Medicine and Health Sciences Commons^™

The Food Factor: Relating Brand Viewership To Behavior And Behavioral Intention, Mckayla Brubaker Nichols, Quisto Settle, Alisha Hardman, Laura Downey

Journal of Human Sciences and Extension

Mississippi residents (n = 404) were surveyed to determine how The Food Factor brand viewership impacted their behavior and behavioral intention. The Food Factor is a weekly Extension mass media program that communicates research-based information about food, nutrition, and healthy lifestyles. A researcher-developed instrument was used to collect information about behavior and behavioral intent, as well as perceptions of The Food Factor using Qualtrics from a representative sample. Respondents were split into viewer and non-viewer categories. Viewers were asked about their viewing frequency and their nutrition-related behaviors and behavioral intention to create a behavioral score. Non-viewers were also asked about …

Barriers And Facilitators To Implementing Healthy Food Retail Programs: Extension Agents’ Perceptions, Kristin Riggsbee, Alexandra Nussbaumer Gardner, Elizabeth L. Hall, Elizabeth Anderson-Steeves, Christopher T. Sneed, Janie Burney, Sarah Colby

Journal of Human Sciences and Extension

The purpose of this cross-sectional study was to understand the perceptions Extension professionals have about healthy food retail programs (HFRPs). Family and Consumer Science (FCS) agents from one state in the southeastern United States were interviewed about their definitions of HFRPs, what challenges and benefits existed, and strategies for successful HFRP implementation. Participants reported that HFRPs would bring immense benefits to their communities, including expanding the recognition of Extension. However, one specific suggestion that was identified was hands-on training needed before initiating HFRPs, particularly on strategies for relationship development with retail store owners.

Full Issue, Volume 9, Number 2, Donna J. Peterson, Kathleen Kelsey, Scott Cummings

Journal of Human Sciences and Extension

No abstract provided.

Move More, Sit Less: Applying The Physical Activity Guidelines For Americans To Extension Programs, Laura E. Balis, Hannah F. Fuerniss, Drew T. Brown, Chance Marshall, Samantha M. Harden

Journal of Human Sciences and Extension

Extension enhances the lives of Americans by translating research-based information related to existing needs into programming that is practical and accessible to the general public. Evidence clearly indicates that physical activity is correlated to positive health outcomes, but despite this conclusion, the majority of Americans do not meet the recommendations for physical activity. The 2nd Edition of the Physical Activity Guidelines for Americans provides guidance for Extension professionals to implement physical activity interventions. We recommend training and technical assistance strategies based on the Interactive Systems Framework to integrate physical activity promotion into all Extension areas.

The Roles Of Tumor-Derived Exosomes In Altered Differentiation, Maturation And Function Of Dendritic Cells, Reza Hosseini, Leila Asef-Kabiri, Hassan Yousefi, Hamzeh Sarvnaz, Majid Salehi, Mohammad Esmaeil Akbari, Nahid Eskandari

School of Graduate Studies Faculty Publications

Tumor-derived exosomes (TDEs) have been shown to impede anti-tumor immune responses via their immunosuppressive cargo. Since dendritic cells (DCs) are the key mediators of priming and maintenance of T cell-mediated responses; thus it is logical that the exosomes released by tumor cells can exert a dominant influence on DCs biology. This paper intends to provide a mechanistic insight into the TDEs-mediated DCs abnormalities in the tumor context. More importantly, we discuss extensively how tumor exosomes induce subversion of DCs differentiation, maturation and function in separate sections. We also briefly describe the importance of TDEs at therapeutic level to help guide …

Racial Disparity And Social Determinants In Receiving Timely Surgery Among Stage I–Iiia Non-Small Cell Lung Cancer Patients In A U.S. Southern State, Paige Neroda, Mei Chin Hsieh, Xiao Cheng Wu, Kathleen B. Cartmell, Rachel Mayo, Jiande Wu, Chindo Hicks, Lu Zhang

