Medicine and Health Sciences Commons^™

2021-04-02_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Risk Factors For Stress Fractures In Female Runners: Results Of A Survey, Therese Johnston, Allison E Jakavick, Caroline A Mancuso, Kathleen C Mcgee, Lily Wei, Morgan L Wright, Jeremy Close, Md, Ayako Shimada, Benjamin E Leiby

Department of Rehabilitation Medicine Faculty Papers

Background: Few studies compare women with and without stress fractures and most focus on younger, elite runners.

Hypothesis/purpose: Compare risk factors between female runners with and without a stress fracture history.

Study design: Case control.

Methods: An online survey targeting women age ≥18 years was distributed primarily via social media. Questions included demographics, running details, cross training, nutrition, injury history, medical/menstrual history, and medications. Women with stress fracture histories answered questions about location, number, and changes made. Data were compared between groups using t-tests, chi-square tests, or Fisher's exact tests. Multivariable logistic regression models simultaneously investigated associations of multiple factors …

Preclinical Evaluation Of Cancer Immune Therapy Using Patient-Derived Tumor Antigen-Specific T Cells In A Novel Xenograft Platform., Gautam N Shenoy, Christopher J Greene, Maulasri Bhatta, Miren L Baroja, Jenni L Loyall, Sathy V Balu-Iyer, Raymond J Kelleher, Beatriz M Carreno, Gerald P Linette, Leonard D. Shultz, Richard B Bankert

Faculty Research 2021

Objectives: With a rapidly growing list of candidate immune-based cancer therapeutics, there is a critical need to generate highly reliable animal models to preclinically evaluate the efficacy of emerging immune-based therapies, facilitating successful clinical translation. Our aim was to design and validate a novel

Methods: Tumor xenografts are established rapidly in the greater omentum of globally immunodeficient NOD-

Results: The tumors progress rapidly and disseminate in the mice unless patient-derived tumor-specific T cells are introduced. An initial T cell-mediated tumor arrest is later followed by a tumor escape, which correlates with the upregulation of the checkpoint molecules programmed cell death-1 …

Human Rights Education In Humanitarian Settings: Opportunities And Challenges, Megan Devonald, Nicola Jones, Silvia Guglielmi, Jennifer Seager, Sarah Baird

Global Health Faculty Publications

Human rights education in humanitarian settings provides an opportunity for adolescent refugees to understand and exercise their human rights, respect the rights of others, and gain active citizenship skills. This paper examines non-formal education programmes and the extent to which they embed education about, through and for human rights; it draws on mixed method data from two diverse contexts–Rohingya refugees in Bangladesh and Syrian refugees in Jordan. We find stark differences in how human rights are reflected in non-formal education programming for refugees. In Jordan, the Makani programme integrates human rights across subjects and teacher pedagogy, and fosters skills …

Risk Stratification Among Survivors Of Cardiac Arrest Considered For Coronary Angiography., Ahmed A Harhash, Teresa L May, Chiu-Hsieh Hsu, Sachin Agarwal, David B Seder, Michael R Mooney, Nainesh C. Patel Md, John Mcpherson, Paul Mcmullan, Richard Riker, Eldar Soreide, Karen G Hirsch, Pascal Stammet, Alison Dupont, Sten Rubertsson, Hans Friberg, Niklas Nielsen, Tanveer Rab, Karl B Kern

Cardiology Division

BACKGROUND: The American College of Cardiology Interventional Council published consensus-based recommendations to help identify resuscitated cardiac arrest patients with unfavorable clinical features in whom invasive procedures are unlikely to improve survival.

OBJECTIVES: This study sought to identify how many unfavorable features are required before prognosis is significantly worsened and which features are most impactful in predicting prognosis.

METHODS: Using the INTCAR (International Cardiac Arrest Registry), the impact of each proposed "unfavorable feature" on survival to hospital discharge was individually analyzed. Logistic regression was performed to assess the association of such unfavorable features with poor outcomes.

