Medicine and Health Sciences Commons^™

Promoting Wellness For College Athletes Through Mindfulness Meditation, Lisa R. Braatz

Theses and Graduate Projects

The practice of mindfulness meditation may be beneficial for college athlete’s mental health and wellness. College athletes are in a period of significant personal growth and experience high amounts of stress related to athletic performance, academics, and peer relationships. Integrating mindfulness meditation for college athletes has been linked to improving relaxation, concentration, and performance while decreasing fatigue and negative emotions related to fear or anxiety. This scholarly project explores the implementation of four mindfulness meditation sessions on perceptions of stress, mental focus, athletic performance, and presence in female college track and field athletes. The participants were attending an urban college …

From Bunks And Bars To Sidewalks And Skies: Support For Reentry From Incarceration, Ashley Ann Steen

Theses and Graduate Projects

Currently, there are over 2.3 million inmates in the prison system throughout the United States (Bureau of Justice Statistics, 2018). Over 10,000 ex-prisoners are released from America's state and federal prisons every week and studies show that approximately two-thirds will likely be rearrested within three years of release (Bureau of Justice Statistics, 2018). This scholarly project will explore the literature on why inmates face such a high rate of recidivism. It will further explore the current programming that is provided to inmates prior to release back to the community and offer a questionnaire to utilize in all reentry programs to …

Complementary Alternative Medicine: An Education Of Guided Self-Care In The Elderly Population For Management Of Chronic Conditions, Janice B. Gerber

Theses and Graduate Projects

The elderly population, specifically the residents in the Skilled Nursing Facility (SNF) or nursing homes, suffer from chronic conditions, many of which have a psychological and behavioral component. Conventional medicine treats the chronic conditions from one symptom to another through pharmacological interventions, which resulted in polypharmacy. Gathering evidenced-base practice of Complementary Alternative Medicine (CAM) will maximize opportunities for the elderly population to manage chronic conditions. The application of Parse’s Theory of Human Becoming (HBT) with self-guided education of CAM modalities in SNF explores the significant concepts of personal meaning, rhythmical patterns, and transcendence. Grounded on HBT, the self- guided education …

Pediatric Obesity: Prevention, Assessment And Treatment In Primary Care, Susan Johnson

Theses and Graduate Projects

People of all ages deserve care for the disease of obesity. Pediatric obesity affects one in three children in the United States, and the number of obese children has tripled since the 1970s (Centers for Disease Control and Prevention (CDC), 2018a). High blood pressure, high cholesterol, type 2 diabetes, and sleep apnea are complications that pediatric patients now face, and these diseases are well known to worsen quality of, and potentially shorten life. This scholarly project addresses the question: How can family nurse practitioners effectively address pediatric obesity in the primary care setting? Interventions early in life, perhaps even pre-conception, …

Social Empowerment Of Children With Attention Deficit Hyperactivity Disorder, Shawna Hanson

Theses and Graduate Projects

Attention deficit hyperactivity disorder is the most common childhood neurodevelopmental disorder, marked by symptoms of inattention, impulsivity, and hyperactivity. These symptoms contribute to difficulties with psychosocial functioning, often leading to feelings of inferiority. Several studies identify that those with attention deficit hyperactivity disorder have lower self-perceptions with risks for comorbidities and poor quality of life. However, few studies have attempted to provide interventions to increase the self-perceptions of children with attention deficit hyperactivity disorder. Most interventions for those with attention deficit hyperactivity disorder focus on giving medications and implementing behavioral modification techniques to externally control behaviors. However, this scholarly project …

Nurse Practitioners And Community Health Workers Improve Community Health, Emmalee F. Voskuil

Theses and Graduate Projects

Addressing health disparities in primary care is essential for the advanced practice nurse practitioner(NP). Recent research demonstrates that the United States spends more money on health care than any other country of equal income but has worse outcomes, including lower life expectancy, higher infant mortality rates, and more stratified health inequities (Papanicolas, Woskie, & Jha, 2018). The NP has many opportunities to improve healthcare by partnering with diverse voices that seek to change the healthcare system. To better address health disparities among marginalized people in Minnesota, this scholarly project will determine best practices for the development and incorporation of community …

Latina Adolescent Dating Violence Public Narrative, Megan Staffen

Theses and Graduate Projects

A scholarly project has been conducted to assess use of public narrative between health care providers (HCPs) and Latina adolescents to reduce dating violence (DV) health consequences. Latina adolescents require an innovative, transcultural approach for dating violence care to reduce barriers to care. Healthcare providers must structure dating violence care to Latina adolescents due to different dating violence patterns and health consequences compared to other ethnicities and generations. There is minimal evidence- based research on the use of public narrative and its effects of use in the healthcare setting. The application of public narrative and the citizen professional will be …

Postpartum Support: Application Of A Local Peer Support, Community Care Model, Stephanie E. Ward

Theses and Graduate Projects

The postpartum period is one of the most influential developmental stages of a women’s life and represents a time of heightened risk for mental health decline. Perinatal mood and anxiety disorders have been implicated as a key influence of negative parenting experiences, poor newborn psychological outcomes, delayed newborn development, and inadequately adaptive family development behaviors. Integrating established resiliency components against mental illness, such as social support, into a postpartum care model can benefit postpartum women and secondarily positively impact the aforementioned outcomes. A community care model highlighting social support for postpartum mothers was integrated into a rural Minnesota region and …

Improving Family Nurse Practitioners’ Knowledge Of Palliative Care Resources, Michelle L. Bond

