Medicine and Health Sciences Commons^™

The Wingate Anaerobic Test: A Comprehensive Literature Review And Update On Reference Values In Athletes, Caleb Christie

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The Wingate Anaerobic test (WAnT) was developed in the 1970s as a measurement of lower extremity anaerobic power (Ayalon, Inbar, Bar-Or, 1974) and has long been used as a measurement tool in athletes, who are often defined by numbers. While numbers are not able to entirely predict or evaluate athletic ability, they are often used as a tool to predict or rate athletes. The WAnT has long been a gold standard in evaluating lower extremity power, which is a highly valuable aspect of many sprint and power-driven sports (e.g., hockey, football, or track and field). The WAnT was originally developed …

No Evidence Of Stochastic Resonance In Postural Sway Response To Noisy Galvanic Vestibular Stimulation In Healthy Young Adults, Dominique Rice

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The transcutaneous application of a sub-sensory electrical stimulation to the vestibular afferents, known as noisy galvanic vestibular stimulation (nGVS), is thought to cause a reduction in postural sway at optimal amplitude intensities due to a mechanism known as stochastic resonance (SR). SR is a phenomenon whereby the addition of low amplitude noise to a non-linear system can be beneficial rather than detrimental. In humans, behavioral markers of SR in postural sway have been inconsistent, potentially due to insufficient power or false positives. Therefore, the main purpose of this study was to determine whether the frequency of observing SR-like effects improves …

Mindfulness-Based Practices For The Impaired Performance Athlete, Mackenzie L. Campbell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Mindfulness-based programs are becoming commonly considered for the improvement of athlete's mental and physical state. However, their usage in improving performance in impaired athletes is limited and not fully understood. The purpose of this thesis was to review the standing literature on the topic of the application of mindfulness to improving athletic performance in wellbeing-impaired athletes. Seventy-three articles were included as references for this paper describing functional mechanisms, clinical significance and anecdotal evidence that points to the effectiveness of mindfulness in sport for the treatment of pain, injury recovery, prevention of injury, and chronic illness. Ultimately, this review supports the …

Tumor-On-Chip Modeling Of Organ-Specific Cancer And Metastasis, Nuala Del Piccolo, Venktesh S Shirure, Ye Bi, S Peter Goedegebuure, Sepideh Gholami, Christopher C W Hughes, Ryan C Fields, Steven C George

2020-Current year OA Pubs

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems that accurately mimic human oncology - a requirement for the development of more effective therapies for these patients - remain elusive. Tumor development is an organ-specific process that involves modification of existing tissue features, recruitment of other cell types, and eventual metastasis to distant organs. Recently, tissue engineered microfluidic devices have emerged as a powerful in vitro tool to model human physiology and pathology with organ-specificity. These organ-on-chip platforms consist of cells cultured in 3D hydrogels and offer precise control over geometry, biological components, and physiochemical properties. …

Efficacy Of Invisalign Attachments: A Retrospective Study, Theresa Karras, Maharaj Singh, Emelia Karkazis, Dawei Liu, Ghada Nimeri, Bhoomika Ahuja

College of Nursing Faculty Research and Publications

Introduction: The purpose of this study was to compare the efficacy of Invisalign's (Align Technology, Santa Clara, Calif) optimized and conventional attachments on rotational and extrusive tooth movements. Methods: Initial, predicted, and achieved digital dental models from 100 orthodontic patients were exported from Invisalign's ClinCheck software as stereolithography files and subsequently imported into the Slicer CMF program (version 4.7.0; http://www.slicer.org) for superimpositions on posterior teeth with no planned movement. Rotational and extrusive measurements for both optimized and conventional attachments were made on 382 teeth from the superimposition of the initial and predicted models (predicted movement) and from the superimposed initial …

Thromboelastography-Based Profiling Of Coagulation Status In Patients Undergoing Bariatric Surgery: Analysis Of 422 Patients, John C Cowling, Xu Zhang, Kulvinder S Bajwa, Ekatarina G Elliott, Melissa M Felinski, Julie Holihan, Michelle Scerbo, Brad E Snyder, Michael D Trahan, Todd D Wilson, Sharon L Courtney, Connie L Klein, Angielyn R Rivera, Erik B Wilson, Shinil K Shah, Davide Cattano

Faculty, Staff and Student Publications

Introduction/purpose: Some clinical indicators suggest hypercoagulability/hyperaggregability in patients with morbid obesity. Thromboelastography (TEG®) has been used to profile coagulation status in surgical patients. We aimed to assess coagulation profiles in patients with morbid obesity undergoing bariatric surgery by correlating demographic and patient characteristics to pre-operative TEG® values.

