Medicine and Health Sciences Commons^™

Rumination Syndrome In Children And Adolescents: A Mini Review., Marc Martinez, Sandeep Rathod, Hunter J. Friesen, John Rosen, Craig A. Friesen, Jennifer Verrill Schurman

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Rumination syndrome involves recurrent regurgitation of food and is believed to be underdiagnosed with patients experiencing long delays in diagnosis. It can be associated with significant social consequences, high rates of school absenteeism, and medical complications such as weight loss. The primary aims of the current review are to assess the literature regarding prevalence, pathophysiology, and treatment outcomes with a focus on neurotypical children and adolescents.

Results: Population studies in children/adolescents, 5 years of age or older, range from 0 to 5.1%. There are fewer studies in clinical settings, but the prevalence appears to be higher in patients with …

The Non-Surgical Treatment Of Class Ii Jaw Relation With Anterior Open Bite, Jyun-Long Wang, Yu-Chuan Tseng

Taiwanese Journal of Orthodontics

This 19-year-old female presents anterior open bite with skeletal Class II jaw relation. The treatment modality was non-surgical treatment with 4-bicuspid extraction and molar intrusion by full-mouth fixed edgewise appliances and temporary anchorage devices. A favorable result of ideal overbite/overjet and improvement of profile change were achieved. The patient was satisfied with the improvement of function and esthetics after treatment.

Hemimandibular Hyperplasia Treated By Orthognathic Surgery And Condylectomy In A Young Woman, Shin Pey Peng, Wen-Ching Ellen Ko, Cheng-Hui Lin, Chung-Yi Ho

Taiwanese Journal of Orthodontics

Hemimandibular hyperplasia is a developmental asymmetry characterized by 3-dimensional enlargement in one half of the mandible. The malformation results in facial asymmetry, associated with tilted occlusal plane and a deviated chin to the contralateral side. These cause esthetic and progressive functional problems and need to be corrected without recurrence.

This report describes a 27-year-old woman presented with skeletal Class III malocclusion, occlusal plane cant and facial asymmetry. Radiographic films showed hyperplasia of half mandible and condyle on the left side. The condylar hyperactivity over left mandibular condyle was also confirmed by 99m-Tc bone scan. In order to correct her skeletal …

Unilateral Premolar Crossbite And Atypical Extraction Case Treated With Clear Aligner, Ting-Fen Chang, Tzu-Ying Wu

Taiwanese Journal of Orthodontics

A unilateral buccal crossbites can be observed in adult patients with skeletal asymmetry and crowded dentition. This case report describes the orthodontic treatment with clear aligners for a 57-year-old female with chin deviation, lower dentition crowding and a unilateral complete buccal crossbite in right premolars. Mandibular single incisor extraction was planned to relieve crowding and the crossbite was resolved by intrusion of upper premolar and uprighting of lower premolar with clear aligners in combined with inter-arch elastic. The entire treatment was completed within 20 months and the treatment result showed good vertical control. This case report demonstrates that clear aligners …

Surgery First Approach For Correcting A Skeletal Class Ii Malocclusion With Impinging Deep Bite, Yu-Ting Chiou, Tzu-Hang Hsu, Sang Heng Kok, Chung-Chen Jane Yao

Taiwanese Journal of Orthodontics

This case report illustrates a surgery-first treatment for surgical correction of Class II malocclusion. A 54- year-old female, presenting a chief complaint of deep bite and gum biting, came to seek for treatment. She had skeletal Class II and dental Class II malocclusion with 11 mm excessive overjet. Intraoral examination revealed large mandibular curve of Spee. Treatment was performed with a surgery-first approach, moving the dentition towards edge-to-edge bite, followed by extruding mandibular posterior teeth and normalizing the overjet and overbite. Finally, good interdigitation was achieved, as well as the improvement of masticatory function. The patient was satisfied with the …

Reliability Of Panoramic Radiography In Assessing Gonial Angle Compared To Lateral Cephalogram In Patients With Class I Malocclusion, Ravi Ranjan Kumar Rajak, Rabindra Man Shrestha, Sushmit Koju

