Medicine and Health Sciences Commons^™

Spiritual Behavior And Stress In Adolescents: An Initial Study, Sumiyati Tarniyah, Laili Nur Hidayati

Jurnal Keperawatan Indonesia

Spirituality is often associated with mental health, including stress. Older people tend to have high rates of involvement in spirituality rather than young people. This study aimed to identify the relationship between spiritual behavior and the stress levels of 152 high school students, using a descriptive correlation research design. The data collection techniques involved a spiritual dimension scale questionnaire and the Depression Anxiety Stress Scale 42 (DASS 42). The data were analyzed using Spearman's rho correlation test. The results show that the spiritual behavior distribution was mostly in the moderate category (53.3%), and stress level distribution was primarily in the …

Future Space Missions And Human Enhancement: Medical And Ethical Challenges, Konrad Szocik, Mark Shelhamer, Martin Braddock, Francis A. Cucinotta, Chris Impey, Pete Worden, Ted Peters, Milan M. Ćirković, Kelly C. Smith, Koji Tachibana, Michael J. Reiss, Ziba Norman, Arvin M. Gouw, Gonzalo Munévar

Health Physics and Diagnostic Sciences Faculty Research

Future human space missions to Mars and beyond may be realized for different research, economic, political or survival reasons. Since space remains a hazardous environment for humans, space exploration and exploitation requires the development and deployment of effective countermeasures. In this paper, we discuss prospects for human enhancement by gene editing, synthetic biology, or implants, for the purposes of future space missions. We argue that there are good reasons to consider such options, and that ethical arguments can be made in favor of human enhancement to enable long-term space exploration.

Towards Laparoscopic Visual Ai: Development Of A Visual Guidance System For Laparoscopic Surgical Palpation, Kerwin G. Caballas, Harold Jay M. Bolingot, Nathaniel Joseph C. Libatique, Gregory L. Tangonan

Electronics, Computer, and Communications Engineering Faculty Publications

Currently, there are numerous obstacles to performing palpation during laparoscopic surgery. The laparoscopic interface does not allow access into a patient's body anything other than the tools that are inserted through the trocars. Palpation is usually done with the surgeon's hands to detect lumps and certain anomalies underneath the skin, muscle, or tissues. It can be useful technique for augmenting surgical decision-making during laparoscopic surgery, especially when discerning operations involving cancerous tumors. Previous research demonstrated the use of tactile sensors and mechanical sensors placed at the end-effectors for palpating laparoscopically. In this study, a visual guidance system is proposed for …

Developing An Epitope-Based Malaria Vaccine Targeting The Circumsporozoite Protein, Lucie Jelinkova

Biomedical Sciences ETDs

Malaria is a life-threatening parasitic disease that is spread to humans by mosquitos. Developing a successful vaccine for malaria has been a remarkable challenge. Plasmodium falciparum, the causative agent of malaria, is a complex organism that transforms into unique forms and infects multiple organs within the human host throughout its life cycle. In these studies we describe a virus-like particle (VLP)-based approach to developing a vaccine for malaria that targets discrete and specific sites on invading sporozoites during the pre-erythrocytic stage of infection. VLPs are noninfectious, self-assembling particles derived from viral structural proteins, and are safe and highly immunogenic. …

The Healthcare Needs Of Families Caring For Patients With Pulmonary Tuberculosis, Astuti Yuni Nursasi, Nadya Tiara Sabila, Muhamad Jauhar

Jurnal Keperawatan Indonesia

Tuberculosis (TB) is a global public health problem. Families need to meet healthcare needs during the treatment of TB sufferers. This study aims to identify healthcare needs of families caring for patients with the disease. The cross-sectional study involved 83 families caring for TB patients. The research was conducted at a Primary Healthcare Center in an urban area in West Java. The results revealed that 60.2% of caregivers were 18–40 years old, 60.2% were female, 51.8% were senior high school educated, 43.4% were housewives, 86.7% had an income under the regional minimum wage, and 55.4% had cared for the TB …

Hypertension Self-Care Management During Covid-19 Pandemic Crisis In The Meranao Tribe: A Phenomenological Inquiry, Jonaid M. Sadang, Sittie Inshirah P. Macaronsing, Narima M. Alawi, Normala M. Taib, Hamdoni K. Pangandaman

