Medicine and Health Sciences Commons^™

A Novel Incremental Simulation Of Facial Changes Following Orthognathic Surgery Using Fem With Realistic Lip Sliding Effect, Daeseung Kim, Tianshu Kuang, Yriu L Rodrigues, Jaime Gateno, Steve G F Shen, Xudong Wang, Kirhyn Stein, Hannah H Deng, Michael A K Liebschner, James J Xia

Faculty, Staff and Students Publications

Accurate prediction of facial soft-tissue changes following orthognathic surgery is crucial for surgical outcome improvement. We developed a novel incremental simulation approach using finite element method (FEM) with a realistic lip sliding effect to improve the prediction accuracy in the lip region. First, a lip-detailed mesh is generated based on accurately digitized lip surface points. Second, an improved facial soft-tissue change simulation method is developed by applying a lip sliding effect along with the mucosa sliding effect. Finally, the orthognathic surgery initiated soft-tissue change is simulated incrementally to facilitate a natural transition of the facial change and improve the effectiveness …

Enhancing The Teaching Environment: 3-Year Follow-Up Of A Resident-Led Residents-As-Teachers Program, Bani M Ratan, Grace J Johnson, Amanda C Williams, Jocelyn T Greely, Charlie C Kilpatrick

Faculty, Staff and Students Publications

BACKGROUND: Previous faculty-driven residents-as-teachers (RAT) models have had limited efficacy and sustainability.

OBJECTIVE: To evaluate the acceptability and effects of a

METHODS: In October 2016, obstetrics and gynecology (OB/GYN) residents at a large academic institution implemented a resident-led RAT program, consisting of a steering committee of peer-selected residents with 2 faculty mentors who planned education-focused resident didactics and journal clubs, organized resident involvement in clerkship activities, and recognized residents who excelled in teaching as Distinguished Educators (DEs). From July 2016 through June 2019, using the Kirkpatrick Model, we evaluated the program with annual resident surveys assessing self-perception of 13 teaching …

Transcriptional Milestones In Dictyostelium Development, Mariko Katoh-Kurasawa, Karin Hrovatin, Shigenori Hirose, Amanda Webb, Hsing-I Ho, Blaž Zupan, Gad Shaulsky

Faculty, Staff and Students Publications

Dictyostelium development begins with single-cell starvation and ends with multicellular fruiting bodies. Developmental morphogenesis is accompanied by sweeping transcriptional changes, encompassing nearly half of the 13,000 genes in the genome. We performed time-series RNA-sequencing analyses of the wild type and 20 mutants to explore the relationships between transcription and morphogenesis. These strains show developmental arrest at different stages, accelerated development, or atypical morphologies. Considering eight major morphological transitions, we identified 1371 milestone genes whose expression changes sharply between consecutive transitions. We also identified 1099 genes as members of 21 regulons, which are groups of genes that remain coordinately regulated despite …

Utilizing Structured Worksheets To Strengthen Resident Teaching On The Ob/Gyn Clerkship, Matthew R Carroll, Charlie C Kilpatrick, Grace Johnson, Neelima Sukhavasi, Bani M Ratan

Faculty, Staff and Students Publications

OBJECTIVE: To determine if structured worksheets can aid resident teaching on the obstetrics and gynecology (OB/GYN) clerkship.

DESIGN: We developed structured worksheets to aid residents in teaching medical students. In this pilot study, we measured the impact of the material by conducting end of clerkship focus groups between October 2017 to June 2018 and administering surveys to medical students who had recently completed the clerkship. We performed analyses of the focus group transcriptions for positive and negative themes and analyzed questionnaire data utilizing unpaired t-test and chi-square test to determine whether resident use of structured worksheets influenced student perception of …

Anti-Neutrophil Cytoplasmic Antibodies: To Care Or Not To Care, Sara Shahid, Syed H Alam, Lillian Gaber, Salman Ahmed

Faculty, Staff and Students Publications

Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis is a disease process with a wide range of presentations, from asymptomatic or minimally symptomatic disease with positive laboratory testing, to florid acute end-organ damage. Consensus has not been established as to the frequency and/or protocol by which ANCA testing should be repeated. We present the case of a 53-year-old woman who initially came to medical attention with persistent dyspnea and pulmonary infiltrates presumed to be due to acute exacerbation of chronic diastolic congestive heart failure. Extensive infectious disease testing was negative, but ANCA testing was positive. However, because antinuclear antibody (ANA) interference in …

