Medicine and Health Sciences Commons^™

Inspire : Vol 4, Issue 8, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Message from the Chair
• Medicine at National and International Forums
• Advance Imaging and Modalities
• Covid-19: Management and Prevention- Updates in Medicine
• In-depth- featuring Prof. Muhammed Tariq
• Featured Faculty- Dr Iffat Khanum “…Belief in Allah, hard work, honesty, dedication, self-confidence and helping people around you are key elements to be successful in life…
• Faculty’s –Favorite poem
• Publications

When A Pandemic Disrupts The Export Of People, Yasmin Y. Ortiga, Karen Anne S. Liao

Research Collection School of Social Sciences

Yasmin Ortiga and Karen Anne S. Liao conducted research supported by the SSRC on the dramatic disruptions that Filipino labor migrants experienced as a result of the Covid-19 pandemic, and the support (or lack thereof) of their plight by the Filipino state. Arguing that labor as well as commodity supply chains have been thrown in upheaval, the authors describe the limits of the Philippines’ labor export strategy. In particular, they focus on two sets of labor migrants—nurses unable to take jobs abroad, and repatriated cruise ship workers—for whom dignified work at home was unavailable. Ortiga and Liao conclude that treating …

Milk Exosomes: Nature's Abundant Nanoplatform For Theranostic Applications, Benilde Adriano, Nycol Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the …

Gender Disparity In Host Responses To Hepatitis B-Related Hepatocellular Carcinoma: A Case Series, Rukaiya Bashir-Hamidu, Divya Chalikonda, Hie-Won Hann

Division of Gastroenterology and Hepatology Faculty Papers

Chronic hepatitis B virus (HBV) infection is one of the most common causes of hepato-cellular carcinoma (HCC), a malignant tumor with high mortality worldwide. One remarkable clinical feature of HBV-related HCC is that the risk of development is higher in males and post-menopausal females compared to other females. Increasing evidence also indicates that the prognosis of HBV-associated HCC may involve gender disparity, with females having more favorable out-comes. The proposed mechanism of this gender disparity is thought to be complex and multifactorial. Attributions have been made to gender differences in behavioral risk factors, host stress, immune response, psychology, metabolic risk …

Women's Perceptions On The Effects Of Covid-19 On Access And Use Of Private Sector Family Planning Services In Nigeria: The Integrate Project, The Integrate Project

Reproductive Health

In Nigeria, Community Pharmacists (CPs) and Patent and Proprietary Medicine Vendors (PPMVs) are the first point of care for many common illnesses. Although CPs and PPMVs are not formally recognized as family planning (FP) service providers, 22% of modern contraceptive users report receiving their last method from a PPMV and 12% from a private pharmacy. PPMVs are popular for FP because of their widespread availability, consistent drug stocks, extended hours, personable interactions, and lack of separate fees for consultations. As in many places, the COVID-19 pandemic poses unprecedented challenges to health services in Nigeria. By limiting person-to-person contact, especially during …

Interprofessional Inconsistencies In The Diagnosis Of Shoulder Instability: Survey Results Of Physicians And Rehabilitation Providers, Constantine P. Nicolozakes, Xinning Li, Timothy L. Uhl, Guido Marra, Nitin B. Jain, Eric J. Perreault, Amee L. Seitz

Physical Therapy Faculty Publications

Background: Clinicians of many specialties within sports medicine care for athletes with shoulder instability, but successful outcomes are inconsistent. Consistency across specialties in the diagnosis of shoulder instability is critical for care of the athlete, yet the extent of divergence in its diagnosis is unknown.

Hypothesis: Physicians differ from rehabilitation providers in which findings they deem clinically important to differentiate shoulder instability from impingement, and in how they diagnose athlete scenarios with atraumatic shoulder instability.

Study Design: Cross-sectional study.

