Medicine and Health Sciences Commons^™

Impact Of Fellow/Resident Involvement During Colonoscopy In A High-Volume Colorectal Surgical Practice, Zachary Chomitzky, William Sangster

Research Scholars

No abstract provided.

Assessing The Clinical Characteristics And Ventilator Parameters Of Covid-19 Mechanically Ventilated Patients At Lehigh Valley Health Network, Andrew Kelly, Kenneth Miller Med, Rrt-Nps

Research Scholars

No abstract provided.

Analysis Of Risk Factors And Outcomes For Obstetric Trauma Patients, Lauren Salbinski, Matthew D. Painter Md, Danielle L. Hashmi Do

Research Scholars

No abstract provided.

Invaplex Functions As An Intranasal Adjuvant For Subunit And Dna Vaccines Co-Delivered In The Nasal Cavity Of Nonhuman Primates, Jeremy V. Camp, Robert L. Wilson, Morgan Singletary, James L. Blanchard, Anna Aldovini, Robert W. Kaminski, Edwin V. Oaks, Pamela A. Kozlowski

School of Graduate Studies Faculty Publications

Development of intranasal vaccines for HIV-1 and other mucosal pathogens has been hampered by the lack of adjuvants that can be given safely to humans. We have found that an intranasal Shigella vaccine (Invaplex) which is well tolerated in humans can also function as an adjuvant for intranasal protein and DNA vaccines in mice. To determine whether Invaplex could potentially adjuvant similar vaccines in humans, we simultaneously administered a simian immunodeficiency virus (SIV) envelope (Env) protein and DNA encoding simian-human immunodeficiency virus (SHIV) with or without Invaplex in the nasal cavity of female rhesus macaques. Animals were intranasally boosted with …

Prevalence And Determinants Of Inappropriate Antibiotic Dispensing At Private Drug Retail Outlets In Urban And Rural Areas Of Indonesia: A Mixed Methods Study, Luh Putu Lila Wulandari, Mishal Khan, Marco Liverani, Astri Ferdiana, Yusuf Ari Mashuri, Ari Probandari, Tri Wibawa, Neha Batura, Gill Schierhout, John Kaldor

Department of Pathology and Laboratory Medicine

Introduction: The aim of this mixed-method study was to determine the extent and determinants of inappropriate dispensing of antibiotics by licensed private drug retail outlets in Indonesia.
Methods: Standardised patients (SPs) made a total of 495 visits to 166 drug outlets (community pharmacies and drug stores) between July and August 2019. The SPs presented three clinical cases to drug outlet staff: parent of a child at home with diarrhoea; an adult with presumptive tuberculosis (TB); and an adult with upper respiratory tract infection (URTI). The primary outcome was the dispensing of an antibiotic without prescription, with or without the client …

An Audit Of Gynae-Oncology Practices In Ovarian Cancer Treatment Based On Enhanced Recovery After Surgery (Eras) Protocol Amongst Two Gynae-Oncology Units, In Uk And In Pakistan, Uzma Chishti, Munazza Akhtar, Aliya Aziz, Amber Ahmed, Desmond Pj Barton

Department of Obstetrics & Gynaecology

Objective: To compare peri-operative practices and complications in ovarian cancer patients undergoing upfront surgery for primary disease under enhanced recovery after surgery protocol and traditional practices.
Methods: The retrospective cross-sectional study was done at the gynaecology departments of St Georges Hospital, United Kingdom, and the Aga Khan Hospital, Pakistan, and comprised data of an equal number of ovarian cancer patients from each centre who underwent ovarian cancer surgery from January 2015 to December 2016. The former centre practiced the enhanced recovery after surgery protocol, while the latter centre followed traditional practices. Data was analysed using SPSS 19.|
Results: Of the …

Variation In Patient Satisfaction Based On Clinician’S Gender, Race, Age, And Degree, Elizabeth Lieb, Grant M. Greenberg M.D., M.H.S.A., M.A., Melanie B. Johnson Mpa

Research Scholars

No abstract provided.

Review Of Covid-19 Patient Demographics At Lvhn Hospitals, Hannah Tan, Judith Sabino Mph, Cdp, Renee Bryant

Research Scholars

No abstract provided.

Identifying Attributes Of Success: A Case Study Of Select Coaches And Lvhn Physician Leadership Training, Madison Smith, Kerri Green Ms, Med.

Research Scholars

No abstract provided.

Six-Month Health Outcomes In Elderly Patients Post Covid-19 (Shoe-P), Nikhil Sharma, Neti N. Vora Md

Research Scholars

No abstract provided.

