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Sacred Heart University Public Health Program Self-Study, Public Health, College Of Health Professions

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From the Introduction:

The public health program began in the fall, 2018. The public health program has only one degree offered, a master’s of public health (MPH) degree with a concentration in community health. The program was developed in response to an observed need. Specifically, Sacred Heart undergraduate students in both the Health Science and Exercise Science undergraduate programs were asking for an MPH program that they could matriculate into after graduating from their undergraduate studies. The current MPH program director, Dr. Anna Greer, was already working at SHU as a behavioral scientist within SHU’s Exercise Science program. Dr. Greer …

Attitudes And Experiences Of Occupational Therapy Practitioners Using Telehealth

The Graduate Review

No abstract provided.

Student Nurses' Association By-Laws, Hazleton State General Hospital

Historical Archives

No abstract provided.

Early Palliative Care Implementation In Metastatic Lung Cancer Patients: A Quality Improvement Project, Megan Joan Biegler, Erin Hamar, Stephanie Spinolo

All Electronic Theses and Dissertations

This was a quality improvement project that will allow improvements to be made in healthcare services offered and the overall health status of Stage IV metastatic lung cancer patients receiving palliative care referrals. Data was collected retrospectively from electronic medical records of Stage IV metastatic lung cancer patients with palliative care referrals between January 2019 and March 2020. The palliative care referrals between January 2019 and August 2019 were given per oncologist discretion in timing compared to August 2019-March 2020 when new patients received nurse navigator driven palliative care referrals immediately upon diagnosis. Data analysis looked at correlations for each …

A Match Made In Heaven: Exploring Views Of Medicine Students, Pharmacy Interns And Facilitators In An Interprofessional Medicines Pilot Study, Eileen M. Mckinlay, Melanie Brown, Debbie Wallace, Caroline Morris, Amanda Garnett, Ben Gray

Internet Journal of Allied Health Sciences and Practice

Purpose: To date, few interprofessional education initiatives have included just medicine and pharmacy learners. This research sought to explore learners’ and facilitators’ views of an interprofessional education medicines pilot study involving medical students and pharmacy interns. Methods: Qualitative feedback was gathered from the participating learners and a facilitator focus group was undertaken. Results: Medical student and pharmacy intern learners reported enjoying taking part and found the simulation and overall initiative to be authentic. They described learning most about each other’s roles and responsibilities and about teamwork, collaborative management, and collaboration. Some logistical improvements were suggested. The facilitators judged that the …

Do Learning And Study Strategies Predict Success In Hybrid-Online Physical And Occupational Therapist Education?, Evan M. Pucillo, Ellen Lowrie Black

Internet Journal of Allied Health Sciences and Practice

Purpose: An understanding of the learning strategies most accurately predictive of success has become increasingly important as health professional education programs scale the utilization of online learning in the wake of COVID-19. The purpose of this study was to examine the predictive relationship between The Learning and Study Strategies Inventory (LASSI) and cumulative professional GPA (cpGPA) in hybrid-online physical (PT) and occupational therapist (OT) education. Methods: A convenience sample collected N=149 entry-level PT and OT students from three campuses across Florida, Texas, and California. A total N(%) of 89(59.7%) PT and 60(40.3%) OT students were included for analysis [48(32.2%) male; …

Evaluating Potential Effects Of Solar Power Facilities On Wildlife From An Animal Behavior Perspective, Rachel Y. Chock, Barbara Clucas, Elizabeth K. Peterson, Bradley Blackwell, Daniel T. Blumstein, Kathleen Church, Esteban Fernández-Juricic, Gabriel Francescoli, Alison L. Greggor, Paul Kemp, Gabriela M. Pinho, Peter M. Sanzenbacher, Bruce A. Schulte, Pauline Toni

United States Department of Agriculture Wildlife Services: Staff Publications

Solar power is a renewable energy source with great potential to help meet increasing global energy demands and reduce our reliance on fossil fuels. However, research is scarce on how solar facilities affect wildlife. With input from professionals in ecology, conservation, and energy, we conducted a research-prioritization process and identified key questions needed to better understand impacts of solar facilities on wildlife. We focused on animal behavior, which can be used to identify population responses before mortality or other fitness consequences are documented. Behavioral studies can also offer approaches to understand the mechanisms leading to negative interactions (e.g., collision, singeing, …

Temporal And Spatial Blood Feeding Patterns Of Urban Mosquitoes In The San Juan Metropolitan Area, Puerto Rico, Matthew W. Hopken, Limarie J. Reyes-Torres, Nicole Scavo, Antoinette J. Piaggio, Zaid Abdo, Daniel Taylor, James Pierce, Donald A. Yee