Jurnal Keperawatan Indonesia

The COVID-19 crisis has been a challenging and stressful event for individuals with known underlying health problems, not to mention their higher risk of contracting the disease. This phenomenological inquiry was conducted to explore the common self-care practices of the Meranao tribe in the Province of Lanao del Sur, Philippines, concerning their management of hypertension amidst the ongoing pandemic health crisis. This study employed a descriptive-phenomenological approach. Ten known hypertensive adults participated in the study selected using purposive sampling. Data collection employed focus group discussion (FGD) and then analyzed using Colaizzi's approach. Four themes were derived which explained the common …

Peripheral Nerve Stimulation: A Review Of Techniques And Clinical Efficacy, Alan D. Kaye, Sasha Ridgell, Edward S. Alpaugh, Aya Mouhaffel, Aaron J. Kaye, Elyse M. Cornett, Azam A. Chami, Rutvij Shah, Bruce M. Dixon, Omar Viswanath, Ivan Urits, Amber N. Edinoff, Richard D. Urman

School of Medicine Faculty Publications

Chronic pain is a common source of morbidity in many patient populations worldwide. There are growing concerns about the potential side effects of currently prescribed medications and a continued need for effective treatment. Related to these concerns, peripheral nerve stimulation has been regaining popularity as a potential treatment modality. Peripheral nerve stimulation components include helically coiled electrical leads, which direct an applied current to afferent neurons providing sensory innervation to the painful area. In theory, the applied current to the peripheral nerve will alter the large-diameter myelinated afferent nerve fibers, which interfere with the central processing of pain signals through …

Gray Matter Volumes Discriminate Cognitively Impaired And Unimpaired People With Hiv, Mikki Schantell, Brittany K. Taylor, Brandon Lew, Jennifer O'Neill, Pamela E. May, Susan Swindells, Tony W. Wilson

Journal Articles: Infectious Diseases

BACKGROUND: Current diagnostic criteria of HIV-associated neurocognitive disorders (HAND) rely on neuropsychological assessments. The aim of this study was to evaluate if gray matter volumes (GMV) can distinguish people with HAND, neurocognitively unimpaired people with HIV (unimpaired PWH), and uninfected controls using linear discriminant analyses.

METHODS: A total of 231 participants, including 110 PWH and 121 uninfected controls, completed a neuropsychological assessment and an MRI protocol. Among PWH, HAND (n = 48) and unimpaired PWH (n = 62) designations were determined using the widely accepted Frascati criteria. We then assessed the extent to which GMV, corrected for intracranial volume, could …

Determinants Of Vaccine Hesitancy In Indonesia: A Scoping Review, Nuril Hanifah, Ike Herdiana, Rahkman Ardi

Makara Human Behavior Studies in Asia

Complete children immunization coverage in Indonesia declined from 59.2% in 2013 to 57.9% in 2016. Therefore, a study on understanding the vaccination barrier is necessary to improve future coverage. This scoping review aims to identify the determinants of vaccine hesitancy using the model of the World Health Organization-Strategic Advisory Group of Expert (WHO-SAGE) working group and to map them on the basis of region, target population, and vaccine. This research used publications from seven databases (Science Direct, Wiley, Scopus, SAGE, PubMed, Springer, and Taylor & Francis) from 2015 to 2020. A total of 10,212 publications were identified and filtered by …

Availability And Adequacy Of Water, Sanitation And Hygiene (Wash) Facilities In Secondary Schools, Rotimi Williams Olatunji, Noeem Thanny Taiwo

Journal of Environmental Science and Sustainable Development

Hand-washing practice, which is globally recognized as the simplest, most affordable and effective way of curtailing the spread of infectious diseases, is still low in developing countries. This is largely influenced by the dearth and adequacy of Water, Sanitation and Hygiene (WASH) facilities. This paper investigated the level of availability and adequacy of WASH facilities in secondary schools in a developing, sub-Sharan country, particularly Lagos State, Nigeria. Protection Motivation Theory (PMT) guided this research. In all, 620 pupils were selected through multi-stage sampling methods. Two local government areas were selected from each of the three senatorial zones in the study …

Contraception Choice And Compliance Among Mothers With Opioid Addiction: Identifying Barriers To Care, Robert C. Bowers, Catherine Waldron, Jennie Yoost, Hayley Weese, Amy Roy

Marshall Journal of Medicine

Introduction

West Virginia leads the nation in substance abuse deaths per capita. This epidemic has given rise to a novel population of high-risk, obstetric patients with opiate abuse. Appropriate education, counseling, and implementation of contraception are of extreme importance among this population, due to the risks of unintended pregnancy.