Cd148 Deficiency In Fibroblasts Promotes The Development Of Pulmonary Fibrosis, Konstantin Tsoyi, Xiaoliang Liang, Giulia De Rossi, Stefan W Ryter, Kevin Xiong, Sarah G Chu, Xiaoli Liu, Bonna Ith, Lindsay J Celada, Freddy Romero, Matthew J Robertson, Anthony J Esposito, Sergio Poli, Souheil El-Chemaly, Mark A Perrella, Yuanyuan Shi, James Whiteford, Ivan O Rosas

Faculty, Staff and Students Publications

Rationale: CD148/PTRJ (receptor-like protein tyrosine phosphatase η) exerts antifibrotic effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, the role of CD148 in human pulmonary fibrosis remains incompletely characterized.

Objectives: We investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis (IPF).

Methods: Conditional CD148 fibroblast-specific knockout mice were generated and exposed to bleomycin and then assessed for pulmonary fibrosis. Lung fibroblasts (mouse lung and human IPF lung), and precision-cut lung slices from human patients with IPF were isolated and subjected to experimental treatments. A CD148-activating 18-aa mimetic peptide (SDC2-pep) derived from …

Impact Of Simple Breastfeeding Initiatives Led By Nurses In A Primary Care Setting, Jessica Semin, Carolyn Hanus, Megan Scott, Amy Ford, Leeza Struwe

Doctor of Nursing Practice Projects: College of Nursing

Background: Breastfeeding is recognized by health experts as the preferred infant feeding method. Health professionals, especially nurses, play a vital role in influencing mothers’ infant feeding decisions. This quality improvement project designed, implemented, and evaluated by nurses explores how the implementation of three simple initiatives impacted healthcare staff’s attitudes, beliefs, and perceptions related to breastfeeding.

Materials and Methods: The project was led by three Doctor of Nursing Practice (DNP) students with guidance from their DNP prepared advisor. It took place in a primary care setting at a federally qualified health center. Prior to and after implementation, staff were …

2021-07-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Tuesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Reduction Of Inpatient Fall Rate In An Adult Acute Care Setting, Manjusha Maprel

Student Scholarly Projects

Practice Problem: Falls are among the most reported hospital-acquired conditions and can lead to severe injuries, increased length of hospital stays, pain, distress, and emotional trauma in the elderly. The Centers for Medicare and Medicaid Services (CMS) identifies falls as preventable and no longer authorizes reimbursement to healthcare systems for treating inpatient fall-related injuries.

PICOT: The PICOT question that guided this project was: In adult, acute care patients admitted to the telemetry unit (P), how does implementing evidence-based multimodal fall prevention strategies (I) compared to routine fall prevention strategies (C) affect inpatient fall rate (O) over a period of 6-8 …

Long-Term Clinical And Functional Outcomes Of Distally Based Sural Artery Flap: A Retrospective Case Series, Pervaiz Hashmi, Abeer Musaddiq, Muhammad Ali, Alizah Hashmi, Marij Zahid, Zohaib Nawaz

Section of Orthopaedic Surgery

Background: Reconstruction of soft tissue defects around the lower leg, foot and ankle is a challenge for orthopedic surgeons. These defects commonly occur as a result of trauma, infection and tumor excision. Sural artery neurovascular island flap is a relatively thin, pliable and insensate flap with minimum donor-site morbidity and acceptable aesthetic outcome.
Methods: A retrospective analysis of a case series was conducted, all operated by a single surgeon over a period of 25 years from July 1996 to February 2020. Data were collected through a structured proforma; the variables included were as follows: demographic data, mechanism of injury, defect …

Thematic Analysis Of Military Medical Ethics Publications From 2000 To 2020—A Bibliometric Approach, Zachary Bailey [*], Peter Mahoney, Marina Miron, Martin Bricknell

Student Publications

There has been external criticism of the compliance of military health personnel with internationally agreed principles in military medical ethics (MME). In response, a number of authors have called for clarity on the principles and topics within the domain of MME. This complements an increased acknowledgment of the need for education in MME for military health personnel. Our paper utilizes bibliometric techniques to identify key themes in MME to inform the development of a curriculum for this subject.