Materials and methods: Pre-operative TEG® values from 422 patients undergoing bariatric surgery were evaluated. TEG® results were analyzed by gender, use of medications known to alter the coagulation profile, and body mass index (BMI).

Results: Patients have a mean of 45.03 ± 11.8 years, female (76.3%), and with a mean BMI of 42 …

Effective Recruitment Strategies For A Sickle Cell Patient Registry Across Sites From The Sickle Cell Disease Implementation Consortium (Scdic), Rita V Masese, Taniya Varughese, Et Al.

2020-Current year OA Pubs

Sickle cell disease (SCD) is a genetic disorder predominantly affecting people of African descent and is associated with significant morbidity and mortality. To improve SCD outcomes, the National Heart Lung and Blood Institute funded eight centers to participate in the SCD Implementation Consortium. Sites were required to each recruit 300 individuals with SCD, over 20 months. We aim to describe recruitment strategies and challenges encountered. Participants aged 15-45 years with confirmed diagnosis of SCD were eligible. Descriptive statistics were used to analyze the effectiveness of each recruitment strategy. A total of 2432 participants were recruited. Majority (95.3%) were African American. …

Phase Ii Study Of Durvalumab Plus Tremelimumab As Therapy For Patients With Previously Treated Anti-Pd-1/Pd-L1 Resistant Stage Iv Squamous Cell Lung Cancer (Lung-Map Substudy S1400f, Nct03373760), Natasha B Leighl, Jeffrey D Bradley, Et Al

2020-Current year OA Pubs

INTRODUCTION: S1400F is a non-match substudy of Lung Cancer Master Protocol (Lung-MAP) evaluating the immunotherapy combination of durvalumab and tremelimumab to overcome resistance to anti-programmed death ligand 1 (PD-(L)1) therapy in patients with advanced squamous lung carcinoma (sq non-small-cell lung cancer (NSCLC)).

METHODS: Patients with previously treated sqNSCLC with disease progression after anti-PD-(L)1 monotherapy, who did not qualify for any active molecularly targeted Lung-MAP substudies, were eligible. Patients received tremelimumab 75 mg plus durvalumab 1500 mg once every 28 days for four cycles then durvalumab alone every 28 days until disease progression. The primary endpoint was the objective response rate …

Progress Towards Antibiotic Use Targets In Eight High-Income Countries, Bryony Simmons, Koya Ariyoshi, Norio Ohmagari, Celine Pulcini, Benedikt Huttner, Sumanth Gandra, Giovanni Satta, Lorenzo Moja, Michael Sharland, Nicola Magrini, Marisa Miraldo, Graham Cooke

2020-Current year OA Pubs

OBJECTIVE: To compare antibiotic sales in eight high-income countries using the 2019 World Health Organization (WHO) Access, Watch and Reserve (AWaRe) classification and the target of 60% consumption of Access category antibiotics.

METHODS: We analysed data from a commercial database of sales of systemic antibiotics in France, Germany, Italy, Japan, Spain, Switzerland, United Kingdom of Great Britain and Northern Ireland, and United States of America over the years 2013-2018. We classified antibiotics according to the 2019 AWaRe categories: Access, Watch, Reserve and Not Recommended. We measured antibiotic sales per capita in standard units (SU) per capita and calculated Access group …

Synergistic Effect Of High Intensity Ultrasound, Antimicrobial Compounds, And Uv-A Light On Microbial Quality Of Dairy Products, Bryce Rodney Hales

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Food spoilage and contamination remains a common problem within the food industry. Furthermore, the continued change of consumer demand and perspective on food quality and products has led the food industry and researchers to find new methods of food preservation. Many of these new methods hope to use non-thermal processes since thermal processes tend to decrease the overall quality of the final product. Some new non-thermal methods that have been looked at are the use of high intensity ultrasound (HIU), ultraviolet light, and the use of natural antimicrobials. In this study, UHT milk inoculated with either E. coli K12 or …

Local And Systemic Effects Of Flavonoid Intake With Submaximal Cycling Exercise: A Randomized Controlled Trial, Stephanie Kung

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Moderate to high intensity endurance exercise is a known cause of exercise-induced gastrointestinal syndrome, a condition often associated with intestinal complaints such as discomfort, cramps, and diarrhea. Oftentimes, elevated intestinal inflammation and permeability (a “leaky gut”) are also observed. Previous research has shown that flavonoids, natural compounds found in many fruits and vegetables, may mitigate these exercise-induced effects. In particular, certain cocoa powders contain high levels of flavonoids, and chocolate milk is a good source of protein and sugars for sustaining intense activity. Thus, the purpose of this study was to evaluate the effects of a dairy pre-workout beverage, with …