United States Department of Agriculture Wildlife Services: Staff Publications

Simple Summary: Understanding the biodiversity of urban ecosystems is critical for management of invasive and pest species, conserving native species, and disease control. Mosquitoes (Culicidae) are ubiquitous and abundant in urban ecosystems, and rely on blood meals taken from vertebrates. We used DNA from freshly blood-fed mosquitoes to characterize the diversity of vertebrate host species in the San Juan Metropolitan Area, Puerto Rico. We collected two mosquito species that fed on a variety of vertebrates. Culex quinquefasciatus fed on 17 avian taxa (81.2% of blood meals), seven mammalian taxa (17.9%), and one reptilian taxon (0.85%). Aedes aegypti blood meals were …

Best Management Practices For Trapping Furbearers In The United States, H. Bryant White, Gordon R. Batcheller, Edward K. Boggess, Clifford L. Brown, Joseph W. Butfiloski, Thomas A. Decker, John D. Erb, Michael W. Fall, David A. Hamilton, Tim L. Hiller, George F. Hubert Jr., Matthew J. Lovallo, John F. Olson, Nathan M. Roberts

United States Department of Agriculture Wildlife Services: Staff Publications

Humans have used wild furbearers for various purposes for thousands of years. Today, furbearers are sustainably used by the public for their pelts, leather, bones, glands, meat, or other purposes. In North America, contemporary harvest of furbearers has evolved along with trap technologies and societal concerns, and is now highly regulated and more closely coupled with harvest analysis and population monitoring. Traps and regulated trapping programs provide personal or cultural rewards that can also support conservation, and can assist with advancing ecological knowledge through research, protecting endangered species, restoring populations or habitats, protecting personal property, and enhancing public health and …

Strategic Considerations For Invasive Species Managers In The Utilization Of Environmental Dna (Edna): Steps For Incorporating This Powerful Surveillance Tool, Jeffrey Morisette, Stanley Burgiel, Kelsey Brantley, Wesley M. Daniel, John Darling, Jeanette Davis, Thomas Franklin, Keith Gaddis, Margaret Hunter, Richard Lance, Tracy Leskey, Yale Passamaneck, Antoinette Piaggio, Brian Rector, Adam Sepulveda, Melissa Smith, Carol A. Stepien, Taylor Wilcox

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive species surveillance programs can utilize environmental DNA sampling and analysis to provide information on the presence of invasive species. Wider utilization of eDNA techniques for invasive species surveillance may be warranted. This paper covers topics directed towards invasive species managers and eDNA practitioners working at the intersection of eDNA techniques and invasive species surveillance. It provides background information on the utility of eDNA for invasive species management and points to various examples of its use across federal and international programs. It provides information on 1) why an invasive species manager should consider using eDNA, 2) deciding if eDNA can …

Reproductive Trade-Offs In The Colorado Checkered Whiptail Lizard (Aspidoscelis Neotesselatus): An Examination Of The Relationship Between Clutch And Follicle Size, Hannah E. Caracalas, S. S. French, S. B. Hudson, B. M. Kluever, A. C. Webb, D. Eifler, A. J. Lehmicke, Lise M. Aubry

United States Department of Agriculture Wildlife Services: Staff Publications

Life history theory predicts that there should be an inverse relationship between offspring size and number, because individuals cannot simultaneously maximize both when resources are limited. Although extensively studied in avian species, the occurrence and determinants of reproductive tradeoffs in oviparous reptiles are far less understood, particularly in parthenogenetic species. We studied this trade-off in the Colorado Checkered Whiptail, Aspidoscelis neotesselatus, a female-only parthenogenetic lizard. Using data previously collected in 2018 and 2019, we tested for clutch and egg size trade-offs and determined whether this relationship could be influenced by female size and aspects of physiological condition. Physiological condition …

Modelling The Factors Affecting The Probability For Local Rabies Elimination By Strategic Control, Johann L. Kotzé, John Duncan Grewar, Aaron M. Anderson

United States Department of Agriculture Wildlife Services: Staff Publications

Dog rabies has been recognized from ancient times and remains widespread across the developing world with an estimated 59,000 people dying annually from the disease. In 2011 a tri-partite alliance consisting of the OIE, the WHO and the FAO committed to globally eliminating dog-mediated human rabies by 2030. Regardless of global support, the responsibility remains with local program managers to implement successful elimination programs. It is well known that vaccination programs have a high probability of successful elimination if they achieve a population-coverage of 70%. It is often quoted that reducing population turnover (typically through sterilizations) raises the probability for …

Virginia Dental Journal (Vol. 98, No. 1, 2021)

Virginia Dental Journal

No abstract provided.

