Medicine and Health Sciences Commons^™

Integrating Occupational Therapy And Animal Assisted Therapy, Erin Trella

OTD Capstone Projects

Pet Partners is a non-profit organization that works to educate and register handlers of multiple species as volunteer therapy teams. While therapy animal programming offered by volunteer handlers provides an invaluable service to communities, there is also a growing body of practitioners who aim to incorporate the healing power of animals into their professionalized settings. The purpose of this project was to delve into the world of AAI in the professional setting and understand the current needs of practitioners in the field. Through interviewing a variety of professionals who utilize AAI in their practice, clear gaps in services were identified, …

Supporting Working Family Caregivers And Older Adults Through An Educational Employer-Based Eldercare Program, Chanté Bowens

OTD Capstone Projects

This doctoral capstone project was completed in partnership with AgeWell Middle TN, a non-profit agency that focuses on informed, positive aging, and being a champion, advocate, and trusted community resource for older adults. Working family caregivers of older adults are struggling to balance work and caregiving duties, while employers are experiencing loss in productivity and financial return. In response, AgeWell is developing a program called “Eldercare Coach” to provide guidance to employers and working caregivers. Thus, the primary focus of this project was to develop educational materials for AgeWell’s Eldercare Coach program. These educational materials include a list of interview …

2021-04-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-04-12_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

In accordance with the Council of State and Territorial Epidemiologists’ outbreak definition, schools that have been found by their local health department to have two (2) or more COVID-19 cases who may have shared exposure at the school grounds and are not from the same household (with the exception of dorms and off-campus housing) are included. If your child’s school is …

Act To Decrease Burnout: Acceptance And Commitment Therapy As An Option To Address Burnout In Occupational Therapy Practitioners, Carissa Parrish

MOT Student Capstones

Introduction: Burnout is a mental health crisis that can occur when a person is overwhelmed and under-appreciated. The research reports that occupational therapy practitioners (OTs) may self-address burnout through yoga or self-reflection (Costa, 2018). However, the research does not support or deny the use of Acceptance and Commitment Therapy (ACT) to address burnout among OTs. ACT has been established in the research as a frame of reference and intervention to utilize with people experiencing burnout (Reeve et al, 20 I 8). This project aims to provide a basis for future research on the topic of ACT to address burnout among …

Mindfulness For The Occupational Therapy Practitioner: Enhancing Client-Centered Practice And Stress Management, Samuel Shepherd

MOT Student Capstones

Background: Occupational therapy can be an emotionally demanding profession that is not immune to the effects of stress and burnout. Studies on mindfulness have found this practice can be a useful tool to relieve the symptoms of burnout. This capstone project aimed to help therapy practitioners working in a high productivity setting of skilled nursing understand the stress and burnout related to healthcare and how mindfulness practice positively influences stress management and client-centered practice. Methods: This project involved an in-service presentation with a pre- and post-survey for therapy practitioner participants educating on research related to stress and burnout experiences for …

Does Computer-Based Classroom Instruction Impact Student Participation?, Paige Hyer

MOT Student Capstones

COVID-19 has caused a disruption of typical teaching methods forcing students to receive instruction virtually. Computer-based classroom instruction was implemented to allow for quick transition between virtual and face-to-face instruction as determined by COVID-19 cases. This research explores how computer-based classroom instruction has impacted student participation within the classroom and the role of occupational therapy to support students who utilize this method of learning. Eighteen elementary school teachers who currently utilize this method of learning were surveyed and data was collected to determine feedback on the impact of computer-based classroom instruction. Data determined that student participation is impacted by computer-based …

Benefits Of Montessori Method Use In Activity Involvement On Individuals With Dementia, Megan Canzoneri

MOT Student Capstones

Background: The Montessori Method was a teaching approach developed by Dr. Maria Montessori for children who did not have access to proper education and materials. She used this method by teaching them through familiar tasks, puzzles, and self-driven interest. This taught them independence, problem-solving, and decision make. This project discusses the use of the method within the geriatric and memory care population to help them remain independent through choosing activities that interest them. These activities consist of familiar tasks such as setting a table, washing dishes, and folding clothes. Method: This project used a needs survey, pre- and post-survey, and …

