Medicine and Health Sciences Commons^™

Investigating The Link Between O-Glcnacylation And Parkin In Parkinson’S Disease, Kathryn E. Henderson

Selected Honors Theses

Parkinson’s Disease (PD) is a devastating neurodegenerative disease (ND) that is believed to impact around 1 million Americans, from both reported and nonreported cases. It is characterized by impaired motor and cognitive functioning resulting from a host of proposed causes, including the loss of dopaminergic neurons in the substantia nigra and the more debated aggregation of proteins. The role of proteins in PD is the focus of the following proposed research, which aims to evaluate the link between O-GlcNAcylation and the phosphorylation states of protein in NDs. This link has been investigated in other NDs such as Alzheimer’s as well …

Staff And Provider Education On Diabetic Foot Exams And Foot Care Using The Ophelia Process, Shasta Pickens

Doctoral Projects

Diabetes mellitus continues to grow in global prevalence and consumes an increasing amount of healthcare resources. Persons that live in disadvantaged groups have a higher prevalence due to a lack of understanding and access to care. Diabetes is one of the leading causes of chronic disease and limb loss worldwide. Diabetes foot care is essential, as diabetes can be dangerous to patients’ feet.

The purpose of this doctoral project was to increase diabetic foot care education and foot exams for staff and providers in a federally qualified health center (FQHC). Many people in this rural community do not understand the …

Alumni Journal - Volume 94, Number 1, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Editorials
2 | From the Editor
4 | From the President
6 | From the Dean

News
7 | This and That
10 | Alumni News
12 | Student News
14 | School of Medicine News
16 | AIMS Report
18 | Department Report: Radiation Medicine

APC 2023
20 | APC 2023 in Review

Features
34 | Alumni Association Celebrates 100 Years of Service
40 | Steps to Effective Spiritual Care
44 | Why I Pray With Patients
46 | Alumni Spotlight
47 | Life After Medicine

In Memoriam
48 | Alumni Remembered Featured Obituaries: James M. Phang '63, William …

Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista

Selected Honors Theses

Cyclopropyl acetylene (CA) is a key intermediate in the synthesis of the human immunodeficiency virus (HIV) reverse transcriptase inhibitor, Efavirenz (EFV), an antiviral drug used to treat HIV. CA is an expensive raw material, difficult to obtain, and employed in the preparation of medications to combat acquired immunodeficiency syndrome (AIDS). It was found that the structure could be synthesized by the utilization of PCl5; however, this resulted in unwanted ring opening products. To address this issue, a one pot synthesis was developed using Ph3PCl2 as a mild chlorinating agent. In addition, a new analog has been proposed substituting the cyclopropyl …

2023- The Twenty-Seventh Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-seventh Annual Symposium of Student Scholars, held on April 18-21, 2023. Includes abstracts from the presentations and posters.

Personalizing Prevention: Advances In Pharmacotherapy For Hiv Prevention., Marisa Brizzi, Elizabeth Sherman, Sarah B. Green, Diana N. Nowicki, Emily N. Drwiega, Melanie R. Nicol, Daniel B. Chastain, Eric G. Sahloff, William R. Truong, David Cluck, Melissa E. Badowski, Sarah M. Michienzi, Spencer H. Durham

HPD Articles

The HIV epidemic continues to pose a significant burden on the healthcare system. Although the incidence of annual new infections is decreasing, health disparities persist and most new infections remain concentrated into different racial, ethnic, and minority groups. Pre-exposure prophylaxis (PrEP), which involves those at high risk of acquiring HIV to take chronic medications to prevent acquisition of the virus, is key to preventing new HIV infections. The purpose of this article is to review medication therapies for PrEP and examine their role in personalizing PrEP in different patient populations. Additionally, new medications currently under development for PrEP are reviewed, …

Neurological-Type Wilson Disease: Epidemiology, Clinical Manifestations, Diagnosis, And Management, Nathaniel Kipker, Kaitlyn Alessi, Marko Bojkovic, Inderbir Padda, Mayur S. Parmar