Allopregnanolone Improves Locomotor Activity And Arousal In The Aged Cgg Knock-In Mouse Model Of Fragile X-Associated Tremor/Ataxia Syndrome., Jared J Schwartzer, Dolores Garcia-Arocena, Amanda Jamal, Ali Izadi, Rob Willemsen, Robert F Berman

Faculty Research 2021

Carriers of the fragile X premutation (PM) can develop a variety of early neurological symptoms, including depression, anxiety and cognitive impairment as well as being at risk for developing the late-onset fragile X-associated tremor/ataxia syndrome (FXTAS). The absence of effective treatments for FXTAS underscores the importance of developing efficacious therapies to reduce the neurological symptoms in elderly PM carriers and FXTAS patients. A recent preliminary study reported that weekly infusions of Allopregnanolone (Allop) may improve deficits in executive function, learning and memory in FXTAS patients. Based on this study we examined whether Allop would improve neurological function in the aged …

Lumos - Low And Intermediate Grade Glioma Umbrella Study Of Molecular Guided Therapies At Relapse: Protocol For A Pilot Study, Benjamin Y Kong, Hao-Wen Sim, Anna K Nowak, Sonia Yip, Elizabeth H Barnes, Bryan W Day, Michael E Buckland, Roel G W Verhaak, Terrance Johns, Cleo Robinson, Et Al

Faculty Research 2021

Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. LUMOS will be a pilot umbrella study for patients with relapsed G2/3 gliomas that aims to match patients to targeted therapies based on molecular screening with contemporaneous tumour tissue. Participants in whom no actionable or no druggable mutation is found, or in whom the matching drug is …

The Gut Microbiome And Substance Use Disorder., Jordan T Russell, Yanjiao Zhou, George M. Weinstock, Jason A. Bubier

Faculty Research 2021

Substance use disorders (SUDs) remain a significant public health challenge, affecting tens of millions of individuals worldwide each year. Often comorbid with other psychiatric disorders, SUD can be poly-drug and involve several different substances including cocaine, opiates, nicotine, and alcohol. SUD has a strong genetic component. Much of SUD research has focused on the neurologic and genetic facets of consumption behavior. There is now interest in the role of the gut microbiome in the pathogenesis of SUD. In this review, we summarize current animal and clinical evidence that the gut microbiome is involved in SUD, then address the underlying mechanisms …

Gender-Based Deep Learning Firefly Optimization Method For Test Data Generation., Wenning Zhang, Chongyang Jiao, Qinglei Zhou, Yang Liu, Ting Xu

Faculty Research 2021

Software testing is a widespread validation means of software quality assurance in industry. Intelligent optimization algorithms have been proved to be an effective way of automatic test data generation. Firefly algorithm has received extensive attention and been widely used to solve optimization problems because of less parameters and simple implement. To overcome slow convergence rate and low accuracy of the firefly algorithm, a novel firefly algorithm with deep learning is proposed to generate structural test data. Initially, the population is divided into male subgroup and female subgroup. Following the randomly attracted model, each male firefly will be attracted by another …

Regen Med Therapeutic Opportunities For Fighting Covid-19., Anthony Atala, Alicia Henn, Martha Lundberg, Taby Ahsan, Jordan Greenberg, Jeff Krukin, Steven Lynum, Cathleen Lutz, Kyle Cetrulo, Mohammad Albanna, Taciana Pereira, Shannon Eaker, Joshua Hunsberger

Faculty Research 2021

This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID-19. This article addresses why SARS-CoV-2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID-19. We describe animal models that depict the mechanism of action for COVID-19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying …

Interpretation Of Psychiatric Genome-Wide Association Studies With Multispecies Heterogeneous Functional Genomic Data Integration., Timothy Reynolds, Emma C Johnson, Spencer B Huggett, Jason A. Bubier, Rohan H C Palmer, Arpana Agrawal, Erich J Baker, Elissa J Chesler

Faculty Research 2021

Genome-wide association studies and other discovery genetics methods provide a means to identify previously unknown biological mechanisms underlying behavioral disorders that may point to new therapeutic avenues, augment diagnostic tools, and yield a deeper understanding of the biology of psychiatric conditions. Recent advances in psychiatric genetics have been made possible through large-scale collaborative efforts. These studies have begun to unearth many novel genetic variants associated with psychiatric disorders and behavioral traits in human populations. Significant challenges remain in characterizing the resulting disease-associated genetic variants and prioritizing functional follow-up to make them useful for mechanistic understanding and development of therapeutics. Model …