RESULTS: Seven unfavorable features (of …

The Secret Sauce Is An Engaged Staff...How A Rehabilitation Department Met The Challenges Of Covid 19, Daniel Sawyer Pt, Dpt, Michael Pechulis Dpt, Ryan Vetter Ms-Otr/L, Elizabeth Wetzler,Pt, Mary Loose Pt, Matthew Nelson Pt, Dpt, Ceeaa, Lee Ann Phillips Ms, Otr/L, Julie M. Skrzat Pt Dpt Phd Ccs

Posters

No abstract provided.

Persistent Disparities In Smoking Among Rural Appalachians: Evidence From The Mountain Air Project, Kathryn Cardarelli, Susan C. Westneat, Madeline Dunfee, Beverly May, Nancy Schoenberg, Steven R. Browning

Health, Behavior & Society Faculty Publications

BACKGROUND: Adult smoking prevalence in Central Appalachia is the highest in the United States, yet few epidemiologic studies describe the smoking behaviors of this population. Using a community-based approach, the Mountain Air Project (MAP) recruited the largest adult cohort from Central Appalachia, allowing us to examine prevalence and patterns of smoking behavior.

METHODS: A cross-sectional epidemiologic study of 972 participants aged 21 years and older was undertaken 2015-2017, with a response rate of 82%. Prevalence ratios and 95% confidence intervals for current smoking (compared to nonsmokers) were computed for the entire cohort then stratified by multiple characteristics, including respiratory health. …

Pandemic Makes Chronic Disease Prevention A Priority., Karen S. Kmetik, Alexis Skoufalos, David B. Nash

College of Population Health Faculty Papers

This article is the authors' final version prior to publication in Population Health Management, Volume 24, Issue 1, February 2021, Pages 1-2

Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/pop.2020.0126

Capsule Carbohydrate Structure Determines Virulence In Acinetobacter Baumannii., Yuli Talyansky, Travis B Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F Feldman, Thomas A Russo, Evgeny Vinogradov, Brian Luna, Meredith S Wright, Mark D Adams, Brad Spellberg

Faculty Research 2021

Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of virulence in A. baumannii remain uncertain. By comparing genomes among a panel of A. baumannii strains we identified a specific gene variation in the capsule locus that correlated with altered virulence. While less virulent strains possessed the intact gene gtr6, a hypervirulent clinical isolate contained a spontaneous transposon insertion in the same gene, resulting in the loss of a branchpoint in capsular carbohydrate structure. By constructing isogenic gtr6 mutants, we confirmed that gtr6-disrupted strains were protected from phagocytosis in vitro and …

Using Asymmetry To Your Advantage: Learning To Acquire And Accept External Assistance During Prolonged Split-Belt Walking, Natalia Sánchez, Surabhi N. Simha, J. Maxwell Donelan, James M. Finley

Physical Therapy Faculty Articles and Research

People can learn to exploit external assistance during walking to reduce energetic cost. For example, walking on a split-belt treadmill affords the opportunity for people to redistribute the mechanical work performed by the legs to gain assistance from the difference in belts’ speed and reduce energetic cost. Though we know what people should do to acquire this assistance, this strategy is not observed during typical adaptation studies. We hypothesized that extending the time allotted for adaptation would result in participants adopting asymmetric step lengths to increase the assistance they can acquire from the treadmill. Here, participants walked on a split-belt …

Creating A Theoretical Framework To Underpin Discourse Assessment And Intervention In Aphasia, Lucy Dipper, Jane Marshall, Mary Boyle, Deborah Hersh, Nicola Botting, Madeline Cruice

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Discourse (a unit of language longer than a single sentence) is fundamental to everyday communication. People with aphasia (a language impairment occurring most frequently after stroke, or other brain damage) have communication difficulties which lead to less complete, less coherent, and less complex discourse. Although there are multiple reviews of discourse assessment and an emerging evidence base for discourse intervention, there is no unified theoretical framework to underpin this research. Instead, disparate theories are recruited to explain different aspects of discourse impairment, or symptoms are reported without a hypothesis about the cause. What is needed is a theoretical framework that …

Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis In The Retina And Causes Visual Dysfunction In Mice, Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H.C. Van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes

School of Medicine Faculty Publications

Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which are enriched in the photoreceptor outer segments (POS). The molecular mechanisms underlying the retinopathy remain, however, elusive. Here, we report that mice with MFP2 inactivation display decreased retinal function already at the age of 3 weeks, which is accompanied by a profound shortening of the photoreceptor outer and inner segments, but with preserved photoreceptor ultrastructure. Furthermore, MFP2 deficient retinas exhibit severe changes in gene expression with …

Characteristic Pancreatic And Splenic Immune Cell Infiltration Patterns In Mouse Acute Pancreatitis, Baibing Yang, Joy M. Davis, Thomas H. Gomez, Mamoun Younes, Xiurong Zhao, Qiang Shen, Run Wang, Tien C. Ko, Yanna Cao

School of Medicine Faculty Publications

Background: A systemic evaluation of immune cell infiltration patterns in experimental acute pancreatitis (AP) is lacking. Using multi-dimensional flow cytometry, this study profiled infiltrating immune cell types in multiple AP mouse models. Methods: Three AP models were generated in C57BL/6 mice via cerulein (CAE) injection, alcohol and palmitoleic acid (EtOH + POA) injection, and alcohol diet feeding and cerulein (EtOH + CAE) injection. Primary pancreatic cells and splenocytes were prepared, and multi-dimensional flow cytometry was performed and analyzed by manual gating and computerized PhenoGraph, followed by visualization with t-distributed stochastic neighbor embedding (t-SNE). Results: CAE treatment induced a time-dependent increase …

Evaluation Of Radiology Request Forms In A Tertiary Care Hospital: An Audit With A Focus On The Impact Of Technological Intervention, Muhammad Danish Barakzai, Zara Za Sheer, Muhammad Azeemuddin, Amna Alvi, Noman Khan, Waseem M. Nizamani, Madiha Beg, Saad Siddiqui

Community Health Sciences

Radiology request forms are the basis of communication between referring physicians and radiologists. These are the sole documents on the basis of which a justification to carry out a radiological procedure is carried out. However, across the globe, there is a problem of inadequately filled radiology request forms. Several interventions like standardization and the use of technology have been proposed worldwide to overcome the shortcomings of inadequately filled radiology request forms. We carried out a two-phase audit assessing the impact of a technological intervention on the quality of radiology requests with the results showing marked improvement in key parameters. A …

Cancer Survivorship In Hematologic Malignancies: Lifestyle Changes After Diagnosis, Pannaga Malalur, Manas Agastya, Sandhya Wahi-Gururaj, Chad L. Cross, Delva Deauna-Limayo, Edwin C. Kingsley

School of Medicine Faculty Research

© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Background: Studies show that patients make lifestyle changes soon after certain solid tumor diagnoses, suggesting that this may be a teachable moment to motivate and promote healthy behaviors. There is a paucity of data regarding changes made after a diagnosis of a hematologic malignancy. Methods: A cross-sectional study of 116 patients at a community oncology center who completed anonymous questionnaires was performed. Questions addressed lifestyle choices made with respect to smoking, alcohol consumption, recreational drug use, diet, and exercise habits before and after diagnosis of a hematologic …

Alcohol Intake And Alcohol–Snp Interactions Associated With Prostate Cancer Aggressiveness, Hui Yi Lin, Xinnan Wang, Tung-Sung Tseng, Yu Hsiang Kao, Zhide Fang, Patricia E. Molina, Chia Ho Cheng, Anders E. Berglund, Rosalind A. Eeles, Kenneth R. Muir, Nora Pashayan, Christopher A. Haiman, Hermann Brenner, Jong Y. Park

School of Public Health Faculty Publications

Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake’s impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol–SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol–SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake …

Social Network Structure Is Related To Functional Improvement From Home-Based Telerehabilitation After Stroke, Archana Podury, Sophia M. Raefsky, Lucy Dodakian, Liam Mccafferty, Vu Le, Alison Mckenzie, Jill See, Robert J. Zhou, Thalia Nguyen, Benjamin Vanderschelden, Gene Wong, Laila Nazarzai, Jutta Heckhausen, Steven C. Cramer, Amar Dhand

Physical Therapy Faculty Articles and Research

Objective: Telerehabilitation (TR) is now, in the context of COVID-19, more clinically relevant than ever as a major source of outpatient care. The social network of a patient is a critical yet understudied factor in the success of TR that may influence both engagement in therapy programs and post-stroke outcomes. We designed a 12-week home-based TR program for stroke patients and evaluated which social factors might be related to motor gains and reduced depressive symptoms.

Methods: Stroke patients (n = 13) with arm motor deficits underwent supervised home-based TR for 12 weeks with routine assessments of motor function and …

Autophagic Reprogramming Of Bone Marrow-Derived Macrophages, Mayada Mahmoud Zaki Mohamed Mazher

Theses and Dissertations

ABSTRACT Background: Macroautophagy is a highly conserved catabolic process among eukaryotes. Autophagosome is a piece of double-membrane machinery that fuses with lysosomes during macroautophagy to form autolysosomes. Autolysosome degrades organelles and organizes the pathogen engulfment during phagocytosis in innate immunity. Macrophages are highly dynamic immune cells that orchestrate the host-pathogen interaction. Interestingly, autophagy is implicated in disease pathophysiologies such as Crohn’s disease, cancer, and neurodegenerative diseases. Therefore, we studied the interplay between autophagy and macrophage polarization (activation) through two approaches: 1- Systems biology approach to construct the genetic regulatory network and pathway analysis. And to predict the target proteins that …

Psychosocial Determinants Of Health In Recreational, Tactical, And Competitive Athletes: Implications For Physical Therapists, Todd E. Davenport, John J. Fraser, Jenna Sawdon-Bea

All Faculty Scholarship

Neuromusculoskeletal (NMSK) injuries are ubiquitous in recreational, tactical, and competitive athletes. Many athletes who sustain a NMSK injury progress to develop chronic conditions that can limit physical activity and result in substantial long-term disability. Both social and psychological factors may drive care-seeking and treatment compliance following NMSK injury, as well as contribute to the chronification of injury. In turn, each of these factors could result in long-term cardiovascular consequences that contribute to morbidity and mortality over a lifetime. Physical therapists have a professional duty to work in communities, operational military units, and in competitive athletic programs to increase accessibility, foster …

Improve The Risk Of Central Line-Associated Bloodstream Infections With Central Line Dressing Changes Through A Team Approach, Jessica Comstock

Student Scholarly Projects

Practice Problem: Central Line Associated Bloodstream Infections (CLABSI) are a preventable hospital acquired infection which contributes to patient morbidity, mortality and rising healthcare costs.

PICOT: The PICOT question that guided this project was: In adult inpatients with central venous catheters, does the use of a two-person dressing change team, compared to a single person procedure, decrease the rate of central line associated bloodstream infections over the course of 8 weeks?

Evidence: The prevention of CLABSI is most effective when multifaceted line maintenance bundles are implemented and adherence to these bundles nears 100% (Schreiber et al. 2018).

Intervention: A two-person, …

The International Perinatal Outcomes In The Pandemic (Ipop) Study: Protocol, Sarah J. Stock, Helga Zoega, Meredith Brockway, Rachel H. Mulholland, Jessica E. Miller, Jasper V. Been, Rachael Wood, Ishaya I. Abok, Belal Alshaikh, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in …

Low-Grade Fibromyxoid Sarcoma Incidentally Discovered As An Asymptomatic Mediastinal Mass: A Case Report And Review Of The Literature, Mir Ibrahim Sajid, Sidra Arshad, Jamshid Abdul Ghafar, Saulat Fatimi, Nasir Ud Din