Methods

This study was a retrospective chart review to determine compliance and uptake of contraceptive methods by patients in a maternal buprenorphine maintenance program prior to and following implementation of standardized contraception education and Medicaid coverage of immediate postpartum long-acting reversible contraceptives (LARC). Rates of planned contraception and rates of actual …

Physician Burnout Among West Virginia Primary Care Providers, Kevin S. Mccann, Adam Baus, Joanna Bailey, Laura Boone, Jennifer Boyd, Martha Cook-Carter, Dan Doyle

Marshall Journal of Medicine

Introduction

Work related burnout is highly prevalent in US physicians and linked to adverse effects on patients, providers and organizations. This study measures burnout in West Virginia (WV) primary care providers, allowing for comparison of results to a similar, recent study of US physicians.

Methods

Anonymous survey through email that included Maslach Burnout Inventory, demographic, workload, and practice characteristics. Responses were analyzed using JMP Pro 13. Analysis used JMP Pro 13 for descriptive statistics, chi-square and regression modeling.

Results

Subjects = 110, female/male ratio 1.4, all primary care physicians (PCP), or advanced practice registered nurses or physician assistants (APRN/PA). PCP …

The Role Of Stenting In Management Of Isolated Symptomatic Basilar Artery Stenosis, Amrita Valluri, Morgan Aguirre, James Reynolds, Justin Nolte

Marshall Journal of Medicine

Isolated basilar artery stenosis (BAS) is a rare etiology of ischemic neurologic conditions. First-line treatment of symptomatic stenosis is typically medical therapy as outlined in the Warfarin–Aspirin Symptomatic Intracranial Disease (WASID) trial and the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial.1,2 We present the case of a male in his 60s with isolated BAS who failed maximal medical treatment but experienced a decrease in transient ischemic attacks and acute ischemic stroke occurrences after angioplasty and stenting.

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Diagnosis Obscured By Concomitant Recreational Drug Use, Paige Lester Ms Ii, Adam M. Franks Md, William Rollyson Ms Iv, Jenna K. Barbour Md, Matthew B. Curry Md

Marshall Journal of Medicine

Anti-NMDA receptor encephalitis (aNMDAre) is a relatively newly discovered autoimmune and inflammatory disorder affecting the limbic system. It has a clinical course that includes Prodromal, Psychiatric, Unresponsive and Hyperkinetic stages. These stages are often confused with mental health issues in the medical literature, but they also share symptoms of various drug intoxication and withdrawal states. Implicit bias in physicians regarding substance use disorder and patient demographics can impair delivery of care and outcomes in patients with aNMDAre, especially in an environment of recreational drug use. When clinical presentation aligns, this diagnosis should be investigated as soon as possible, even in …

Bethlem Myopathy Demonstrated In Three Generations Of A Rural West Virginia Family Carrying An Autosomal Dominant Col6a3 Mutation, Holly Farkosh, Dominika Lozowska Md

Marshall Journal of Medicine

Mutations in the genes that code for type VI collagen can lead to what are known as the collagenopathies (collagen VI myopathies), such as Bethlem myopathy (BTHLM1), which affect structural tissues like muscles and tendons. We present the case of a young female and her two relatives, who were discovered to share the autosomal dominant COL6A3 mutation and whose presentation in clinic varied from mild to severe. Type VI collagenopathies represent a clinically and genetically heterogeneous spectrum of disorders generally characterized by muscle weakness and joint contractures. We highlight the importance of examining close relatives whenever possible and documenting a …

Plasmablastic Lymphoma Of The Kidney In A Previously Undiagnosed Hiv Patient, Amrita Valluri, Adarsh Sidda, Anisha Valluri, Gurusidda Manu, Niru Nahar