An Electrophysiological And Pharmacological Study Of The Properties Of Human Ipsc-Derived Neurons For Drug Discovery, Robert F. Halliwell, Hamed Salmanzadeh, Leanne Coyne, William S. Cao

School of Pharmacy Faculty Articles

Human stem cell-derived neurons are increasingly considered powerful models in drug discovery and disease modeling, despite limited characterization of their molecular properties. Here, we have conducted a detailed study of the properties of a commercial human induced Pluripotent Stem Cell (iPSC)-derived neuron line, iCell [GABA] neurons, maintained for up to 3 months in vitro. We confirmed that iCell neurons display neurite outgrowth within 24 h of plating and label for the pan-neuronal marker, βIII tubulin within the first week. Our multi-electrode array (MEA) recordings clearly showed neurons generated spontaneous, spike-like activity within 2 days of plating, which peaked at one …

Hubungan Kondisi Psikologis Stress Dengan Hipertensi Pada Penduduk Usia Diatas 15 Tahun Di Indonesia, Aenaya Delavera, Kemal N. Siregar, Ryza Jazid Bahar, Tris Eryando

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Stress adalah bagian normal dari kehidupan yang tidak bisa dihindari. Tetapi terlalu banyak stress dapat mempengaruhi kesehatan. Bertambahnya tingkat stress akan memungkinkan terjadinya peningkatan prevalensi hipertensi. Hipertensi adalah masalah kesehatan masyarakat global dan menjadi penyebab utama kematian dini di seluruh dunia dan memiliki tren yang selalu meningkat setiap tahunnya. Penelitian ini bertujuan untuk mengetahui hubungan antara kondisi psikologis stress dengan hipertensi pada penduduk usia ≥ 15 tahun di Indonesia. Metode penelitian dilakukan dengan analisis data sekunder Indonesian Family Life Survey 5 (IFLS 5) tahun 2014 yang memiliki desain cross sectional. Sampel berjumlah 13.667 responden yang memiliki data lengkap terkait …

Gambaran Perilaku Hidup Bersih Dan Sehat (Phbs) Di Era Pandemi Corona Virus Disease (Covid-19) Di Indonesia, Febby Anugrah Utami, Faridah Sani

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Berdasarkan Riskesdas tahun 2018 proporsi anggota rumah tangga yang berperilaku benar cuci tangan dengan benar di Indonesia yaitu 49,8%, prevalensi merokok penduduk umur > 10 tahun di Indonesia sebanyak 29,3%. Jumlah kasus positif Covid-19 di Indonesia sampai tanggal 10 Januari 2021 yaitu 828.026 kasus dengan angka kematian 24.129 dan angka kesembuhan 681.024 orang. Untuk mencegah penularan Covid-19 dapat dilakukan dengan menerapkan Perilaku Hidup Bersih dan Sehat (PHBS). Tujuan dari penelitian ini yaitu menjelaskan gambaran Perilaku Hidup Bersih dan Sehat (PHBS) dalam mencegah penularan Corona Virus Disease (Covid-19) di Indonesia. Metode yang digunakan dalam penelitian ini adalah metode tinjauan kepustakaan (literatur review) …

Latihan Senam Dapat Menurunkan Kadar Glukosa Darah Pada Penderita Diabetes Melitus Tipe Ii, Rifa Fadhilah Lubis, Ramadya Kanzanabilla

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Diabetes melitus tipe II adalah suatu keadaan hiperglikemia yang disebabkan gangguan pada resistensi insulin dan sekresi insulin sehingga metabolisme tubuh juga terganggu, merupakan masalah yang serius dan menjadi salah satu penyakit penyebab kematian yang cukup besar di Indonesia. Salah satu cara diabetes ini adalah dengan latihan fisik. Latihan fisik yang dianjurkan salah satunya adalah senam aerobik, yang bertujuan meningkatkan dan mempertahankan kesegaran tubuh dan dilaksanakan sesuai prinsip F.I.T.T (Frekuensi, Intensitas, Time dan Tipe). Penelitian ini bertujuan untuk menunjukkan dengan latihan senam secara rutin dapat mengontrol dan menurunkan kadar glukosa darah pada penderita diabetes melitus tipe II. Metode yang digunakan adalah …

Kajian Pustaka: Kurangnya Kualitas Tidur Dapat Meningkatkan Risiko Kejadian Diabetes Melitus, Novi Mesrina Cicionta Br Ginting, Pralampita Kori Mufidah