Medical College Documents

Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor characterized by bland histological features and aggressive clinical course. The most common anatomic locations of occurrence are the lower extremities, thorax, inguinal area, and upper limbs. Primary mediastinal sarcomas are even rarer. To the best of our knowledge, only seven cases of primary mediastinal LGFMS have been reported in the literature. Here, we report a case of primary mediastinal LGFMS.
Case presentation: A 26-year-old Pakistani man presented with fever and vomiting for the past 2 months. On a routine chest x-ray, a mediastinal mass was incidentally found. Computed tomography (CT) scan …

Genomic Variations In Patients With Myelodysplastic Syndrome And Karyotypes Without Numerical Or Structural Changes, Cristiano Luiz Ribeiro, Irene P. Pinto, Samara S. S. Pereira, Lysa B. Minasi, Fernanda De S. M. Kluthcouski, Adriano De M. Arantes, Aparecido D. Cruz, Marcio Almeida, Tom E. Howard

School of Medicine Publications

Myelodysplastic syndrome (MDS) is an onco-hematologic disease with distinct levels of peripheral blood cytopenias, dysplasias in cell differentiation and various forms of chromosomal and cytogenomic alterations. In this study, the Chromosomal Microarray Analysis (CMA) was performed in patients with primary MDS without numerical and/or structural chromosomal alterations in karyotypes. A total of 17 patients was evaluated by GTG banding and eight patients showed no numerical and/or structural alterations. Then, the CMA was carried out and identified gains and losses CNVs and long continuous stretches of homozygosity (LCSHs). They were mapped on chromosomes 1, 2, 3, 4, 5, 6, 7, 9, …

Lkb1 And Ampk Instruct Cone Nuclear Position To Modify Visual Function, Courtney A Burger, Nicholas E Albrecht, Danye Jiang, Justine H Liang, Ross A Poché, Melanie A Samuel

Faculty, Staff and Students Publications

Cone photoreceptors detect light and are responsible for color vision. These cells display a distinct polarized morphology where nuclei are precisely aligned in the apical retina. However, little is known about the mechanisms involved in cone nuclear positioning or the impact of this organization on retina function. We show that the serine/threonine kinase LKB1 and one of its substrates, AMPK, regulate cone nuclear positioning. In the absence of either molecule, cone nuclei are misplaced along the axon, resulting in altered nuclear lamination. LKB1 is required specifically in cones to mediate this process, and disruptions in nuclear alignment result in reduced …

Length Of Hospital Stay Following Temporary Pacing Post-Transcatheter Valve Replacement, Sean Mccarthy, Marvin Eng M.D.

Medical Student Research Symposium

Transcatheter valve replacement (TVR) provides a minimally invasive method of valve replacement. During TVR, conduction abnormalities can develop, but only some will require permanent pacing, and use of temporary pacing provides immediate support until a decision of temporary pacing is made. Henry Ford Health System has two methods of pacing lead placement: balloon tipped leads and screw-in leads. Currently, the impact of different types of temporary pacing leads on recovery time is still unknown. This project investigated the differences in the length of hospital and ICU stay between patients who received the balloon tipped and screw-in leads. Data was collected …

Evaluation Of Intestinal Transplantation For Short Bowel Syndrome Due To Gun Violence Versus Other Causes: A Single Center Experience, Leya Maliekal, Nemie Beltran, Shunji Nagai, Syed-Mohammed Jafri

Medical Student Research Symposium

Introduction: Short Bowel Syndrome (SBS) due to trauma is a rarely examined problem with a unique solution in Intestine Transplantation. We discuss factors that may have contributed to variations in patient outcome after intestinal transplant surgery secondary to SBS due to gun violence.

Methods: A retrospective chart review was conducted for intestinal transplant patients at an urban medical center. Two patients underwent intestinal transplants secondary to SBS after small bowel resections for gunshot related injury (GSW). Trends were noted and compared to trends found among patients comprising the intestinal transplant recipient registry (n=26) at the same medical center.

