Medicine and Health Sciences Commons^™

Nrf1 Association With Auts2-Polycomb Mediates Specific Gene Activation In The Brain, Sanxiong Liu, Kimberly A Aldinger, Chi Vicky Cheng, Takae Kiyama, Mitali Dave, Hanna K Mcnamara, Wukui Zhao, James M Stafford, Nicolas Descostes, Pedro Lee, Stefano G Caraffi, Ivan Ivanovski, Edoardo Errichiello, Christiane Zweier, Orsetta Zuffardi, Michael Schneider, Antigone S Papavasiliou, M Scott Perry, Jennifer Humberson, Megan T Cho, Astrid Weber, Andrew Swale, Tudor C Badea, Chai-An Mao, Livia Garavelli, William B Dobyns, Danny Reinberg

Faculty, Staff and Student Publications

The heterogeneous family of complexes comprising Polycomb repressive complex 1 (PRC1) is instrumental for establishing facultative heterochromatin that is repressive to transcription. However, two PRC1 species, ncPRC1.3 and ncPRC1.5, are known to comprise novel components, AUTS2, P300, and CK2, that convert this repressive function to that of transcription activation. Here, we report that individuals harboring mutations in the HX repeat domain of AUTS2 exhibit defects in AUTS2 and P300 interaction as well as a developmental disorder reflective of Rubinstein-Taybi syndrome, which is mainly associated with a heterozygous pathogenic variant in CREBBP/EP300. Moreover, the absence of AUTS2 or mutation in its …

Depression In Black Men: Disparities In Diagnosis And Treatment, Amy Nwaobasi, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

• Review epidemiology
• Review risk factors and protective factors that are associated with depression in black men
• Understand causes of disparities in diagnosis
• Understand barriers to treatments
• Explore ways physicians can address these disparities

The Impact Of Disease Control Measures On The Spread Of Covid-19 In The Province Of Sindh, Pakistan, Bilal Ahmed Usmani, Mustafain Ali, Muhammad Abul Hasan, Amna Rehana Siddiqui, Sameen Siddiqi, Aaron Guanliang Lim, Saad Ahmed Qazi

Community Health Sciences

The province of Sindh reported the first COVID-19 case in Pakistan on 26th February 2020. The Government of Sindh has employed numerous control measures to limit its spread. However, for low-and middle-income countries such as Pakistan, the management protocols for controlling a pandemic are not always as definitive as they would be in other developed nations. Given the dire socio-economic conditions of Sindh, continuation of province-wise lockdowns may inadvertently cause a potential economic breakdown. By using a data driven SEIR modelling framework, this paper describes the evolution of the epidemic projections because of government control measures. The data from reported …

Deletion Of The Stress Response Gene Ddr48 From Histoplasma Capsulatum Increases Sensitivity To Oxidative Stress, Increases Susceptibility To Antifungals, And Decreases Fitness In Macrophages, Logan T. Blancett, Kauri A. Runge, Gabriella M. Reyes, Lauren A. Kennedy, Sydney C. Jackson, Sarah E. Scheuermann, Mallory B. Harmon, Jamease C. Williams, Glenmore Shearer

Faculty Publications

The stress response gene DDR48 has been characterized in Saccharomyces cerevisiae and Candida albicans to be involved in combating various cellular stressors, from oxidative agents to antifungal compounds. Surprisingly, the biological function of DDR48 has yet to be identified, though it is likely an important part of the stress response. To gain insight into its function, we characterized DDR48 in the dimorphic fungal pathogen Histoplasma capsulatum. Transcriptional analyses showed preferential expression of DDR48 in the mycelial phase. Induction of DDR48 in Histoplasma yeasts developed after treatment with various cellular stress compounds. We generated a ddr48∆ deletion mutant to further …

Genetic Studies Of Metabolic Syndrome In Arab Populations: A Systematic Review And Meta-Analysis, Zahrah Al-Homedi, Nariman Afify, Mashal Memon, Habiba Alsafar, Guan Tay, Herbert F. Jelinek, Mira Mousa, Nadia Abu-Samra, Wael Osman

Research outputs 2014 to 2021

Background:

The metabolic syndrome (MetS) is prevalent in Arabian populations. Several small-scale studies have been performed to investigate the genetic basis of MetS. This systematic review and meta-analysis aimed to examine whether candidate gene polymorphisms are associated with MetS susceptibility among ethnic groups of the Arabian world and to suggest possible directions for future research regarding genetic markers and MetS.