Methods: Physicians (orthopaedic surgeons, primary care sports medicine physicians) and rehabilitation providers (physical therapists, athletic trainers) were asked via an online …

Maternal Health Care Professionals’ Experiences And Views On The Use Of Obstetric Ultrasound In Rwanda: A Cross-Sectional Study, Ingrid Mogren, Joseph Ntaganira, Jean Paul Semasaka Sengoma, Sophia Holmlund, Rhonda Small, Lan Pham Thi, Hussein Kidanto, Matilda Ngarina, Cecilia Bergström, Kristina Edvardsson

Obstetrics and Gynaecology, East Africa

Background: This study, undertaken in Rwanda, aimed to investigate health professionals’ experiences and views on the following topics: current clinical guidelines for ultrasound from second trimester at the clinic, regional and national levels, and adherence to clinical guidelines; medically indicated ultrasound examinations; non-medical use of ultrasound including ultrasounds on maternal request; commercialisation of ultrasound; the value of ultrasound in relation to other clinical examinations in pregnancy; and ultrasound and medicalisation of pregnancy.

Methods: A cross-sectional design was adopted. Health professionals providing antenatal care and delivery services to pregnant women in 108 health facilities were invited to complete a survey, which …

Musculoskeletal Injuries And Conditions In The Orthopaedic Surgeon: A Survey, Katherine Swank, Jamie Furness, Erin A. Baker, Corinn Gehrke, Rachel S. Rohde

Conference Presentation Abstracts

Musculoskeletal conditions are common in orthopaedic surgeons and may lead to morbidity and missed work.

The Effects Of Real-Time Computerized Needle Tip Location Feedback On State Anxiety And Immediate Performance Of Simulated Ultrasound-Guided Regional Anesthesia, Joseph Janakes

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Complications of ultrasound-guided regional anesthesia (UGRA) in the clinical setting are severe and frequently related to improper needle tip placement, which is a challenging skill for novice student learners. Accordingly, anesthesia education programs are incorporating simulation-based teaching methods that use expensive procedural task trainers to aid in UGRA training. However, it was unknown if the task trainers with real-time computerized needle tip location feedback affect student anxiety and immediate simulated UGRA performance, leaving educators wondering if the cost was justified.Aims: The purpose of the study was to examine the effects of real-time computerized needle tip location feedback on students’ …

Are Gaming And Gambling Disorders Related? Examining The Roles Of Money, Relative Deprivation, And Upward Mobility, Anthony J. King

UNLV Theses, Dissertations, Professional Papers, and Capstones

Few studies have examined the financial motives and risks involved in modern video games, as well as the psychosocial factors contributing to this type of gaming involvement. Previous research on gambling has shown financial motives alone to be a major risk factor for the development of gambling disorder, with higher levels of personal relative deprivation (PRD) identified as a main contributor to this relationship. Therefore, the present study investigated whether this association applied to US adult video gamers, and if it would predict their problematic gaming behaviors. We hypothesized PRD and gaming disorder severity would have a positive association, with …

Autophagy Regulation By Lipid Factors With Implications For Parkinson's Disease, Alejandro Soto-Avellaneda

Boise State University Theses and Dissertations

Parkinson’s disease is the second most common neurodegenerative disorder. It is characterized by the death of dopaminergic neurons in the substantia nigra and a series of debilitating motor symptoms. Macroautophagy (hereafter referred to as autophagy) is a cellular process by which cells degrade proteins, lipids, organelles or dysfunctional components. Autophagy is thought to play an important role in Parkinson’s disease, because it is the only cellular process known to remove large protein aggregates, such as those seen in Parkinson’s disease pathology. Historically, a large body of work has focused on reporting on protein effectors of autophagy, and regulation of autophagy …

Differentiating The Need For Neurosurgical Interventions In Patients With A Mild Traumatic Brain Injury And A Positive Ct Scan, Joseph Pasquale, Justin Pasquale, Mark Cipolle Md

Research Scholars

No abstract provided.

Do Virtual Visits Have An Effect On Outpatient Antibiotic Prescribing For Uris?, Sydney Harris, Eric Young, Jarrod W. Kile Rphd, Kathryn Zaffiri Mph

Research Scholars

No abstract provided.