Marshall Journal of Medicine

We present the case of a 61-year-old male who presented with flank pain and dysuria. A biopsy and histopathological analysis of a mass found in the left kidney led to the diagnosis of plasmablastic lymphoma (PBL). The kidney is not a commonly reported site of presentation for PBL in the current literature.^1,2 As a part of routine workup, HIV testing was ordered resulting in positive preliminary and confirmatory results. The patient denied awareness of his HIV status. Chemotherapy with uricosuric agents and antiretroviral therapy was initiated, but the patient developed tumor lysis syndrome with phosphate nephropathy leading to discontinuation …

Rem Behavior Disorder And Sleep Related Hallucinations: A Case Study, Sammar Atassi Md, Katherine Atassi Phd, Megan Sandberg Ms4

Marshall Journal of Medicine

This is a case study of Idiopathic REM Behavior Disorder (RBD) lasting 5 years with superimposed Idiopathic Complex Nocturnal Visual Hallucination Disorder (CNVHD).

The coexistence of these two distinct idiopathic sleep disorders has not been reported in the literature, even though they both carry similar etiologies and strong association with neurodegenerative diseases. Greater awareness, education, and further research are warranted.

Hospitalists Stare Down The Covid-19 Pandemic, Sutoidem Akpanudo

Marshall Journal of Medicine

Hospital medicine is the country's fastest growing medical specialty. The role of hospitalists has evolved greatly in the past few decades. Hospitalists have become the quarterbacks in the effort to fight against the COVID-19 pandemic. The pandemic has brought about a transformational change to the practice of Hospital Medicine.

From Opportunity To Necessity: Development Of An Asynchronous Online Interprofessional Learning Experience, Kristen Mchenry, S. Alicia Williams, Florence M. Weierbach, Kate E. Beatty, Brian Cross

International Journal of Health Sciences Education

Incorporating interprofessional collaboration competencies into both undergraduate pre-licensure and graduate health science students poses challenges for academic health science centers. Certain student groups may have less opportunity to participate in interprofessional learning experiences due to demands of individual programs of study and conflicts in scheduling time with other disciplines. A group of interprofessional higher education faculty members created an innovative online asynchronous interprofessional experience with the primary goals of meeting accreditation standards for specific programs and providing interprofessional education (IPE) to students who were unable to participate in traditional face-to-face IPE experiences already established at the institution. This guide will …

Development And Implementation Of An Evaluation Tool For Measuring Cultural Competency Learning Activities In Health And Sport Science Undergraduate Students, Diana Cuy Castellanos, Haozhou Pu, Rachel Piero

International Journal of Health Sciences Education

Due to the diversity within the healthcare system, it is important to promote cultural competency in healthcare providers. The integration of pedagogical approaches to cultural competency into health-related programs cannot be understated. Therefore, the purpose of this study was to develop an instrument to examine the student engagement in cultural competency-related activities within health-related degree programs and determine the relationship between engagement and cultural competency. Participants of the study included first- and fourth-year undergraduate students studying within a health-related program at a mid-sized, private university in the Midwestern US. Participants completed a cultural competency inventory questionnaire which included activities identified …

Effectiveness Of An Adapted Virtual Medication Reconciliation Osce Compared With In Person Osce, Rick Hess, Kelly L. Covert, Mckenzie Calhoun Highsmith, Jennifer Trotter, Brian Cross

International Journal of Health Sciences Education

Introduction:

The objective of this study was to measure virtually-based objective structured clinical exam (OSCE) pass rates of student pharmacists who received remote, synchronous instruction on medication reconciliation compared with OSCE pass rates from the previous class, who received face to face synchronous instruction and OSCEs. The secondary objective was to measure student perceptions of remote instruction and OSCE preparation.

Materials and Methods:

Second year student pharmacists attended four online preparatory labs to learn and practice the process of performing a medication reconciliation. A virtually-based OSCE was used to assess student competency of identifying the primary or life-threatening medication related …

A Thematic Analysis Of The Attitudes And Perceptions Of Faculty Towards Inclusion Of Interprofessional Education In Healthcare Curriculum, Jitendra Singh, Tracy Eisenschenk

International Journal of Health Sciences Education

This qualitative study aimed to explore attitudes and perceptions of faculty towards inclusion of interprofessional education (IPE) in healthcare curriculum. Efforts were made to explore faculty members’ definition of IPE, significance of including IPE in content and curriculum and resources available to implement such initiatives in healthcare education programs. Further, challenges faced while including IPE in curriculum were also explored. Face to face semi structured interviews were conducted, and a six-step thematic analysis framework was utilized to analyze the collected data. Further, four dimension criteria was utilized to establish the rigor of the study. Eleven participants across undergraduate and graduate …