Methods:

A search was conducted for peer-reviewed articles that examined the genetic association of MetS in Arabian populations in the following databases: Medline, Embase, Scopus, Direct Science, Web of Science, ProQuest, and Google Scholar until March 31, 2021. Articles were …

A Scholarly Publishing Opportunity For Residents And Fellows, Heather Brown, Kari Nelson

Medical Institutional Repositories in Libraries (MIRL)

Purpose: This lightning talk describes the development and impact of an institutional repository-based journal created to promote scholarship within the graduate medical education community. Description: Scholarly and professional communication is an important educational activity for residents and fellows at academic medical centers. The Office of Graduate Medical Education (GME) at the University of Nebraska Medical Center established a journal to provide medical residents and fellows with the opportunity to publish scholarly journal articles. The GME department partnered with the McGoogan Health Sciences Library, which provides a journal platform through its institutional repository, DOI minting, and publishing advice and information. Launched …

Building A Unique Collection Through Collaboration, Patricia Hinegardner, Na Lin

Medical Institutional Repositories in Libraries (MIRL)

The UMB Digital Archive (DA) is the institutional repository for the University of Maryland, Baltimore (UMB), the health sciences and human services campus of the University System of Maryland. The Health Sciences and Human Services Library (HSHSL) launched the DA over ten years ago. Its purpose is to collect, preserve, and distribute the academic works and history of UMB as well as highlight special collections within the HSHSL. Content in the DA ranges from historical collections such as the original James Carroll, Yellow Fever Commission Letters to current UMB dissertations. This lightning talk will focus on a unique collection within …

Development Of An Archive At Monmouth Medical Center, Frederic Pachman

Medical Institutional Repositories in Libraries (MIRL)

Monmouth Medical Center, founded in 1887, was the first hospital at the Jersey Shore. Over the past thirty years there was a limited effort to develop archival and historical collections that document this rich history. In conjunction with the medical center's 125th anniversary in 2012, a consultant was retained to evaluate the archives, develop operational policies and prepare exhibits. Public programs and exhibits about the medical center have been presented to state and local organizations, and a schedule of historical programs is offered in-house during National Hospital Week. The archival collections were actively used to celebrate the medical center's anniversary …

Data Catalogs, Metadata, And Data Discovery: How Data Catalogs Extend And Enhance The Ir Ecosystem, Anthony Dellureficio

Medical Institutional Repositories in Libraries (MIRL)

Data catalogs contain metadata-only records for datasets, code, analytical tools, or other research outputs not traditionally included in bibliographic catalogs. The records include curated, enhanced descriptive metadata in order to supply additional access points, provide access instructions or explain data restrictions, connect researchers working on common topics, connect datasets with relevant analytical tools, track publications and funding associated with datasets, and highlight otherwise undiscoverable datasets while still accommodating concerns over PHI exposure. The Data Discovery Collaboration (DDC), a multi-institutional consortium providing a platform-agnostic community of practice to support research data discoverability through metadata, outreach, and software development, is focusing on …

Manuscript Repository To Support Rigor In Dnp Scholarship, Marina Cuneo, Claire Sharifi, Jo Ann Loomis

Medical Institutional Repositories in Libraries (MIRL)

The Doctor of Nursing Practice (DNP) degree process supports the dissemination of nursing scholarship. Peer reviewed nursing journals have reported an increase in volume of student submissions over the past decade, but only some of them are initially publishable. As an alternative or supplement to journal submission, the University of San Francisco has developed a library-based institutional repository collection for these manuscript submissions that is globally findable, searchable, and accessible. Submission to the repository does not compromise rigor, and manuscripts can be submitted to peer reviewed journals when and if student and faculty are committed to the editorial process.

Individual Authorship Reports, Sarah Ellsworth

Medical Institutional Repositories in Libraries (MIRL)

While authors can access the IR dashboard and readership directly, creating a streamlined highlights and stats annual report for individual authors has been very popular. I will show examples, how it has improved IR investment, and how I will improve upon these reports for the end of 2021.