Improving Patient Access Knowledge, Xinyi He, Krista Bott Md, Sean Quinlan-Davidson Md

Research Scholars

No abstract provided.

Outcome Of Surgical Ultrasonic Aspirator Use For Patients With Severe Mitral Annular Calcification For Mitral Valve Replacement, Zachary Appel, James K. Wu Md

Research Scholars

No abstract provided.

Relationships Between Mindfulness, Nonacademic Factors, Stress, And Test Performance: A Cross-Sectional Study, Rebecca A. Baumeister

UNLV Theses, Dissertations, Professional Papers, and Capstones

Successful test performance is essential to nursing students. Poor performance comes with consequences such as inability to progress or removal from the program, leading to attrition. The influence of academic factors on test performance have been widely researched and stress is known to hinder it, yet other factors may also impact test performance.

Dispositional mindfulness has the potential to support test performance, but no known studies have focused on these two variables among undergraduate nursing students. A gap also exists in relation to the influence of nonacademic factors on undergraduate nursing students’ test performance. Due to the ongoing nursing shortage, …

Job Burnout: An Examination Of Outpatient Clinics, Aysa M. Chavarria

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to examine job burnout of medical providers in outpatient clinics. Job burnout is a psychological syndrome resulting from job interpersonal stressors; it is measured using three dimensions: (1) emotional exhaustion – feelings of being emotionally overextended and exhausted by one’s work, (2) depersonalization -a unfeeling and impersonal response toward patients, and (3) personal accomplishment – feelings of competence and achievement in one’s work (Maslach & Jackson, 2020). Using a convenience sample, healthcare providers in Southern Nevada were asked to participate. The study was approved by the University of Nevada, Las Vegas, Internal Review Board …

Turning Up The Sound! Senior-Level Sonographers' Perspectives On The Workforce Readiness/Competency Of Entry-Level Sonographers In The Workplace, Janice L. Glasper

UNLV Theses, Dissertations, Professional Papers, and Capstones

There has been a longstanding preoccupation with the workforce readiness and competency of our nation’s graduates since the release of the National Commission on Excellence in Education’s, April 1983 landmark report, A Nation at Risk: “The Imperative for Educational Reform”, which indicated that the educational foundations of our society were being eroded by a rising tide of mediocrity that threatened our very future as a Nation and a people. Now, more than 35 years since the release of A Nation at Risk, it appears that little has changed. Extensive research continues to report that graduates of post-secondary institutions are unprepared …

Effects Of A Discourse Intervention On End-Of-Life Knowledge And Attitudes Of Bsn Nursing Students, Jayme Gullone Haynes

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction. A number of challenges exist to providing effective, formalized end of life (EOL) education for undergraduate nursing students. Despite advanced resources provided by the End-of-Life Nursing Education Consortium (ELNEC), many nursing program curricula are overloaded with content and have little opportunity to incorporate other content and information.

In addition, the topic of EOL care may elicit significant emotional responses from nursing students with numerous studies indicating nursing students experience fear and anxiety when caring for patients at EOL. Recent research demonstrates the need to approach emotionally laden topics such as EOL care from a pedagogical perspective that acknowledges and …

Health-Related Quality Of Life Of Children With Gastroesophageal Reflux Disease After Nissen Fundoplication And Gastrostomy Tube Insertion, Felix Wafula Musibi

Master of Medicine in Paediatrics and Child Health

Background: Gastroesophageal reflux disease (GERD) negatively impacts the health-related quality of life (HRQoL). Nissen fundoplication is done when medical treatment fails. Goal of therapy is to eliminate symptoms and improve quality of life. Justification: HRQoL is a key indicator that we can use to evaluate the impact of our interventions so that we can make evidence-based decisions and advice our patients appropriately based on the outcomes of these interventions. Objectives: The primary objective was to assess the HRQoL of children with GERD after Nissen fundoplication alone or Nissen fundoplication and gastrostomy tube insertion. Methods: Design- Observational retrospective cohort study. Setting- …

