, Jessica Bowman, Victoria Descenza, Xiaochen Zhang, Brian Focht

International Journal of Exercise Science: Conference Proceedings

Head and neck cancer (HNCa) patients report some of the lowest quality of life (QOL) compared to other cancer populations, due to the clinically meaningful deficits in muscle mass, called cancer cachexia, and physical function that are associated with the established standard of care, which includes Chemoradiation therapy (CRT). PURPOSE: Determine the feasibility and preliminary efficacy of implementing a group-mediated cognitive behavioral (GMCB) resistance exercise (RE) intervention in HNCa patients undergoing CRT. METHODS: The HNCaRE study was a single-arm, pilot trial designed to evaluate the safety, feasibility, and preliminary efficacy of implementing a GMCB personalized RE intervention in …

Promoting Self-Management Of Breast Cancer-Related Lymphedema Through The Remotivation Process, Kaye Rubio, Patricia Bowyer, Sherry Hite, Vidya Pingale, Wyona Freysteinson, Gayle Hersch, Christine Raber Phd, Otr/L

The Open Journal of Occupational Therapy

Background. Lymphedema affects a significant number of women with breast cancer. Self-Management Programs (SMP) are important in the long-term management of chronic conditions such as lymphedema. Motivation is crucial in the daily performance of the SMP. The study explored the effect of the Remotivation Process on the motivation of women with breast cancer-related lymphedema to incorporate an SMP into their daily routine.

Methodology. The study was a within-subjects quasi-experimental design that used the Volitional Questionnaire, frequency count of the SMP, and circumferential measurement as outcome measures. Eleven participants (n = 11) with breast cancer-related lymphedema completed the study …

Prevalence Of Geriatric Syndromes In Elderly Undergoing Chemotherapy, Aulia Rizka, Helda Helda, Findy Prasetyawaty, Arcita Hanjani

Jurnal Penyakit Dalam Indonesia

Introduction. Geriatric syndromes is associated with poor survival, poor quality of life and increased chemotoxicity risk in elderly receiving chemotherapy. Geriatric syndromes is currently not routinely evaluated in pre-chemotherapy clinical setting. This study aimed to identify the prevalence of some geriatric syndromes in elderly patients undergoing chemotherapy.Methods. This study is part of primary study investigating geriatric syndromes in elderly with cancer. A descriptive cross sectional study during March 2020 – March 2021 was conducted to elderly patients before chemotherapy administration in Cipto Mangunkusumo Hospital, a national referral hospital in Jakarta. Patients were recruited consecutively. Patients underwent Comprehensive Geriatric Assesment (CGA), …

Cancer Patient Beliefs And Attitudes Regarding Immune Checkpoint Inhibitor Therapy, Nedal Darwish, Delaney C. Stuhr, Haily M. Datz, Halima Bakillah, Tenzin Tseky, Mohamed Manaa, Serge Dauphin

Advances in Clinical Medical Research and Healthcare Delivery

The development and widespread use of immune checkpoint inhibitors (ICIs) have advanced the field of oncology in a short period of time. Despite this, patient perception regarding this new medication class has not been adequately assessed, which may affect treatment decisions and adherence. The Belief about Medicines Questionnaire (BMQ) is a validated survey composed of 18 questions which analyzes patient’s beliefs about the necessity of prescribed medication and concern about the potential adverse events caused by the medication. General medication overuse and harm are also determined. This is the first study to utilize the BMQ for patients on ICI therapy.

The Lived Experiences Of Middle Eastern Immigrant Women During Their Cancer Survivorship Journey: A Phenomenological Study, Enam Alsrayheen, Khaldoun Aldiabat, Catherine Aquino-Russell

The Qualitative Report

The number of Middle Eastern immigrant women (MEIW) living in Canada has significantly increased. However, this group of women is underrepresented in health research and there is a gap in knowledge of their cancer survivorship experiences in Canada. This phenomenological qualitative approach was employed to uncover the meaning of the lived experiences of MEIW during their cancer survivorship journey (CSJ). Data were collected through unstructured interviews and one written description from three MEIW. The participants' perspectives of cancer risk factors were believed to be the cause of their cancer, and their CSJ was fear-inducing and anxiety-provoking. There appears to be …