Taiwanese Journal of Orthodontics

Purpose: To investigate whether panoramic radiograph can be used as an alternative to lateral cephalogram for measuring the gonial angle in skeletal Class I patients. Patients and Methods: Panoramic radiograph and lateral cephalogram were collected from the pretreatment records of 100 patients of the age 16-30 years from the Department of Orthodontics. Radiographs were manually traced and the gonial angle was measured. Paired t-test was used to find the difference in mean gonial angle between the panoramic radiograph and lateral cephalogram. A simple regression analysis was performed to find the relationship between the gonial angles in two different …

Class Ii, Division 2 Malocclusion: What The Clinician Should Know About Treatment Of This Malocclusion (Part Ii), Ib Leth Nielsen

Taiwanese Journal of Orthodontics

Treatment of Class II, Div. 2 malocclusion can be a challenging undertaking for the orthodontists. The facial growth pattern and in particular the mandibular growth pattern can greatly influence the outcome of treatment and the long-term stability. In this article we will discuss factors determining the best time for treatment, the choice of treatment mechanics and the indications for extraction versus non-extraction. Criteria for treatment with two upper bicuspid extraction will be discussed and we provide 8 rules to consider for a successful outcome of treatment. Factors influencing long-term stability will be discussed and a protocol to improve stability will …

2021-08-18_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-08-18_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-08-18_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

The Penn State Protein Ladder System For Inexpensive Protein Molecular Weight Markers, Ryan T Santilli, John E Williamson, Yoshitaka Shibata, Rosalie P Sowers, Andrew N. Fleischman, Song Tan

Department of Anesthesiology Faculty Papers

We have created the Penn State Protein Ladder system to produce protein molecular weight markers easily and inexpensively (less than a penny a lane). The system includes plasmids which express 10, 15, 20, 30, 40, 50, 60, 80 and 100 kD proteins in E. coli. Each protein migrates appropriately on SDS-PAGE gels, is expressed at very high levels (10–50 mg per liter of culture), is easy to purify via histidine tags and can be detected directly on Western blots via engineered immunoglobulin binding domains. We have also constructed plasmids to express 150 and 250 kD proteins. For more efficient production, …

Innate Immune Activation By Checkpoint Inhibition In Human Patient-Derived Lung Cancer Tissues, Teresa W. M. Fan, Richard M. Higashi, Huan Song, Saeed Daneshmandi, Angela L. Mahan, Matthew S. Purdom, Therese J. Bocklage, Thomas A. Pittman, Daheng He, Chi Wang, Andrew N. Lane

Center for Environmental and Systems Biochemistry Faculty Publications

Although Pembrolizumab-based immunotherapy has significantly improved lung cancer patient survival, many patients show variable efficacy and resistance development. A better understanding of the drug’s action is needed to improve patient outcomes. Functional heterogeneity of the tumor microenvironment (TME) is crucial to modulating drug resistance; understanding of individual patients’ TME that impacts drug response is hampered by lack of appropriate models. Lung organotypic tissue slice cultures (OTC) with patients’ native TME procured from primary and brain-metastasized (BM) non-small cell lung cancer (NSCLC) patients were treated with Pembrolizumab and/or beta-glucan (WGP, an innate immune activator). Metabolic tracing with ¹³C₆-Glc/ …

Trident - Autumn 2021, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Gross Hematuria: An Unusual Presenting Symptom Of Systemic Wild-Type Transthyretinamyloidosis., Sage A. Vincent, Daniel Christensen, Perry R. Weiner

Department of Urology Faculty Papers

Amyloidosis of the urinary bladder is a rare cause of gross hematuria. In patients with systemic amyloidosis, identification is nearly always related to cardiac complaints; urologic presenting symptoms are extremely uncommon. We present a 77-year-old male patient with painless gross hematuria ultimately found to be secondary to systemic wild-type transthyretin amyloidosis. He underwent transurethral resection of the bladder lesion and was initiated on transthyretin stabilizing medication. In the 6 months since starting treatment, the patient has had no further episodes of gross hematuria, but will require cystoscopic surveillance for evidence of recurrence or concomittment urothelial carcinoma.

