Medicine and Health Sciences Commons^™

Serious Mental Illness In Nursing Homes: Quality Concerns, Dylan J. Jester

USF Tampa Graduate Theses and Dissertations

Objective: This dissertation is made of two academic papers followed by a chapter discussing policy implications of the findings. The objective of this dissertation is to better understand if high-serious mental illness (SMI) nursing homes (NHs) provide poorer quality of care (e.g., operationalized as staffing levels, NH Compare quality star ratings, and health deficiencies) and whether quality in high-SMI NHs is confounded by payer mix (e.g., the proportion of residents who are Medicaid-reimbursed). A modified Donabedian Structure, Process, Outcome (SPO) Model was used as the main theoretical framework.

Methods: Data came from the Certification and Survey Provider Enhanced Reports (CASPER) …

Can Racial Disparities In Poor Birth Outcomes Be Partially Attributed To Stress: A Mendellian Randomization Study, Madeline Travers

Dissertations and Theses

In the United States, low birth weight (LBW) is a leading cause of infant death overall, and the leading cause of death for Black infants. Understanding and preventing adverse birth outcomes is a major public health priority. Observationally, there is some evidence to support the hypothesis that maternal stress may be associated with LBW. To clarify the effect of maternal stress exposure on LBW, I conducted three separate-sample instrumental variable analyses with genetic instruments (Mendelian randomization) based on single nucleotide polymorphisms (SNP), from genome wide association studies, strongly (p-value < 5 × 10⁻⁶) and independently associated with neuroendocrine, vascular, and immune measures …

Comparative Analysis Of 1152 African-American And European-American Men With Prostate Cancer Identifies Distinct Genomic And Immunological Differences., Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, Ashutosh K. Tewari

Department of Radiation Oncology Faculty Papers

Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P < 0.001) and ETS (P = 0.02) expression, decreased SPINK1 expression (P < 0.001), and basal-like (P < 0.001) molecular subtypes. After adjusting for confounders, the AAM group was associated with higher expression of CRYBB2, GSTM3, and inflammation genes (IL33, IFNG, CCL4, CD3, ICOSLG), and lower expression of mismatch repair genes (MSH2, MSH6) (p < 0.001 for all). At the pathway level, the AAM group had higher expression of genes sets related to the immune response, apoptosis, hypoxia, and reactive oxygen species. EAM group was associated with higher levels of fatty acid metabolism, DNA repair, and WNT/beta-catenin signaling. Based on cell lines data, AAM were predicted to have higher potential response to DNA damage. In conclusion, biological characteristics of prostate tumor were substantially different in AAM when compared to EAM.

National Health Insurance Program In Nepal: Early Experiences And Its Effect On Health Service Utilization, Rajani Bharati

Dissertations and Theses

Introduction: Nepal initiated the Health Insurance program in 2016 to achieve Universal Health Coverage by 2030. However, the enrollment rate is low, and people are already starting to drop out. Therefore, this study aimed to explore the demand and supply side (service providers) experiences with Nepal's National Health Insurance Program and its effect on insurance enrollment and health service utilization.

Methods: We employed a mixed-method design. Ethnographic methods were used to explore the rich holistic insights into people's views and actions. We conducted 14 focus group discussions and 20 key informant interviews, mainly in Kailali and Baglung districts. …

The Association Of Psychosocial Stressors With Childhood Asthma: A Cross-Sectional Study Using The National Survey Of Children's Health 2018, Sharon Joseph

Dissertations and Theses

ABSTRACT

Background: Asthma is recognized as a major public health issue for US children. Evidence suggests that psychosocial stressors experienced by parents and caretakers of children and the children themselves can also be associated with childhood asthma prevalence. Psychosocial stressors such as parents’ perception of neighborhood safety/support, as well as experiencing bullying and/or racial/ethnic discrimination can cause physiologic changes in the body favorable for asthma symptoms. However, there is a paucity of evidence regarding associations of these specific psychosocial stressors with the prevalence of childhood asthma. The goals of this study were to investigate the association between three common psychosocial …

