Medicine and Health Sciences Commons^™

Ethics Of Neurocognitive Disorders, Jenna Schneider

Honors Theses

Many individuals have misperceived ideas of what neurocognitive disorders are and how to effectively treat and care for individuals that have these disorders. Individuals working in healthcare need education on what neurocognitive disorders are to be able to provide ethical interventions, and have general knowledge on how to provide care to these people. Neurocognitive disorders, especially among older individuals, is a prevalent health complication that needs attention in order to prevent misunderstanding, and increase the possibly of knowing when intervention is needed. Additional training directed towards ethical practices is essential for both the understanding of caregivers and for the safety …

Projecting Effects Of Stress And Anxiety In Out-Of-State Students, Bryar Brooks

Honors Theses

This study investigated the effects of stress and anxiety on undergraduate in-state, out-of-state, and international students. The current statistics on stress and anxiety in college students in general is mind blowing. Almost 50% of college students say they have moderate levels of stress and 25% of college students say that they have high stress levels. In addition, 44% of students struggle with depression and 50% struggle with anxiety. These have a direct correlation with their sleep habits as well. With these statistics in mind, the goal of this study was to see the statistically significant difference in stress and anxiety …

Genetic And Non-Genetic Factors Affecting The Expression Of Covid-19-Relevant Genes In The Large Airway Epithelium, Silva Kasela, Victor E Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L Buschur, Igor Z Barjaktarevic, R Graham Barr, Eugene R Bleecker, Russell P Bowler, Alejandro P Comellas, Christopher B Cooper, David J Couper, Gerard J Criner, Jeffrey L Curtis, Meilan K Han, Nadia N Hansel, Eric A Hoffman, Robert J Kaner, Jerry A Krishnan, Fernando J Martinez, Merry-Lynn N Mcdonald, Deborah A Meyers, Robert Paine, Stephen P Peters, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Elliot Israel, Nizar N Jarjour, Bruce D Levy, Xingnan Li, Wendy C Moore, Sally E Wenzel, Charles Langelier, Prescott G Woodruff, Tuuli Lappalainen, Stephanie A Christenson

Faculty, Staff and Student Publications

BACKGROUND: The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be partially mediated by the differential regulation of the genes that interact with the SARS-CoV-2 virus or are involved in the subsequent host response. Here, we comprehensively investigated non-genetic and genetic factors influencing COVID-19-relevant bronchial epithelial gene expression.

METHODS: We analyzed RNA-sequencing data from bronchial epithelial brushings obtained from uninfected individuals. We related ACE2 gene expression to host and environmental factors in the SPIROMICS cohort of smokers with …

Disclosing Bad News Of Cancer Diagnosis: Patients' Preference For Communication, Sabah Uddin Saqib, K. M. Inam Pal

Section of General Surgery

The majority of relatives of cancer patients in Pakistan request their clinicians to adopt a "do not tell approach" while counselling the patients regarding their disease. The current study aimed to assess patients' understanding of their disease and how they would prefer the physicians to deliver news about cancer diagnosis and its management plan. This was a cross-sectional study in which both patients and their immediate relatives were interviewed. The study enrolled 55 patients with six different types of cancers. The study showed that 35 (65.5%) patients did not know the stage of their illness at the time of diagnosis, …

Assessing Arthropod Responses To Volatile Organic Compounds From The Algal Microbiome Of A Sloth Using Drosophila Melanogaster, Lilli Gordon

Honors Theses

Sloths contain an unexplored ecosystem of microbial diversity in their fur, including algae, fungi, bacteria, and arthropods. These symbionts are able to communicate through the chemicals they release, including volatile organic compounds (VOCs), which can lead to unique ecological interactions. The VOCs released from the algal polycultures of sloth hairs merit further investigation in their ability to cause a response from other organisms in this microbial community and within a broader ecological context. This research team aimed to assess the response of Drosophila melanogaster as test subjects when exposed to VOCs of the algal microbiome of a sloth. Exploratory research …