Abstracts From The 2022 Health Care Systems Research Network (Hcsrn) Annual Conference

Journal of Patient-Centered Research and Reviews

The Health Care Systems Research Network (HCSRN) is comprised of 20 health systems with embedded research units. The network’s annual conference serves as a forum for research teams from member institutions to disseminate scientific findings, explore new collaborations, and share insights about conducting research in real-world care delivery settings. Abstracts accepted for presentation at HCSRN 2022 are published in this supplement of Journal of Patient-Centered Research and Reviews, the official journal of HCSRN’s annual conference proceedings.

An Investigation Into Use Of Natural Mistletoe Extracts And Their Formulations As Potential Anti-Cancer Treatments In Human Carcinomas, Rebecca Healy, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

Cancer is a prevalent disease that is responsible for around 10 million deaths a year. Cases and deaths will continue to rise daily if nothing is done to find the most effective treatment. Mistletoe is an evergreen, semi-parasitic plant that grows on trees. This plant contains a number of biologically active compounds that contribute to its anti-cancer properties e.g., lectins. Mistletoe is obtained from nature and has been shown to be safe, potent, and effective in treating cancer. Herein we review the biological effects of mistletoe on cancer cells, formulations that can be used in cancer treatment and discuss the …

The Risk And Prognosis Of Covid-19 Infection In Cancer Patients: A Systematic Review And Meta-Analysis, Ghada M. Elgohary, Shahrukh Hashmi, Jan Styczynski, Mohamed A. Kharfan-Dabaja, Rehab M. Alblooshi, Rafael De La Camara, Sherif Mohmed, Alfadel Alshaibani, Simone Cesaro, Nashwa Abd El-Aziz, Reem Almaghrabi, Usama Gergis, Navneet S. Majhail, Roy F. Chemaly, Mahmoud Aljurf, Riad El Fakih

Hematology/Oncology and Stem Cell Therapy

Numerous studies have been published regarding outcomes of cancer patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causing the coronavirus disease 2019 (COVID-19) infection. However, most of these are single-center studies with a limited number of patients. To better assess the outcomes of this new infection in this subgroup of susceptible patients, we performed a systematic review and meta-analysis to evaluate the impact of COVID-19 infection on cancer patients. We performed a literature search using PubMed, Web of Science, and Scopus for studies that reported the risk of infection and complications of COVID-19 in cancer patients …

Epigenetics And Cancer: Mechanisms, Diagnostics, And Treatment, Sophie Kopyar

D.U.Quark

Epigenetics connects the divide between genotype and phenotype without completely altering the genome. Modifications to certain genes can affect cell functions and produce diseased phenotypes, such as cancer. In some forms of cancer, epigenetic changes cause the cell to irregularly reproduce, avoid immunological responses, and operate under unsuitable conditions. This review explores the epigenetic changes that can occur to produce an oxygen deficient, hypoxically functioning environment that increases cancer vitality. More specifically, this review will focus on epigenetic alterations to HIF and p53 genes and briefly cover other genes that can be affected in cancerous cells. This review found there …

The Incidence And The Type Of Stomatognathic Disorders In Patients With Gardner Syndrome. A Systematic Review, Olga Preuss, Aleksandra Jaron, Anna Grzywacz, Magda Aniko-Wlodarczyk, Grzegorz Trybek

Baltic Journal of Health and Physical Activity

Background: Diseases of genetic origin are very often associated with oral disorders. One of them is Gardner syndrome (GS) a rare variant of familial adenomatous polyposis (FAP), whose main manifestation is colon cancer. Its most common oral cavity symptoms include osteomas, odontomas and impacted or supernumerary teeth. Material and methods: Medline (PubMed), Medline (Ebsco), Scopus and Google Scholar databases were searched oral manifestations of Gardner Syndrome.Results: Thirty-eight articles met inclusion criteria. The most frequently mentioned oral changes included osteomas, impacted teeth, supernumerary teeth and odontomas. Conclusion: This review provides evidence for associating FAP with oral disorders. Dentists can be the …