Integrate Project Results: Family Planning Knowledge And Quality Of Care Received From Community Pharmacists And Patent And Proprietary Medicine Vendors, The Integrate Project

Reproductive Health

In Nigeria, Community Pharmacists (CPs) and Patent and Proprietary Medicine Vendors (PPMVs) are the first point of care for many common illnesses. Although CPs and PPMVs are not formally recognized as family planning (FP) service providers, 22% of modern contraceptive users report receiving their last method from a PPMV and 12% from a private pharmacy. PPMVs are popular for FP because of their widespread availability, consistent drug stocks, extended hours, personable interactions, and lack of separate fees for consultations. As the Federal Ministry of Health explores expanding its task sharing policy to include CPs and PPMVs, evidence is needed on …

Investing In Social And Behavior Change Is Cost-Effective For Improving Malaria Behaviors In Côte D’Ivoire, Breakthrough Research

Sexual and Reproductive Health, Rights, and Choices

Social and behavior change (SBC) interventions are considered an essential part of malaria prevention and treatment interventions, yet gaps in information on the cost and impact of SBC mean decisionmakers have underappreciated the value of SBC for contributing to improved health outcomes. To address this issue, Breakthrough RESEARCH has leveraged evidence from 112 studies on the impact of SBC interventions on malaria health behaviors and 70 studies on general SBC intervention costs to model the cost-effectiveness of SBC programming for malaria in the Business Case for Investing in Social and Behavior Change for Malaria.

Using The Comfort-B Scale In The Picu, Taylor Kerstetter Bsn, Rn, Marissa Campo Bsn, Rn, Heather Harwin Rn, Mary Pomponio Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Interdisciplinary Communication And Collaboration, Jaiden Coyne Bsn, Rn, Alexa D'Andrea Bsn, Rn, Jocelyn Foley Bsn, Rn, Brittney Ritchey Bsn, Rn, Rebecca Roberts Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Pooled Safety Analysis Of Tisagenlecleucel In Children And Young Adults With B Cell Acute Lymphoblastic Leukemia., John E. Levine, Stephan A. Grupp, Michael A. Pulsipher, Andrew C. Dietz, Susana Rives, Douglas Myers, Keith August, Michael R. Verneris, Jochen Buechner, Theodore W. Laetsch, Henrique Bittencourt, Andre Baruchel, Michael W. Boyer, Barbara De Moerloose, Muna Qayed, Stella M. Davies, Christine L. Phillips, Timothy A. Driscoll, Peter Bader, Krysta Schlis, Patricia A. Wood, Rajen Mody, Lan Yi, Mimi Leung, Lamis K. Eldjerou, Carl H. June, Shannon L. Maude

Manuscripts, Articles, Book Chapters and Other Papers

Background: Tisagenlecleucel, an anti-CD19 chimeric antigen receptor T cell therapy, has demonstrated efficacy in children and young adults with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL) in two multicenter phase 2 trials (ClinicalTrials.gov, NCT02435849 (ELIANA) and NCT02228096 (ENSIGN)), leading to commercialization of tisagenlecleucel for the treatment of patients up to age 25 years with B-ALL that is refractory or in second or greater relapse.

Methods: A pooled analysis of 137 patients from these trials (ELIANA: n=79; ENSIGN: n=58) was performed to provide a comprehensive safety profile for tisagenlecleucel.

Results: Grade 3/4 tisagenlecleucel-related adverse events (AEs) were reported in 77% of …