Characterization And Immobilization Of Thermophilic Lipases For The Interesterification Of Soybean Oil, Teif A. Najm

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Lipases are currently used in food technology for the modification of fats and oils. Lipase can synthesize, hydrolyze, and rearrange fatty acids, thus, resulting in their extensive use in industrial applications. The thermal stability of lipase is an essential characteristic for this application. Thermophilic bacteria are an important source for producing thermostable lipases because of their tolerance to high heat. Lipolytic enzymes can be purified using several purification methods, but these purification processes are often expensive and complex. Results from this study showed that lipases can be extract from thermophilic bacteria (Geobacillius stearothermophilus (GS) and Anoxybacillus flavithermus (AF)). Molecular …

Effect Of High-Intensity Ultrasound On Bubble Dynamics, Oxidation, And Crystallization Behavior Of Fats, Juhee Lee

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Partially hydrogenated oils (PHOs) provide desired texture, stability, and extended shelf life in food products. These types of lipids have been commonly used in food industry. However, the Food and Drug Administration (FDA) decided to remove generally recognized as safe (GRAS) status of PHOs in 2015 due to the association between PHOs and coronary heart disease (CHD), type 2 diabetes and other metabolic diseases. Hence, it is necessary to find alternative new healthy lipids or novel processing conditions that can be used to replace the functionality of PHO. Among the processing methods to be used in alternative PHOs fats, high-intensity …

Utilization Of Protective Cultures To Reduce Late Gas Formation By Paucilactobacillus Wasatchensis, Ireland R. Green

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cheesemaking is a process susceptible to defects caused by microbes not purposefully added by the manufacturer. While these bacteria are not a health concern, they can cause problems such as producing carbon dioxide inside the cheese. This can cause slits and cracks in cheese making cheese unsuitable for slicing. One such bacteria identified by cheese researchers at Utah State University and Weber State University is Paucilactobacillus wasatchensis. When present in cheese, it can cause gas formation by using galactose to supply its energy. In doing so, it takes this six-carbon sugar and converts it into a five-carbon sugar and …

Comparison Of Microbial Diversity Of Fifteen Aged Cheddar Cheeses From Different Regions Using Next Generation Sequencing, Sophie L. Overbeck

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This project was funded by BUILD Dairy to test the efficacy of using next generation sequencing to study Cheddar cheese microbiomes. The 15 different cheese samples used in this study were purchased in the retail market from various manufacturers and different origins of manufacture. Sequencing was done by the Center for Integrated Biosystems at Utah State University using Illumina MiSeq.

The aim of this project is to provide further understanding of how using next generation sequencing can benefit the study of bacterial communities and their influence during the aging process of Cheddar cheese and the possibility of identifying defect causing …

Social Media Usage And Psychological Well-Being In Adolescents: A Comparison Among Demographics, Heather A. Mccall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to examine social media use of adolescents in the U.S. and their psychological well-being to expand the research of this quickly changing topic. The researcher collected online responses from 409 adolescents between the ages of 13-17 years old concerning their social media use and psychological well-being.

Variables in the research included time spent on social media, number of platforms used, active use, parental mediation, and emotional connection. The two variables that had a statistically significant relationship with psychological well-being included parental mediation and emotional connection to social media.

Recommendations for continued research could include …

Exploring The Relationship Between The Distance Of Parks And Rates Of Adult Obesity In El Paso, Texas, Shawna Payan

Open Access Theses & Dissertations

Background: In El Paso, areas of the city do not have access to parks within walking distance. The rates of people suffering from obesity and the comorbidities that come with obesity are rising annually. Physical activity has been shown to increase lifespan and provide positive health outcomes for the individual. Increasing physical activity in adults by using the parks can decrease their risk for heart disease and diabetes. Objectives: The overall aim of the procedure is to determine a relationship between park density and distance from residence to the nearest park, adult population density, and the obesity rate density within …

Systematic Review Of Alternative Interventions For Construction Workers To Manage Work-Related Musculoskeletal Pain And Discomfort, Isaac Abraham Rodriguez

Open Access Theses & Dissertations

Background: The prevalence of Work-Related Musculoskeletal Pain and Discomfort (WRMSPD) among construction workers in 2017 was almost 20,000 injuries. Close to 60% were overexertion, others included lifting and lowering. The most common form of WRMSPD could originate from the upper back to lower back and neck pain. It was reported that the highest prevalence of WRMSPD were in the upper extremities (nearing 60%) because of the physically demanding factor of the job (heavy lifting and repetitive movement). Over 250,000 cases were reported to be WRMSPD in the private sector of the U.S. Purpose: The purpose of this systematic review was …