Type 2 Mi Induced By A Single High Dose Of Isoproterenol In C57bl/6j Mice Triggers A Persistent Adaptive Immune Response Against The Heart., Elvira Forte, Mona Panahi, Nicoleta Baxan, Fu Siong Ng, Joseph J Boyle, Jane Branca, Olivia Bedard, Muneer G. Hasham, Lindsay Benson, Sian E Harding, Nadia Rosenthal, Susanne Sattler

Faculty Research 2021

Heart failure is the common final pathway of several cardiovascular conditions and a major cause of morbidity and mortality worldwide. Aberrant activation of the adaptive immune system in response to myocardial necrosis has recently been implicated in the development of heart failure. The ß-adrenergic agonist isoproterenol hydrochloride is used for its cardiac effects in a variety of different dosing regimens with high doses causing acute cardiomyocyte necrosis. To assess whether isoproterenol-induced cardiomyocyte necrosis triggers an adaptive immune response against the heart, we treated C57BL/6J mice with a single intraperitoneal injection of isoproterenol. We confirmed tissue damage reminiscent of human type …

A New Graph-Based Clustering Method With Application To Single-Cell Rna-Seq Data From Human Pancreatic Islets., Hao Wu, Disheng Mao, Yuping Zhang, Zhiyi Chi, Michael L. Stitzel, Zhengqing Ouyang

Faculty Research 2021

Traditional bulk RNA-sequencing of human pancreatic islets mainly reflects transcriptional response of major cell types. Single-cell RNA sequencing technology enables transcriptional characterization of individual cells, and thus makes it possible to detect cell types and subtypes. To tackle the heterogeneity of single-cell RNA-seq data, powerful and appropriate clustering is required to facilitate the discovery of cell types. In this paper, we propose a new clustering framework based on a graph-based model with various types of dissimilarity measures. We take the compositional nature of single-cell RNA-seq data into account and employ log-ratio transformations. The practical merit of the proposed method is …

A Validated Integrated Clinical And Molecular Glioblastoma Long-Term Survival-Predictive Nomogram., Sherise D Ferguson, Tiffany R Hodges, Nazanin K Majd, Kristin Alfaro-Munoz, Wajd N Al-Holou, Dima Suki, John F De Groot, Gregory N Fuller, Lee Xue, Miao Li, Carmen Jacobs, Ganesh Rao, Rivka R Colen, Joanne Xiu, Roel G W Verhaak, David Spetzler, Mustafa Khasraw, Raymond Sawaya, James P Long, Amy B Heimberger

Faculty Research 2021

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adulthood. Despite multimodality treatments, including maximal safe resection followed by irradiation and chemotherapy, the median overall survival times range from 14 to 16 months. However, a small subset of GBM patients live beyond 5 years and are thus considered long-term survivors.

Methods: A retrospective analysis of the clinical, radiographic, and molecular features of patients with newly diagnosed primary GBM who underwent treatment at The University of Texas MD Anderson Cancer Center was conducted. Eighty patients had sufficient quantity and quality of tissue available for next-generation sequencing and immunohistochemical …

Decreased Glucocerebrosidase Activity And Substrate Accumulation Of Glycosphingolipids In A Novel Gba1 D409v Knock-In Mouse Model., Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dave

Faculty Research 2021

Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically by homozygous mutations in GBA1, is linked to the lysosomal storage disorder Gaucher's disease (GD) and distinct or heterozygous mutations in GBA1 are associated with increased Parkinson's disease (PD) risk. While numerous genes have been linked to heritable PD, GBA1 mutations in aggregate are the single greatest risk factor for development of idiopathic PD. The importance of GCase in PD necessitates preclinical models in which to study GCase-related mechanisms …

Life In Hampton Roads Survey Press Release #3: Health & Experiences With Covid & Vaccines, Social Science Research Center, Old Dominion University

Life in Hampton Roads Survey Report

Life in Hampton Roads 2021 – Health & Experiences with COVID & Vaccines

More than 72% of respondents rated the quality of their own health as excellent (17.9%) or good (54.4%). This is lower than previous years, which is not surprising given ongoing pandemic conditions. Further, the percentage of respondents rating their health as excellent or good has been declining over recent years (e.g., from 82% in 2017).