Allergy And Anaphylaxis From The Prehospital Perspective, Anthony E. Conrardy

Dissertations and Theses

Anaphylaxis is considered a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy causing substance. It is estimated that up to 5% of the population has experienced anaphylaxis, with 1% of hospitalizations and 0.1% of emergency department patients having fatal outcomes. We characterized the population of patients encountered by the EMS agency (786 patients) that had a provider impression of “allergic reaction” and then utilized logistic regression models to estimate associations with the administration of epinephrine in the prehospital setting. Additionally, we used incident location data for all patient encounters of the EMS agency …

Caregiving Stress And Self-Rated Health During The Covid-19 Pandemic: The Mediating Role Of Resourcefulness, Elliane Irani, Atsadaporn Niyomyart, Jaclene A. Zauszniewski

Faculty Scholarship

Family caregivers faced unprecedented circumstances and experienced increased levels of stress during the COVID-19 pandemic. Resourcefulness can minimize the effect of stress on health outcomes. The purpose of this study was to examine the associations between caregiving stress during the pandemic, resourcefulness, and self-rated health and assess the mediating effect of resourcefulness. A convenience sample of 70 family caregivers of adults with chronic and/or disabling conditions was recruited using social media groups and professional networking platforms. Data were collected using an online survey and analyzed using linear regression. Mediation analysis was conducted using the PROCESS macro. Higher levels of caregiving …

Generalizing The Predictive Relationship Between 1-Month Motor Skill Retention And Rey–Osterrieth Delayed Recall Scores From Nondemented Older Adults To Individuals With Chronic Stroke: A Short Report, Jennapher Lingo Vangilder, Andrew Hooyman, Pamela R. Bosch, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Motor learning is fundamental to motor rehabilitation outcomes. There is growing evidence from non-neurological populations supporting the role of visuospatial memory function in motor learning, but current predictive models of motor recovery of individuals with stroke generally exclude cognitive measures, thereby overlooking the potential link between motor learning and visuospatial memory. Recent work has demonstrated that a clinical test of visuospatial memory (Rey–Osterrieth Complex Figure Delayed Recall) may predict 1-month skill learning in older adults; however, whether this relationship persists in individuals with chronic stroke remains unknown. The purpose of this short report was to validate previous findings using Rey–Osterrieth …

The Embodiment Of Discovery: An Adapted Framework For Qualitative Analysis Of Lived Experiences, Helen B. Hernandez, Laurie P. Dringus

The Qualitative Report

We reflect on our process of working with an adapted framework as an effective strategy for analyzing and interpreting the results of our qualitative study on the lived experiences of insulin pump trainers. Interpretative Phenomenological Analysis (IPA) was applied as the overarching research methodology and was encapsulated into a framework adapted from Bonello and Meehan (2019) and from Chong (2019). We describe this framework as the “embodiment of discovery” to posit the researcher’s tangible experience of discovering the meaning of data that also brought transparency to the researcher’s process for data analysis and interpretation. We present challenges the doctoral student …

Examining The Effect Of Explanation On Satisfaction And Trust In Ai Diagnostic Systems, Lamia Alam, Shane Mueller

Michigan Tech Publications, Part 1

Background: Artificial Intelligence has the potential to revolutionize healthcare, and it is increasingly being deployed to support and assist medical diagnosis. One potential application of AI is as the first point of contact for patients, replacing initial diagnoses prior to sending a patient to a specialist, allowing health care professionals to focus on more challenging and critical aspects of treatment. But for AI systems to succeed in this role, it will not be enough for them to merely provide accurate diagnoses and predictions. In addition, it will need to provide explanations (both to physicians and patients) about why the diagnoses …

Assessing Health-Related Quality Of Life, Morbidity, And Survival Status For Individuals With Down Syndrome In Pakistan (Ds-Pak): Protocol For A Web-Based Collaborative Registry, Ayat Siddiqui, Laila Akber Cassum, Abdul Momin Kazi, Sidra Kaleem Jafri, Fizza Akbar, Salman Kirmani

Department of Paediatrics and Child Health

Background: Down syndrome is the most common chromosomal disorder, with a global incidence of 1 in 700 live births. However, the true prevalence, associated morbidities, and health-related quality of life (HRQOL) of these individuals and their families are not well documented, especially in low- and middle-income countries such as Pakistan. Disease-specific documentation in the form of a collaborative registry is required to better understand this condition and the associated health outcomes. This protocol paper describes the aims and processes for developing the first comprehensive, web-based collaborative registry for Down syndrome in a Pakistani cohort.
Objective: This study aims to assess …