School of Medicine Faculty Publications

Delayed surgery is associated with worse lung cancer outcomes. Social determinants can influence health disparities. This study aimed to examine the potential racial disparity and the effects from social determinants on receipt of timely surgery among lung cancer patients in Louisiana, a southern state in the U.S. White and black stage I–IIIA non-small cell lung cancer patients diagnosed in Louisiana between 2004 and 2016, receiving surgical lobectomy or a more extensive surgery, were selected. Diagnosis-to-surgery interval >6 weeks were considered as delayed surgery. Social determinants included marital status, insurance, census tract level poverty, and census tract level urbanicity. Multivariable logistic …

Gene Expression Analysis Of Environmental Temperature And High-Fat Diet-Induced Changes In Mouse Supraclavicular Brown Adipose Tissue, Yufeng Shi, Honglei Zhai, Sharon John, Yi-Ting Shen, Yali Ran, Giang Hoang, Miao-Hsueh Chen

Children’s Nutrition Research Center Staff Publications

Obesity, a dysregulation of adipose tissue, is a major health risk factor associated with many diseases. Brown adipose tissue (BAT)-mediated thermogenesis can potentially regulate energy expenditure, making it an attractive therapeutic target to combat obesity. Here, we characterize the effects of cold exposure, thermoneutrality, and high-fat diet (HFD) feeding on mouse supraclavicular BAT (scBAT) morphology and BAT-associated gene expression compared to other adipose depots, including the interscapular BAT (iBAT). scBAT was as sensitive to cold induced thermogenesis as iBAT and showed reduced thermogenic effect under thermoneutrality. While both scBAT and iBAT are sensitive to cold, the expression of genes involved …

Nutrition, A Tenet Of Lifestyle Medicine But Not Medicine?, Leigh A. Frame

Clinical Research and Leadership Faculty Publications

Nutrition is a foundation of health and one of six pillars of Lifestyle Medicine. The importance of nutrition in clinical care is now widely recognized by health care professionals and the public. However, clinicians are not comfortable counselling their patients on nutrition due to inadequate or lack of training, leaving a significant need in patient care. This gap can be closed with evidence-based curricula in medical schools and in the trainings of other health care professionals. This communication presents the current state of nutrition knowledge in health care, emphasizing nutrition education for physicians, and presents a model of how pre- …

Integration Of Circulating Tumor Cell And Neutrophil-Lymphocyte Ratio To Identify High-Risk Metastatic Castration-Resistant Prostate Cancer Patients., Weelic Chong, Zhenchao Zhang, Rui Luo, Jian Gu, Jianqing Lin, Qiang Wei, Bingshan Li, Ronald E. Myers, Phd, Dsw, Grace Lu-Yao, William Kevin Kelly, Chun Wang, Hushan Yang

Department of Medical Oncology Faculty Papers

BACKGROUND: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and circulating tumor cells (CTCs) have been associated with survival in castration-resistant prostate cancer (CRPC). However, no study has examined the prognostic value of NLR and PLR in the context of CTCs.

METHODS: Baseline CTCs from mCRPC patients were enumerated using the CellSearch System. Baseline NLR and PLR values were calculated using the data from routine complete blood counts. The associations of CTC, NLR, and PLR values, individually and jointly, with progression-free survival (PFS) and overall survival (OS), were evaluated using Kaplan-Meier analysis, as well as univariate and multivariate Cox models.

RESULTS: …

Exploring The Perceived Barriers And Benefits Of Physical Activity Among Wounded, Injured, And/Or Sick Military Veterans, Robert Walker, Caroline Limbert, Paul M. Smith

Journal of Social, Behavioral, and Health Sciences

Wounded, injured, and/or sick (WIS) military veterans face significant physical and psychosocial challenges following discharge from service. Physical activity can have many positive effects on the holistic wellbeing of such individuals. However, little knowledge exists regarding the perceived barriers and benefits of physical activity within this population, creating challenges surrounding physical activity promotion. Therefore, this study was designed to identify key barriers and benefits among this population, so that informed approaches to encourage participation in physical activity can be developed. A questionnaire related to the perceived barriers and benefits of physical activity was completed by 105 WIS British military veterans. …

Transient Leukopenia, Thrombocytopenia, And Severe Neutropenia Associated With Acute Sars-Cov-2 Infection, Austin Schatzman, Julia Vandenheuvel Md, Tibisay Villalobos Md, Kris Rooney Md

Department of Pediatrics

No abstract provided.