Capstone Project: Early Active Motion Versus Early Passive Motion Following A Flexor Tendon Repair, Matthew Angle

MOT Student Capstones

Flexor tendon injuries are relative)y rare, occurring in 7.0/100,000 people. An early active motion or early passive motion protocol have been the two primary methods used by occupational therapists for rehabilitation of a flex or tendon repair. Each of these methods have their own strengths and weaknesses, but the intervention that leads to a better outcome while maintaining integrity of the flexor tendon repair was researched. Common complications that occur during the rehabilitation of a flex or tendon that can affect the integrity of the repair included tendon lag, scar adhesions, tendon rupture, and joint contracture. Research focused on the …

An Occupational Therapy Approach To Ergonomic Intervention, Kristy Hege

MOT Student Capstones

The occurrence of work-related shoulder and neck injuries is on the rise for computer workers due to extended work hours, fewer breaks, and repetitive movements involving neck rotation, shoulder movement, and awkward posture. The individual's workstation and environment's design play a key role contributing to neck and shoulder injuries. An occupational therapist is equipped with the knowledge and skills to modify and adapt a person's workstation and improve their shoulder and neck pain or injuries. The capstone project's purpose was developed to identify risk factors, promote an occupational therapy ergonomic intervention program, suggest workstation and environment modification/adaptations, and promote posture …

Expressive Arts In Occupational Therapy: Children Traumatized From Opioid-Addicted Caregivers, Laura Maclean

MOT Student Capstones

Occupational therapy has been associated with expressive arts and the act of healing the body and mind since the inception of the profession. Children use expressive arts to self-express, explore, and enhance the development of the brain and body. Children that have experienced trauma may have trouble recognizing and expressing emotions, thus react with negative behaviors, poor social skills, and learning challenges. Trauma may occur in children from caregivers' behaviors due to opioid addiction. The use of expressive arts through occupational therapy's holistic perspective provides traumatized children with a guide to recognize and express emotions, increase attention, and improve social …

Increasing Law Enforcement Understanding Of Special Needs And Disability Populations: The Role Of The Occupational Therapist, Rekha Tabjula

MOT Student Capstones

Incidences of fatalities and injuries among populations with disabilities continue to occur during police interactions. There is an increased need to address this concern with a new method, or reform, to training that has not allowed law enforcement to properly and safely engage with those who have Autism Spectrum Disorder, Intellectual Disabilities, Traumatic Brain Injuries, and mental health conditions. Occupational therapists can provide a collaborative approach to increasing law enforcement's awareness, knowledge, and confidence to these aforementioned 0 conditions. Law enforcement officers from the Charlotte-Mecklenburg Police Department viewed a training video on various conditions with a supplemental video with guest …

Promotion Of Fine Motor Skills Through Video Supports, Kaitlin Hasher

MOT Student Capstones

Pediatric occupational therapists working with students in a school-based setting are consistently facing challenges with time management due to their high caseload numbers and limited documentation time in school-based settings. Along with time constraint issues, schoolbased occupational therapists find it difficult to communicate with caregivers on the skills being practiced in the school setting due to limited face-to-face time with caregivers. Children continue to require therapeutic services in school-based settings, however as occupational therapists continue to take on more responsibilities in this setting it becomes more challenging to find time to provide effective and efficient means to educate and reinforce …

Saaw Kickoff: The Psychological Perspective Of Sexual Assault, Erin Terada

Sexual Assault Awareness Week (SAAW)

In collaboration with PSYCH Club, BELLAs is hosting guest speaker and clinical psychologist Dr. Erin Terada, who will explain the psychological effects of sexual assault, what trauma looks like, and how counseling can help.

Dr. Terada holds a Doctorate in Clinical Psychology from the Illinois School of Professional Psychology. She specifically works with individuals who have: trauma related disorders, anxiety, OCD, eating and feeding disorders, and more. She currently works as a licensed clinical psychologist at The OCD and Anxiety Center.

