Medicine and Health Sciences Commons^™

Effectiveness Of A Postpartum Breastfeeding Protocol For Avoiding Pregnancy And Descriptive Analysis Of The Physiology Of The Postpartum Transition, Mary Schneider

Dissertations (1934 -)

Traditionally, postpartum breastfeeding women used Natural Family Planning (NFP) methods that required observation of cervical mucus and basal body temperature as indicators of return to fertility. These indicators resulted in high unintended pregnancy rates (i.e., 14-32 over 12 months of use). High pregnancy rates were due to the inaccuracy and subjectivity of those fertility indicators which required extended periods of abstinence. Ineffectiveness of NFP methods is also related to changing patterns of fertility during lactation amenorrhea (LA) and the first six menstrual cycles postpartum.Studies of a NFP protocol where women used objective urine hormone biomarkers were 92-98% effective for …

Therapeutic Potential Of Trp Channels In The Targeting Of Rheumatoid Arthritis Synovial Fibroblasts, Brittany Isabella Schwam

Theses and Dissertations (ETD)

Rheumatoid arthritis is a chronic inflammatory disease primarily affecting the synovium, articular cartilage, and bone within a joint, but it is a unique form of arthritis wherein effects are systemic. The cause of this autoimmune disease remains unknown, but there are many environmental and genetic factors that play into susceptibility. Research is still far from drug-free remission despite great advancements over the past few decades. The majority of therapies developed rely on immunosuppressant or immunomodulator molecules and come with risk of infection, high costs, and toxic, uncontrolled side effects. Those diagnosed maintain a significant unmet need for targeted therapies.

There …

Occupational Engagement And Integration Among Egyptian Coptic Orthodox Immigrants, Sherry Manoly

Student Capstone Papers

Background: The Egyptian Coptic Orthodox (Copt) population in America has grown exponentially due to religious intolerance in Egypt. Many Copts experience feelings of helplessness because of the stark difference in American culture compared to their home culture. Occupational therapy (OT) is a profession that can impact the experience of Copts through participation in meaningful occupations. This qualitative study sought to answer the research question, “what is the current state of occupational engagement for recently immigrated Coptic immigrants?”

Methods: Eighteen participants filled out the 9-question open-ended survey concerning overall perceptions about moving to America. Data was analyzed using thematic …

Perceived Neighborhood Characteristics And Cognitive Function Among Older Adults: Examining The Role Of Depression, Allison Sullivan, Mph

Electronic Theses and Dissertations

Purpose: African American older adults have a greater risk of cognitive impairment compared to White older adults. While some research has established that neighborhoods are an important determinant of health, relatively little research has examined the relationship between perceived neighborhood characteristics and cognitive functioning among older adults. Moreover, little is known about how depression is implicated in the relationship between perceived neighborhood characteristics and cognitive functioning, and if racial differences exist. Thus, this thesis aims to determine the mediating and moderating role of depression in the association between perceived neighborhood characteristics and cognitive functioning in older African American and White …

Reporting Health Data In Waiting Rooms With Mobile Technology: Patient Expectation And Confirmation, Iris Reychav, Ankur Arora, Rajiv Sabherwal, Karina Polyak, Jun Sun, Joseph Azuri

Information Systems Faculty Publications

Objectives: Hospitals and medical staff use digital devices such as mobile phones and tablets to treat patients. Prior research has examined patient-reported outcomes, and the use of medical devices to do diagnosis and prognosis of patients, but not whether patients like using, and intend to use in future, mobile devices to self-report medical data. We address this research gap by developing a theoretical model based on the expectancy confirmation model (ECM) and testing it in an empirical study of patients using mobile technology to self-report data.

Design: This study adopts a non-interventional cross-sectional research design. Randomly-selected patients provided data via …

Gme Action Learning: Gmec Re-Design, Margaret A. Hadinger Edd, Ms

Department of Education

No abstract provided.