Trends In Hysterectomy In Hospital And Ambulatory Settings In Kentucky 2017-2020., Felicia A. Pugh

Electronic Theses and Dissertations

Hysterectomy is the most common treatment for benign uterine conditions in the United States. Data suggest that one in nine women will have the procedure in their lifetime (1). Previous studies indicate that abdominal hysterectomy rates for non-malignancies are declining as alternative methods are increasing for decades; however, those trends do not apply for all women in the country (2-5). In this cross-sectional study, hysterectomy procedures completed between 2017-2020 are described in Kentucky Cabinet for Health and Family Services data. Multivariable logistic regression is used to assess the odds of abdominal hysterectomy for benign indications in Kentucky. Conclusion: Rates of …

Development Of 3d-Bioprinted Scaffolds For Oral Probiotic Application., Jhanvi Patel

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis adheres to and invades gingival epithelial cells, resulting in decreased cell viability. Previous studies have indicated that probiotics are effective against dental pathogens; however, few approaches provide sustained-delivery of active agents in the oral cavity. Hypothesis: Probiotics will limit P. gingivalis effects on Telomerase Immortalized Gingival Keratinocyte (TIGK) cells and 3D-printed scaffolds will prolong probiotic release. Methods: Lactobacillus acidophilus, Lactobacillus reuteri, and Bifidobacterium bifidum were assessed with adhesion and antibiotic protection assays to limit P. gingivalis effects on TIGKs. Scaffolds were printed with a select probiotic and evaluated for release kinetics. Results: Free L.a., …

Top Comorbidities Associated With Patient Malnutrition On 30 Day Readmission Rate, Kaitlyn Mcginley, Melissa Faura Rd, Ldn, Ann Flickinger Ms, Rd, Ldn, Kimberly Procaccino Mba, Rd, Ldn

Research Scholars

No abstract provided.

Telehealth Assessment In The Elderly Using The 4m'S, Janet Obonyo

Nursing Capstones

COVID-19 has accelerated an already urgent need for telehealth in the United States. While health care systems have been providing telehealth for years, the number of providers and patients who need to participate in telehealth has ballooned overnight. Though telehealth has been in use for a while, the geriatric population seems to be disadvantaged, especially those who reside in rural settings. Due to increased COVID 19 cases among the elderly population in North Dakota, the Geriatric Workforce Enhancement Program (GWEP) allocated a grant to the University of North Dakota to promote telehealth in the elderly receiving homecare services in rural …

Alarm Fatigue, Taylor Fogel Adn, Rn, Bree Hoffman Adn, Rn, Caroline Zaharick Adn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Gestational Weight Gain In 4 Low- And Middle-Income Countries And Associations With Birth Outcomes: A Secondary Analysis Of The Women First Trial., Melissa S Bauserman, Carla M Bann, K Michael Hambidge, Ana L Garces, Lester Figueroa, Jamie L Westcott, Jackie K Patterson, Elizabeth M Mcclure, Vanessa R Thorsten, Sumera Ali Aziz, Sarah Saleem, Robert L Goldenberg, Richard Derman, Veena Herekar, Manjunath Somannavar, Marion W Koso-Thomas, Adrien L Lokangaka, Antoinette K Tshefu, Nancy F Krebs, Carl L Bose, Shivaprasad Goudar, Sangappa Dhaded, Bhalchandra Kodkany, Omrana Pasha, Abhik Das, Menachem Miodovnik, N K Raju Tonse

Global Health Articles

BACKGROUND: Adequate gestational weight gain (GWG) is essential for healthy fetal growth. However, in low- and middle-income countries, where malnutrition is prevalent, little information is available about GWG and how it might be modified by nutritional status and interventions.

OBJECTIVE: We describe GWG and its associations with fetal growth and birth outcomes. We also examined the extent to which prepregnancy BMI, and preconception and early weight gain modify GWG, and its effects on fetal growth.

METHODS: This was a secondary analysis of the Women First Trial, including 2331 women within the Democratic Republic of Congo (DRC), Guatemala, India, and Pakistan, …

Nutrinews: August, 2021, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Shopping in Season: Jackfruit, Sustainability of Local Food, and Dietary Habits of Iranians

Predictors Of Aggression Among Adolescent Girls, Sarah Joy Park

Loma Linda University Electronic Theses, Dissertations & Projects

Women and girls will often deny what they feel and think to maintain their relationships. Silencing the self can be detrimental to the physical and mental health of teenage girls. This stifling of the self is related to depression, earlier first intercourse, eating disorders, and less relationship satisfaction. Girls who silence their voices are also likely to have difficulty expressing themselves when they feel angry. In this study we explored the relationship between silencing the self and physical, verbal, and indirect aggression. Our sample consisted of 88 teenage girls from two high schools, with a mean age of 16. They …

Accuracy And Reproducibility Of Cone Beam Computed Tomographs For The Assessment Of Bony Tissues, An Ex-Vivo Study, Saad Hamad Almujel

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The purpose of this study was to evaluate the impact of implant blooming artifact on the assessment of the peri-implant buccal bone thickness, the accuracy of two CBCT devices, and the reproducibility of CBCT images obtained in different exposure timelines.

