Medicine and Health Sciences Commons^™

2021-07-30_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

The Impact Of Covid-19 On Church Gatherings In The Philippines: A Policy Analysis, Grace Zurielle Malolos, Joseph Christian Obnial, Rena Mallillin, Pamela Bianca Pasco, Erika Ong, Arianne Andes, Faith Ann Apat, Emma Teresa Carmela Aportadera, Rafael Valencia, Don Eliseo Lucero-Prisno Iii

Ateneo School of Medicine and Public Health Publications

The Philippines is the largest Christian-majority country in Asia. With church gatherings playing a vital role in the nature of Christianity in the Filipino culture, the advent of the coronavirus disease (COVID-19) pandemic in the Philippines posed challenges to public religious practices amid efforts to mitigate COVID-19 community transmission. Various policy pronouncements from both the government-led Inter-Agency Task Force (IATF) on Emerging Diseases and the church-led Catholic Bishops’ Conference of the Philippines (CBCP) were issued. These guidelines were implemented in order to address the two-pronged problem on healthcare and religious obligations. While these guidelines were initially contributory to the mitigation …

Field Safety Experience With An Autologous Cancer Vaccine In Tumor-Bearing Cats: A Retrospective Study Of 117 Cases (2015-2020), Michael D. Lucroy, Alexa M. Kugler, Ferris El-Tayyeb, Ryan M. Clauson, Ashley E. Kalinauskas, Mark A. Suckow

Office of the Attending Veterinarian Academic Publications

OBJECTIVES: The aim of this study was to determine the frequency and severity of adverse events (AEs) reported from use of an adjuvanted whole-cell autologous cancer vaccine in cats with solid tumors under field conditions.

METHODS: The case accession database at Torigen Pharmaceuticals was searched to identify client-owned cats that underwent biopsy or surgical resection of their primary tumor, had histologic confirmation of neoplasia and received at least one subcutaneous dose of an adjuvanted whole-cell autologous cancer vaccine. Records were reviewed for any reported AEs.

RESULTS: In total, 117 cats met the inclusion criteria and received 422 doses of autologous …

Online-Delivered Group And Personal Exercise Programs To Support Low Active Older Adults' Mental Health During The Covid-19 Pandemic: Randomized Controlled Trial, Mark R. Beauchamp, Ryan M. Hulteen, Geralyn R. Ruissen, Yan Liu, Ryan E. Rhodes, Colin M. Wierts, Katrina J. Waldhauser, Samantha H. Harden, Eli Puterman

Faculty Publications

Background: In response to the COVID-19 pandemic, experts in mental health science emphasized the importance of developing and evaluating approaches to support and maintain the mental health of older adults.

Objective: The aim of this study was to assess whether a group-based exercise program relative to a personal exercise program (both delivered online) and waitlist control (WLC) can improve the psychological health of previously low active older adults during the early stages of the COVID-19 pandemic.

Methods: The Seniors COVID-19 Pandemic and Exercise (SCOPE) trial was a 3-arm, parallel randomized controlled trial conducted between May and September 2020 in which …

Toward The Total Synthesis Of Dragonamide E And Its Potential Medicinal Application Against Leishmaniasis, Nathaniel M. Smith

Chemistry Theses

Leishmaniasis is one of the world’s most neglected tropical diseases, with hundreds of thousands of cases occurring worldwide annually. The disease originates from being infected by protozoa of the Leishmania genus, which are parasites that destroy mammalian cells as part of their life cycle. Currently utilized treatment strategies for leishmaniasis have many disadvantages, warranting the search for a new leishmaniasis treatment.