Sportsman’S Authority In The Perspective Of Man’S Weakness, Marcin Pasek

Baltic Journal of Health and Physical Activity

Background: History of glory and fall of the cyclist Lance Armstrong refers to the issues from the borderline of sociology, psychology, pharmacology and qualified sport. It stirs many emotions and extreme opinions in which human attitudes are focused on phenomena impossible to be interpreted unequivocally. The purpose of this research was to learn opinions on the life path of Lance Armstrong, regarding his struggle both with cancer and his rivals in the peloton, but at the same time marked with forbidden doping. Material and methods: The research was carried out using the survey method, which asked one question about the …

Choosing To Thrive: An Autoethnographic Journey Of Cancer, Companionship, And Carrots, Bruce Lilyea

The Qualitative Report

In this autoethnography, I explore the companionship experience of someone supporting a cancer patient who is endeavoring to thrive in the face of this disease. A wide range of studies has been conducted on the emotional and social issues relating to cancer and specifically to breast cancer. Appropriately, most of the research relating to the personal narrative focuses on the stories of the person who has been diagnosed with cancer, and limited research has highlighted the perspective and experiences of their companions. My primary goals for this autoethnographic research are to: (1) Begin to answer the question: What role do …

Clinical Diagnosis Support With Convolutional Neural Network By Transfer Learning, Spencer Fogleman, Jeremy Otsap, Sangrae Cho

SMU Data Science Review

Breast cancer is prevalent among women in the United States. Breast cancer screening is standard but requires a radiologist to review screening images to make a diagnosis. Diagnosis through the traditional screening method of mammography currently has an accuracy of about 78% for women of all ages and demographics. A more recent and precise technique called Digital Breast Tomosynthesis (DBT) has shown to be more promising but is less well studied. A machine learning model trained on DBT images has the potential to increase the success of identifying breast cancer and reduce the time it takes to diagnose a patient, …

Colorectal Cancer In Hadhramout Characteristics And Trends, Rasheed Mohammed Bamekhlah, Abdullah Saleh Bin Nabhan, Hussain Saeed Alghazli

Hadhramout University Journal of Natural & Applied Sciences

Colorectal cancer is an important public health problem in the world, and there is no previous study in Hadhramout, Republic of Yemen about it so we aimed to describe characteristics and trends of colorectal cancer registered in Hadhramout National Oncology Center. A retrospective analysis of all registered cancers (2988) between 2002-2012, to describe colorectal cancer with regards to age, sex, subsites and histopathology and clinical presentation. The results indicate that digestive system cancers are the most common cancers (15%); and colorectal cancer (30.9%) is the most common of these. It was more common in males (57.2%). Colorectal cancer is the …

Understanding Disparities In Clinical Trials For Native Hawaiian Men, Gabriela A. Layi, Kevin Cassel, Maile Taualii, Jeffrey L. Berenberg, Erin O. Bantum

Journal of Health Disparities Research and Practice

Understanding low rates of participation by minority populations in clinical trials is critical for reducing and eliminating disparities. We examined beliefs and attitudes of Native Hawaiian men related to illness and cancer to better understand their rates of participation in clinical trials. We conducted face-to-face interviews with Native Hawaiian key informants throughout the State of Hawai‘i using quota sampling methods to obtain a range of perspectives about attitudes towards health care seeking to provide insight into low clinical trials participation. Interviews were audio-taped, transcribed, and independently coded by researchers. Thematic analysis guided the extraction of relevant data from the discussions. …

Continuous Liquid-Liquid Extraction Of Lomustine Synthesis, Devna Grover

The Journal of Purdue Undergraduate Research

No abstract provided.

Conference Proceedings: Select Abstracts Presented At 2021 Advocate Aurora Health Scientific Day

Journal of Patient-Centered Research and Reviews

Abstracts published within this supplement were presented at the 47th annual Advocate Aurora Health Scientific Day, held virtually on May 26, 2021. This research symposium provides a forum for disseminating results from studies conducted by faculty, fellows, residents, and other allied health professionals associated with Midwest-based health system Advocate Aurora Health, which publishes the Journal of Patient-Centered Research and Reviews.