Medicine and Health Sciences Commons^™

Regression Analyses Assessing The Impact Of Environmental Factors On Covid-19 Transmission And Mortality, El Hussain Shamsa, Kezhong Zhang

Medical Student Research Symposium

No abstract provided.

Hospital-Acquired Venous Thromboembolism Or Bleeding Following Total Joint Arthroplasty: A Systematic Review And Meta-Analysis For The Association Of The Gene Polymorphism., Michael Debeau

Medical Student Research Symposium

This review seeks to understand the current existing literature on genetic polymorphisms to VTE following orthopedic surgery. Using PRISMA guidelines, 234 studies were retrieved from PubMed and Cochrane. The eligibility assessment yielded 16 studies including a systematic review. A STREGA and STROBE quality assessment found these studies to have high methodological quality. A significant association was found between the PAI-1 4G/4G genotype and resistance to anticoagulation therapy (OR = 2.692; 95% CI = 1.302 - 4.702). Moreover, the MTHFR C677T and A1298C polymorphisms significantly increased the incidence of VTE in patients that are compound heterozygotes (OR = 2.89; 95% CI …

Weight-Based Vs. Bsa-Based Fluid Resuscitation Predictions In Pediatric Burn Patients, Jan Stevens, Nina Prieto, Elika Ridelman Ph.D, Justin D. Klein Md, Christina Shanti Md

Medical Student Research Symposium

Fluid resuscitation for pediatric burns uses formulas that estimate fluid requirements based on weight, and/or body surface area (BSA) along with percent total burn surface area (TBSA). Adult studies have shown that these formulas can cause fluid overload in obese patients and increase risk of complications. These findings have not been validated in pediatric patients. This study provides a retrospective review conducted with 110 children (≤ 18 years old) admitted to an ABA-verified urban pediatric burn center from October 2008 to May 2020. Patients were resuscitated with the weight-based Parkland formula, and had fluids titrated to urine output every two …

Massive Pulmonary Embolism From Worsening Of Gouty Arthritis Due To The Covid-19 Pandemic, Thomas L. Mccune, Muhammad Osto, Radhika Gaddipati Md

Medical Student Research Symposium

Abstract: Gout is the most common inflammatory arthritis in men and is associated with increased mortality and is an independent risk factor for cardiovascular disease such as myocardial infarction and stroke. In addition, several other types of inflammatory arthritis have been linked to increased risk of venous thromboembolism (VTE). VTE is associated high mortality of around 9.7% for PE and 4.6% for DVT. However, only a handful of studies have been conducted to estimate the risk of VTE in patients with gout before or after diagnosis. Most recent study in Canada concluded that patients with gout have around a 20% …

Collaborating To Build And Implement A Shared Health Equity Research Agenda: A Report On The Three Campus Community Conversation, University At Albany, State University Of New York

Three Campus Community Conversation Final Report

In March of 2020 New York State’s Gov. Andrew Cuomo charged Havidan Rodríguez, President of the University at Albany, SUNY, with leading a team of public health, social welfare, emergency preparedness and other experts from both research and practice in a study of the environmental, socioeconomic and occupational factors causing Latinx and Black individuals in the state to be disproportionately harmed by COVID-19. See www.albany.edu/mhd.

In pursing this charge and at the request of President Rodríguez, the Vice President for Research at the University at Albany, Dr. James Dias partnered with the Vice President for Research from SUNY Downstate Health …

Assessing Social Influencers Of Health And Education, The Center For Health And Health Care In Schools (Chhcs)

Health Policy and Management Issue Briefs

No abstract provided.

A Study On Child Abuse, And Its Relationship With The Attitude Of Adults And Socio – Demographic Variables In Udupi Dist., Sangeetha Priyadarshini

Manipal College of Nursing, Manipal Theses and Dissertations

No abstract provided.

Effectiveness Of Developmental Supportive Care Program (Dscp) On The Health Status Of Preterm Infants, Knowledge, And Practice Of Care Providers In A Selected Neonatal Unit Of Tertiary Care Hospital., Yashoda Sathish

Manipal College of Nursing, Manipal Theses and Dissertations

No abstract provided.

Tackling Covid-19 In Thailand, Singapore Management University

Perspectives@SMU

How can the country balance the need to restart the economy and keeping another wave of infections at bay?