Cyanobacteria have been discovered to synthesize a wide variety of cytotoxic chemicals as part of their own defense mechanism. One strain of cyanobacteria, Lyngbya majuscula, produces several families of compounds, one of which is known as the “dragonamides”. …

A Distinct Difference Between Air And Mucosal Temperatures In Human Respiratory Tract, Mehdi Khosravi, Ruei-Lung Lin, Ashish P. Maskey, Subodh Pandey, An-Hsuan Lin, Lu-Yuan Lee

Internal Medicine Faculty Publications

xtensive evidence indicates that several types of temperature-sensitive ion channels are abundantly expressed in the sensory nerves innervating airway mucosa. Indeed, airway temperature is known to play an important role in regulating respiratory functions. However, the actual airway mucosal temperature and its dynamic changes during the respiratory cycle have not been directly measured. In previous studies, airway tissue temperature was often estimated by indirect measurement of the peak exhaled breath temperature (PEBT). In view of the poor thermal conductivity of air, we believe that the airway tissue temperature cannot be accurately determined by the exhaled air temperature, and this study …

Graphical Models In Reconstructability Analysis And Bayesian Networks, Marcus Harris, Martin Zwick

Complex Systems Faculty Publications and Presentations

Reconstructability Analysis (RA) and Bayesian Networks (BN) are both probabilistic graphical modeling methodologies used in machine learning and artificial intelligence. There are RA models that are statistically equivalent to BN models and there are also models unique to RA and models unique to BN. The primary goal of this paper is to unify these two methodologies via a lattice of structures that offers an expanded set of models to represent complex systems more accurately or more simply. The conceptualization of this lattice also offers a framework for additional innovations beyond what is presented here. Specifically, this paper integrates RA and …

Introduction Of A Nursing Evidenced-Based Practice Model To Improve Heart Failure At A Rural Community Hospital, Brandi Fields

Graduate Theses, Dissertations, and Capstones

Abstract

BACKGROUND: This project took place at a community-based rural hospital in eastern Kentucky. During completion of a needs assessment, adoption of an evidence-based nursing practice model and improvement of clinical outcomes of the community’s heart failure patient population were revealed as opportunities.

PURPOSE: The purpose of this project was to introduce the organization’s key stakeholders to the Johns Hopkins Nursing Evidence-Based Practice Model (JHNEBP), encourage implementation of an evidence-based practice (EBP) committee, and to use heart failure as an exemplar to facilitate discussions and stakeholder education.

METHODS: The goal of this project was to develop a supportive EBP culture …

A Multidimensional Welfare Status Of Leprosy Patients Living In A Suburban Area, Yunia Irawati, Sri Linuwih Sw Menaldi, Melinda Harini, Luh Karunia Wahyuni, Wanarani Alwin, Astari Dwiranti, Adhityawarman Menaldi, Sonny Tirta Luzanil, Qaishum Matsurah, Dadun ., Rico Kurniawan, Ida Ruwaida, Gunawan Wicaksono, Muhammad Hidayat Sahid, Febrina Rahmayanti, Florentina Priscilia, Anis Fitriana, Tri Rahayu, Made Susiyanti, Gitalisa Andayani, Anna Puspitasari Bani, Hisar Daniel, Yeni Dwi Lestari

ASEAN Journal of Community Engagement

Leprosy has a high incidence of physical complications that will impact directly the physiological, economic, and social status of patients. Indonesia has a high burden of the disease, and several leprosy settlements are still spread in the country. Neglasari Village, Sitanala, Tangerang serves as one of the places of residence of people who have had leprosy. A health service initiative known as Identifikasi Tanda-Tanda Mata, Ekstremitas, dan Kulit pada Kusta (KATAMATAKU) was launched as a collaboration of health services among multi-departments (ophthalmology, dermatovenereology, and medical rehabilitation). Sitanala has a relatively high incidence of people who have had leprosy with disabilities …

Transformational Leadership In The Psychiatric-Mental Health Setting, Alan Ryan

Graduate Theses, Dissertations, and Capstones

This evidence based practice quality improvement project examines the effectiveness of transformational leadership practices in the acute psychiatric setting. Literature shows the psychiatric mental health setting causes extreme stress for employees.  Individuals entering the acute psychiatric setting, as well as regulating bodies, count on exceptional leadership from administrators guided by the Five Practices of Exemplary Leadership (Kouzes & Posner, 2012, p. 15).  Fully functioning and cohesive clinical and administrative components of a healthcare organization makes a facility viable.  The findings of this project identify important factors relating to transformational leadership practices and their impact among psychiatric inpatient staff and patient …