The Use Of Mobile Apps To Increase Physical Activity Level: A Systematic Review, Dziyana Nazaruk, Kelli Rouser

Health Policy & Community Health: Faculty Publications

Background: About 82% of the U.S. adult population owns a smartphone. More than half of that population downloaded a fitness or health app to increase the physical activity level. The current review included studies that have utilized mobile apps in conjunction with other intervention strategies to increase physical activity levels. Methods: The search was conducted in five electronic databases. Studies were included if they were randomized controlled trials, utilized mobile apps, physical activity was the primary outcome, written in English, and conducted between the years of 2007 and 2019. Results: Thirteen studies were included in the final review. Results indicated …

Future Directions Of Doctor Of Public Health Education In The United States: A Qualitative Study, Chulwoo Park, Gene Migliaccio, Mark Edberg, Seble Frehywot, Geralyn Johnson

Faculty Research, Scholarly, and Creative Activity

Background: The Doctor of Public Health (DrPH) degree is an advanced and terminal professional degree that prepares the future workforce to engage in public health research, teaching, practice, and leadership. The purpose of the present research was to discuss the desirable future direction and optimal education strategies for the DrPH degree in the United States.

Methods: A total of 28 Council on Education for Public Health (CEPH)-accredited DrPH programs in the United States was identified through the Association of Schools and Programs of Public Health (ASPPH) Academic Program Finder. Then, a qualitative analysis was conducted to obtain perspectives from …

Global Analysis Of High Cited Papers On “Impact Of Covid-19 On Mental Health” During 2020-21, Ghouse Modin Nabeesab Mamdapur Mr., Brij Mohan Gupta Dr., Sandeep Grover Dr.

Library Philosophy and Practice (e-journal)

A bibliometric analysis based on 160 highly cited papers extracted from the Scopus international database was carried out to provide insights into literature characteristics and publication performances of various participating actors on “Impact of COVID-19 on Mental Health”. Quantitative and qualitative Indicators were applied to measure the productivity and citation impact of most productive participating countries, organizations, authors, journals and significant keywords and to visualise and measure collaborative interaction among them using VOSviewer software. Results obtained from this study can provide valuable information for researchers and policy-makers to identify present and future hotspots in research on “Impact of COVID-19 on …

Analysis Of The Interdependence Of Physical And Technical Training Of Handball Players, Shuhrat Furkatjanovich Tulaganov

Eurasian Journal of Sport Science

Purpose: The purpose of the research was to study the relationship between the physical training of highly qualified handball players and technical training, to give methodological instructions for their improvement.

Methods: 1. Analysis of the existing special scientific and methodological literature and study of their experience 2. Pedagogical observation of the training and competitive processes of handball players 3. Acceptance of control standards from athletes 4. Mathematical and statistical methods (comparison method).

Results: As a result of the study, the physical training of highly qualified handball players and their relationship with the effectiveness of technical and tactical movements were studied. …

Features Of Motor Skills Display By Young Gymnasts At The Stage Of Initial Training, Djamshid Khasanovich Umarov

Eurasian Journal of Sport Science

Purpose: The purpose of this study is to show the dynamics of development of speed and power capabilities of preschool and young children.

Methods: 1. Pedagogical observations; 2. Questionnaires; 3. Electrical registration of time parameters; 4. Pedagogical experiment; 5. Mathematical and statistical analysis.

Results: During the experiment, a close relationship was revealed between the flight time indicator and the results of a jump up from a place: at the age of 5, with the result of a jump up from a place with a wave of the hands-r=0.763, and at the age of 6 and 7, with the results of …

Medical School Watercooler Newsletter - June 2, 2021, Lindsey Lyle

Watercooler Newsletter

This is the June 2, 2021 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Medical students create video to answer COVID-19 vaccine questions in Spanish
• Video online: 'Treating the Enlarged Prostate in the Modern Era'
• Meet a Med Student: Isabelle Delplanche
• Faculty Spotlight: Abu-Bakr Al-Mehdi, M.D., Ph.D.
• Alumna reflects on groundbreaking career as a Black female gynecologic surgeon