Risk Of Atrial Fibrillation And Stroke After Bariatric Surgery In Patients With Morbid Obesity With Or Without Obstructive Sleep Apnea, Ahmed Dalmar, Maharaj Singh, Zoe Heis, Tabitha L. Cumpian, Cheryl Ceretto, M. Eyman Mortada, Atul Bhatia, Imran Niazi, Thomas Y. Chua, Jasbir Sra, Arshad Jahangir

College of Nursing Faculty Research and Publications

Background and Purpose:

Weight loss in morbidly obese patients reduces atrial fibrillation (AF); however, it is unknown whether similar benefits are maintained in patients with obstructive sleep apnea (OSA). We sought to determine whether incident AF and stroke rates are affected by OSA after weight loss and to identify predictors of AF and stroke.

Methods:

Differences in laparoscopic adjustable gastric banding–induced weight loss on incident AF and stroke events in those with and without OSA in the entire and in propensity-matched cohorts were determined longitudinally, and independent predictors of AF and stroke were identified.

Results:

Of 827 morbidly obese patients …

Impaired 26s Proteasome Assembly Precedes Neuronal Loss In Mutant Ubqln2 Rats., Wenjuan Zhang, Bo Huang, Limo Gao, Cao Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Proteasomal dysfunction is known to be associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). Our previous reports have shown that a mutant form of ubiquilin-2 (UBQLN2) linked to ALS/FTD leads to neurodegeneration accompanied by accumulations of the proteasome subunit Rpt1 in transgenic rats, but the precise pathogenic mechanisms of how this mutation impairs the proteasome remains to be elucidated. Here, we reveal that this UBQLN2 mutation in rats disrupted the proteasome integrity prior to neurodegeneration, that it dissociated the 26S proteasome in vitro, and that its depletion did not affect 26S proteasome assembly. During both disease progression and in …

Black Maternal Mortality In The United States, Grace Phelps

Honors College Theses

Black maternal mortality is a looming issue in the United States as the rate of Black maternal deaths is 3-4 times higher than the average rate for White women. Research establishes that this is a multifaceted issue of care quality, preexisting health, biases and racism, and structural inequalities. This study aims to discuss the statistics, contributing factors, and possible solutions to the issue of Black maternal mortality. Specifically, this study aims to educate nursing students on the matter and test the implications an educational session has on knowledge about Black maternal mortality and how health care professionals can be part …

Sarcopenia: A Functional Chronic Disease, Mike Haines, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

• Define sarcopenia as a clinical diagnosis as described by the European Working Group on Sarcopenia in Older Persons (EWGSOP2)
• Recognize, identify, and describe sarcopenia as a distinct disease process
• Review impact on health outcomes and healthcare costs
• Explain tools used to aid in diagnosis in clinical practice
• Explore the nuances of therapeutic interventions
• Discuss role of the primary care physician

Outline

● What is sarcopenia?

• Definition provided by EWGSOP2
• Brief overview of pathophysiology

● Why is it important?

• Epidemiology
• Impact on health outcomes
• Healthcare costs

● Diagnosis

• Review EWGSOP2 framework for clinical practice
• Questionnaires
• Office based testing
• Imaging

● …

A Shocking Case Of Far-Field Atrial Oversensing In Giant-Cell Myocarditis, Tanuka Datta, Md, S. Melnick, Do, Bharaniabirami Rajaram, Md, Behzad B. Pavri

Division of Cardiology Faculty Papers

We report a unique case of delivery of inappropriate implantable cardioverter-defibrillator therapies related to a “perfect storm”: presence of an integrated lead, insufficient lead slack related to right heart dilation resulting in shock coil misplacement, myocarditis with loss of R waves, and the concomitant occurrence of an incessant atrial tachycardia. (Level of Difficulty: Advanced.)