HPD Articles

Wilson disease (WD) is a complex metabolic disorder caused by disruptions to copper regulation within the body, leading to an unregulated accumulation of copper within various tissues. A less understood organ affected by the collection of copper is the brain, which further leads to the generation of oxygen-free radicals and resultant demyelination. Healthcare providers must keep the neurological form of WD in their list of differentials when patients present with diverse neurological manifestations. The initial step to diagnosis will be to distinguish the characteristic disease presentation with a thorough history and physical and neurological examination. A high clinical disease suspicion …

Field Research Safety And Community Engagement, Reyna Tlamasico, Tristan Ferguson

2023 Midwest Ecology & Evolution Conference

Community engagement and safety are an important aspect of GPS tree logging fieldwork. As part of the Green Heart Louisville Project, we conducted field work to GPS log trees and conducted concurrent community engagement and implemented a health and safety plan (HASP). To make ourselves visible to the community, we made it a requirement to always wear visible Green Heart branding, such as t-shirts, hats, and backpacks. We fielded many inquiries about our presence, so we would politely inform them about why we were there, what we were doing, and explain to them about the nature of the Green Heart …

Data Management Of Environmental Monitoring Data For Human Health Studies, Mia Jeftic

2023 Midwest Ecology & Evolution Conference

Data Management of Environmental Monitoring Data for Human Health Studies

As part of a study to evaluate exposures in health, samples were taken from 26 participants monitoring air quality inside of their homes over a 4-year period. Our study contained 7 air quality monitors which took recordings every 10 seconds, per participant, per visit and stored it for future use. This led to millions of data points which, after finishing each visit, were extracted, downloaded, and transformed into text files. These files were initially very unorganized and needed to be arranged in a way for them to be useful for …

Spatiotemporal Patterns Of Ticks And Tick-Borne Disease Dynamics At Neon Sites Across A Sub-Continental Scale., Ana Sofia Rivera

2023 Midwest Ecology & Evolution Conference

At local scales, dynamics of ticks and tick-borne diseases such as Lyme disease are driven by resource pulses, such as mast seeding in forest trees, that creates increases in tick hosts. Tick-borne diseases in humans have nearly doubled between 1940 and 2004 and understanding the dynamics of infectious diseases has long been of interest for ecologists. The family Ixodidae is the most capable of transmitting pathogens to humans and tick-borne diseases are the most common vector of illness in the United States. The objective of this research is to characterize the spatiotemporal dynamics of ticks and tick-borne diseases, which may …

Examination Of Explicit And Implicit Emotions And Relationship With The Intention To Support Breastfeeding In Public: A Descriptive Study, Kaitlin Overgaard, Lauren M. Dinour, Adrian Kerrihard, Yeon K. Bai

Department of Nutrition and Food Studies Scholarship and Creative Works

Objectives

Current social norms in the United States do not favor breastfeeding in public. This study examined associations between college students’ explicit and implicit emotions of breastfeeding in public and their intention to support public breastfeeding.

Methods

Twenty-two student participants viewed images of a breastfeeding woman with a fully-covered, fully-exposed, or partially-exposed breast in a public setting. After viewing each image, participants’ explicit emotions (self-reported) of the image were measured using a questionnaire and their implicit emotions (facial expression) were measured using FaceReader technology. We examined if a relationship exists between both emotions [toward images] and intention to support breastfeeding …

Colorimetric Redox Reactions To Determine Base Composition In Unknown Monomeric Dna Samples, James T. Dials, Mara J. Stout, Elizabeth M. Thomas

2023 Celebration of Student Scholarship - Poster Presentations

Deoxyribonucleic acid (DNA) codes for proteins using a unique order of four major nitrogenous bases adenine, thymine, cytosine, and guanine. In several biological applications, such as the determination of DNA stability, production of biologic based drugs, and even taxonomic reorganization of species, it becomes necessary to understand the relative amounts of each nucleotide in a DNA sample, regardless of their sequence. However, most assays used to determine base composition use expensive equipment, harsh chemicals, and advanced computer software. In addition, the determination of base composition is an important educational tool in undergraduate laboratories, but these limitations are infeasible for many …

2022-2023 Program And Abstracts: Celebration Of Student Scholarship, Morehead State University. Undergraduate Research Fellowship Program.