Tissue Biodistribution And Tumor Targeting Of Near-Infrared Labelled Anti-Cd38 Antibody-Drug Conjugate In Preclinical Multiple Myeloma, Nicholas Cho, Sooah Ko, Monica Shokeen

Open Access Publications

Daratumumab (DARA) is an FDA-approved high-affinity monoclonal antibody targeting CD38 that has shown promising therapeutic efficacy in double refractory multiple myeloma (MM) patients. Despite the well-established clinical efficacy of DARA, not all heavily pretreated patients respond to single-agent DARA, and the majority of patients who initially respond eventually progress. Antibody-drug conjugates (ADCs) combine the highly targeted tumor antigen recognition of antibodies with the cell killing properties of chemotherapy for effective internalization and processing of the drug. In this study, we evaluated the anti-tumor efficacy of DARA conjugated to the maytansine derivative, mertansine (DM1), linked via a non-cleavable bifunctional linker. The …

Exploring Voice Hearers' Occupational Experience Of Romantic And Sexual Relationships, Karen Mccarthy, Kristen Gottheil, Emilio Villavicencio, Huilim Jeong

Occupational Therapy | Faculty Scholarship

Background: Limited research has been conducted that explores the occupational experience of hearing voices, including the impact it has on romantic and/or sexual relationships. This study aims to address this gap by capturing the experience of romantic and sexual relationships for those who hear voices.

Method: A phenomenological approach was used to gather data from a survey, electronic diaries, and interviews of three voice hearers who were interested or actively in a casual or serious relationship.

Results: All of the participants reported that the voices in some way impacted their past or current romantic and sexual relationships. …

Social Participation In College Students With Chronic Pain, Karen Mccarthy, Megan Chamberlain, Megan Chinn, Jennifer Pineda, Camille Santiago, Jamie Spitzer, Patricia Tran

Occupational Therapy | Faculty Scholarship

Background: College students with invisible disabilities, including chronic pain, often experience difficulty engaging in social occupations, both on and off campus, because of stigma, misconceptions, or social exclusion. Previous research has examined the use of academic accommodations to address these concerns or focused on the physical barriers to participation, failing to address the psychosocial and holistic impact of pain. Chronic pain can affect a variety of occupations, including social participation, which is a significant occupation for college students. This research explores the lived experience of chronic pain for college students and the impact of pain on social participation from …

Assessing How A Tobacco-Free Campus Leads To Attitude Change And Support Among Students, Faculty, And Staff., Trevin E. Glasgow, Carrie A Miller, D Jeremy Barsell, Elizabeth K. Do, Bernard F Fuemmeler

Health Sciences Education Research

INTRODUCTION: Universities are increasingly considering tobacco-free campus policies to help promote a healthy learning and working environment. We assessed attitudes of students, faculty, and staff, before and after the implementation of a tobacco-free campus policy at a large, urban university. We also examined individual factors associated with these attitudes.

METHODS: An independent panel design method was used to assess students, faculty and staff about their tobacco product use, attitudes towards tobacco policies, and support for cigarette and e-cigarette bans 3 months before and 7 months after a university-wide policy change to ban tobacco and e-cigarettes on campus. Survey participants before …

How To Launch And Continually Enhance An Effective Medical Campus Faculty Development Program: Steps For Implementation And Lessons Learned., Ellen Childs, Christy D. Remein, Robina M Bhasin, Angelique C Harris, Alyssa Day, Lisa M Sullivan, David L Coleman, Emelia J Benjamin

Health Sciences Education Research

Purpose: Drawing on the decade of experience of Boston University Medical Campus' Faculty Development Office, this paper reports strategies used to launch and continually improve faculty development programming within an academic health sciences campus.

Patients and Methods: The authors explain the steps that Boston University Medical Campus took to institute their set of faculty development programs, including an overview of resources on how to periodically conduct needs assessments, engage key institutional stakeholders, design and evaluate an array of programming to meet the needs of a diverse faculty, and institute real-time program modifications.

Results: In a step-by-step guide, and by highlighting …

Community Health Center Residency Training: Improving Staffing, Service, And Quality, Candice Chen, Nicholas Chong, Qian Luo, Jeongyoung Park

Health Sciences Education Research

BACKGROUND AND OBJECTIVES: Community-based residency programs are an important strategy to address rural and underserved primary care shortages, however, health centers report both benefits and challenges to training. This study aims to understand the impact of new Teaching Health Center (THC) residency programs on health center staffing, patient service, quality of care, and provider productivity.

METHODS: Using the Uniform Data System, we used inverse propensity score weighting to create a balanced sample of new THC and non-THC health centers in 2010. Using 2018 data, we applied propensity score weighted regressions to examine changes in staffing, service, quality of care, and …