Grass Roots Efforts To Find Champions For Share, Heather Steel

Medical Institutional Repositories in Libraries (MIRL)

The IR at Children’s Mercy Kansas City (SHARE@Children’s Mercy) has technically existed for four years; however, the IR previously operated in a silo and few staff members were aware of its existence. In the last year and a half, the IR has experienced a complete overhaul not only in administration, but also in terms of self-promotion. This change was brought about due to staff changes in the library team responsible for the IR and a dedicated effort to promote the IR across the hospital. This presentation will address the steps the library services team undertook to bring the IR out …

Re-Envisioning The Virginia Journal Of Public Health: Leveraging The Institutional Repository For Publishing Success, Mark Lane, Maria Devalpine, Rebecca Kruse, Carolyn Schubert

Medical Institutional Repositories in Libraries (MIRL)

This case study presents what happened when new leadership for the Virginia Journal of Public Health brought new questions about journal quality, value, and impact. Conversations initially began with the liaison librarian about the nature of journal publishing and open access today. As the conversation evolved, the Digital Collections team joined the working group to think through journal publishing for this title. This session will describe this collaborative evolution and how we worked to re-envision and migrate the journal from its prior website to the university’s institutional repository. The session will feature considerations for publishing with the institutional repository, highlight …

Henry Ford Hospital Medical Journal (1953-1992): Modernizing Historical Research, Joann Krzeminski, Steven Moore, Julia Pope

Medical Institutional Repositories in Libraries (MIRL)

The Henry Ford Hospital Medical Bulletin began publication in 1953, and was published quarterly by Henry Ford Hospital and the Edsel B. Ford Institute for Medical Research. It was meant as a venue for recording and distributing the professional activities of Henry Ford Hospital staff, residents, and alumni, as well as materials related to academic and scientific meetings and symposia hosted by Henry Ford Hospital. In 1967, the bulletin's name changed to the Henry Ford Hospital Medical Journal. The journal ceased publication in 1992. In 2019, Sladen Library of Henry Ford Hospital created an institutional repository to preserve and publicize …

When Mergers Happen: Doubling Your Institutional Repository’S Scope Overnight, Jennifer Deal, Karen Hanus

Medical Institutional Repositories in Libraries (MIRL)

Aurora Health Care in Wisconsin and Advocate Health Care in Illinois merged into Advocate Aurora Health in 2018. Advocate Aurora Health is a large, multistate health care system that has 26 hospitals, over 500 sites of care, and 75,000 employees. Aurora Health Care implemented an institutional repository (IR) in 2013. Through the merger we were able to expand our IR to include Advocate content in the summer of 2020. In this presentation, we will discuss: Key stakeholder relationships that helped us build the reputation of the IR at legacy Aurora Health Care and ultimately secured support at a system level …

Publishing Partnership: Facilitating Open Access Through Libraries Collaboration With Clinical Departments, Jessica Petrey, Sarah Frankel, Rachel Howard

Medical Institutional Repositories in Libraries (MIRL)

When the University of Louisville Libraries launched the ThinkIR institutional repository on the bepress Digital Commons platform in 2015, we anticipated offering open access journal publishing several years in the future. However, the Division of Infectious Diseases’ eagerness to find a venue to facilitate the equitable movement of research and information into the larger global community resulted in a partnership beginning in 2016 to publish two open access journals on the platform, which then served as a model for other health sciences journals, including one from the Emergency Medicine Department. The benefits, including the opportunity to provide free open access …

Undertaking A Digital Collection Platform Evaluation At A Health Sciences Library, Pamela Pierce, Steve Duckworth, Marijane White

Medical Institutional Repositories in Libraries (MIRL)

This presentation will discuss the process of completing a comprehensive digital collection platform evaluation at Oregon Health & Science University (OHSU). Guided by its mission to advance the effective, efficient and ethical use of information in support of education, research and healthcare, the OHSU Library serves institutional faculty, staff and students, as well as external health science professionals and researchers, and residents of the State of Oregon and surrounding areas. Our unique physical and virtual collections include over 8 TB of digital files, which document the institution’s history, research and scholarly output.; learning from primary source materials is facilitated by …

Next Generation Research Information Hub: Esploro Smart Harvesting In 2021—Enabling Comprehensive, Accurate, And Automated Coverage Of Your Scholarly Assets And Expertise, Dave Stout