2023 Celebration of Student Scholarship - Poster Presentations

The 2022-2023 Program and Abstracts for the Celebration of Student Scholarship at Morehead State University held on April 19, 2023. A Showcase of Student Research, Scholarship, Creative Work, and Performance Arts.

The Miracle Doctor Vs. Pcos, Ellen Nguyen '24, Sindhu Chalasani '24, Iris Amit '24, Karina Byers '24

Human Diseases Graphic Novels

No abstract provided.

Diabetes Type 2 Management, Thuy H. Trinh, Shannon Harris, Anthony Labady

Poster Presentations

Diabetes is a complex and chronic disease. Patients with diabetes may suffer complications such as microvascular and macrovascular diseases [1]. In 2018, the prevalence of diabetes was estimated to affect 34.2 million people, or 10.5% of the US population [2]. About 1 in 10 adults in Georgia has diabetes, a health condition that can be prevented with weight loss and lifestyle changes [3]. In 2018, diabetes-related emergencies accounted for 17 million emergency room visits, with 248,000 for hyperglycemia and 242,000 for hypoglycemia [4]. The purpose of this study was to implement a personalized, clinic-based diabetes management program with healthy lifestyles, …

Improving Annual Diabetic Foot Examinations At A Rural Primary Care Clinic, Michaela Moore, Shannon Harris, Christy Mnzava

Poster Presentations

The goal of this quality improvement project was to increase the number of adult patients who receive an annual diabetic foot examination through the education and training of clinicians and support staff.

Reducing Blood Pressure Through Education On Lifestyle Interventions, Charlotte M. Fuller, Shannon Harris, Mohammad A. Naeem

Poster Presentations

The purpose of this study was to develop an educational plan for patients with elevated blood pressure to increase their knowledge and self-efficacy of lifestyle interventions proven to help lower blood pressure rates.

Benefits Of Individualized Weight Loss Program In The Overweight Adult Population In Primary Care, Susan Mcguire, Shannon Harris, Nasir Asghar

Poster Presentations

The purpose of this project was to increase health by implementing a personalized, clinic-based weight loss program for overweight/obese patients leading to a decrease in weight, BMI, and waist circumference and an increase in muscle mass by using resistance training (RT) exercises as an adjunct to diet, therefore helping to decrease comorbidities associated with obesity. This project aimed to use strength training exercises as an adjunct therapy to lifestyle changes (diet, exercise, counseling) to decrease body weight by 8 pounds, decrease BMI by at least 1%, decrease waist circumference by at least 1 inch, and increase muscle mass percentage by …

Implementing Adverse Childhood Experiences (Aces) In A Youth Regional Treatment Center, Lauren Russell-Smith

Poster Presentations

In 2019, 57% of Adolescents who have substance or alcohol abuse disorders experienced at least one ACE, and 25 % experienced two or more ACEs; this means that over half of the patients admitted to an adolescent substance and alcohol abuse program have experienced childhood trauma (Gomez et al., 2017).

This study investigated ACE awareness amongst staff working with a population known to have high ACE scores. The intended purpose was to evaluate staff understanding of ACEs and their impact on patient satisfaction scores.

The AIM of this project was to increase staff awareness of ACE to 85% and increase …

Reducing Blood Pressure Through Education On Lifestyle Interventions, Charlotte M. Fuller, Shannon Harris, Mohammad A. Naeem

Virtual Presentations

This is the virtual presentation on a quality improvement study conducted in fulfillment of the Doctor of Nursing Practice degree requirements. The purpose of this study was to develop an educational plan for patients with elevated blood pressure to increase their knowledge and self-efficacy of lifestyle interventions proven to help lower blood pressure rates.