Long-Term Sports Participation And Satisfaction After Ucl Reconstruction In Amateur Baseball Players., Robert A Jack, Somnath Rao, Taylor D'Amore, Donald Willier Iii, Robert Gallivan, Steven B. Cohen, Christopher C Dodson, Michael G. Ciccotti

Rothman Institute Papers

Background: While the incidence of ulnar collateral ligament reconstruction (UCLR) has increased across all levels of play, few studies have investigated the long-term outcomes in nonprofessional athletes.

Purpose: To determine the rate of progression to higher levels of play, long-term patient-reported outcomes (PROs), and long-term patient satisfaction in nonprofessional baseball players after UCLR.

Study Design: Case series; Level of evidence, 4.

Methods: We evaluated UCLR patients who were nonprofessional baseball athletes aged(KJOC), the Timmerman-Andrews (T-A) Elbow score, the Mayo Elbow Performance Score (MEPS), and a custom return-to-play questionnaire.

Results: A total of 91 baseball players met the inclusion criteria, and …

Advances In The Diagnosis And Treatment Of Krabbe Disease, David A Wenger, Paola Luzi, Mohammad Rafi

Department of Neurology Faculty Papers

Krabbe disease is an autosomal recessive leukodystrophy caused by pathogenic variants in the galactocerebrosidase (GALC) gene. GALC activity is needed for the lysosomal hydrolysis of galactosylceramide, an important component of myelin. While most patients are infants, older patients are also diagnosed. Starting in 1970, a diagnosis could be made by measuring GALC activity in leukocytes and cultured cells. After the purification of GALC in 1993, the cDNA and genes were cloned. Over 260 disease-causing variants as well as activity lowering benign variants have been identified. While some pathogenic variants can be considered “severe,” others can be considered “mild.” The combination …

Frailty Index In The Colonias On The Us-Mexico Border: A Special Report, Eron G. Manusov, Carolina Gomez De Ziegler, Vincent P. Diego, Gerardo Munoz-Monaco, Sarah Williams-Blangero

School of Medicine Publications

Frailty is the age-related decline in well-being. The Frailty index (FI) measures the accumulation of health deficits and reflects biopsychosocial and cultural determinants of well-being. Frailty is measured as a static phenotype or as a Frailty Index comprising a ratio of suffered health deficits and total deficits. We report a Frailty Index calculated from routinely measured clinical variables gathered from residents of two Colonias (neighborhoods) in South Texas. A Colonia is a predominantly Hispanic, economically distressed, unincorporated neighborhood. We analyzed retrospective data from 894 patients that live in two Colonias located on the Texas-Mexico border. We calculated the FI with …

2021-08-17_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays, and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Coronavirus Update 8-17-21, The Coronavirus Planning Team

University Briefings & Virtual Events

We are looking forward to meeting with you in the coming days to answer your questions about protocols for fall.

2021 August 17 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Forward Together Update [Bookstore Gift Card, Vaccination Clinics, & Cdc Recommendations For Face Coverings], August 17, 2021, University Of Northern Iowa

UNI Response to COVID-19

Announces students who have been fully vaccinated are eligible to receive a UNI Bookstore gift card and the availability of on-campus vaccination clinics. Also reminds about the CDC recommendations for face coverings.

Cxcl1: A New Diagnostic Biomarker For Human Tuberculosis Discovered Using Diversity Outbred Mice., Deniz Koyuncu, Muhammad Khalid Khan Niazi, Thomas Tavolara, Claudia Abeijon, Melanie L Ginese, Yanghui Liao, Carolyn Mark, Aubrey Specht, Adam C Gower, Blanca I Restrepo, Daniel M Gatti, Igor Kramnik, Metin Gurcan, Bülent Yener, Gillian Beamer

Faculty Research 2021

More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which afflicts millions of people in high-burden countries. However, the protein biomarker pipeline is small. Here, we used the Diversity Outbred (DO) mouse population to address this gap, identifying five protein biomarker candidates. One protein biomarker, serum CXCL1, met the World Health Organization's Targeted Product Profile for a triage test to diagnose active TB from latent M.tb infection (LTBI), non-TB lung disease, and normal sera in HIV-negative, adults from South Africa …