Identification Of Leishmania Spp. And T. Cruzi Parasites In Bats Captured In El Paso, Texas Region: Bats As A New Reserviour, Edith Sandoval

Open Access Theses & Dissertations

Background: Recognized by the World Health Organization (WHO) as two of the world’s thirteen most neglected tropical diseases (NTD), both T. cruzi and Leishmania spp. parasites are accountable for Chagas disease and Leishmaniasis, respectively and they continue to rank among the most important public health problems in South America. Together, Leishmaniasis and Chagas affect 300 million people. Wildlife reservoirs play an important role in the maintenance and transmission of parasites in sylvatic transmission cycles. In the last decade studies have been conducted in this region of El Paso, Texas, and other parts of the world to detect both parasites in …

J Mich Dent Assoc August 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on “Diversity, Equity, Inclusion, and Dentistry: Understanding the MDA’s Perspective”.
• A feature article, “Diversity, Equity, Inclusion, and Dentistry: Its Impact on Oral Health — You Can Make a Difference!”.
• A feature article from the Journal’s DEI series, “Welcoming Diversity, Equity, and Inclusion with Students Considering Careers in Dentistry”.
• A feature clinical article …

Changes In The Gut Microbiome Influence The Hypoglycemic Effect Of Metformin Through The Altered Metabolism Of Branched-Chain And Nonessential Amino Acids, Yujin Lee, Andrew Hyoungjin Kim, Eunwoo Kim, Seunghwan Lee, Kyung-Sang Yu, In-Jin Jang, Jae-Yong Chung, Joo-Youn Cho

2020-Current year OA Pubs

AIMS: Although metformin has been reported to affect the gut microbiome, the mechanism has not been fully determined. We explained the potential underlying mechanisms of metformin through a multiomics approach.

METHODS: An open-label and single-arm clinical trial involving 20 healthy Korean was conducted. Serum glucose and insulin concentrations were measured, and stool samples were collected to analyze the microbiome. Untargeted metabolomic profiling of plasma, urine, and stool samples was performed by GC-TOF-MS. Network analysis was applied to infer the mechanism of the hypoglycemic effect of metformin.

RESULTS: The relative abundances of Escherichia, Romboutsia, Intestinibacter, and Clostridium were changed by metformin …

The Effect Of Sub 5% Oxygen Tension On In Vitro Human Embryo Development, Bradley James Link

EVMS School of Health Professions Theses & Dissertations

Objective: To determine the impact of < 5% O₂ tension on the in vitro development of human pre-implantation embryos. It was hypothesized that the optimal O₂ tension would differ from the commonly utilized 5%, as shown by beneficial effects after the implementation of a more physiological O₂ tension such as 2% for either the partial or full duration of in vitro culture.

Aim: To conduct a randomized controlled study to determine the effect of O₂ tension during in vitro human embryo culture on the production of reactive oxygen species (ROS), apoptosis, gene expression and embryo development.

Background: The …

Efficacy Of Neratinib Plus Capecitabine In The Subgroup Of Patients With Central Nervous System Involvement From The Nala Trial, Sara A Hurvitz, Ron Bose, Et Al

2020-Current year OA Pubs

BACKGROUND: Neratinib has efficacy in central nervous system (CNS) metastases from HER2-positive metastatic breast cancer (MBC). We report outcomes among patients with CNS metastases at baseline from the phase III NALA trial of neratinib plus capecitabine (N + C) versus lapatinib plus capecitabine (L + C).

MATERIALS AND METHODS: NALA was a randomized, active-controlled trial in patients who received two or more previous HER2-directed regimens for HER2-positive MBC. Patients with asymptomatic/stable brain metastases (treated or untreated) were eligible. Patients were assigned to N + C (neratinib 240 mg per day, capecitabine 750 mg/m

RESULTS: Of 621 patients enrolled, 101 (16.3%) …

Race And Ethnicity Representation In Clinical Trials: Findings From A Literature Review Of Phase I Oncology Trials, D Ross Camidge, Haeseong Park, Karen E Smoyer, Ira Jacobs, Lauren J Lee, Zemfira Askerova, Justin Mcginnis, Yousef Zakharia

2020-Current year OA Pubs

No abstract provided.