Ischemic Volkmann Contracture From Intrauterine Compartment Syndrome, Julia Vandenheuvel Md, Robert Teixeira Md, Ethan Song Ba, Scott Kozin Md, Scott Rice Md

Department of Pediatrics

No abstract provided.

Developmental Ethanol Exposure Causes Central Nervous System Dysfunction And May Slow The Aging Process In A Drosophila Model Of Fetal Alcohol Spectrum Disorder, Khaoula Belhorma, Nahed Darwish, Elizabeth Benn-Hirsch, Annalisa Duenas, Hillary Gates, Navneet Sanghera, Jodie Wu, Rachael L. French

Faculty Research, Scholarly, and Creative Activity

Alcohol is a known teratogen, and developmental exposure to ethanol results in fetal alcohol spectrum disorder (FASD). Children born with FASD can exhibit a range of symptoms including low birth weight, microcephaly, and neurobehavioral problems. Treatment of patients with FASD is estimated to cost 4 billion dollars per year in the United States alone, and 2 million dollars per affected individual's lifetime. We have established Drosophila melanogaster as a model organism for the study of FASD. Here we report that mutations in Dementin (Dmtn), the Drosophila ortholog of the Alzheimer's disease-associated protein TMCC2, convey sensitivity to developmental ethanol exposure, …

The Digital Divide And Health: Examining Digital Access As A Social Determinant Of Health, Elizabeth Melissa Withers

Dissertations and Theses

This dissertation is comprised of three papers that consider ways in which one's level of digital access may impact self-rated health. Data are from multiple years of three separate nationally representative cross-sectional surveys: National Health Interview Survey, General Social Survey, and Health Information National Trends Survey to address the primary overarching research question: Is there an association between digital access and health? The examination of the relationship between digital access and health is situated within a social determinants of health perspective and draws on van Dijk's (2005) causal and sequential model of digital access. Education, income, race and ethnicity, work …

Sustainability Of Community Engagement At Institutions Of Higher Education: A Look At Compassion Fatigue And The College Student Mental Health Crisis, Katherine A. Chiu, Briana G. Craig, Naomi L. Rabago

VA Engage Journal

This study investigated one of the many factors contributing to the sustainability of community engagement efforts at institutions of higher education. Extensive literature shows that burnout and compassion fatigue disproportionately affect those in caring roles and helping professions. Moreover, studies have found significant correlations between levels of burnout and compassion fatigue and the likelihood of human error, which directly affects the safety and long-term outcomes of people within their care. However, there is still limited exploration of how these phenomena may manifest, and similarly, cause unintentional harm to vulnerable populations, in the context of student community engagement efforts. This paper …

Iatrogenic Electrocautery Damage And Cellular-Based Corrosion Of Total Joint Arthroplasty Biomaterials, Kirsten Carol Miller

Theses and Dissertations (ETD)

Introduction. The number of patients undergoing a Primary Total Knee Arthroplasty (PTKA) has been increasing steadily each year. Of those PTKA patients, 20% report long-term pain and/or some functional deficit. Cobalt-Chromium-Molybdenum (CoCrMo) alloy is one of the most used materials in Total Joint Arthroplasty (TJA) implants due the material’s high strength, high corrosion resistance, and biocompatibility. The release of metal ions and potential occurrence of metallosis in TJA has been shown to be detrimental to the longevity of the implant. The mechanisms leading to this increase in metal ion concentrations have been up for debate, with some believing it is …

Near-Field Electrospinning And Characterization Of Biodegradable Small Diameter Vascular Grafts, William E. King Iii

Theses and Dissertations (ETD)

The ideal “off the shelf” tissue engineering, small-diameter (< 6 mm inner diameter (ID)) vascular graft hinges on designing a template that facilitates transmural ingrowth of capillaries to regenerate an endothelized neointimal surface. Previous traditionally electrospun (TES) approaches to create bioresorbable vascular grafts lack the pore sizes required to facilitate transmural capillary ingrowth required for successful in situ neovascular regeneration. Therefore, the ability to create scaffolds with program-specific architectures independent of fiber diameter via the relatively recent sub-technique of near-field electrospinning (NFES) represents a promising solution to create tissue engineering vascular grafts. These programmed large pore sizes are anticipated to promote in situ regeneration and improve the outcomes as well as the quality of life of patients with arterial disease.