Local Versus Systemic Control Of Bone And Skeletal Muscle Mass By Components Of The Transforming Growth Factor-Β Signaling Pathway., Yewei Liu, Adam Lehar, Renata Rydzik, Harshpreet Chandok, Yun-Sil Lee, Daniel W Youngstrom, Joshy George, Martin M Matzuk, Emily L Germain-Lee, Se-Jin Lee

Faculty Research 2021

Skeletal muscle and bone homeostasis are regulated by members of the myostatin/GDF-11/activin branch of the transforming growth factor-β superfamily, which share many regulatory components, including inhibitory extracellular binding proteins and receptors that mediate signaling. Here, we present the results of genetic studies demonstrating a critical role for the binding protein follistatin (FST) in regulating both skeletal muscle and bone. Using an allelic series corresponding to varying expression levels of endogenous Fst, we show that FST acts in an exquisitely dose-dependent manner to regulate both muscle mass and bone density. Moreover, by employing a genetic strategy to target Fst expression …

Covid-19 Newsletter (Vol. 85), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Strongyloides Stercoralis Hyperinfection And Disseminated Tuberculosis, Hernan Terroba, Alejandra González, Diana Vera Gonzalez, Roxana Mariela Godoy, Analia Santos, Marisol Arrojo

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Association Between Post-Hospital Clinic And Telephone Follow-Up Provider Visits With 30-Day Readmission Risk In An Integrated Health System, Huong Q. Nguyen, Aileen Baecker, Timothy Ho, Dan N. Huynh, Heather L. Watson, Jing Li, Ernest Shen

Center for Health Services Research Faculty Publications

BACKGROUND: Follow-up visits with clinic providers after hospital discharge may not be feasible for some patients due to functional limitations, transportation challenges, need for physical distancing, or fear of exposure especially during the current COVID-19 pandemic.

METHODS: The aim of the study was to determine the effects of post-hospital clinic (POSH) and telephone (TPOSH) follow-up provider visits versus no visit on 30-day readmission. We used a retrospective cohort design based on data from 1/1/2017 to 12/31/2019 on adult patients (n = 213,513) discharged home from 15 Kaiser Permanente Southern California hospitals. Completion of POSH or TPOSH provider visits within …

2021-08-17_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Does Supportive Supervision Intervention Improve Community Health Worker Knowledge And Practices For Community Management Of Childhood Diarrhea And Pneumonia? Lessons For Scale-Up From Nigraan And Nigraan Plus Trials In Pakistan, Wafa Aftab, Suneel Piryani, Fauziah Rabbani

Community Health Sciences

Background: Lack of programmatic support and supervision is one of the underlying reasons of the poor performance of Pakistan's Lady Health Worker Program (LHWP). This study describes the findings and potential for scale-up of a supportive supervision intervention in two districts of Pakistan for improving LHWs skills for integrated community case management (iCCM) of childhood diarrhea and pneumonia.
Methods: The intervention comprised an enhanced supervision training to lady health supervisors (LHSs) and written feedback to LHWs by LHSs, implemented in Districts Badin and Mirpur Khas (MPK). Clinical skills of LHWs and LHSs and supervision skills of LHSs were assessed before, …

Postoperative Subcutaneous Emphysema Following Percutaneous Nephrolithotomy: A Rare Complication, Hussam Uddin Soomro, Isaac Mawalla, Shabbir Adamjee, Nadeem Kassam, Authar Ali

Faculty of Health Sciences, East Africa

Percutaneous Nephrolithotomy (PCNL) is a common urological procedure performed for complicated upper urinary tract stones. The advantages of PCNL include lower morbidity and mortality rates and quicker recovery compared to traditional open surgery. A number of complications have been reported which can be life threatening. Here we present a case of 71 years old lady, who developed subcutaneous emphysema following PCNL.

Global, Regional, And National Progress Towards Sustainable Development Goal 3.2 For Neonatal And Child Health: All-Cause And Cause-Specific Mortality Findings From The Global Burden Of Disease Study 2019, Katherine R. Paulson, Nicholas J. Kassebaum, Arianna Maever L. Amit, Veincent Christian F. Pepito, Gbd 2019 Under-5 Mortality Collaborators, 735 Co-Authors

Ateneo School of Medicine and Public Health Publications

Background

Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include …