Need For Clinical Guidelines For Management Of Osteoporosis And Way Forward For Pakistan, Aysha Habib Khan, Manju Chandran

Department of Pathology and Laboratory Medicine

No abstract provided.

2021 Spring Newsletter, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2021 Spring Newsletter of the Department of Nursing at Morehead State University.

Mitochondrial Transfer From Mesenchymal Stem Cells Improves Neuronal Metabolism After Oxidant Injury In Vitro: The Role Of Miro1, Nancy Tseng, Scott C Lambie, Christopher Q Huynh, Bridget Sanford, Manisha Patel, Paco S Herson, D Ryan Ormond

Faculty, Staff and Students Publications

Stroke-induced cerebral ischemia is a major cause of death and disability. The disruption of blood flow results in neuronal and glial cell death leading to brain injury. Reperfusion restores oxygen to the affected tissue, but can also cause damage through an enhanced oxidative stress and inflammatory response. This study examines mitochondrial transfer from MSC to neurons and the role it plays in neuronal preservation after oxidant injury. We observed the transfer of mitochondria from MSC to mouse neurons in vitro following hydrogen peroxide exposure. The observed transfer was dependent on cell-to-cell contact and led to increased neuronal survival and improved …

Automated Software-Assisted Diagnosis Of Esophageal Squamous Cell Neoplasia Using High-Resolution Microendoscopy, Mimi C Tan, Sheena Bhushan, Timothy Quang, Richard Schwarz, Kalpesh H Patel, Xinying Yu, Zhengqi Li, Guiqi Wang, Fan Zhang, Xueshan Wang, Hong Xu, Rebecca R Richards-Kortum, Sharmila Anandasabapathy

Faculty, Staff and Students Publications

BACKGROUND AND AIMS: High-resolution microendoscopy (HRME) is an optical biopsy technology that provides subcellular imaging of esophageal mucosa but requires expert interpretation of these histopathology-like images. We compared endoscopists with an automated software algorithm for detection of esophageal squamous cell neoplasia (ESCN) and evaluated the endoscopists' accuracy with and without input from the software algorithm.

METHODS: Thirteen endoscopists (6 experts, 7 novices) were trained and tested on 218 post-hoc HRME images from 130 consecutive patients undergoing ESCN screening/surveillance. The automated software algorithm interpreted all images as neoplastic (high-grade dysplasia, ESCN) or non-neoplastic. All endoscopists provided their interpretation (neoplastic or non-neoplastic) …

Rev-Erb In Gabaergic Neurons Controls Diurnal Hepatic Insulin Sensitivity, Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher I Amos, Yong Xu, Li Chen, Zheng Sun

Faculty, Staff and Students Publications

Systemic insulin sensitivity shows diurnal rhythm with a peak at wakening1,2. The molecular mechanism underlying such a temporal pattern is unclear. Here we demonstrate that nuclear receptors Rev-erbα/β in the GABAergic neurons in the suprachiasmatic nucleus (SCNGABA) control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production in mice, without affecting diurnal eating or locomotor behaviors under the regular light-dark cycles. Rev-erb regulates the rhythmic expression of genes involved in neurotransmission in the SCN and modulates the oscillatory firing activity of SCNGABA neurons. Chemogenetic stimulation of SCNGABA neurons at wakening causes glucose intolerance, while restoration …

Determination Of The Presence Of Rickettsia Spp. And Borrelia Spp. Carried By Tortoise Ticks From Madagascar, Anna Phan

Biological Sciences Theses & Dissertations

Ticks were removed from three species of Malagasy tortoises, Astrochelys yniphora, A. radiata, and Pyxis arachnoides (comprising two subspecies P. a. arachnoides and P. a. oblonga), between 2012 and 2015. The ticks were presumed to be from the genus Amblyomma. Ticks were morphologically identified and then checked molecularly to confirm their classification or identify any ticks that could not be morphologically identified. Molecular identification was done via end-point PCR that amplified tick cytochrome oxidase (CO1) and tick 12S rRNA genes. Ticks were screened via a real-time polymerase chain reaction assay for the presence of Rickettsia spp. …

March / April 2021, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy.