In this dissertation, we manufactured via NFES as well as characterized biodegradable polydioxanone (PDO) small-diameter vascular grafts. Chapter 1 introduces the need for off-the-shelf, small-diameter vascular grafts to facilitate in situ regeneration, the process and pore size limitations of TES vascular grafts, and the promising use of NFES to develop precisely tailored PDO vascular grafts. Chapter 2 describes the process of NFES and details the current progress in NFES of biomedical polymers as well as the major limitations that exist in the field. Chapters 3, 4, and 5 contain primary research …

The Effects Of Coronavirus Victimization Distress And Coronavirus Racial Bias On Mental Health Among Aian, Asian, Black, And Latinx Young Adults, Celia B. Fisher, Xiangyu Tao, Tiffany Yip

Covid-19 Digital Research

Rationale U.S. Racial/ethnic minorities have been disproportionately impacted by the COVID-19 pandemic in rates of infection and morbidity. Pre-pandemic racial discrimination has been associated with depression and general anxiety. However, the effect of Coronavirus specific forms of discrimination on mental health have not been examined. This study assessed the effect of previously identified social determinants of mental health and COVID-19 specific victimization and racial bias beliefs on depression and anxiety among young adults of color in the U.S.

Methods A national online survey of 399 AIAN, Asian, Black, and Latinx adults (18 – 25 years) included demographic variables, COVID-19 health …

Perceived Impact Of Healthcare, Asha K B

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Designing A Comprehensive Framework Of Immunization Information System For Routine Immunisations Services During The Pandemic., Renu Nair

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Accuracy Of Underlying Cause Of Death: A Cross-Sectional Study Among Multispecialty Hospitals In An Urban Setting, Nadar Christlin Louis Albert Raj

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Comparison Of Knowledge, Attitude, And Practice Towards The Use Of Sunscreen In Daily Life Between First -And Third -Year Medical Students, Aarushi Lall

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

A Systematic Review Of Recommendations For Behavioral Health Services For Transgender And Gender Diverse Adults: The Three-Legged Stool Of Evidence-Based Practice Is Unbalanced, Natalie Holt, Allura L. Ralston, Debra A. Hope, Richard Mocarski, Nathan Woodruff

Trans Collaborations Academic Papers

There is a growing literature of clinical recommendations for transgender and gender diverse (TGD) affirming behavioral health care, yet it is unknown to what extent these recommendations are rooted in evidence-based practice (EBP). This systematic review included 65 articles published between 2009 and 2018 with recommendations for behavioral health services with TGD adults, emphasizing general clinical care. Coded variables included type of article, participant demographics, aspects of EBP, and whether care was informed by objective assessment. Most articles did not equally draw from all components of EBP. Recommendations for specific clinical problems are increasingly available and address diversity within TGD …

Recorded Maternal Song To Reduce Crying Duration In Neonatal Abstinence Syndrome, Alecia Cunniff

Yale School of Medicine Physician Associate Program Theses

Neonatal abstinence syndrome is a constellation of symptoms that include high pitched crying and irritability resulting from abrupt postnatal cessation of opioid exposure. Maternal recorded song reduces crying duration in preterm and full-term infants. However, the effect of maternal recorded song on crying duration in affected infants is unknown. In this prospective single-blind randomized control trial, we compare the effect of maternal recorded song and ambient noise in reducing crying duration in infants with neonatal abstinence syndrome. We hypothesize that exposure to maternal recorded song will result in a significant difference in mean duration of crying compared to ambient noise …

Computerized Cognitive Behavioral Therapy In Adolescents And Young Adults With Substance Use Disorder, Madeline Sadlowski

Yale School of Medicine Physician Associate Program Theses

Substance use disorder is a condition that affects the brain and results in the inability of a person to manage their substance use. Approximately 9% of adolescents and young adults in the United States suffer from a substance use disorder, and the majority that receive treatment relapse within 6 months. Adolescents and young adults, especially those with low socioeconomic status, have access to fewer resources for treatment. In this study, we will assess an accessible computer-based cognitive behavioral therapy for treatment in adolescents and young adults with substance use disorders as an efficacious and durable treatment. We will use a …