Genetic And Non-Genetic Factors Affecting The Expression Of Covid-19-Relevant Genes In The Large Airway Epithelium, Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, John Blangero, Joanne E. Curran, Juan M. Peralta

School of Medicine Publications

Background: The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be partially mediated by the differential regulation of the genes that interact with the SARS-CoV-2 virus or are involved in the subsequent host response. Here, we comprehensively investigated non-genetic and genetic factors influencing COVID-19-relevant bronchial epithelial gene expression. Methods: We analyzed RNA-sequencing data from bronchial epithelial brushings obtained from uninfected individuals. We related ACE2 gene expression to host and environmental factors in the SPIROMICS cohort of smokers with …

2021-04-20_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Determining Optimal Assessment Battery For Collegiate Soccer And Lacrosse Athletes Experiencing Frequent Repetitive Head Impacts, Megan Dowdal-Osborn Pt, Phd, Elijah Luken, Elizabeth Mcmahon, Elena Morrisette, Jacob Paust

DPT Capstone Posters

Introduction

Female collegiate soccer and lacrosse athletes are subject to repetitive subconcussive head impacts; defined as “cranial impacts that do not result in known or diagnosed concussion on clinical grounds.” These impacts may result in vestibulo-oculomotor (V-O) system dysfunction. Identifying V-O dysfunction is critical in order to better understand the potential consequences of these impacts.

Purposes

Retrospectively examine four years of pilot data to:

1. Describe the evolution of an assessment battery for cleared to play athletes.
2. Identify the assessment tools most frequently positive in cleared to play athletes and non-athletes.
3. Provide direction for clinical practice and future research endeavors.

Participants …

Policies, Practices, And Pedagogies: A Qualitative Study Of Lgbtq+ Representation In The Physical Therapy Profession, Jeanne Lojovich Pt, Phd, Laura Wangsness-Willemsen Phd, Brennan Swan, Jennifer Miller, Jordan Litschewski, Naga Rumicho

DPT Capstone Posters

Introduction

• APTA collects demographic data regarding racial diversity, but ignores gender and sexual diversity
• In the US, 4.5 percent of adults identified as LGBTQ+
• In Minnesota, 4.1 percent of adults identified as LGBTQ+

Objective

• Gain an improved understanding of the shared experiences and the potential underlying barriers that practicing and student PTs and PTAs from gender/sexual minorities in Minnesota encounter
• Results of the study will be used to assist MNPTA task force to improve diversity in PT/PTA education and practice in Minnesota

Methods

• The seven participants were practicing PT/PTAs or student from Minnesota
• Recruitment through flyer via email and distributed …

Forward Together Update [Update On Vaccination Clinics & Update On Cdc Guidelines On Cleaning Surfaces], April 20, 2021, University Of Northern Iowa

UNI Response to COVID-19

Gives an update on the vaccination clinic held the week of April 12th and lists opportunities for vaccinations available off campus. The memo also provides an update on Center for Disease Control and Prevention guidelines on cleaning surfaces.

2021 April 20 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Implementation Of The Centor Score In The Assessment Of Pharyngitis In An Atypical Setting During A Pandemic, Holly C. Wright

Nursing DNP Projects

Pharyngitis is a self-limited illness. Antibiotics are indicated if group A streptococcus (GAS) is present, yet 60% of patients receive a prescription. Implementation of the Centor Score at the time of triage can lead to appropriate collection of a rapid strep test (RST). Centor Scores were completed on adult patients presenting for an RST during the COVID-19 pandemic at a drive-up testing site. All five patients who had an RST had a negative GAS result and did not receive an antibiotic. A Centor Score completed at the time of nursing triage can provide guidance related to antibiotic prescribing for pharyngitis.

Coronavirus Update 4-20-2021, The Coronavirus Planning Team

University Briefings & Virtual Events

We are pleased to share that we are now opening our dedicated vaccine clinics on Thursday and Sunday to all students, including graduate students, and to faculty and staff. These Pfizer clinics give you the opportunity to conveniently be vaccinated where you attend classes or work.