The Financing Need For Expanding Paid Maternity Leave To Support Breastfeeding In The Informal Sector In The Philippines, Valerie Gilbert Ulep, Paul Zambrano, Janice Datu-Sanguyo, Mireya Vilar-Compte, Graciela Materuel Belismelis, Rafael Pérez-Escamilla, Grace J. Carrol, Roger Mathisen

Department of Public Health Scholarship and Creative Works

In low- and middle-income countries, almost three-fourths of women in the labour force lack maternity protection. In the Philippines, current laws do not guarantee paid maternity leave to workers in the informal economy. A non-contributory maternity cash transfer to informal sector workers could be used to promote social equity and economic productivity and could provide health benefits by helping mothers meet their breastfeeding goals. The objective of the study is to provide a realistic cost estimate and to assess the financial feasibility of implementing a publicly financed, non-contributory maternity cash transfer programme to the informal sector in the Philippines. Using …

Effects Of Personal Fm System Use During Phonological Awareness Instruction For Children At Risk For Dyslexia, Gabriella Rose Reynolds

Theses and Dissertations

Students with reading impairments, including dyslexia, account for the largest proportion of students receiving special education services in the United States (NCES, 2016). Developmental dyslexia is characterized by slow and inaccurate word decoding (Lyon et al., 2003). This word decoding difficulty results from deficits in phonological awareness, a sound-based skill (Swan & Goswami, 1997). Classrooms are known to have high levels of background noise and are inconsistent with recommendations for optimal listening (Picard & Bradley, 2001) or accepted standards (ASHA, n.d.). Furthermore, degraded acoustic conditions have been related to poorer performance on speech-recognition tasks even for children with normal hearing …

Association Of Nsaids And Acetaminophen Prescriptions During Pregnancy With Autism Spectrum Disorders In The Child, Mohiuddin Ahsanul Kabir Chowdhury

Theses and Dissertations

Neurodevelopmental disorders in children including Autism Spectrum Disorders (ASD) and Intellectual disability (ID) are the topics of growing concern and recently many studies looked for the risk factors of these disorders. Although antidepressants and antiepileptics consumption during pregnancy have been reported to be associated with ASD, the effect of NSAID or acetaminophen, two most common drugs used during pregnancy, have been under researched. We conducted a prospective cohort study linking data from Medicaid, Department of Education, and Department of Disabilities and Special Needs with birth certificate data from mothers and children between 2010-2017. Beside exposure variables, NSAID and acetaminophen, and …

Global Sex Disparity Of Covid-19: A Descriptive Review Of Sex Hormones And Consideration For The Potential Therapeutic Use Of Hormone Replacement Therapy In Older Adults, Samuel C. Okpechi, Jordyn T. Fong, Shawn S. Gill, Jarrod C. Harman, Tina H. Nguyen, Queendaleen Chukwurah, Ifeanyichukwu O. Onor, Suresh K. Alahari

School of Graduate Studies Faculty Publications

The 2019-2020 SARS-related coronavirus-2 (SARS-CoV-2) pandemic has brought unprecedented challenges to healthcare sectors around the world. As of November 2020, there have been over 64 million confirmed cases and approaching 2 million deaths globally. Despite the large number of positive cases, there are very limited established standards of care and therapeutic options available. To date, there is still no Food and Drug Administration (FDA) approved vaccine for COVID-19, although there are several options in various clinical trial stages. Herein, we have performed a global review evaluating the roles of age and sex on COVID-19 hospitalizations, ICU admissions, deaths in hospitals, …

A Diverse Nation Calls For A Diverse Healthcare Force., Autumn L Saizan, Annyella Douglas, Nada Elbuluk, Susan Taylor