Materials and Methods: Four dental implants were placed in the mandible of a cadaver head. The distances between dental implants and the thickness of the peri-implant buccal bone were measured with a high precision caliper. The cadaver head was scanned using 2 different CBCT devices, 12 repeated scans were made while the cadaver head in its initial …

Management Of Early Pregnancy Loss In Rural And Urban New Mexico, Anwar Jackson

Biomedical Sciences ETDs

Early pregnancy loss (EPL) is a common pregnancy condition that can be easily and effectively managed. However, there is limited data on the availability of management options, particularly in rural areas. Issues concerning limited data on early pregnancy loss management were analyzed in three ways. A literature review was performed exploring the role midwives play in EPL care. Findings from this review were written in the form of a review article. Original research was then conducted exploring differences in EPL care provision between rural and urban New Mexico. This research consisted of a questionnaire given to clinicians practicing in rural …

Using Population Health Management To Reduce Heart Diseases And Health Disparities Among African Americans: A Narrative Review, Adolfo Gonzalez

Electronic Theses, Projects, and Dissertations

The integration of Population Health Management (PHM) within the U.S. health care system may effectively decrease heart disease and health disparities among African American adults. Population Health Management strategies look at whether the health care system is meeting the needs of health care access, medical coverage, quality of care, and to reducing health disparities within specific population. Population Health Management strategies could be used to mitigate and reduce health disparities.

The purpose of this study is to discuss the potential impacts of Population Health Management within our health care system and how its influence can reduce heart diseases among African …

Epithelial Memory Of Resolved Inflammation Limits Tissue Damage While Promoting Pancreatic Tumorigenesis, I-Lin Ho

Dissertations and Theses (Open Access)

Inflammation is a major risk factor for pancreatic ductal adenocarcinoma. When occurring in the context of pancreatitis, mutations of KRAS accelerate tumor development. We discovered that long after its complete resolution, a transient inflammatory event primes pancreatic epithelial cells to subsequent transformation by oncogenic KRAS. Upon recovery from acute inflammation, epithelial cells of the pancreas display an enduring adaptive response associated with sustained transcriptional and epigenetic reprogramming. Such adaptation enables the prompt reactivation of acinar-to-ductal metaplasia (ADM) upon subsequent inflammatory events, thus efficiently limiting tissue damage via rapid decrease of zymogen production. We propose that since activating mutations of KRAS …

Manipulating Enhancer Rna Activity To Study Their Roles In Gene Regulation And Cancer, Zian Liao

Dissertations and Theses (Open Access)

Enhancers are essential regulatory elements that precisely control gene transcription during development and disease. Especially in cancer, enhancers modulate tumor gene expression, and in some cases directly drive tumorigenesis. With the recent advances in next-generation sequencing, researchers discovered that active enhancers are pervasively transcribed into RNAs, which are named enhancer RNAs (eRNAs). Studies have suggested that eRNAs have a functional role in the enhancer action mechanism. Studying their roles will provide a new understanding of gene regulation and cancer development. In my MS study, I focused on using novel methods to study eRNA functions. Using a breast-cancer-specific eRNA, I have …

Effect Of Lactoferrin To Increase Drug Permeability Of Primary Pulmonary Mycobacterial Granulomas, Thao Nguyen, Thao Kt Nguyen

Dissertations and Theses (Open Access)

Despite extensive research and worldwide eradication efforts, Mycobacterium tuberculosis (Mtb) remains a major infectious pathogen to the human population with about 10 million cases of infection per year globally. The host-pathogen interaction, pulmonary granuloma formation, and Mtb adaptions result in increased complexity of the disease. Granulomas are formed by active immune responses generated during Mtb infection, and serve to contain and limit bacterial dissemination. The major mycobacterial surface mycolic acid, trehalose 6,6'-dimycolate (TDM), functions in multiple ways to enhance immune cell recruitment of sites of infection, to induce inflammation and granulomatous responses, and to initiate survival strategies for …