Video Cognitive Behavioral Therapy To Prevent Depression In Patients With Inflammatory Bowel Disease, Monica Narsolis

Yale School of Medicine Physician Associate Program Theses

Inflammatory bowel disease patients have higher rates of depression and anxiety compared to other diseases and the general population, which can lead to a lower quality of life. There is a critical need to investigate treatments for mental health in patients with inflammatory bowel disease. Cognitive behavioral therapy is widely studied and has proven effective in improving depression. There are no randomized controlled trials comparing early psychotherapeutic intervention with standard of care for this population. We hypothesize that early initiation of cognitive behavioral therapy will reduce depression and anxiety severity and improve quality of life in newly diagnosed inflammatory bowel …

Timing The Ischemic Stroke By Multiparametric Quantitative Magnetic Resonance Imaging, Bryony Mcgarry, Risto Kauppinen

Books/Book Chapters

The advent of recanalization therapies has transformed the management of acute ischemic stroke patients. The timing of symptom onset is one of the key criteria for selecting the recanalization method as pharmacological and non- pharmacological recanalization therapies are only safe when administered within strict, but evolving, time windows. Magnetic resonance imaging (MRI) reveals ischemia within minutes and estimates ischemia duration in brain parenchyma. Preclinical studies have shown that by combining diffusion and relaxometric MRI, timing ischemic strokes is possible with clinically acceptable accuracy. MRI-based stroke timing techniques have been adopted in stroke clinics to stratify patients with unknown onset time …

Rap1a Regulates Cardiac Fibroblast Contraction Of 3d Diabetic Collagen Matrices By Increased Activation Of The Age/Rage Cascade, Stephanie D. Burr, James A. Stewart

Faculty and Student Publications

Cardiovascular disease is a common diabetic complication that can arise when cardiac fibroblasts transition into myofibroblasts. Myofibroblast transition can be induced by advanced glycated end products (AGEs) present in the extracellular matrix (ECM) activating RAGE (receptor for advanced glycated end products) to elicit intracellular signaling. The levels of AGEs are higher under diabetic conditions due to the hyperglycemic conditions present in diabetics. AGE/RAGE signaling has been shown to alter protein expression and ROS production in cardiac fibroblasts, resulting in changes in cellular function, such as migration and contraction. Recently, a small GTPase, Rap1a, has been identified to overlap the AGE/RAGE …

Risk Factors For Development Of Initial Clostridioides Difficile Infection, Jamie L. Wagner, Kayla R. Stover, Allison M. Bell, Katie E. Barber

Faculty and Student Publications

Objectives: The purpose of this study was to identify risk factors for initial complicated Clostridioides difficile infection (CDI). Methods: This retrospective cross-sectional study included adult patients with initial episodes of CDI who received ≥72 h of CDI-active antimicrobials. Patients were categorised into one of two groups: complicated CDI or uncomplicated CDI. A total of 513 patients were screened for inclusion, with complicated CDI patients exhibiting abnormal abdominal CT findings or experiencing death within 30 days post-CDI diagnosis. Results: A total of 203 patients met the inclusion criteria, comprising 143 (70.4%) with uncomplicated CDI and 60 (29.6%) with complicated CDI. Complicated …

Evidence That Maackia Amurensis Seed Lectin (Masl) Exerts Pleiotropic Actions On Oral Squamous Cells With Potential To Inhibit Sars-Cov-2 Infection And Covid-19 Disease Progression, Stephanie A. Sheehan, Kelly L. Hamilton, Edward P. Retzbach, Premalatha Balachandran

Faculty and Student Publications

COVID-19 was declared an international public health emergency in January, and a pandemic in March of 2020. There are over 125 million confirmed COVID-19 cases that have caused over 27 million deaths worldwide as of March 2021. COVID-19 is caused by the SARS-CoV-2 virus. SARS-CoV-2 presents a surface “spike” protein that binds to the ACE2 receptor to infect host cells. In addition to the respiratory tract, SARS-Cov-2 can also infect cells of the oral mucosa, which also express the ACE2 receptor. The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection. Maackia …