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Unprecedented Migratory Bird Die-Off: A Citizen-Based Analysis On The Spatiotemporal Patterns Of Mass Mortality Events In The Western United States, Di Yang, Anni Yang, Jue Yang, Rongting Xu, Han Qiu

United States Department of Agriculture Wildlife Services: Staff Publications

Extensive, severe wildfires, and wildfire-induced smoke occurred across the western and central United States since August 2020. Wildfires resulting in the loss of habitats and emission of particulate matter and volatile organic compounds pose serious threatens to wildlife and human populations, especially for avian species, the respiratory system of which are sensitive to air pollutions. At the same time, the extreme weather (e.g., snowstorms) in late summer may also impact bird migration by cutting off their food supply and promoting their migration before they were physiologically ready. In this study, we investigated the environmental drivers of massive bird die-offs by …

Critical Data Literacy: Addressing Race As A Variable In A Preclinical Medical Education Session, Stacy Brody, Susan Koenig

Himmelfarb Library Faculty Posters and Presentations

At the Himmelfarb Health Sciences Library, librarians conduct instruction sessions on various aspects of evidencebased medicine for first- and second-year medical students. One of these sessions, the Chest Pain Formative Observed Simulated Clinical Experience (FOSCE), introduces the Framingham Study, later cohort studies, and the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Calculator to first-year medical students. This calculator includes race as an input and over or underestimates risk for certain groups. This session previously mentioned the need to diversify study populations and described the evolution of the algorithm, but it did not highlight these as critical issues for discussion. Beyond noting this …

An Unexpected Growth Journey: A Review And Self-Study Of Health Habits & Why It Matters Today, Jacob Correa 21

Honor Scholar Theses

Before we jump in, it is important to make clear to the reader what this thesis will do and what it will not do. First, I will review the empirical evidence behind the main health habits that I decided to start and implement. Then, I will detail how I practiced these habits on myself, how I assessed any change for certain health constructs, and review my experience of this self-study. Most importantly, I will describe why practicing health habits, like meditation, is crucially important in our present moment as a result of the mental health crisis being exacerbated by COVID-19. …

Medical Veracity And The Erosion Of The American Physician-Patient Trust Relationship, Jonah Jerabek 21

Honor Scholar Theses

Medical Veracity and the Erosion of the American Physician-Patient Trust Relationship investigates the relationship between medical professionals and their patients from a medical ethics point of view. The thesis includes the history and the major theories of veracity as well an analysis of a survey for both non-medical and medical professionals regarding veracity. The Ethical Background section describes the theory of medical veracity and the nature of the Physician-Patient Trust Relationships as well as includes historical views and theories on medical veracity, including Western medicine’s paternalistic roots and the theory of benevolent deception. A description of modern medical veracity, particularly …

Art-Making And Wellbeing With Professional Artists During A Pandemic, Ilyse Lindsey, Schelsey Mahammadie-Sabet, Nicole Rademacher

LMU Theses and Dissertations

This research project aims to explore the relationship between art-making and wellbeing in professional artists during the COVID-19 pandemic. The study involves 14 respondents who were invited to complete a Qualtrics survey as well as a process of arts-based inquiry. Researchers analyzed participants’ survey and art responses using an iterative collaborative process to identify emergent themes. These themes included a non-optional and internally-located drive to create; positive emotional, social, and physiological impacts associated with art-making and art-sharing; and, positive impacts on art practice associated with the pandemic. These findings emphasized the unique strengths and challenges associated with the professional artist …

Art-Making During A Global Pandemic: A Collaborative Autoethnography, Caitlin Carey, Parisa Frost, Jon Harguindeguy, Sarah Heller, Susan Lee, Christina Smith, Eva Wang