Impact Of Genotype, Serum Bile Acids, And Surgical Biliary Diversion On Native Liver Survival In Fic1 Deficiency., Daan B E Van Wessel, Richard J. Thompson, Emmanuel Gonzales, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Talal Algoufi, Nejat Mazhar, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Björn Fischler, Jan B F Hulscher, Daniele Serranti, Cigdem Arikan, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Muñoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsőfi, Pier Luigi Calvo, Dorothee Krebs-Schmitt, Steffen Hartleif, Wendy L. Van Der Woerd, Jian-She Wang, Li-Ting Li, Özlem Durmaz, Nanda Kerkar, Marianne Hørby Jørgensen, Ryan T. Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Noémie Laverdure, Cristina Targa Ferreira, Felipe Ordonez, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey-Ling Chen, Elisa Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Estella M. Alonso, Ronald J. Sokol, Frederick J. Suchy, Kathleen M. Loomes, Patrick J. Mckiernan, Philip Rosenthal, Yumirle Turmelle, Girish S. Rao, Simon Horslen, Binita M. Kamath, Maria Rogalidou, Wikrom W. Karnsakul, Bettina Hansen, Henkjan J. Verkade, Natural Course And Prognosis Of Pfic And Effect Of Biliary Diversion Consortium

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIMS: Mutations in ATPase phospholipid transporting 8B1 (ATP8B1) can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive familial intrahepatic cholestasis type 1. The rarity of FIC1 deficiency has largely prevented a detailed analysis of its natural history, effects of predicted protein truncating mutations (PPTMs), and possible associations of serum bile acid (sBA) concentrations and surgical biliary diversion (SBD) with long-term outcome. We aimed to provide insights by using the largest genetically defined cohort of patients with FIC1 deficiency to date.

APPROACH AND RESULTS: This multicenter, combined retrospective and prospective study included 130 patients with compound …

Progress Towards Antibiotic Use Targets In Eight High-Income Countries, Bryony Simmons, Koya Ariyoshi, Norio Ohmagari, Celine Pulcini, Benedikt Huttner, Sumanth Gandra, Giovanni Satta, Lorenzo Moja, Michael Sharland, Nicola Magrini, Marisa Miraldo, Graham Cooke

2020-Current year OA Pubs

OBJECTIVE: To compare antibiotic sales in eight high-income countries using the 2019 World Health Organization (WHO) Access, Watch and Reserve (AWaRe) classification and the target of 60% consumption of Access category antibiotics.

METHODS: We analysed data from a commercial database of sales of systemic antibiotics in France, Germany, Italy, Japan, Spain, Switzerland, United Kingdom of Great Britain and Northern Ireland, and United States of America over the years 2013-2018. We classified antibiotics according to the 2019 AWaRe categories: Access, Watch, Reserve and Not Recommended. We measured antibiotic sales per capita in standard units (SU) per capita and calculated Access group …

Telehealth Assessment In The Elderly Using The 4ms, Melissa Koehl

Nursing Capstones

The current 2019 novel coronavirus, or COVID-19, has presented new threats and challenges in healthcare, especially when attempting to conduct wellness exams amongst the most vulnerable. Older adults with underlying medical conditions are at great risk for exposure and infection of COVID-19. The Geriatric Workforce Enhancement Program (GWEP) grant was given to the University of North Dakota (UND) to create a geriatric telehealth team and implement a telehealth project, promoting the use of telehealth technologies amongst older adults utilizing the 4Ms (mentation, medication, mobility, and what matters). A modified wellness assessment tool was created and administered through telehealth technology to …

An Education Intervention In Integrating The Mobile Applications In Treating Disruptive Sleep Patterns In Mental Health Patients, Agnes M. Aondo

Nursing Capstones

Background: Disruptive sleep patterns in patients with mental health disorders are a common occurrence. Unfortunately, many people are often treated for their mental health disorders solely or prescribed more medications to manage sleep, leaving sleep evaluation, and management addressed inadequately in the clinical setting. There is extensive evidence supporting the benefits of integrating mobile applications into clinical practice.

Objective: The purpose of the clinical project was to determine if an educational intervention would increase APRN’s knowledge about the mobile app in the care of mental health patients who experience disruptive sleep patterns in primary care outpatient clinics

Methodology: A one-group …

Evaluating The Correlation Of Academic Pursuits And Relative Value Unit Reimbursement In Trauma Surgery, Erin Gilbert, Joseph J. Stirparo Md

Research Scholars

No abstract provided.