Crosstalk Of Cancer Signaling Pathways By Cyclic Hexapeptides And Anthraquinones From Rubia Cordifolia, Premalatha Balachandran, Mohamed Ali Ibrahim, Jin Zhang, Mei Wang

Faculty and Student Publications

The anticancer activities of Rubia cordifolia and its constituents have been reported earlier, but their influence on the crosstalk of complex cancer-related signaling metabolic pathways (i.e., transcription factors; TF) has not yet been fully investigated. In this study, R. cordifolia root extract was subjected to the cancer signaling assay based bioactivity-guided fractionation, which yielded the following compounds viz., three anthraquinones, namely alizarin (1), purpurin (2), and emodin (3); two lignans, namely eudesmin (4) and compound 5; and two cyclic hexapeptides, namely deoxybouvardin RA-V (6), and a mixture of 6+9 (RA-XXI). The structures of the isolated compounds were determined by NMR …

Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka

Faculty and Student Publications

The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the temporary pore-forming agent. The thermal analysis showed that both the drug and C-888 preserved their crystallinity within a solid …

Pandemic Sparks Innovation In Virtual Care Education, Bonnie L. Rogulj

Physical Therapy Collection

As a result of COVID-19 the physical therapy profession has required increased use of technology to manage patients and clients Telerehabilitation has allowed PTs to provide cost-effective services to patients and clients at a distance. This article describes an effort to create a series of interactive virtual activities related to the cervical spine and upper extremities for novice students enrolled in the Applied Anatomy course (see example below). It also explores important considerations for educators when utilizing technology to teach physical therapy telemedicine skills.

Nsu Cop Students On Rotations Contribute To The Vaccination Efforts, Silverman College Of Pharmacy

Archived News and Events

Broward Health Medical Center began administering the COVID19 vaccine to healthcare workers, EMS and patients aged 65 and over in January 2021. They opened a community vaccination site at Inter Miami CF Stadium in Fort Lauderdale. NSU students taking introductory and advanced pharmacy practice rotations within a Broward Health Hospital or Clinic had an opportunity to contribute to the vaccination effort.

NSU P4 student Angela Sanichar immunized her preceptor and alumni, Dr. Kaleed Mohammed ('09), Regional Manager of Pharmacy Services at Broward Health. Dr. Mohammed said, "Vaccine dose number 2 done! How cool is it to have your student give …

2021-02-01_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Himmelfarb Headlines - February/March 2021, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News, information, and resources relating to Himmelfarb Library that is of interest to patrons.

Rural Hiv Prevalence And Service Availability In The United States: A Chartbook, Katherine Ahrens Phd, Amanda Burgess Mppm, Louisa Munk, Erika Ziller Phd

Population Health

This chartbook examines 2016 HIV prevalence and the availability of HIV prevention, testing, and treatment services across the rural-urban continuum and by US Census region. Publicly available county-level HIV prevalence data from the CDC and state-produced HIV surveillance reports were used to estimate HIV prevalence across the rural-urban continuum. HIV prevalence data include all diagnoses of HIV infection, with or without a stage 3 (AIDS) diagnosis. Geocoded data on organizations that provide prevention, testing, and treatment services related to HIV were obtained from the National Prevention Information Network.

HIV prevalence is higher in urban counties than rural counties (399 per …

Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive And Electrophysiological Impairments In Tg2576 App Transgenic Mice, Madhumathi Gnanaprakash, Agnieszka Staniszewski, Hong Zhang, Rose Pitstick, Michael P. Kavanaugh, Ottavio Arancio, Russell E. Nicholls

Biomedical and Pharmaceutical Sciences Faculty Publications

Background: The serine/threonine protein phosphatase, PP2A, is thought to play a central role in the molecular pathogenesis of Alzheimer’s disease (AD), and the activity and substrate specificity of PP2A is regulated, in part, through methylation and demethylation of its catalytic subunit. Previously, we found that transgenic overexpression of the PP2A methyltransferase, LCMT-1, or the PP2A methylesterase, PME-1, altered the sensitivity of mice to impairments caused by acute exposure to synthetic oligomeric amyloid-β (Aβ).

Objective: Here we sought to test the possibility that these molecules also controlled sensitivity to impairments caused by chronically elevated levels of Aβ produced in vivo. …

Opioid-Related Visits To Rural Emergency Departments, Erika C. Ziller Phd, Jean A. Talbot Phd, Deborah Thayer Mba, Carly Milkowski Mph

Mental Health / Substance Use Disorders

Increased rates of acute opioid poisoning and related emergency department (ED) visits in the United States have occurred at the same time as rural EDs face a number of resource constraints. Researchers at the Maine Rural Health Research Center conducted this study to gain insight about rural ED visits for acute opioid poisoning and how they compare with urban ED visits. The authors used data from the 2006 and 2013 Nationwide Emergency Department Sample to examine rural and urban opioid-related visits (ORVs) to EDs, including rate change over time, and the outcomes of these ED visits (treatment and release, inpatient …

Supplemental Ascorbate Diminishes Dna Damage Yet Depletes Glutathione And Increases Acute Liver Failure In A Mouse Model Of Hepatic Antioxidant System Disruption, Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt

Biomedical and Pharmaceutical Sciences Faculty Publications

Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific codisruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH). Although most mice with TrxR1/Gsr-null livers exhibit long-term survival, ~25% die from spontaneous liver failure between 4- and 7-weeks of age. Here we tested whether liver failure was ameliorated by ascorbate supplementation. Following ascorbate, dehydroascorbate, or mock treatment, we assessed survival, liver histology, or hepatic redox markers including GSH and GSSG, redox enzyme activities, and oxidative damage markers. Unexpectedly, rather than providing protection, ascorbate …

White Adipose Remodeling During Browning In Mice Involves Ybx1 To Drive Thermogenic Commitment, Atefeh Rabiee, Kaja Plucińska, Marie Sophie Isidor, Erin Louise Brown, Marco Tozzi, Simone Sidoli, Patricia Stephanie S. Petersen, Marina Agueda-Oyarzabal, Silje Bøen Torsetnes, Galal Nazih Chehabi, Morten Lundh, Ali Altıntaş, Romain Barrès, Ole Nørregaard Jensen, Zachary Gerhart-Hines, Brice Emanuelli

School of Pharmacy Faculty Articles

Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive. Our study examined the molecular determinants driving the differentiation of precursor cells into thermogenic adipocytes. Methods: In this study, we conducted temporal high-resolution proteomic analysis of subcutaneous white adipose tissue (scWAT) after cold exposure in mice. This was followed by loss- and gain-of-function experiments using siRNA-mediated knockdown and CRISPRa-mediated induction of gene expression, respectively, to evaluate the function of the transcriptional regulator Y box-binding protein 1 (YBX1) during adipogenesis of brown pre-adipocytes …

Impact Of A Multidisciplinary Group On Management Of Patent Foramen Ovale In Cryptogenic Stroke And Outcome Measures: A Retrospective Study, Laura Meissner, Diana L. Tzeng, Md

Phase 1

Patent foramen ovale (PFO) is a common cardiac abnormality present in roughly 25% of the adult population. Although typically benign, patients with a PFO account for 50% of the population of cryptogenic stroke, an ischemic stroke with an unknown cause. Guidelines suggest closure in patients with a cryptogenic stroke found to have a PFO; however, it is unclear whether medical treatment should be given to all patients, regardless of PFO closure, and data is limited on the treatment outcomes. This retrospective chart analysis of 80 patients with a cryptogenic stroke found to have a PFO will investigate the criteria a …

Assessing Food Quality And Regulations At Homeless Shelters In Philadelphia, Emily Casaletto, Rickie Brawer, Phd, Mph, Mches

Phase 1

Introduction: Nutritional diseases such as hypertension, diabetes, and cholesterol disorders are particularly high among individuals experiencing homelessness in comparison to the general United States population, leading the propagation of chronic health conditions and overuse of expensive healthcare resources. In addition, the food served in homeless shelters is the main source of nutrition for those living in these shelters, most notably when there is no option for food storage available. Despite the disproportionate prevalence of nutrition-related diseases among the homeless population, there is limited research on the quality of the food provided in homeless shelters and there are few policies to …

Genetic Profiling Of Cell Types In The Pathogenesis Of Nonalcoholic Steatohepatitis (Nash), Yanki Yarman, Raj Vadigepalli

Phase 1

NASH is the progressive form of non-alcoholic fatty liver disease (NAFLD) which affects 25% of adults in the US. We are interested in identifying genetic markers for specific cell populations in the liver and hypothesize that cells undergo genetic reprogramming to handle the molecular stresses of the NASH disease state.

Using previously published single-cell RNA sequencing datasets from mouse liver whole tissue, we identified the top 25 most highly variable genes per cell type in NASH liver tissue. Using R-programming language, datasets from both healthy and diseases livers were deconvoluted, normalized, linearized and dimensionally reduced to create a 3D map …

Evaluating Barriers To Clinical Trial Enrollment In Head And Neck Surgical Oncology, Gregory Schneider, Emily Sagalow, Kealan Hobelmann, Md, Richard Goldman, Md, David Cognetti, Md, Joseph M. Curry, Md, Adam Luginbuhl, Md

Phase 1

Introduction and Objectives: Clinical trials are an important focus in academic otolaryngology practices, but busy practices may pose difficulty for identification and enrollment of patients eligible for trials. We will identify barriers to enrollment from the perspective of both head and neck surgical oncologists and their patients.

Methods: Patients who were eligible for any of the eight clinical trials offered at Jefferson between August and November 2020 were identified. We utilized an Epic EMR phrase to capture if a trial was offered or not and why, whether a patient refused enrollment and why, and patient wait time.