Cxcl11 And Smica As Predictive Biomarkers For Efficacy Of Anti-Ctla4 Immunotherapy, Keith Sadoon Bahjat, Helena Maria Hoen, Yoshinobu Koguchi, Alan J. Korman

Technology Transfer - Patents

Provided herein are methods for selecting a cancer patient for anti-CTLA-4 immunotherapy, or predicting whether a cancer patient will respond to anti-CTLA4 immunotherapy, based on measured levels of CXCL1 1 and/or sMICA. Such methods are useful for determining whether an anti-CTLA-4 immunotherapy is likely to improve overall survival of a cancer patient. Also provided herein are methods of treating a cancer patient with an anti-CTLA-4 immunotherapy, wherein the patient is first tested for levels of CXCL1 1 and/or sMICA. Also provided are methods for treating a cancer patient with a CXCL1 1 antagonist or sMICA ant agonist alone, or in …

Biochemistry 4455g: Final Reflection, Jacklyn Krizsan

Community Engaged Learning Final Projects

No abstract provided.

2021-04-20_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Spirituality And Opioid Addiction Recovery, Carol A. Ammon, Msn, Mba, Dnp, Stacey Boyer, Psyd, Stephen Dutton, Mdiv, Pd, Courtney Slater, Phd

Full-Text Theses & Dissertations

Purpose: Opioid Use Disorder (OUD) is chronic relapsing disease and requires intense rehabilitation. A link between spirituality and addiction recovery. The purpose of this study was to investigate whether addressing spiritual concerns among hospitalized patients with OUD warrants a specific intervention to assist patients with their unique spiritual needs.

Methods: This qualitative-only study recruited fourteen eligible participants and resulted in five qualitative interviews. The FICA Spiritual Assessment Tool© was used to conduct the interviews and all interviews were coded for theme development.

Results: The results of this study demonstrated that spirituality as a phenomenon in addiction recovery can be determined …

2021-04-20_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Lost In Translation: Simple Steps In Experimental Design Of Neurorehabilitation-Based Research Interventions To Promote Motor Recovery Post-Stroke, Natalia Sánchez, Carolee J. Winstein

Physical Therapy Faculty Articles and Research

Stroke continues to be a leading cause of disability. Basic neurorehabilitation research is necessary to inform the neuropathophysiology of impaired motor control, and to develop targeted interventions with potential to remediate disability post-stroke. Despite knowledge gained from basic research studies, the effectiveness of researchbased interventions for reducing motor impairment has been no greater than standard of practice interventions. In this perspective, we offer suggestions for overcoming translational barriers integral to experimental design, to augment traditional protocols, and re-route the rehabilitation trajectory toward recovery and away from compensation. First, we suggest that researchers consider modifying task practice schedules to focus on …

Blood Transcriptome Profiling As Potential Biomarkers Of Suboptimal Health Status: Potential Utility Of Novel Biomarkers For Predictive, Preventive, And Personalized Medicine Strategy, Hao Wang, Qiuyue Tian, Jie Zhang, Hongqi Liu, Jinxia Zhang, Weijie Cao, Xiaoyu Zhang, Xingang Li, Lijuan Wu, Manshu Song, Yuanyuan Kong, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

The early identification of Suboptimal Health Status (SHS) creates a window opportunity for the predictive, preventive, and personalized medicine (PPPM) in chronic diseases. Previous studies have observed the alterations in several mRNA levels in SHS individuals. As a promising “omics” technology offering comprehension of genome structure and function at RNA level, transcriptome profiling can provide innovative molecular biomarkers for the predictive identification and targeted prevention of SHS. To explore the potential biomarkers, biological functions, and signalling pathways involved in SHS, an RNA sequencing (RNA-Seq)–based transcriptome analysis was firstly conducted on buffy coat samples collected from 30 participants with SHS and …