Ethiopian Medicinal Plants Traditionally Used For The Treatment Of Cancer; Part 3: Selective Cytotoxic Activity Of 22 Plants Against Human Cancer Cell Lines, Solomon Tesfaye, Hannah Braun, Kaleab Asres, Ephrem Engidawork

Faculty and Student Publications

Medicinal plants have been traditionally used to treat cancer in Ethiopia. However, very few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro‐ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol extracts of 22 plants against human peripheral blood mononuclear cells (PBMCs), as well as human breast (MCF‐7), lung (A427), bladder (RT‐4), and cervical (SiSo) cancer cell lines. Active extracts were further screened against human large cell lung carcinoma (LCLC‐103H), pancreatic cancer (DAN‐G), ovarian cancer (A2780), and squamous cell carcinoma of …

2021-06-02_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-06-02_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-06-02_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Adopting A Conceptual Validity Framework For Testing In Speech-Language Pathology, Olivia Daub, Barbara Jane Cunningham, Marlene P. Bagatto, Andrew M. Johnson, Elaine Y. Kwok, Rachael E. Smyth, Janis Oram Cardy

Communication Sciences and Disorders Publications

Purpose Limited evidence-based guidelines for test selection continue to result in inconsistency in test use and interpretation in speech-language pathology. A major barrier is the lack of explicit and consistent adoption of a validity framework by our field. In this viewpoint, we argue that adopting the conceptual validity framework in the Standards for Educational and Psychological Testing (American Educational Research Association et al., 2014) would support both the development of more meaningful and feasible clinical tests and more appropriate use and interpretation of tests in speech-language pathology. Method We describe and evaluate the (American Educational Research Association et al., 2014) …

Detection Methods And Clinical Applications Of Circulating Tumor Cells In Breast Cancer, Hongyi Zhang, Xiaoyan Lin, Yuan Huang, Minghong Wang, Chunmei Cen, Shasha Tang, Marcia R. Dique, Lu Cai, Manuel A. Luis, Jillian Smollar, Yuan Wan, Fengfeng Cai

Publications and Research

Circulating Tumor Cells (CTCs) are cancer cells that split away from the primary tumor and appear in the circulatory system as singular units or clusters, which was first reported by Dr. Thomas Ashworth in 1869. CTCs migrate and implantation occurs at a new site, in a process commonly known as tumor metastasis. In the case of breast cancer, the tumor cells often migrate into locations such as the lungs, brain, and bones, even during the early stages, and this is a notable characteristic of breast cancer. Survival rates have increased significantly over the past few decades because of progress made …

Maximizing The Potential Of Aggressive Mouse Tumor Models In Preclinical Drug Testing., M Tarek Elghetany, Jia-Min Ho, Lois Hew Shi-Qi, Sekar Karthik, Jack M F Su, Qi Lin, Yuchen Du, Jianhe Shen, Wing-Yuk Chow, Ching C Lau, Adekunle Adesina, Angela Major, Anat Erdreich-Epstein, Kam-Man Hui, Xiao-Nan Li, Wan-Yee Teo

Faculty Research 2021

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive embryonal brain tumor among infants and young children. Two challenges exist for preclinical testing in ATRT. First, genetically quiet, ATRT is a difficult tumor to target molecularly. Tumor cells need to divide to propagate tumor growth-intercepting the common crossroads in cell cycle progression is a feasible strategy. KIF11 is needed for bipolar spindle formation in metaphase. We identified KIF11 as a universal target of all ATRT-molecular-subtypes. Ispinesib, a KIF11-inhibitor, effectively inhibited tumor proliferation in all seven cell lines. A second challenge-a major challenge in preclinical drug testing in-vivo among aggressive tumor models, …

Examining The Feasibility Of Partnering With Cooperative Extension To Advance Statewide Physical Education Policies In Oregon, Nina Taylor, Thomas Packebush, Tammy Winfield, Kathy Gunter

Journal of Human Sciences and Extension

Optimizing physical education (PE) is a proven approach to increase children’s physical activity. Oregon law requires elementary schools to provide PE for > 150 minutes/week. One strategy to meet the required minutes is for classroom teachers to deliver PE, which is permissible using curricula aligned to national PE standards. Be Physically Active 2Day (BEPA 2.0) is a unique classroom-based physical activity brain break curriculum aligned to PE standards. We evaluated the effectiveness of training school faculty to use BEPA 2.0 via a unique partnership with Cooperative Extension. Extension trainers (ET) were trained by a BEPA 2.0 Master Trainer (MT). School faculty …

