Medicine and Health Sciences | Open Access Articles

How General Practitioners And Patients Discuss Type 2 Diabetes Mellitus And Cardiovascular Diseases Concerns During Consultations: Implications For Digital Health, Urvashi Rohilla, Jayashanthi P. Ramarao, Jared Lane, Neha N. Khatri, James Smith, Kathleen Yin, Annie Y. S. Lau

Research outputs 2022 to 2026

Objective: To analyse general practitioner–patient consultations about type 2 diabetes mellitus or cardiovascular diseases and describe (i) the nature of self-management discussions; (ii) actions required from patients during and after consultation regarding self-management; and (iii) implications for digital health to support patients during (and after) consultation. Method: This study screened 281 general practitioner consultations conducted in 2017 within the UK general practice setting from an existing dataset containing videos and transcripts of consultations between GPs and patients. Secondary analysis was conducted using a multi-method approach, including descriptive, content, and visualisation analysis, to inform the nature of self-management discussions, what actions …

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It's Quite Good Fun: A Qualitative Study Of A Singing/Songwriting Programme For People With Parkinson's Disease And Their Spouses, Deborah Hersh, Shi J. Kong, Jessica Smith

Research outputs 2022 to 2026

Background: : Group singing for people with Parkinson's disease (PD) is an established intervention not only to improve voice and speech difficulties but also for emotional and social benefit. Less is known about the experiences of group singing on the couple—the person with PD and their spouse or partner together—and studies have not specifically tracked impact through time or in combination with songwriting. Aims: : To understand the impact of group singing/songwriting on couples (participants with PD and their spouses) to unpack whether this broader view might help explain why such interventions are reported as beneficial. Using a trajectory approach, …

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Lepidium Meyenii Walp (Maca)-Derived Extracellular Vesicles Ameliorate Depression By Promoting 5-Ht Synthesis Via The Modulation Of Gut–Brain Axis, Rui Hong, Lan Luo, Liang Wang, Zhao-Li Hu, Qi-Rong Yin, Ming Li, Bin Gu, Bin Wang, Tao Zhuang, Xin-Yue Zhang, Yuan Zhou, Wan Wang, Lin-Yan Huang, Bing Gu, Su-Hua Qi

Research outputs 2022 to 2026

Depression is a common and debilitating condition for which effective treatments are needed. Lepidium meyenii Walp (Maca) is a plant with potential medicinal effects in treating depression. Recently, there has been growing interest in plant-derived extracellular vesicles (EVs) due to their low toxicity and ability to transport to human cells. Targeting the gut–brain axis, a novel strategy for depression management, may be achieved through the use of Maca-derived EVs (Maca-EVs). In this study, we successfully isolated Maca-EVs using gradient ultracentrifugation and characterized their shape, size, and markers (CD63 and TSG101). The in vivo imaging showed that the Dil-labeled Maca-EVs crossed …

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Location Of Pathogenic Variants In Psen1 Impacts Progression Of Cognitive, Clinical, And Neurodegenerative Measures In Autosomal-Dominant Alzheimer's Disease, Stephanie A. Schultz, Zahra Shirzadi, Aaron P. Schultz, Lei Liu, Colleen D. Fitzpatrick, Eric Mcdade, Nicolas R. Barthelemy, Alan Renton, Bianca Esposito, Nelly Joseph-Mathurin, Carlos Cruchaga, Charles D. Chen, Alison Goate, Ricardo F. Allegri, Tammie L. S. Benzinger, Sarah Berman, Helena C. Chui, Anne M. Fagan, Martin R. Farlow, Nick C. Fox, Brian A. Gordon, Gregory S. Day, Neill R. Graff-Radford, Jason J. Hassenstab, Bernard J. Hanseeuw, Anna Hofmann, Clifford R. Jack Jr, Mathias Jucker, Celeste M. Karch, Robert A. Koeppe, Jae-Hong Lee, Allan I. Levey, Johannes Levin, Ralph Martins, Hiroshi Mori, John C. Morris, James Noble, Richard J. Perrin, Pedro Rosa-Neto, Stephen P. Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Chengjie Xiong, Keith A. Johnson, Randall J. Bateman, Reisa A. Sperling, Jasmeer P. Chhatwal, Dominantly Inherited Alzheimer Network Investigators

Research outputs 2022 to 2026

Although pathogenic variants in PSEN1 leading to autosomal-dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomarker change are observed in ADAD. We hypothesized that this interindividual variability may be associated with the location of the pathogenic variant within PSEN1. PSEN1 pathogenic variant carriers participating in the Dominantly Inherited Alzheimer Network (DIAN) observational study were grouped based on whether the underlying variant affects a transmembrane (TM) or cytoplasmic (CY) protein domain within PSEN1. CY and TM carriers and variant non-carriers (NC) who completed clinical evaluation, multimodal neuroimaging, and lumbar puncture for collection …

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Physical Activity And Brain Amyloid Beta: A Longitudinal Analysis Of Cognitively Unimpaired Older Adults, Michael G. Slee, Stephanie R. Rainey-Smith, Victor L. Villemagne, James D. Doecke, Hamid R. Sohrabi, Kevin Taddei, David Ames, Vincent Dore, Paul Maruff, Simon M. Laws, Colin L. Masters, Christopher C. Rowe, Ralph N. Martins, Kirk I. Erickson, Belinda M. Brown