Assessment Of Video Capsule Endoscopy In The Management Of Acute Gastrointestinal Bleeding During The Covid-19 Pandemic, Shahrad Hakimian, Daniel Raines, George Reed, Mark Hanscom, Lilia Stefaniwsky, Matthew Petersile, Prashanth Rau, Anne Foley, David Cave

School of Medicine Faculty Publications

Importance: Evaluation of acute gastrointestinal (GI) bleeding using invasive endoscopic procedures comprising the standard of care (SOC) - upper endoscopy and colonoscopy - can expose the endoscopy staff to SARS-CoV-2. Video capsule endoscopy (VCE) does not generate aerosols and only requires 1 person to manage the procedure. Objective: To examine the safety of VCE for the initial evaluation of GI bleeding at the peak of the COVID-19 pandemic to identify signs of active bleeding while minimizing patient and personnel exposure, saving personal protective equipment, and avoiding invasive or unnecessary procedures. Design, Setting, and Participants: A multicenter (UMass Memorial Medical Center …

Barriers And Facilitators To Promoting Resilience To Hiv/Aids: A Qualitative Study On The Lived Experiences Of Hiv-Positive, Racial And Ethnic Minority, Middle-Aged And Older Men Who Have Sex With Men From Ontario, Canada, Renato M. Liboro, Sherry Bell, Brandon Ranuschio, Lianne Barnes, Jenna Despres, Aruna Sedere, Trinity Puno, Paul A. Shuper

Psychology Faculty Research

Evidence-based research has highlighted the need for exploring factors that support the mental health of men who have sex with men living with HIV/AIDS (MSMLWH), and environmental influences that promote their resilience to HIV/AIDS. This exploratory study utilized a community-based participatory research approach to investigate barriers and facilitators to promoting resilience to HIV/AIDS, specifically among racial and ethnic minority, middle-aged and older MSMLWH, a population that continues to be significantly impacted by HIV/AIDS today. This collaborative, qualitative study recruited participants who identified as racial or ethnic minority MSMLWH, were aged 40 or older, and resided in Ontario, Canada. Participants (n …

Structural Basis For +1 Ribosomal Frameshifting During Ef-G-Catalyzed Translocation., Gabriel Demo, Howard Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, Andrei A. Korostelev

Department of Biochemistry and Molecular Biology Faculty Papers

Frameshifting of mRNA during translation provides a strategy to expand the coding repertoire of cells and viruses. How and where in the elongation cycle +1-frameshifting occurs remains poorly understood. We describe seven ~3.5-Å-resolution cryo-EM structures of 70S ribosome complexes, allowing visualization of elongation and translocation by the GTPase elongation factor G (EF-G). Four structures with a + 1-frameshifting-prone mRNA reveal that frameshifting takes place during translocation of tRNA and mRNA. Prior to EF-G binding, the pre-translocation complex features an in-frame tRNA-mRNA pairing in the A site. In the partially translocated structure with EF-G•GDPCP, the tRNA shifts to the +1-frame near …

The Cgas–Sting Pathway In Diabetic Retinopathy And Age-Related Macular Degeneration, Shannon Erhardt, Mingjie Zheng, Xiaolei Zhao, Tram P Le, Tina O Findley, Jun Wang

Faculty, Staff and Student Publications

The neural crest (NC) is a multipotent and temporarily migratory cell population stemming from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells (NCCs), a specified subpopulation of the NC, are vital for normal cardiovascular development, as they significantly contribute to the pharyngeal arch arteries, the developing cardiac outflow tract (OFT), cardiac valves, and interventricular septum. Various signaling pathways are shown to orchestrate the proper migration, compaction, and differentiation of cardiac NCCs during cardiovascular development. Any loss or dysregulation of signaling pathways in cardiac NCCs can lead to abnormal cardiovascular development during embryogenesis, resulting in abnormalities categorized as …

Prevalence Of Dementia In Latin America: A Collaborative Study Of Population-Based Cohorts, Ricardo Nitrini, Cássio M. C. Bottino, Cecilia Albala, Nilton Santos Custodio Capuñay, Carlos Ketzoian, Juan J. Llibre Rodriguez, Gladys E. Maestre, Ana Teresa A. Ramos-Cerqueira

School of Medicine Publications

Background:

Dementia is becoming a major public health problem in Latin America (LA), yet epidemiological information on dementia remains scarce in this region. This study analyzes data from epidemiological studies on the prevalence of dementia in LA and compares the prevalence of dementia and its causes across countries in LA and attempts to clarify differences from those of developed regions of the world.