Results: Two …

Catheter Direct Thrombolysis As A Modality Of Management For Pulmonary Embolism: Risk Stratifying With The Pulmonary Embolism Severity Index, Dhruvil A. Patel, Vijaya Arun Kumar, Brian Reed

Medical Student Research Symposium

Catheter Directed Thrombolysis (CDT) or Systemic Thrombolysis (ST) are current standards of care for patients experiencing a Massive (MPE) or Submassive (SPE) Pulmonary Embolism which are categories that are defined by AHA guidelines for the Emergency Department. The Pulmonary Embolism Severity Index (PESI), a five-tier system, is a composite metric that can risk stratify PE into low risk (tiers 1,2) for SPE and high risk (tiers 3,4,5) for MPE, predicting mortality and outcomes. This study aims to determine if CDT or ST/no intervention (ST/NI) has better outcomes for MPE and SPE patients, while using PESI as a risk stratification tool. …

Angiotensin 1-7 Rescues Cognitive Decline And Neuronal Loss Following Traumatic Brain Injury In Mice, Esther H. Bae, Michael Gaub Md, Dez Coleman, Alexander J. Sandweiss Md/Phd, Bellal Joseph Md, Tally Largent-Milnes Phd, Todd W. Vanderah Phd

Medical Student Research Symposium

Purpose of study: Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S., accounting for approximately 30% of all injury deaths and 3 million TBI-related emergency visits yearly. There is limited research in the area of mitigating the post-inflammatory effects of non-fatal traumatic brain injury. Angiotensin 1-7, an endogenous peptide that acts on the MAS receptor, has recently shown to be anti-inflammatory, anti-oxidative, and vasodilatory unlike its relative, angiotensin II. We asked the question of whether Ang 1-7 modulates neuroinflammation and improves cognitive function in mice following traumatic brain injury.

Methods: A controlled cortical …

Factors Associated With 5-Year Glaucomatous Progression In Glaucoma Suspect Eyes: A Retrospective Longitudinal Study, Aravindh Nirmalan, Shibandri Das, Nariman Nassiri, Vaama Patel, Dhir Patwa, Alexandra Heriford, Chaesik Kim, Haoxing Chen, Faisal Ridha Al-Timimi, Justin R. Tanner, Anju Goyal, Mark S. Juzych, Bret A. Hughes

Medical Student Research Symposium

Purpose: To study the association of 5-year glaucomatous progression with several demographic, clinical, visual field and optical coherence tomography (OCT) variables in glaucoma suspect eyes. Methods: A retrospective chart review of 365 eyes of 288 patients were included (323 eyes with suspicious cup-to-disc ratio and 42 eyes with ocular hypertension). The study subjects were divided into two groups: eyes that progressed to glaucoma and those that did not. We calculated the percentage of glaucoma suspect eyes that progressed to glaucoma within 5 years. The inclusion criteria were glaucoma suspect eyes (i.e., suspicious cup-to-disc ratio and/or intraocular pressure >21 mm Hg), …

Learning Without Contingencies Induces Higher Order Asynchrony In Brain Networks In Schizophrenia, Elizabeth L. Martin, Asadur Chowdury, Vaibhav Diwadkar, Sazid Hasan, Munajj Ul-Huq, Shahira Baajour, Dalal Khatib, Usha Rajan, Jeffrey Stanley

Medical Student Research Symposium

Schizophrenia (SCZ) is characterized by both cognitive and reward impairments. A recent study suggests that SCZ is associated with a loss of synchrony between learning and reward circuits (Robison et al., 2019) and higher levels of dis-organization of functional brain networks may underpin failures in learning that characterize SCZ (Hütt et al., 2014). Therefore, here we examined inter-group (HC ≠ SCZ) 4^th order differences in statistical regularity across a connectome of cognition and reward brain circuits. The analyses were conducted on fMRI time series data from a previous learning paradigm (Stanley et al., 2017) with periods of Encoding and …