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Diabetes melitus merupakan suatu penyakit yang ditandai dengan kadar glukosa di dalam darah tinggi karena tubuh tidak dapat melepaskan atau menggunakan insulin secara adekuat. Penderita diabetes sering kita jumpai dan tingkat insiden terus meningkat tahun demi tahun. Tidur memiliki fungsi metabolik, dan beberapa penelitian menunjukkan korelasi antara kurangnya kualitas tidur dan peningkatan risiko diabetes melitus. Penelitian ini bertujuan untuk mengetahui bahwa kurangnya kualitas tidur dapat meningkatkan risiko kejadian diabetes mellitus pada orang dewasa. Penelitian ini menggunakan metode kajian pustaka. Ada 5 jurnal yang membahas kualitas tidur dan diabetes melitus serta memenuhi kriteria inklusi yaitu kurangnya kualitas tidur meningkatkan risiko kejadian …

Analisis Penerimaan Sistem Informasi Pencatatan Dan Pelaporan Kasus Covid-19 (Aplikasi Silacak Versi 1.2.5) Menggunakan Technology Acceptance Model (Tam) Di Upt Puskesmas Cipadung Kota Bandung, Nurfatia Negari, Tris Eryando

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Salah satu upaya untuk mengendalikan laju COVID-19 ialah dengan memperkuat sistem surveilans di fasilitas kesehatan tingkat dasar. Salah satu poin yang menjadi peran kunci dalam pemutusan rantai penularan COVID-19 adalah kegiatan pelacakan kontak. Kegiatan ini mengharuskan pelacak kontak untuk terus mencatat dan melaporkan kasus. Untuk itu, penggunaan sistem pencatatan dan pelaporan pelacakan kontak (Silacak) menjadi penting dalam menentukan kebijakan yang akan dibuat. Tujuan penelitian ini adalah menelaah penggunaan sistem pencatatan dan pelaporan COVID-19 dengan aplikasi Silacak serta penerimaan pengguna terhadap sistem informasi Silacak di UPT Puskesmas Cipadung Kota Bandung. Penelitian ini merupakan studi kualitatif dengan menggunakan desain studi kasus. Aplikasi …

Analisis Spasial Kasus Diare Pada Balita Di Kabupaten Banyumas Tahun 2019, Dyah Nurmarastri Sasabil Sidqi, Novia Anasta, Pralampita Kori Mufidah

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Diare merupakan penyebab kematian balita terbesar kedua di seluruh dunia. Indonesia sendiri prevalensi diare untuk balita merupakan tertinggi dari seluruh kelompok umur sebesar 11,5% pada tahun 2018. Hingga tahun 2019 angka penemuan diare pada balita di Kabupaten Banyumas masih belum mencapai target yang ditentukan. Belum adanya gambaran spasial daerah yang rentan akan peningkatan kasus diare balita mempersulit upaya penemuan kasus yang penting dilakukan untuk mencegah terjadinya KLB. Tujuan penelitian ini yaitu mendeskripsikan, dan melakukan analisis spasial untuk melihat korelasi faktor risiko dengan kasus diare pada balita secara geografis melalui peta kerentanan serta menghasilkan peta buffer jangkauan pelayanan puskesmas di Kabupaten …

Using Virus-Like Particles To Combat Cardiovascular Disease And Identify An Immunogenic Target Of Natural Zika Virus Infection In Humans, Alexandra Marie Fowler

Biomedical Sciences ETDs

Virus-like particles (VLPs) derived from bacteriophages have been utilized as highly immunogenic vaccine platforms for displaying antigen targets of interest. Bacteriophage VLPs have a highly repetitive structure made of protein subunits that self-assemble into an icosahedral particle. These structures can strongly activate the immune system, especially B cells. Arraying antigens on the surface of VLPs in a multivalent manner can, in turn, confer the ability to induce strong antibody responses to virtually any target. This technique can even be used to elicit antibody responses against self-antigens. Here we have exploited these features for developing VLP-based vaccines that target self-molecules involved …

Child-Rearing By Imprisoned Women: Sadness, Anxiety, And Feelings Of Guilt, Umi Hani, Agus Setiawan, Poppy Fitriyani