Results: During the …

Reduced Recovery Times With Total Intravenous Anesthesia In Patients With Obstructive Sleep Apnea, Leonard Estephan, Matthew Stewart, Maurits Boon, Colin Huntley

Phase 1

Introduction: There are currently no specific anesthetic guidelines for patients with obstructive sleep apnea (OSA) undergoing upper airway surgery. Two consistently utilized anesthetic approaches during such procedures include inhalational gas anesthesia and total intravenous anesthesia (TIVA), however whether either is more efficacious remains undefined. We hypothesize that administration of TIVA will lead to reduced post-operative recovery time in patients with comorbid OSA undergoing upper airway surgery.

Methods: A retrospective chart review was performed for patients with comorbid OSA that underwent surgery (upper airway stimulation, nasal surgery, palate surgery) between January 2019 and December 2019. Included patients received either inhaled …

Litce, Emily Huang, Madalyne Sunday, Shreyas Chandragiri, Young Sheng, Colin Yost, Heli Patel, Jasmine Phun, Geoffrey Hayden, Md

Phase 1

• Identify patients with low health literacy
• Improve the ability of medical students to communicate with these patients
• Establish a clinical workflow that addresses low health literacy

Demographic Backgrounds And Career Goals Of First-Generation Medical Students, Brianna Kunes, Ricky Burns, Allison Casola, Phd, Mph

Phase 1

Purpose: Little research is available on the demographics and career goals of first-generation medical students. Undergraduate research suggests first-generation students are more likely to come from lower-income households, speak English as a second language, and experience higher drop-out rates. These diverse experiences could make first-generation medical students valuable members of the healthcare team. However, without more information, it is difficult for medical schools to identify and support them. Therefore, the purpose of this study is to define the following inquiry statements: What are the demographic backgrounds and intended career goals of first-generation medical students; How do they differ from non-first-generation …

A Comparative Analysis Of Anterior & Lateral Cranial Base Csf Leaks, Rahul Alapati, Glen D. Souza, Md, Prachi Patel, Chandala Chitguppi, Md, Rashiqah Syed, Tawfiq Khoury, Md, Mindy R. Rabinowitz, Md, Christopher J. Farrell, Md, Elina Toskala, Md, Phd, Marc R. Rosen, Md, James J. Evans, Md, Gurston Nyquist, Md

Phase 1

Introduction

The optimal strategy for management of Idiopathic Intracranial Hypertension (IIH) in anterior and lateral cranial base meningoencephaloceles remains debated. The purpose of this study is to present a comparison of the surgical management of anterior and lateral cranial base meningoencephalocele and a treatment algorithm for the diagnosis and management of IIH in this patient population.

Methods

Retrospective study of 109 patients who underwent anterior or lateral CSF leak repair at TJU from 2004-2020. Epic & RedCap were utilized to record data. Patient demographics, presenting symptoms, imaging, Beta-2 Transferring testing, surgery, repair, and post-op data were collected. Two-sided Chi-squared tests …

Comparison Of Endovascular Therapy Versus Medical Therapy In The Management Of Descending Thoracic Aortic Dissection, Eli Cehelyk, Babak Abai, Md

Phase 1

Introduction: This retrospective review aimed to compare clinical outcomes between patients with descending aortic dissections, with and without organ malperfusion, who were managed with thoracic endovascular aortic repair (TEVAR) or best medical therapy (BMT).

Methods: Thirty-eight patients diagnosed with descending aortic dissections between 2013 and 2020 were identified for analysis. Patients with dissection secondary to trauma and death unrelated to cardiothoracic pathology were excluded. Participants were divided into three groups based on their management: TEVAR (without side branch stenting), TEVAR+ (with additional branch stenting) and BMT. The primary outcome measure was length of hospital stay (LOS) and statistics were analyzed …

Otologic Opioid Usage And Pain Control In The Postoperative Period, Matthew Stewart, Eric Mastrolonardo, Joann Butkus, Raphael Banoub, Md, Tingting Zhan, Phd, Sophia Dang, Md, David Cognetti, Md, Rebecca Chiffer, Md, Thomas Wilcox, Md

Phase 1

Introduction: Patients’ unused prescription opioids can be diverted and increase the overall opioid burden on society. Therefore, otolaryngologists can reduce opioid influx by minimizing excess tablets in opioid prescriptions. We hypothesize that otology patients at TJUH receive more opioid tablets than needed to effectively manage postoperative pain.

Methods: Patients ages ≥18 years old who received otologic surgery at TJUH were included in this prospective observational study between November 2019 and August 2020. Patients were provided a survey for recording pain on postoperative days 0, 1, 3, and 7 and the amount of remaining opioids from their prescription. Opioid amounts were …