Implementing Adverse Childhood Experiences (Ace) In A Youth Regional Treatment Center, Laruen Russell-Smith

Virtual Presentations

The purpose of this study was to investigate Adverse Childhood Experiences (ACE) awareness among staff working with a population known to have high ACE scores. The intended purpose was to evaluate staff understanding of ACEs and their impact on patient satisfaction scores.

Virtual Osce Solutions For Nurse Practitioner Students During Covid, Lori Prewitt Moore, Shannon Harris

Virtual Presentations

This presentation discusses the Objective Structured Clinical Examinations (OSCE) utilized for evaluating the clinical skills of graduating nursing students. The OSCE method assesses clinical competency in a structured manner with an emphasis on objectivity. The framework involves multiple stations where students rotate and perform designated tasks for assessment in healthcare disciplines.

Will Clinical Decision Support Mechanisms Reduce The Amount Of Unnecessary Computed Tomography?, Andrea Ciarmello

Dissertations and Theses

Clinical Decision Support Mechanisms (CDSMs) are to patient safety. When used in Radiology, CDSMs can improve radiation dose, quality assurance, and patient care. When paired with the electronic health record, CDSMs provide clinicians with patient-specific data that will help lower healthcare costs and improve patient outcomes. This study demonstrates how introducing clinical decision support mechanisms in electronic health record software will help improve unnecessary CT scans and hinder patient radiation exposure. The ordering physician can now consistently and reliably choose the proper scan each time.

The Innovator - Spring 2023, Matthew Hamel

Faculty Affairs & Research Newsletters - The Innovator

Newsletter published by the Offices of Faculty Affairs & Research

Himmelfarb Library Liaison Letter - April 2023, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Using Ot-Based Yoga Programs To Improve Sleep Health Across Populations, Hillary Williams

MOT Student Capstones

Sleep dysfunction affects all ages and inhibits successful engagement in everyday activities. Pain and psychological issues are common factors that contribute to sleep health. There is demand for holistic approaches to promote sleep health due to undesirable effects of medications. Yoga has been shown to improve health and wellness of those who practice and can be a tool to improve symptoms leading to poor sleep health. Sleep is an occupational domain that is underrecognized compared to the full scope of occupational therapy (OT). OTs can implement yoga programs to promote sleep health across the lifespan, because they are skilled in …

Occupational Therapy's Role In Increasing Asl (American Sign Language) Intelligibility In Deaf And Hard Of Hearing Students, Bailey S. Matney

MOT Student Capstones

Over the years, the occupational therapy profession has worked diligently to provide holistic treatment to all populations throughout the lifespan; however, gaps in practice do exist. One gap that was identified, by this paper's author, involves the Deaf and hard of hearing (D/hh) student population. In American Sign Language (ASL), there are twenty-two different handshapes that make up the twenty-six letters of the alphabet, all of which must be formed through the use of fine motor movements of the wrist, forearm, and digits. In typically developing children, these fine motor movements that ASL production requires are not challenging, but they …

The Proposed Implementation Of An Occupation-Based Wellness Program To Reduce Chronic Disease And Illness For Employees Of A Large Factory Corporation, Sarah Dixon, Rikki Lara

MOT Student Capstones

Chronic disease and illness can have debilitating effects on factory workers, their productivity, number of missed workdays due to sickness, and quality of life. As employers grapple with increased amounts of missed workdays due to sickness, subsequent loss of money, pushed-back deadlines, and scrambling to cover shifts of sick individuals, the need for occupation-based wellness programs is increasing. Occupation-based wellness programs are beneficial as they are client-centered. To combat the issue of chronic disease and illness among factory workers, an in-service was created and presented to members of management within a large factory corporation. Objectives of the presentation included educating …

Hk 711: Measurement Theory And Practice, Minsoo Kang

GMAS Course Syllabi

No abstract provided.

Phad 781: Applied Multivariate Analysis, John P. Bentley Ph.D.

GMAS Course Syllabi

No abstract provided.