A Process Evaluation Of The Happyhealthy Social Marketing Campaign, Laura H. Downey, Kristy Terp, Sylvia H. Byrd

Journal of Human Sciences and Extension

Social marketing campaigns are effective in promoting health behavior changes in individuals and communities. Mississippi State University Extension Service’s (MSU Extension) Office of Nutrition Education launched a statewide social marketing campaign branded HappyHealthy to target nutrition and healthy lifestyle-related behaviors of Supplemental Nutrition Assistance Program-eligible individuals and families. In this study, a process evaluation was conducted with MSU Extension staff to assess perceptions of the campaign’s relative advantage, compatibility, complexity, trialability, and observability. In the early stages of the campaign, external evaluators conducted in-depth interviews with MSU Extension staff members (n = 17). After the campaign had been active for …

Dating App Use Among Rural Men Who Have Sex With Men And Its Relationship To Hiv Prevention And Risk Behaviors: A Mixed-Methods Analysis, Lauren Bineau, Danielle Lambert, Natalia Truszczynski, Nathan Hansen, Carolyn Lauckner

Center for Health Equity Transformation Faculty Publications

INTRODUCTION: Men who have sex with men (MSM) in rural areas have limited access to HIV prevention and education resources. Given the growing usage of mobile dating apps among the wider MSM population, this research sought to explore their use among MSM in rural areas and their potential for delivering HIV prevention information.

METHODS: Participants were recruited from different areas of the rural Southern USA. This mixed-methods study consisted of an online survey (n=85) and follow-up qualitative phone interviews with 20 survey respondents. The survey assessed dating app use, sexual behaviors, and pre-exposure prophylaxis (PrEP) awareness, usage, and attitudes among …

Discovery Of Widespread Transcription Initiation At Microsatellites Predictable By Sequence-Based Deep Neural Network., Mathys Grapotte, Manu Saraswat, Chloé Bessière, Christophe Menichelli, Jordan A Ramilowski, Jessica Severin, Yoshihide Hayashizaki, Masayoshi Itoh, Michihira Tagami, Mitsuyoshi Murata, Miki Kojima-Ishiyama, Shohei Noma, Shuhei Noguchi, Takeya Kasukawa, Akira Hasegawa, Harukazu Suzuki, Hiromi Nishiyori-Sueki, Martin C Frith, Fantom Consortium, Clément Chatelain, Piero Carninci, Michiel J L De Hoon, Wyeth W Wasserman, Laurent Bréhélin, Charles-Henri Lecellier, Judith A. Blake, Carol J Bult

Faculty Research 2021

Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene and initiate at unconventional regions, outside promoters or enhancers. Here, we probe these unassigned TSSs and show that, in all species studied, a significant fraction of CAGE peaks initiate at microsatellites, also called short tandem repeats (STRs). To confirm this transcription, we develop Cap Trap RNA-seq, a technology which combines cap trapping and long read MinION sequencing. We train sequence-based deep …

Rebuilding Trust On Routine Immunization In Era Of Covid-19 Fear-Role That Civil Society Organizations Can Play Hands-In-Hand With Immunization Program, Ameer Muhammad, Daniyaal Ahmad, Eleze Tariq, Yasir Shafiq

Medical College Documents

No abstract provided.

A Qualitative Analysis Of Young Adults’ Health And Wellness Perceptions, Behaviors, And Information Seeking, Heejae Lee, Sheri Worthy

Journal of Human Sciences and Extension

Access to health- and wellness-related resources is unprecedented, and the desire to attain and use that information is high. However, the information is not always accurate, and individuals may be selectively choosing the information they read and follow. Additionally, although Americans have access to more health and wellness information than ever before, rates of obesity, hypertension, and sedentary lifestyles are still high. This study investigated information seeking for health and wellness-related resources by healthy, educated, young adults and their health and wellness perceptions and behaviors. Five focus groups were conducted with 35 young adults to gather information about diet, exercise, …