Effects Of Socioeconomic Status On Glycemic Control In Children And Young Adults With Type 1 Diabetes, Julianna Morgan

Undergraduate Research and Scholarship Symposium

The purpose of this research presentation is to identify the relationship between socioeconomic status and glycemic control in children and young adults living with Type 1 diabetes. Poor blood glucose regulation can often lead to various lasting complications such as chronic kidney disease, loss of eyesight, infection, and even death. These can be devastating to an individual, yet preventable. The complications resulting from the lack of strict glucose regulation are a significant problem currently facing healthcare and disproportionally affecting patients from lower socioeconomic groups. Using CINAHL, research studies about the relationship between type 1 diabetes control and socioeconomic status were …

Development Of A Rapid Drug Detection Method For Insects Using Paper Spray Ionization Mass Spectrometry (Psi-Ms), Alexandria Plyler

Undergraduate Research and Scholarship Symposium

Insects have the ability to reflect the chemical environment that they have developed in. Thus, necrogenous insects can reflect the chemical environment of cadavers they have fed on. Forensic scientists can potentially utilize insect larvae as an alternate biological matrix to detect drugs in cadavers that are skeletonized, burned, or otherwise badly damaged. Analysis of insects using paper spray ionization mass spectrometry (PSI-MS), an analytical method requiring little to no sample preparation, could prove a rapid, cost-effective, and non-destructive alternative form of toxicological analysis. Traditional tissue analysis via GC and LC-MS often require lengthy sample preparation, use expensive reagents, and …

Development Of Continuous Flow Sonogashira Coupling Of Lead Anti-Cancer Small Molecule Inhibitors For Potential Treatment Of Acute Myeloid Leukemia, Yuta W. Moriuchi, Shruti A. Biyani, David H. Thompson

Discovery Undergraduate Interdisciplinary Research Internship

As the technology for science develops, the research strategy in medicines and therapeutics also improves. In this paper, I will cover the process of Sonogashira cross-coupling and Amide Coupling reaction for an anticancer agent in both batch and flow chemistry. Continuous Flow Chemistry has advantages such as being more efficient, safer, and faster. This paper studies the synthesis of HSNO608, an anticancer lead compound for Acute Myeloid Leukemia (AML), which has a specific potent activity to FTL3 Kinase. Inhibition of FLT3 Kinase leads to inhibition of downstream pathways such as MPK and P13K pathways. In this two-step experiment, the Sonogashira …

2021-04-12_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Nbtxr3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across A Large Panel Of Human Cancer Models., Ping Zhang, Julie Marill, Audrey Darmon, Naeemunnisa Mohamed Anesary, Bo Lu, Md, Sébastien Paris

Department of Radiation Oncology Faculty Papers

Purpose: The side effects of radiotherapy induced on healthy tissue limit its use. To overcome this issue and fully exploit the potential of radiotherapy to treat cancers, the first-in-class radioenhancer NBTXR3 (functionalized hafnium oxide nanoparticles) has been designed to amplify the effects of radiotherapy.

Patients and Methods: Thanks to its physical mode of action, NBTXR3 has the potential to be used to treat any type of solid tumor. Here we demonstrate that NBTXR3 can be used to treat a wide variety of solid cancers. For this, we evaluated different parameters on a large panel of human cancer models, such as …

Immunization Verification At Christian Camps, Katherine Stacey

Senior Honors Theses

No standard exists among Christian camps regarding immunization verification for program participants. The best practice for Christian camps regarding immunization verification is debated because of religious reasons, camper and staff safety, and state mandates. This research examines the current practice of Christian Camp and Conference Association (CCCA) affiliated camps regarding immunization verification. It was conducted by emailing a seven-question survey to over 700 CCCA camps. Just over 100 camps responded. The study found that roughly two-thirds of CCCA camps practice no method of immunization verification. In response to this result, the researchers propose a best practice for Christian camps regarding …

Gastrointestinal Microenvironment And The Gut-Lung Axis In The Immune Responses Of Severe Covid-19, Yun Yang, Weishan Huang, Yubo Fan, Guo-Qiang Chen

Faculty Publications

The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented threat to the human health. A close association of the digestive tract is implied by the high frequency of gastrointestinal syndromes among COVID-19 patients. A better understanding of the role of intestinal microenvironment in COVID-19 immunopathology will be helpful to improve the control of COVID-19 associated morbidity and mortality. This review summarizes the immune responses associated with the severity of COVID-19, the current evidence of SARS-CoV-2 intestinal tropism, and the potential involvement of gut microenvironment in COVID-19 severity. Additionally, we …

Implementing Telemental Health To Improve Access To Mental Healthcare In Rural Vermont, Julia Mcdougal Ronconi

Doctor of Nursing Practice Scholarly Projects

BACKGROUND: Mental health access in rural areas is a national problem. Of strategies to increase access, telemental health has the highest level of evidence.