Jurnal Keperawatan Indonesia

The number of imprisoned women continues to increase. Imprisonment of women affects them as perpetrators of crime and those who have relationships with and ties to them, such as children. This phenomenological study aims to explore the experience of imprisoned women in Jakarta in playing the role of mother. In-depth interviews were conducted to explore the experiences of seven imprisoned women. Through a thematic content analysis, we identified specific key- words, the results revealing the sadness, anxiety, and feelings of guilt experienced by imprisoned mothers in relation to their child-rearing. Imprisoned mothers also experience difficulties in meeting their children's needs, …

Abdominal Aortic Calcification Is Associated With A Higher Risk Of Injurious Fall-Related Hospitalizations In Older Australian Women, Abadi K. Gebre, Marc Sim, Alexander J. Rodríguez, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Pawel Szulc, Nicola Bondonno, Kun Zhu, Catherine Bondonno, Douglas P. Kiel, John T. Schousboe, Richard L. Prince, Joshua R. Lewis

Research outputs 2014 to 2021

Backgrounds and aims: Abdominal aortic calcification (AAC) is associated with weaker grip strength, an established risk factor for fall-related hospitalizations. However, its association with long-term fall-related hospitalisations remains unknown. This study investigated the association between AAC and long-term fall-related hospitalizations in community-dwelling older women.

Methods: Fall-related hospitalizations were obtained from linked data over 14.5-years in a prospective cohort of 1053 older women (mean age 75.0 ± 2.6 years). At baseline (1998/99), AAC was assessed from lateral spine images obtained using dual-energy X-ray absorptiometry, and scored using a semi-quantitative method (AAC24, range 0–24). The presence of any AAC was defined by …

Maternal Factors In Stunting Among Vulnerable Children, Stefanus Mendes Kiik, Muhammad Saleh Nuwa

Jurnal Keperawatan Indonesia

Children with stunting in Indonesia and other low-middle countries remains a serious problem. This study aimed to identify the association between maternal education, maternal age, maternal height, preceding birth interval, and ANC clinic visits, and stunting among vulnerable children in Kupang Regency, Indonesia. A cross-sectional study was con- ducted of two villages in Kupang Regency. The study sample comprised female ex-refugees from Timor Leste who had children aged 24–59 months. The subjects were chosen using consecutive sampling, with a total number of 154. Data were collected from both primary and secondary sources. There was a significant relationship between maternal education …

The Effectiveness Of Spiritual Intervention In Overcoming Anxiety And Depression Problems In Gynecological Cancer Patients, Lina Anisa Nasution, Yati Afiyanti, Wiwit Kurniawati

Jurnal Keperawatan Indonesia

Anxiety and depression are psychological distress that often occurs in gynecological cancer patients. However, there are few studies related to interventions to overcome these problems. The purpose of this study was to determine the effect of a spiritual intervention on anxiety and depression in such cancer patients. The research design was quasi-experimental, employing pretest and posttest on the intervention and the control groups. The total number of respondents was 108 patients, consisting of 54 in each group. The instrument used in the study was the Hospital Anxiety and Depression Scale (HADS). The spiritual intervention consisted of four sessions, namely an …

The Smoking Behavior Of Health Workers In Asia: A Literature Review, Arif Rahman, Titih Huriah

Jurnal Keperawatan Indonesia

Health workers are role models in preventing smoking behavior, yet many are smokers themselves. This study reviews and analyzes the smoking behavior of health workers in Asian countries, based on databases such as PubMed, EBSCO, and Google Scholar in 2013–2018. It is shown that the prevalence of smoking amongst health workers was 4.6–44%, with the nursing profession showing a higher level than other health professions and with a higher ratio of male to female smokers. Health workers are aware of the dangers of smoking, including the effects of cardiovascular disease, respiratory disease, oral cancer, atherosclerosis, hypertension, fetal disorders, and infertility. …

Suppression Of Dc-Sign And Gh Reveals Complex, Subset-Specific Mechanisms For Kshv Entry In Primary B Lymphocytes, Nancy Palmerin, Farizeh Aalam, Romina Nabiee, Murali Muniraju, Javier Gordon Ogembo, Jennifer Totonchy