Abdominal Vascular Injuries- What General/ Trauma Surgeons Should Know?, Zia Ur Rehman

Department of Surgery Docs

Abdominal vascular injuries are the common cause of death post-trauma. These are challenging injuries to manage due to severe haemodynamic instability, other associated injuries and difficulty in accessing and controlling these deep-seated vessels. Early control of bleeding can decrease mortality in these patients. Abdominal vasculature is divided into three zones, each requiring different operative strategy for exposure. Standard vascular surgery principles of achieving proximal and distal control before exploring any haematoma are followed when managing these injuries. Resuscitative endovascular balloon occlusion of aorta is a minimally invasive method of achieving proximal aortic occlusion. This also acts as bridge for definitive …

Relationships Between Perceived Quality Of Life And Spiritual Beliefs, Education Level, Socioeconomic Status, Gender, And Ethnicity In Cancer Patients And Cancer Survivors, Eva Arjona

Theses and Dissertations

The purpose of this study was to identify a relationship between perceived Quality of Life and religious/spiritual beliefs. Additionally, it aimed to explore relationships between perceived QOL and age, gender, ethnicity, education level, and Socioeconomic Status (SES). The research question examined in this study was: What is the relationship between perceived quality of life and spiritual beliefs, education level, socioeconomic status, age gender, and ethnicity in cancer patients and cancer survivors? A total of 100 cancer patients or cancer survivors were surveyed for this study. A regression analysis was conducted to explore relationships among the variables; the alpha level was …

Blood Pressure Thresholds In Pregnancy For Identifying Maternal And Infant Risk: A Secondary Analysis Of Community-Level Interventions For Pre-Eclampsia (Clip) Trial Data, Jeffrey N. Bone, Laura A. Magee, Joel Singer, Hannah Nathan, Rahat Qureshi, Charfudin Sacoor, Esperança Sevene, Andrew Shennan, Mrutyunjaya B. Bellad, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

Background: Blood pressure measurement is a marker of antenatal care quality. In well resourced settings, lower blood pressure cutoffs for hypertension are associated with adverse pregnancy outcomes. We aimed to study the associations between blood pressure thresholds and adverse outcomes and the diagnostic test properties of these blood pressure cutoffs in low-resource settings.
Methods: We did a secondary analysis of data from 22 intervention clusters in the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials (NCT01911494) in India (n=6), Mozambique (n=6), and Pakistan (n=10). We included pregnant women aged 15-49 years (12-49 years in Mozambique), identified in their …

Exploration Of Patient Variables And Characteristics Best Suited For Medical Marijuana Treatment For Anxiety And Depressive Disorders, Corey Gazoo

Dissertations

Individuals with posttraumatic stress, anxiety and depressive disorders are currently being prescribed medical marijuana as a treatment in many states across the United States. However, marijuana is still considered a schedule one narcotic by the Drug Enforcement Administration and federal government, which provides several barriers and challenges to conduct research such as approval from the U.S. Food and Drug Administration and following guidelines from the National Institute on Drug Abuse issued by the DEA. Additionally, individuals prescribed medical marijuana for mental health disorders are not always thoroughly instructed on the type of medical marijuana, the dosage, and how frequently to …

Orofacial Manifestations Of Lyme Disease: A Systematic Review, Brenda Bradshaw, Kelsey M. Jones, Joleen M. Westerdale-Mcinnis, Holly Gaff

Dental Hygiene Faculty Publications

Purpose: Orofacial manifestations of Lyme disease can affect head and neck anatomical structures that are frequently examined by dental professionals. The purpose of this systematic review was to examine the literature for types and frequencies of orofacial manifestations documented in populations in the United States (US) with Lyme disease.

Methods: Four electronic databases (Dentistry and Oral Sciences, PubMed, Cinahl Plus, and Medline) were systematically searched during the summer of 2019 using keywords and MeSH terms to identify relevant studies. Search term alterations and synonyms were cross-checked using the US National Library of Medicine Unified Medical Language System Metathesaurus. Full-text, English …

Peaking For Maximal Strength: Muscular Adaptations And Performance Outcomes, Spencer K. Travis

Electronic Theses and Dissertations

The purposes of this dissertation were to 1) determine what tapering and peaking practices appear to be most effective via systematic review, 2) to identify the tapering and peaking practices used by North American powerlifters, 3) to experimentally compare muscular adaptations and performance changes following two different training cessation periods, and 4) to experimentally compare the two most common taper models following a training program aimed at peaking maximal strength. Based on the scientific literature, a step and exponential taper appeared to be the most effective tapering models used when volume-load is reduced by half over 2±1 week. Interestingly, North …