PURPOSE: This project aimed to implement a telemental health program in rural Vermont to: (a) increase the number of rural-dwelling patients who enter treatment for anxiety and depression, (b) evaluate the effectiveness of telemental health for depression, anxiety, and overall functioning, and (c) evaluate patient satisfaction with the accessibility, quality, and affordability of the service.

METHODS: Adult psychiatric diagnostic evaluation, medication management and psychotherapeutic interventions were delivered via telemental health. The service was marketed to Health …

Ada News - 04/12/2021, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Relationship Between Optimism And Perceived Health In Generation-Z An Explanatory Investigation, Natalie D. Woodward

Honors College Theses

Research has found possible links between optimism, happiness, and perceived health in past generations (Peterson & Bazio, 1991). Little research has been found examining these variables within Generation Z. Thus, the purpose of this study is to examine the relationship between optimism, happiness, and perceived health in Generation Z. A secondary purpose of this study is to examine the relationship between optimism, happiness and perceived health between genders and races. A third purpose of this study is to predict happiness by examining optimism, perceived health, and sleep within Generation Z. 2287 Generation Z participants took the Life Orientation Test, the …

Invasive Pneumococcal Serotype 3 Disease Despite Pneumococcal Polysaccharide Vaccine-23, B. Frank Parker Jr, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Pneumococcal disease has a high global morbidity and mortality. We report a case of a 63-year old female with a history of vaccination with pneumococcal polysaccharide vaccine-23 (PPSV-23) who was transferred to a tertiary care facility with fever and seizures due to an unknown etiology. The diagnosis of invasive pneumococcal disease (IPD) was based the identification of Streptococcus pneumoniae in the blood (culture; serogroup 3) and cerebrospinal fluid (antigen), and the finding of purulence under pressure at craniotomy. The pneumococcal vaccine should provide protection from IPD. The findings reported here display that IPD can overcome immunity proffered by the pneumococcal …

Promoting Awareness And Healing In Persons In Mental Health And Addiction Recovery In Middle Tennessee, Savannah Rain Flint

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Healing Arts Project, Inc., also known as HAPI. HAPI exists to fill a gap in recovery and rehabilitation services by providing free art supplies and art classes at partnered facilities, by providing art exhibition and publication opportunities for HAPI program participants, and by participating in outreach events throughout the year. These opportunities help spread awareness and inclusivity of mental health and addiction recovery within the community and helps artists to externalize their personal struggles, thoughts, and feelings through various creative outlets.

My project focus was to increase community awareness of HAPI …

Functional Interpretation Of Atad3a Variants In Neuro-Mitochondrial Phenotypes, Zheng Yie Yap, Yo Han Park, Saskia B Wortmann, Adam C Gunning, Shlomit Ezer, Sukyeong Lee, Lita Duraine, Ekkehard Wilichowski, Kate Wilson, Johannes A Mayr, Matias Wagner, Hong Li, Usha Kini, Emily Davis Black, Kristin G Monaghan, James R Lupski, Sian Ellard, Dominik S Westphal, Tamar Harel, Wan Hee Yoon

Faculty, Staff and Students Publications

BACKGROUND: ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane-anchored protein involved in diverse processes including mitochondrial dynamics, mitochondrial DNA organization, and cholesterol metabolism. Biallelic deletions (null), recessive missense variants (hypomorph), and heterozygous missense variants or duplications (antimorph) in ATAD3A lead to neurological syndromes in humans.