Medical Institutional Repositories in Libraries (MIRL)

Historically, a primary challenge for repository managers has been successfully capturing and exposing as close to 100% of an institution’s research assets and activities as possible. It is traditionally a resource- and time-intensive endeavor. Ex Libris’s Esploro addresses this challenge head-on with our Smart Harvesting AI, first by leveraging the industry leading Central Discovery Index (CDI) (which drives the Primo and Summon discovery services), and second by automating the routines needed to harvest repository content. The CDI provides clients immediate access to an incredible foundation of over 4.5 billion records from which they can populate their Esploro IR and comprehensively …

Figshare Repositories: New Data-Sharing Features For Researchers And Librarians, Andrew Mckenna-Foster

Medical Institutional Repositories in Libraries (MIRL)

With expanding funder data sharing policies, especially the new NIH data management and sharing policy slated for 2023, we expect that researchers from medical research institutions will increasingly need trusted repositories to share data and all of the other products of their research. However, the complexity of sharing medical research data, even when anonymized, means data are often not shared despite funder policies. In the past year, Figshare, a trusted repository platform that meets funder requirements across the globe, released a suite of new features to fit data sharing needs, increase impact, and encourage sharing. Useful to both researchers and …

Community-Driven Repository Infrastructure Programs At Lyrasis—An Overview, Paolo P. Gujilde, Sheila Rabun, Hannah Rosen

Medical Institutional Repositories in Libraries (MIRL)

Academic libraries, and institutional repositories in particular, play a key role in the ongoing quest for ways to gather metrics and connect the dots between researchers and research contributions in order to measure “institutional impact,” while also streamlining workflows to reduce administrative burden. Identifying accurate metrics and measurements for illustrating “impact” is a goal that many academic research institutions share, but these goals can only be met to the extent that all organizations across the research and scholarly communication landscape are using best practices and shared standards in research infrastructure. For example, persistent identifiers (PIDs) such as ORCID iDs (Open …

A New Partnership: An Institutional Repository And A Systematic Review Search Deposit Service, Stephanie Roth, Will Dean

Medical Institutional Repositories in Libraries (MIRL)

In fall 2020, Temple University Libraries launched the university’s first institutional repository, TUScholarShare, as a place to collect, manage, and provide public access to Temple’s research, data, and teaching outputs. Shortly thereafter, this initiative prompted a collaborative effort of the Libraries Research Data Services and Systematic Review Search Service to deposit search strategies and citation results as data in TUScholarShare. With these deposits, we hope to make systematic reviews more open and reproducible by making the search strategies and results discoverable to the research community at Temple University and beyond. We created specialized documentation for these deposits to streamline the …

Digitizing The Accolades: Documenting Institutional Research Impact With A Video Time-Capsule, Jeanette Aprile

Medical Institutional Repositories in Libraries (MIRL)

The Health Sciences Library at New York Medical College has made its annual Faculty Author Celebration and Awards event a tradition 27 years-running. Over the last quarter century, the event has evolved with the digital age, finding an archival home in our institution’s digital repository, Touro Scholar, beginning in 2018. While we have used Touro Scholar to publish our annual awards list, depict the event in photos, and of course collect New York Medical College faculty publications - 2020 was the first year that our repository has been used to host the Faculty Author Celebration and Awards event itself. We …

Finding Our Stride – A Health System Repository 4 Years In / “Providence Patents – Using An Institutional Repository To Promote Technology Transfer, Heather J. Martin, Amanda Schwartz

Medical Institutional Repositories in Libraries (MIRL)

In 2018 Providence launched its Digital Commons Institutional Repository (IR) becoming one of only a small group of large health systems providing such a service. In nearing the end of Year 4 there has been sustained growth and continued engagement of this initiative. Expanding on the initial ask from senior leadership to simply track and compile Providence scholarly activity, subsequent years saw significant development in scope and scale of the IR. New projects included the creation of special collections, including: COVID-19 Research; Environmental Stewardship; Genomics; Diversity & Inclusion; and a Patents collection. The library partnered with nursing and graduate medical …

Going Beyond The Ir: Using Content-Specific Platforms And Targeted Outreach To Provide Integrated Access To A Medical School’S Education Scholarship, Brandon T. Pieczko, Hannah J. Craven