Methods:

A database search for population studies on rates of dementia in LA was performed. Abstracts were also included in the search. Authors of the publications were invited to participate in this collaborative study by sharing missing …

Medical School Watercooler Newsletter - July 29, 2021, Lindsey Lyle

Watercooler Newsletter

This is the July 29, 2021 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Students take part in Summer Research Day
• Welcome to medical school, Class of 2025
• Video online: 'Artificial Intelligence and Women’s Heart Disease'
• Faculty Spotlight: Randall Harrison Trammell, D.O.
• Alumnus named governor of Mississippi Chapter of the American College of Physicians
• Meet a Med Student: Marjorie Jones

2021-07-29_Michiganoverview_Misc, Michigan Department Of Health & Human Services

Michigan COVID-19 MIS-C Data

The MIS-C Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_104661---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by health care providers and local health departments. Data is updated on the first and third Thursdays of the month.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, …

"What Keeps Me Awake At Night": Assisted Living Administrator Responses To Covid-19., Jason Z. Kyler-Yano, Ozcan Tunalilar, Serena B. Hasworth, Jacklyn N. Kohon, Jaclyn M. Winfree, Riley A. Wilton, Aliza Tuttle, Paula C. Carder

Institute on Aging Publications

Assisted living (AL) constitutes an important sector of residential long-term care, yet there has been limited research about the impact of the coronavirus disease 2019 (COVID-19) pandemic in this setting. This qualitative study sought to understand the impact of the early stages of the pandemic (February-August 2020) from AL administrators' perspectives.

Implementation Of Telehealth Education In A Pre-Licensure Bsn Nursing Program In Rural Southeast Kansas, Anna Beth Gilmore

Doctor of Nursing Practice Scholarly Project

The purpose of this project was to facilitate the implementation of a successful telehealth education program in a pre-licensure nursing program at a regional university in the Midwest. The project took place at Pittsburg State University Irene Ransom Bradley School of Nursing. Participants included eighty-six undergraduate senior students in their last semester of nursing school enrolled in Community Health Nursing preparing to begin their nursing career. The group completed a 20-hour self-paced telehealth educational program offering made available through a partnership with Dr.’s Carolyn Rutledge and Tina Gustin of Old Dominion University Center for Telehealth Innovation, Education and Research (C-TIER). …

Hereditary Angioedema., Helen Lesser, Jason E Cohn

Otolaryngology (ENT) Resident Research

A 14-year-old African American female presented to the emergency department with spontaneous, sudden-onset lip swelling for 1 h. On examination, there was significant water-bag edema of the upper lip extending to the philtrum and premaxilla. Nasopharyngeal laryngoscopy revealed a patent airway without edema. She was initiated on intravenous dexamethasone, famotidine, and diphenhydramine, after which her edema improved but did not resolve. She was subsequently transferred to a local pediatric hospital and upon further testing she was found to have a C1 esterase inhibitor de novo gene mutation. Angioedema causes localized, non-pitting edema of the dermis, subcutaneous and submucosal tissue, and …

What About The Rest Of Them? Fatal Injuries Related To Production Agriculture Not Captured By The Bureau Of Labor Statistics (Bls) Census Of Fatal Occupational Injuries (Cfoi), Bryan Weichelt, Erika Scott, Rick Burke, John Shutske, Serap Gorucu, Wayne T. Sanderson, Murray Madsen, Emily Redmond, Dennis J. Murphy, Risto Rautiainen

Biosystems and Agricultural Engineering Faculty Publications

Surveillance of injuries in production agriculture is necessary to inform stakeholders about workplace hazards and risks in order to improve and advance injury prevention policies and practices for this dangerous industry. The most comprehensive fatal injury surveillance effort currently in the United States is the Bureau of Labor Statistics (BLS) Census of Fatal Occupational Injuries (CFOI), which covers occupational fatalities in all U.S. industries, including production agriculture. However, this surveillance does not include many categories of fatalities that occur during agricultural work or on production agriculture worksites. To better capture the human cost of production agriculture, the authors of this …