Measuring Language Development In Children With Down Syndrome Who Use Aac, Ji Sun Park

Speech and Hearing Sciences ETDs

Purpose: This study examined the inter-observer agreement (IOA) and within-observer agreement as well as the clinical potential of newly proposed measures that are designed to monitor language progress of children with Down syndrome who use AAC. Measures were explored based on the Graphic Symbol Utterance and Sentence Development Framework.

Method: Participants included 8 preschoolers with Down syndrome. Four graduate student observers coded 13 measures across 57 intervention sessions. Each session was coded by two observers for IOA, and all sessions were recoded for within-observer agreement. Statistical analyses were completed on utterance level and session level.

Results: Across all observers and …

Affecting Absenteeism Through School-Based Health Services Delivery: A Configurational Comparative Methods Study Of Oregon's Public Secondary Schools, Kelly Elizabeth Coates

Dissertations and Theses

A student's ability to attend school regularly can be profoundly affected by poor health-related behaviors, illnesses, and chronic diseases that are left unaddressed and unattended. The delivery of health services in the school environment is uniquely positioned to interrupt the effects these health barriers to learning (HBLs) can have on subsequent diminished educational and health outcomes. The literature widely acknowledges the intersectionality between health and education, but no comprehensive overview exists of how different structures and processes within a school work (or do not work) together to lead to higher or lower student absenteeism. This research sought to fill that …

2021-07-30_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-07-30_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Doses Administered, Doses by Vaccine, Doses Metrics, Coverage, Coverage Metrics, State Level Metrics, Enrolled …

Coronavirus Update 7-30-21, The Coronavirus Planning Team

University Briefings & Virtual Events

Message Highlights

1. Students, faculty and staff will need to have at least one dose of the vaccine before coming back to campus. Students must upload their proof of vaccination (even if it is only a first dose) to their SPA health portal.
2. Everyone needs to have their second injection by September 15 and will need to upload the information by that date.
3. Students may apply for a religious or medical exemption.
4. Unvaccinated students with an approved exemption will need to provide a negative PCR test taken within five days prior to their arrival on campus.
5. As part of our attempt …

Update Coronavirus Update 7-30-21, The Coronavirus Planning Team

University Briefings & Virtual Events

It has just been announced that the CDC is including Fairfield County as an area with substantial COVID-19 community transmission. Consequently, as of now we will be putting an indoor masking requirement in place until further notice.

2021-07-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Tuesday and Friday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Prmt1-Dependent Regulation Of Rna Metabolism And Dna Damage Response Sustains Pancreatic Ductal Adenocarcinoma, Virginia Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono, Caleb Class, Christopher A. Bristow, Erika Suzuki, Lionel A. Sanz, Guang Gao, Jason P. Gay, Ningping Feng, Johnathon L. Rose, Hideo Tomihara, Joseph R. Daniele, Michael D. Peoples, Jennifer P. Bardenhagen, Mary K. Geck Do, Qing E. Chang, Bhavatarini Vangamudi, Christopher Vellano, Haoqiang Ying, Angela K. Deem, Kim-Anh Do, Giannicola Genovese, Timothy P. Heffernan, Jeffrey J. Kovacs, Michael Kim, Jason B. Fleming, Ernesto Guccione, Andrea Viale, Anirban Maitra, M. Emilia Di Francesco, Timothy A. Yap, Philip Jones, Giulio Draetta, Alessandro Carugo, Frederic Chedin, Timothy P. Heffernan

Scholarship and Professional Work – COPHS

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-derived PDAC models. Through this, we identify protein arginine methyltransferase 1 (PRMT1) as a critical dependency required for PDAC maintenance. Genetic and pharmacological studies validate the role of PRMT1 in maintaining PDAC growth. Mechanistically, using proteomic and transcriptomic analyses, we demonstrate that global inhibition of asymmetric arginine methylation impairs RNA metabolism, which includes RNA splicing, alternative polyadenylation, and transcription termination. This triggers a robust downregulation of multiple …