Pharmacy Faculty Articles and Research

Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of multiple cancers in immunocompromised patients including two lymphoproliferative disorders associated with KSHV infection of B lymphocytes. Despite many years of research into the pathogenesis of KSHV associated diseases, basic questions related to KSHV molecular virology remain unresolved. One such unresolved question is the cellular receptors and viral glycoproteins needed for KSHV entry into primary B lymphocytes. In this study, we assess the contributions of KSHV glycoprotein H (gH) and the cellular receptor DC-SIGN to KSHV infection in tonsil-derived B lymphocytes. Our results show that (1) neither KSHV-gH nor DC-SIGN are essential …

Establishing Reference Interval For Thyroid-Stimulating Hormone In Children Below Two-Year Ages In Pakistani Population, Siraj Muneer, Imran Siddiqui, Hafsa Majid, Lena Jafri, Khadija N Humayun, Sibtain Ahmed, Aysha Habib Khan

Department of Pathology and Laboratory Medicine

Introduction: Reference intervals (RIs) of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) are age, assay and population specific. Currently, the age and assay-specific RIs for TSH are not available for children under two years of age. This study aimed to establish reference intervals for serum concentrations of TSH and FT4 in healthy children aged 1-24 months as per CLSI C28-A3 guidelines.
Methods: This prospective cross-sectional study was conducted in children from 1 to 24 months visiting the clinical laboratory for serum vitamin D testing but without any recent illness, hospitalization, medication and history of maternal thyroid diseases from August 2018 …

A Tale Of Itam Tails: New Insights Into The Molecular Mechanisms That Tune Fcɛri Signaling, William K. Kanagy

Biomedical Sciences ETDs

Immunoreceptor Tyrosine-based Activating Motif (ITAM) receptors are critical in sensing extracellular antigen and initiating an immune response. The ITAM receptor FcɛRI, termed the high affinity IgE receptor, is the primary promoter of inducing the Type 1 allergic response and is primarily expressed in mast cells and basophils. In this dissertation, I worked to determine how early signaling events initiated at the FcɛRI ITAM interface tune downstream signaling outcomes. I began by determining that differential phospho-tyrosine ITAM patterns produce unique recruitment profiles of the accessory kinases proteins Syk and Lyn. I next determined the differential signaling ITAM capabilities of Lyn and …

Regulation Of H2s Production And Signaling Within Vascular Endothelium, Perenkita J. Mendiola

Biomedical Sciences ETDs

Hydrogen sulfide (H2S) is a vasodilator primarily produced by cysthathionine

gamma-lyase (CSE) within the vasculature. Previous studies suggest there are

differences in CSE expression and the contribution of H2S to vasodilation in

different sized arteries. This led us to postulate that there are also regional

differences of regulators of H2S-mediated vasodilatory pathways.

This study examined the role of endothelial cell plasma membrane (EC

PM) cholesterol in regulating H2S-induced vasodilation and the role of

intracellular calcium [Ca2+]i in regulating CSE activity in vascular EC. We

hypothesized that CSE activation in EC by receptor-dependent second

messenger signaling enhances H2S production and subsequent …

Rac1 In Ovarian Cancer Metastasis And Tumor Microenvironment Remodeling: An Experimental And Computational Analysis, Melanie Rivera

Biomedical Sciences ETDs

Ovarian cancer is the leading cause of gynecologic malignancies, and the patient survival rate has not changed significantly in 20 years. Patients are often diagnosed at an advanced stage of disease with widespread tumor cell dissemination and metastasis. Therefore, drivers of ovarian cancer metastasis need to be identified. In Chapter 2, we reveal the role of Rac1 in ovarian cancer metastasis using a combination of experimental and computational approaches. In Chapter 3, we demonstrate that changes in gene expression and cytokine levels within the immunosuppressive ovarian cancer tumor microenvironment are dependent on Rac1 expression and activity. Collectively, the …

Spiritual Behavior And Stress In Adolescents: An Initial Study, Sumiyati Tarniyah, Laili Nur Hidayati

Jurnal Keperawatan Indonesia

Spirituality is often associated with mental health, including stress. Older people tend to have high rates of involvement in spirituality rather than young people. This study aimed to identify the relationship between spiritual behavior and the stress levels of 152 high school students, using a descriptive correlation research design. The data collection techniques involved a spiritual dimension scale questionnaire and the Depression Anxiety Stress Scale 42 (DASS 42). The data were analyzed using Spearman's rho correlation test. The results show that the spiritual behavior distribution was mostly in the moderate category (53.3%), and stress level distribution was primarily in the …