Predictors Of Chronic Opioid Therapy In Medicaid Beneficiaries With Hiv Who Initiated Antiretroviral Therapy, Gyeon Oh, Emily S. Brouwer, Erin L. Abner, David W. Fardo, Patricia R. Freeman, Chris Delcher, Daniela C. Moga

Epidemiology and Environmental Health Faculty Publications

The factors associated with chronic opioid therapy (COT) in patients with HIV is understudied. Using Medicaid data (2002-2009), this retrospective cohort study examines COT in beneficiaries with HIV who initiated standard combination anti-retroviral therapy (cART). We used generalized estimating equations on logistic regression models with backward selection to identify significant predictors of COT initiation. COT was initiated among 1014 out of 9615 beneficiaries with HIV (male: 10.4%; female: 10.7%). Those with older age, any malignancy, Hepatitis C infection, back pain, arthritis, neuropathy pain, substance use disorder, polypharmacy, (use of) benzodiazepines, gabapentinoids, antidepressants, and prior opioid therapies were positively associated with …

Laser Irradiation As A Novel Alternative To Detach Intact Particulate Matter Collected On Air Filters, Seyed-Mohammadreza Samaee, Rahim Molaei, Robert A. Yokel, Hedieh Pazokian

Pharmaceutical Sciences Faculty Publications

Airborne particulate matter (PM) is collected on specific filters. For subsequent testing, the PM should be detached intact from the filter. Liquid extraction (LE), the standard method to detach PM from air filter surfaces, is challenging and can be tedious. Laser irradiation has been used to characterize PM on filters, but not to detach PM from filters for subsequent testing. A feasibility study was conducted to assess the potential of laser irradiation to detach PM from air filters. Laser-detached PM was deposited on a pre-weighed glass plate. PM detachment and collection were conducted in a single step. PM-coated air filters …

Translation And Examination Of The Reliability And Validity Of The Spanish Version Of The Smoking Self-Efficacy Questionnaire Among Latino Smokers., Francisco Cartujano-Barrera, Scott Mcintosh, Lisa Sanderson Cox, Evelyn Arana-Chicas, Delwyn Catley, Edward F Ellerbeck, Deborah J Ossip, Ana Paula Cupertino

Manuscripts, Articles, Book Chapters and Other Papers

The 12-item Smoking Self-Efficacy Questionnaire (SEQ-12) is a valid and reliable instrument to assess confidence in one's ability to refrain from smoking in a variety of different situations. This study evaluated the psychometric properties of the Spanish version of the 12-item Smoking Self-Efficacy Questionnaire (SEQ-12) among a sample of Spanish-speaking Latino smokers engaged in a smoking cessation research study. A forward-backward translation procedure guided the translation of the SEQ-12 into Spanish. The Spanish version of the SEQ-12 showed promising internal consistency reliability and construct validity among Latino smokers, with potential applications in both research and clinical settings.

Scleral Buckling For Primary Retinal Detachment: Outcomes Of Scleral Tunnels Versus Scleral Sutures., Matthew R. Starr, Edwin H. Ryan, Anthony Obeid, Claire Ryan, Xinxiao Gao, Malika L. Madhava, Sean M. Maloney, Adam Z. Adika, Krishi V. Peddada, Kareem Sioufi, Luv G. Patel, Michael J. Ammar, Nora J. Forbes, Antonio Capone, Geoffrey G. Emerson, Daniel P. Joseph, Dean Eliott, Carl Regillo, Jason Hsu, Omesh P. Gupta, Yoshihiro Yonekawa, For The Primary Retinal Detachment Outcomes Pro Study Group

Wills Eye Hospital Papers

Purpose: There are primarily two techniques for affixing the scleral buckle (SB) to the sclera in the repair of rhegmatogenous retinal detachment (RRD): scleral tunnels or scleral sutures.

Methods: This retrospective study examined all patients with primary RRD who were treated with primary SB or SB combined with vitrectomy from January 1, 2015 through December 31, 2015 across six sites. Two cohorts were examined: SB affixed using scleral sutures versus scleral tunnels. Pre- and postoperative variables were evaluated including visual acuity, anatomic success, and postoperative strabismus.