Research outputs 2022 to 2026

Introduction: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ) over 15 years in a cohort of cognitively unimpaired older adults. Methods: PA and A measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A . Moderation analyses examined apolipoprotein E (APOE) 4 carriage impact on the PA-A relationship. Results: PA was not associated with brain A at baseline ( = –0.001, p = 0.72) …

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Reporting And Mapping Research Evidence On Perceptions Of Clinical Hypnosis Among The General Population And Patients Receiving Health Care Including Cancer Care: A Scoping Review, Malwina Szmaglinska, Deborah Kirk, Lesley Andrew

Research outputs 2022 to 2026

Despite empirical evidence supporting clinical hypnosis for numerous conditions, its utilization in healthcare is limited due to skepticism and misconceptions. This review identifies and maps research on clinical hypnosis perceptions among the general population, healthcare patients, and more specifically patients with cancer. A systematic search following JBI PRISMA ScR guidelines was conducted in EBSCOhost, ProQuest, PubMed, and PMC, resulting in 18 peer-reviewed, English language articles (2000–2023). Most studies employed quantitative methods, which were complemented by some qualitative and one mixed-methods approach. The results found attitudes toward hypnotherapy, especially when administered by licensed professionals, are consistently positive; however, awareness of hypnosis …

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Survey Of Attitudes Toward Performing And Reflecting On Required Team Service-Learning (Sasl): Psychometric Data And Reliability/Validity For Healthcare Professions Students In Preclinical Courses, Lon J. Van Winkle, Shane L. Rogers, Bradley O. Thornock, Brian D. Schwartz, Alexis Horst, Jensen A. Fisher, Nicole Michels

Research outputs 2022 to 2026

Purpose: Previously we assessed healthcare professional students’ feelings about team-based learning, implicit bias, and service to the community using an in-house paper survey. In this study, we determined whether this survey is a reliable and valid measure of prospective medical students’ attitudes toward required service-learning in an Immunology course. To our knowledge, no published questionnaire has been shown to be dependable and useful for measuring such attitudes using only eight survey items. Methods: Fifty-eight prospective medical students in Colorado (CO) and 15 in Utah (UT) completed the same Immunology course using remote technology. In addition to the usual course content, …

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The Effects Of Cognitive-Linguistic Interventions To Treat Aphasia In The First 90 Days Post-Stroke: A Systematic Review, Emily Eley, Maayken Van Den Berg, Miranda L. Rose, John E. Pierce, Abby Foster, Edwina Lamborn, Sarah D’Souza, Erin Godecke, Lucette Lanyon, Ciara Shiggins, Ian Kneebone, Caroline Baker

Research outputs 2022 to 2026

Background: Cognitive-linguistic interventions for aphasia are behavioural-based approaches to therapy that aim to treat language impairment skills post-acquired brain injury. The purpose of cognitive-linguistic intervention is to restore and rehabilitate language impairment skills through targeting phonologic, semantic and syntactic systems, which may support goals to improve everyday communication. Aims: The aim of this systematic review was to investigate the effects of cognitive-linguistic interventions on language processing for aphasia in the first 90 days post-stroke. Secondary aims include the investigation of the effects of these interventions on functional communication and quality of life. Methods: A systematic search was conducted across six …

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The Effect Of Self-Perineal Care Education On Knowledge, Episiotomy Pain And Wound Healing Among Primipara Mothers, G.P Lazarus Lilly Mary

Student Works (2020-2029)

A nurse-midwife ensures all mothers receive the best care to be safe and healthy throughout pregnancy and childbirth. However, it is challenging for midwives to provide holistic nursing care as postpartum mothers spend only a brief period in the postnatal ward due to the high demand for the facilities there. The primary objective of this study was to investigate the effect of self-perineal care education (SPC education) on knowledge, episiotomy pain, and wound healing outcomes among primipara mothers and explore their opinions regarding self-perineal care education and their challenges and practices at home. Mixed-methods research using the embedded design was …

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Full-Text Articles in Medicine and Health Sciences

How General Practitioners And Patients Discuss Type 2 Diabetes Mellitus And Cardiovascular Diseases Concerns During Consultations: Implications For Digital Health, Urvashi Rohilla, Jayashanthi P. Ramarao, Jared Lane, Neha N. Khatri, James Smith, Kathleen Yin, Annie Y. S. Lau

Research outputs 2022 to 2026

It's Quite Good Fun: A Qualitative Study Of A Singing/Songwriting Programme For People With Parkinson's Disease And Their Spouses, Deborah Hersh, Shi J. Kong, Jessica Smith

Research outputs 2022 to 2026

Research outputs 2022 to 2026

Research outputs 2022 to 2026

Research outputs 2022 to 2026

Reporting And Mapping Research Evidence On Perceptions Of Clinical Hypnosis Among The General Population And Patients Receiving Health Care Including Cancer Care: A Scoping Review, Malwina Szmaglinska, Deborah Kirk, Lesley Andrew

Research outputs 2022 to 2026

Research outputs 2022 to 2026

Research outputs 2022 to 2026

The Effect Of Self-Perineal Care Education On Knowledge, Episiotomy Pain And Wound Healing Among Primipara Mothers, G.P Lazarus Lilly Mary

Student Works (2020-2029)