Effect Of Ultrasound Pressure On The Distribution Of Bovine Serum Albumin Delivered By Focused Ultrasound-Mediated Blood-Brain Barrier Opening In Cleared Mouse Brains, Yajie Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Most common diagnosis and therapeutic methods have low effectiveness when used on brain diseases. The key obstacle is that the blood-brain barrier (BBB) prevents most drugs from entering the brain. Some strategies have been developed to improve the efficiency of drug delivery crossing BBB. Among all these strategies, focused ultrasound-mediated BBB opening (FUS-BBB Opening) stands out since it is noninvasive and can be located to the target area. Detailed studies are required on the distribution of drugs delivered by FUS-BBB opening and the effects of FUS parameters on the distribution. This thesis proposes a pipeline involving tissue clearing and lightsheet …

A Novel Incremental Simulation Of Facial Changes Following Orthognathic Surgery Using Fem With Realistic Lip Sliding Effect, Daeseung Kim, Tianshu Kuang, Yriu L Rodrigues, Jaime Gateno, Steve G F Shen, Xudong Wang, Kirhyn Stein, Hannah H Deng, Michael A K Liebschner, James J Xia

Faculty, Staff and Students Publications

Accurate prediction of facial soft-tissue changes following orthognathic surgery is crucial for surgical outcome improvement. We developed a novel incremental simulation approach using finite element method (FEM) with a realistic lip sliding effect to improve the prediction accuracy in the lip region. First, a lip-detailed mesh is generated based on accurately digitized lip surface points. Second, an improved facial soft-tissue change simulation method is developed by applying a lip sliding effect along with the mucosa sliding effect. Finally, the orthognathic surgery initiated soft-tissue change is simulated incrementally to facilitate a natural transition of the facial change and improve the effectiveness …

Anti-Neutrophil Cytoplasmic Antibodies: To Care Or Not To Care, Sara Shahid, Syed H Alam, Lillian Gaber, Salman Ahmed

Faculty, Staff and Students Publications

Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis is a disease process with a wide range of presentations, from asymptomatic or minimally symptomatic disease with positive laboratory testing, to florid acute end-organ damage. Consensus has not been established as to the frequency and/or protocol by which ANCA testing should be repeated. We present the case of a 53-year-old woman who initially came to medical attention with persistent dyspnea and pulmonary infiltrates presumed to be due to acute exacerbation of chronic diastolic congestive heart failure. Extensive infectious disease testing was negative, but ANCA testing was positive. However, because antinuclear antibody (ANA) interference in …

Rare Silent Ischemic Ventricular Septal Aneurysm And Rupture: A Multimodality Diagnostic Approach, Hong Loan Nguyen, Nicolas Palaskas, Nasser Lakkis, Rashed Tabbaa

Faculty, Staff and Students Publications

A multimodality approach in addition to high level of clinical suspicion and thorough physical examination is important in the diagnosis and management of left ventricular aneurysm and rupture after a silent inferior infarction.

Use Of Convalescent Plasma In Covid-19 Patients With Immunosuppression, Jonathon W Senefeld, Jeffrey P Henderson, Et Al.

2020-Current year OA Pubs

In the absence of effective countermeasures, human convalescent plasma has been widely used to treat severe acute respiratory syndrome coronavirus 2, the causative agent of novel coronavirus disease 19 (COVID-19), including among patients with innate or acquired immunosuppression. However, the association between COVID-19-associated mortality in patients with immunosuppression and therapeutic use of convalescent plasma is unknown. We review 75 reports, including one large matched-control registry study of 143 COVID-19 patients with hematological malignancies, and 51 case reports and 23 case series representing 238 COVID-19 patients with immunosuppression. We review clinical features and treatment protocols of COVID-19 patients with immunosuppression after …

Variants In Prkar1b Cause A Neurodevelopmental Disorder With Autism Spectrum Disorder, Apraxia, And Insensitivity To Pain, Felix Marbach, Marisa V Andrews, Dorothy K Grange, Et Al.

2020-Current year OA Pubs

PURPOSE: We characterize the clinical and molecular phenotypes of six unrelated individuals with intellectual disability and autism spectrum disorder who carry heterozygous missense variants of the PRKAR1B gene, which encodes the R1β subunit of the cyclic AMP-dependent protein kinase A (PKA).

METHODS: Variants of PRKAR1B were identified by single- or trio-exome analysis. We contacted the families and physicians of the six individuals to collect phenotypic information, performed in vitro analyses of the identified PRKAR1B-variants, and investigated PRKAR1B expression during embryonic development.

RESULTS: Recent studies of large patient cohorts with neurodevelopmental disorders found significant enrichment of de novo missense variants in …