Medical Institutional Repositories in Libraries (MIRL)

To increase local contributions to medical education scholarship, a medical school began hosting an annual school-wide conference in 2020. Two librarians worked proactively with conference organizers to preserve and provide access to presentation materials and session recordings. This targeted outreach became more effective in the second year as students and faculty were invited on the conference submission form to express interest in contributing materials to the university’s institutional repository. The librarians were able to use this list of interested participants to obtain permissions, additional information, and address potential questions rather than relying on a post-hoc solicitation of conference materials. Workflow …

‘Open-Ish Access’ And Collaborative Solutions For Sensitive Information: The University Of New Mexico’S Native Health Database, Jonathan Pringle

Medical Institutional Repositories in Libraries (MIRL)

For over 25 years, the UNM Native Health Database (NHD-www.nativehealthdatabase.net) has functioned as a centralized repository for abstracts describing Indigenous health information, though content was frequently hidden behind physical, digital, and monetary barriers. In 2020, UNM’s Health Sciences Library and Informatics Center began a project to migrate over 10,000 records into a new database, supported by the Mukurtu CMS (www.mukurtu.org) platform. In addition to providing direct access through embedded content, this new platform provides for the ability to establish nuanced access protocols to prevent unintended access to sensitive materials. The creation of these protocols is predominantly Indigenous-led, with content creators …

Riding The Wave: Getting Faculty On Board With The Ir During The Pandemic, Jennifer M. Langford, Randall Watts

Medical Institutional Repositories in Libraries (MIRL)

The emergence of the Covid-19 pandemic initially caused widespread academic conference cancellations, leaving many University of Tennessee Health Science Center (UTHSC) faculty members without a means to present scholarship required for the annual review process. Faculty members concerned about meeting their scholarship requirements appealed to campus administration for assistance. UTHSC’s Health Sciences Library (HSL) was able to step in and offer the library-managed UTHSC Digital Commons repository as a solution to this dilemma. The urgency of faculty concerns, combined with positive messaging about Digital Commons coming from campus administration, increased campus interest in the repository. Ultimately, as conferences transitioned to …

Online Academic Days: Using The Ir To Showcase Student And Resident Scholarly Activity During A Pandemic, Leanna Stager, Stacy Posillico

Medical Institutional Repositories in Libraries (MIRL)

For many years, the Zucker School of Medicine and Northwell Health System has held Academic Days. These highly attended in-person events showcase the scholarly work of our many graduate and undergraduate academic trainee programs. Due to COVID-19, this event was required to be fully online in both 2020 and 2021. The library has partnered with the Academic Day Committee to create an online showcase of posters and abstracts using the School of Medicine’s Bepress repository to compliment the live Academic Day Zoom events. We will discuss the creation of the online collection, addressing faculty concerns over security, the expansion of …

Characteristics And Causal Factors For The Receptive-Expressive Gap In Typically Developed Spanish-English Adult Bilinguals, Rachael Janelle Javaherian

LSU Master's Theses

A receptive-expressive language gap occurs when a standardized receptive score is statistically greater than an expressive score in either a primary or a second language. In bilingual children, gap studies already exist for determining language impairment. In adults, there are few studies; nevertheless, one needs to distinguish between typical language patterns of bilingualism due to non-pathological loss of L1 skills versus problems resulting from accidents, disease, or age. To this end, the present study attempted to expand findings of studies by Gibson et al. (2012 and 2014) that focused on analysis of the gap and possible factors influencing its existence …

Keynote Presentation: A Captivating Future: The Vital Need For Curation, Access, Preservation, And Transparency In Scientific Communications, Kathryn Funk

Medical Institutional Repositories in Libraries (MIRL)

MIRL 2021 Keynote by Kathryn Funk, Program Manager, PubMed Central, US National Library of Medicine. The title of Kathryn Funk's talk is "A CAPTivating Future: The vital need for curation, access, preservation, and transparency in scientific communications"

Conference Program: Medical Institutional Repositories In Libraries 2021 (Mirl 2021), Medical Institutional Repositories In Libraries

Medical Institutional Repositories in Libraries (MIRL)

Program for the Medical Institutional Repositories in Libraries (MIRL 2021) Symposium that took place on Wednesday, November 17, 2021.