LMU Theses and Dissertations

Between March 11, 2020 and May of 2021, the World Health Organization (WHO) counted over 100 million cases of COVID-19, resulting in three million deaths worldwide (WHO, 2021). In order to examine the effects of art-making on social and psychological well-being, seven graduate students from the Marital and Family Art Therapy Program at LMU conducted the following study utilizing a qualitative, arts-based research approach through collaborative autoethnography (CAE). The research question — What are the effects of personal art-making on well-being during the COVID-19 pandemic? — was posed by the seven graduate student authors. The data revealed that pandemic-time art-making …

Bundled Payment Models In Spine Surgery., Kevin Hines, Nikolaos Mouchtouris, Charles Getz, Glenn Gonzalez, Thiago Montenegro, Adam Leibold, James Harrop

Department of Neurosurgery Faculty Papers

STUDY DESIGN: The following is a narrative discussion of bundled payments in spine surgery.

OBJECTIVE: The cost of healthcare in the United States has continued to increase. To lower the cost of healthcare, reimbursement models are being investigated as potential cost saving interventions by driving incentives and quality improvement in fields such a spine surgery.

METHODS: Narrative overview of literature pertaining to bundled payments in spine surgery synthesizing findings from computerized databases and authoritative texts.

RESULTS: Spine surgery is challenging to define payment modes because of high cost variability and surgical decision-making nuances. While implementing bundled care payments in spine …

Attention Deficit Hyperactivity Disorder: Treatment, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Social Isolation: Impact On Physical And Mental Health, Alexa Waters, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Learning Objectives

• Review the impact of social isolation and loneliness on important aspects of health and well-being, with a focus on older adults
• Review risk and protective factors for social isolation and loneliness
• Discuss how the health care system and primary care physicians can better identify and address social isolation
• Briefly highlight interventions to enhance social connectedness and reduce loneliness

Outline

• Background
• Impacts of social isolation and loneliness on health and well-being
• Risk and protective factors for social isolation and loneliness
• Role of the health system and primary care in addressing social isolation and loneliness
• Cases throughout

Preparticipation Evaluation Of The Special Olympics Athlete, Mary M. Stephens, Md, Mph

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

• By the end of this module the student will be able to describe the components of a pre-participation sports evaluation.
• By the end of this module the student will be able to articulate an assessment for atlantoaxial instability.
• By the end of this module the student will be able to apply the learned knowledge from the module to a case study.
• By the end of this module the student will be able to recommend appropriate anticipatory guidance to the athlete.

Nhanes Iii Mortality Follow Up: Social Determinants Creating Disparity Within The Health Outcomes Of Persons With Diabetes, Claire B. Adams

University Honors Theses

Given the recent research into the social determinants affecting health outcomes, the goal of this thesis is to examine whether a non-urban setting, among other social determinants of health, increases the risk of mortality among the United States diabetic population. We examined the relationship of urban and non-urban diabetes rates among those aged 40-74 years using a national sample of diabetic and nondiabetic Americans. The data was pulled from the Third National Health and Nutrition Examination Survey (NHANES III) which was conducted from 1988 to 1994. After excluding pregnant women, those who did not complete a fasting AM glucose, and …

Neurodevelopment Correlates With Gut Microbiota In A Cross-Sectional Analysis Of Children At 3 Years Of Age In Rural China, Sarah E. Rothenberg, Qiurong Chen, Yanfen Nong, Hua Nong, Eva P. Trinh, Fred J. Biasini, Jihong Liu, Xiaoyun Zeng, Yunfeng Zou, Fengxiu Ouyang, Susan A. Korrick

Faculty Publications

We investigated cross-sectional associations between children’s neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed using 16S rRNA gene profiling. Microbial diversity was characterized using alpha diversity patterns. Additionally, 3 coabundance factors were determined for the 25 most abundant taxa. Multivariable linear regression models were constructed to examine the relationships between Bayley scores (MDI and PDI) and children's gut microbiota. In adjusted …