METHODS: To expand the mutational spectrum of ATAD3A variants and to provide functional interpretation of missense alleles in trans to deletion alleles, we performed exome sequencing for identification of single nucleotide variants (SNVs) and copy number variants (CNVs) in ATAD3A in individuals with neurological and mitochondrial phenotypes. A Drosophila Atad3a Gal4 …

Proteogenomic And Metabolomic Characterization Of Human Glioblastoma, Liang-Bo Wang, Alla Karpova, Marina A Gritsenko, Jennifer E Kyle, Song Cao, Yize Li, Dmitry Rykunov, Antonio Colaprico, Joseph H Rothstein, Runyu Hong, Vasileios Stathias, Macintosh Cornwell, Francesca Petralia, Yige Wu, Boris Reva, Karsten Krug, Pietro Pugliese, Emily Kawaler, Lindsey K Olsen, Wen-Wei Liang, Xiaoyu Song, Yongchao Dou, Michael C Wendl, Wagma Caravan, Wenke Liu, Daniel Cui Zhou, Jiayi Ji, Chia-Feng Tsai, Vladislav A Petyuk, Jamie Moon, Weiping Ma, Rosalie K Chu, Karl K Weitz, Ronald J Moore, Matthew E Monroe, Rui Zhao, Xiaolu Yang, Seungyeul Yoo, Azra Krek, Alexis Demopoulos, Houxiang Zhu, Matthew A Wyczalkowski, Joshua F Mcmichael, Brittany L Henderson, Caleb M Lindgren, Hannah Boekweg, Shuangjia Lu, Jessika Baral, Lijun Yao, Kelly G Stratton, Lisa M Bramer, Erika Zink, Sneha P Couvillion, Kent J Bloodsworth, Shankha Satpathy, Weiva Sieh, Simina M Boca, Stephan Schürer, Feng Chen, Maciej Wiznerowicz, Karen A Ketchum, Emily S Boja, Christopher R Kinsinger, Ana I Robles, Tara Hiltke, Mathangi Thiagarajan, Alexey I Nesvizhskii, Bing Zhang, D R Mani, Michele Ceccarelli, Xi S Chen, Sandra L Cottingham, Qing Kay Li, Albert H Kim, David Fenyö, Kelly V Ruggles, Henry Rodriguez, Mehdi Mesri, Samuel H Payne, Adam C Resnick, Pei Wang, Richard D Smith, Antonio Iavarone, Milan G Chheda, Jill S Barnholtz-Sloan, Karin D Rodland, Tao Liu, Li Ding, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Students Publications

Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of genomic, proteomic, post-translational modification and metabolomic data on 99 treatment-naive GBMs provides insights to GBM biology. We identify key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches mediating oncogenic pathway activation, as well as potential targets for EGFR-, TP53-, and RB1-altered tumors. Immune subtypes with distinct immune cell types are discovered using bulk omics methodologies, validated by snRNA-seq, and correlated with specific expression and histone acetylation patterns. Histone H2B acetylation in classical-like and immune-low GBM …

Differences In The Genital Microbiota In Women Who Naturally Clear Chlamydia Trachomatis Infection Compared To Women Who Do Not Clear; A Pilot Study, Patricia Dehon Mott, Christopher M. Taylor, Rebecca A. Lillis, Caleb M. Ardizzone, Hannah L. Albritton, Meng Luo, Kaitlyn G. Calabresi, David H. Martin, Leann Myers, Alison J. Quayle

School of Graduate Studies Faculty Publications

In vitro studies indicate IFNγ is central to Chlamydia trachomatis (Ct) eradication, but its function may be compromised by anaerobes typically associated with bacterial vaginosis (BV), a frequent co-morbidity in women with Ct. Here we investigated the associations between natural clearance of cervical Ct infection, the vaginal microbiome, and the requirements for IFNγ by evaluating the vaginal microbial and cytokine composition of Ct treatment visit samples from women who cleared Ct infection in the interim between their Ct screening and Ct treatment visit. The pilot cohort was young, predominantly African American, and characterized by a high rate of BV that …

Using Handmade Cloning To Reduce Oocyte Mitochondria In Reconstructed Embryos, Laura Adams

Student Research Symposium

Mitochondrial heteroplasmy, the presence of more than one population of mitochondrial DNA (mtDNA) in one cell, can cause metabolic issues and reduced ATP synthesis, even at relatively low levels. The presence of this condition in somatic cell nuclear transfer (SCNT) embryos likely contributes to reduced prenatal and postnatal viability: the majority of the oocyte’s mitochondria is still present at the time of nuclear transfer, as well as through any further embryonic development post-fusion and activation. Though the somatic cell also contributes its mitochondria (which can successfully communicate with its nucleus), the oocyte’s mitochondria compose a greater proportion of the total …