Stress And Coping Among American Indian And Alaska Natives In The Age Of Covid-19, Tristesse Burton, Johanna E. Adlam, Megan Murphy-Belcaster, Melva Thompson-Robinson, Carolee Dodge Francis, Daryl Traylor, Eboni Anderson, Kristina Ricker-Boles, Sutton King

Honors College Faculty Research

The COVID-19 pandemic compounds stressors of daily life among American Indian/Alaska Natives. This study investigated the impact of COVID-19 among American Indian/Alaska Natives and non-Hispanic whites by examining depressive symptoms, overall stress, resilience, and coping, utilizing the Transactional Model of Stress and Coping. Of the 207 individuals participating in this study, 109 identified as American Indian/Alaska Native and 98 as non-Hispanic white. Despite demographic similarities, American Indian/Alaska Natives exhibited more stressors related to COVID-19 as well as higher depressive symptom scores compared to non-Hispanic whites. Furthermore, COVID-19 stressors were more positively correlated with depressive symptoms for American Indian/Alaska Natives than …

Application Of An Evidence-Based, Out-Patient Treatment Strategy For Covid-19: Multidisciplinary Medical Practice Principles To Prevent Severe Disease☆, Elliot M. Frohman, Nicole R. Villemarette-Pittman, Adriana Rodriguez, Robert Glanzman, Sarah Rugheimer, Oleg Komogortsev, Scott S. Zamvil, Roberto A. Cruz, Thomas C. Varkey, Ashley N. Frohman

School of Medicine Publications

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of …

Solvent Exposed Occupations And Risk Of Parkinson Disease In Finland, Susan Searles Nielsen, Mark N Warden, Markku Sallmén, Markku Sainio, Sanni Uuksulainen, Harvey Checkoway, Christer Hublin, Brad A Racette

2020-Current year OA Pubs

INTRODUCTION: Epidemiologic and toxicology studies suggest that exposure to various solvents, especially chlorinated hydrocarbon solvents, might increase Parkinson disease (PD) risk.

METHODS: In a population-based case-control study in Finland, we examined whether occupations with potential for solvent exposures were associated with PD. We identified newly diagnosed cases age 45-84 from a nationwide medication reimbursement register in 1995-2014. From the population register, we randomly selected non-PD controls matched on sex, along with birth and diagnosis years (age). We included 11,757 cases and 23,236 controls with an occupation in the 1990 census, corresponding to age 40-60. We focused on 28 occupations with …

An Ensemble Of The Icluster Method To Analyze Longitudinal Lncrna Expression Data For Psoriasis Patients, Suyan Tian, Chi Wang

Internal Medicine Faculty Publications

BACKGROUND: Psoriasis is an immune-mediated, inflammatory disorder of the skin with chronic inflammation and hyper-proliferation of the epidermis. Since psoriasis has genetic components and the diseased tissue of psoriasis is very easily accessible, it is natural to use high-throughput technologies to characterize psoriasis and thus seek targeted therapies. Transcriptional profiles change correspondingly after an intervention. Unlike cross-sectional gene expression data, longitudinal gene expression data can capture the dynamic changes and thus facilitate causal inference.

METHODS: Using the iCluster method as a building block, an ensemble method was proposed and applied to a longitudinal gene expression dataset for psoriasis, with the …

Non-Nutritive Suck Burst Pattern Stability In Extremely Premature Infants, Alejandra Marquez

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The development of non-nutritive suck (NNS) burst dynamics in preterm infants reflects the integrity of the brain and is used clinically to assess feeding readiness and orofacial motor development (Mizuno and Ueda, 2005). The application of NNS analytics in the present report represents one outcome measurement set that is part of an ongoing clinical trial involving extremely preterm infants (EPI’s,[GA]) randomized to receive either pulsed orocutaneous stimulation therapeutics or a sham (blind pacifier), in conjunction with salivary sampling twice weekly to map gene expression of key proteins involved in neural development and molecular sensing of feeding related pathways in the …