Results: The mean preoperative logMAR VA for the belt loop cohort was 1.05 ±" …

Effects Of A Dvd-Delivered Randomized Controlled Physical Activity Intervention On Functional Health In Cancer Survivors, Elizabeth A Salerno, Neha P Gothe, Jason Fanning, Lindsay L Peterson, Graham A Colditz, Edward Mcauley

2020-Current year OA Pubs

BACKGROUND: Supervised physical activity interventions improve functional health during cancer survivorship, but remain costly and inaccessible for many. We previously reported on the benefits of a DVD-delivered physical activity program (FlexToBa™) in older adults. This is a secondary analysis of the intervention effects among cancer survivors in the original sample.

METHODS: Low active, older adults who self-reported a history of cancer (N = 46; M time since diagnosis = 10.7 ± 9.4 years) participated in a 6-month, home-based physical activity intervention. Participants were randomized to either the DVD-delivered physical activity program focused on flexibility, toning, and balance (FlexToBa™; n = …

Targeting Human Langerin Promotes Hiv-1 Specific Humoral Immune Responses., Jérôme Kervevan, Aurélie Bouteau, Juliane S Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonné, Marion Bonnet, Cécile Lefebvre, Hakim Hocini, Romain Marlin, Aurélie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelièvre, Gerard Zurawski, Véronique Godot, Sandrine Henri, Botond Z. Igyártó, Yves Levy, Sylvain Cardinaud

Department of Microbiology and Immunology Faculty Papers

The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb). In mouse and non-human primate models, targeting of skin Langerhans cells (LC) with anti-Langerin mAbs fused with HIV-1 Gag antigen drives antigen-specific humoral responses. The development of these immunization strategies in humans requires a better understanding of early immune events driven by human LC. We therefore produced anti-Langerin mAbs fused with the HIV-1 gp140z Envelope (αLC.Env). First, we show that primary skin human LC and …

Nanozyme: A Developing Nanotechnology For The Detection Of Foodborne Pathogens, Nilamben D. Panchal

Electronic Theses & Dissertations

Increasing foodborne illnesses have led to global health and economic burdens. E. coli O157:H7 is one of the most common disease-provoking pathogens and known to be lethal Shiga toxin-producing E. coli (STEC) strains. With a low infection dose in addition to person-to-person transmission, STEC infections are easily spread. As a result, specific and rapid testing methods to identify foodborne pathogens are urgently needed. Nanozymes have emerged as enzyme-mimetic nanoparticles, demonstrating intrinsic catalytic activity that could allow for rapid, specific, and accurate pathogen identification in the agrifood industry. In this study, we explored a trimodal nanoplatform utilizing colorimetric kinetics based on …

Associations Between Physiological Biomarkers And Psychosocial Measures Of Pregnancy-Specific Anxiety And Depression With Support Intervention, Karen L Weis, Tony T Yuan, Katherine C Walker, Thomas F Gibbons, Wenyaw Chan

Faculty, Staff and Student Publications

Stress and anxiety significantly impact the hypothalamic-pituitary axis, and in pregnancy, the subsequent maternal-fetal response can lead to poor outcomes. The objective of this study was to assess the association between psychosocial measures of pregnancy-specific anxiety and physiologic inflammatory responses. Specifically, to determine the effectiveness of the Mentors Offering Maternal Support (M-O-M-S

Oral Factors That Impact The Oral Microbiota In Parkinson's Disease, Natalia S Rozas, Gena D Tribble, Cameron B Jeter

Faculty, Staff and Student Publications

Patients with Parkinson's disease (PD) are at increased risk of aspiration pneumonia, their primary cause of death. Their oral microbiota differs from healthy controls, exacerbating this risk. Our goal was to explore if poor oral health, poor oral hygiene, and dysphagia status affect the oral microbiota composition of these patients. In this cross-sectional case-control study, the oral microbiota from hard and soft tissues of patients with PD (n = 30) and age-, gender-, and education-matched healthy controls (n = 30) was compared using 16S rRNA gene sequencing for bacterial identification. Study participants completed dietary, oral hygiene, drooling, and …