Theses and Graduate Projects

The shift in healthcare indicates Americans are living longer with progressive chronic illnesses subsequently reducing quality-of-life. Primary care providers have opportunities to assess the need for and implement palliative care to offer holistic symptom management to improve patient’s quality-of-life. The purpose of this scholarly project, guided by Jean Watson’s Theory of Human Caring, is to assess primary care providers knowledge and comfort regarding initiating palliative care while determining if additional education improves their familiarity. The objectives were to review current palliative care literature identifying barriers and inadequacies, determine evidence-based practice to develop an educational presentation and resources to improve communication, …

Advance Care Planning Education For Older Adults, Jamie E. Seaquist

Theses and Graduate Projects

Advanced care planning guides health care professionals and surrogate decision-makers choices on end of life (EOL) care when individuals are no longer able to speak for themselves. Advanced care plans can benefit patients in their last six months of life by improving their quality of life and by reducing family members anxiety, depression, and stress when dealing with EOL treatment options. Aside from these benefits, poor communication and knowledge deficits often create barriers when medical staff, families or patients try to broach the subject of EOL care. Barriers can be overcome when health care professionals facilitate advanced care planning conversations …

The Context-Dependent Impact Of Integrin-Associated Cd151 And Other Tetraspanins On Cancer Development And Progression: A Class Of Versatile Mediators Of Cellular Function And Signaling, Tumorigenesis And Metastasis, Sonia F. Erfani, Hui Hua, Yueyin Pan, Binhua P. Zhou, Xiuwei H. Yang

Molecular and Cellular Biochemistry Faculty Publications

As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to mediate tumor development, growth, and progression in oncogenic context- and cell lineage-dependent manners. In the current review, we summarize recent advances in mechanistic understanding of the function and signaling of integrin-associated CD151 and other tetraspanins in multiple cancer types. We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial-mesenchymal transition …

Nmr Solution Structures Of Runella Slithyformis Rna 2'-Phosphotransferase Tpt1 Provide Insights Into Nad+ Binding And Specificity, Sébastien Alphonse, Ankan Banerjee, Swathi Dantuluri, Stewart Shuman, Ranajeet Ghose

Publications and Research

Tpt1, an essential component of the fungal and plant tRNA splicing machinery, catalyzes transfer of an internal RNA 2′-PO₄ to NAD⁺ yielding RNA 2′-OH and ADP-ribose-1′,2′-cyclic phosphate products. Here, we report NMR structures of the Tpt1 ortholog from the bacterium Runella slithyformis (RslTpt1), as apoenzyme and bound to NAD⁺. RslTpt1 consists of N- and C-terminal lobes with substantial inter-lobe dynamics in the free and NAD⁺-bound states. ITC measurements of RslTpt1 binding to NAD⁺ (K_D ∼31 μM), ADP-ribose (∼96 μM) and ADP (∼123 μM) indicate that substrate affinity is determined primarily by …

2021-04-21_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Preference Of Inhalants Over Pills/Injections Among Pulmonary Tuberculosis Patients In Western India: A Cross-Sectional Study, Nirmal Ahuja

Harrisburg University Faculty Works

Background:

Presently, pills and injections are the two modes of therapeutic treatment available for tuberculosis (TB) patients. Many researchers have hypothesized inhalation drug delivery for reducing treatment times and possibly limiting the insurgence of drug resistance. This study was aimed at identifying and assessing the preferences of inhalation therapy over injections/pills among pulmonary TB patients.

Method:

Cross-sectional study design was used and a sample of 477 participants were recruited at selected three Directly Observed Treatment Short-Course (DOTS) centers in Bhiwandi city. Data was collected through a self-reported questionnaire. Descriptive statistics were reported, and binomial regression models were applied for data …

Hybrid Diffusion Imaging Reveals Altered White Matter Tract Integrity And Associations With Symptoms And Cognitive Dysfunction In Chronic Traumatic Brain Injury., Jennifer Muller, Devon Middleton, M. Alizadeh, George Zabrecky, Nancy Wintering, Anthony J. Bazzan, Ji Lang, Chengyuan Wu, Daniel A. Monti, Qianhong Wu, Andrew B. Newberg, Feroze B. Mohamed

Department of Radiology Faculty Papers

The detection and association of in vivo biomarkers in white matter (WM) pathology after acute and chronic mild traumatic brain injury (mTBI) are needed to improve care and develop therapies. In this study, we used the diffusion MRI method of hybrid diffusion imaging (HYDI)to detect white matter alterations in patients with chronic TBI (cTBI). 40 patients with cTBI presenting symptoms at least three months post injury, and 17 healthy controls underwent magnetic resonance HYDI. cTBI patients were assessed with a battery of neuropsychological tests. A voxel-wise statistical analysis within the white matter skeleton was performed to study between group differences …

Avi & U.S And Hungary Healthcare, Khyla Jones

Masters Theses/Capstone Projects

The American Virtual Institute began as an opportunity to teach Hungarian high school students about American Culture in different areas of life. These meetings were to occur every Saturday over Zoom, starting in October of 2020. There were 14 different presentations, dispersed among the 3 AVI members to present on their corresponding day. AVI participants and Hungarian successfully collaborated to obtain more knowledge on each country through this practicum in regard to wellness, leadership, and understating culture.

Optimized Polyepitope Neoantigen Dna Vaccines Elicit Neoantigen-Specific Immune Responses In Preclinical Models And In Clinical Translation, Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W Kim, John M Herndon, Michelle K Becker-Hapak, Beatriz M Carreno, Nancy B Myers, Mark A Sturmoski, Michael D Mclellan, Christopher A Miller, Tanner M Johanns, Benjamin R Tan, Gavin P Dunn, Timothy P Fleming, Ted H Hansen, S Peter Goedegebuure, William E Gillanders

2020-Current year OA Pubs

BACKGROUND: Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can integrate multiple neoantigens simultaneously. We therefore sought to optimize the design of polyepitope DNA vaccines and test optimized polyepitope neoantigen DNA vaccines in preclinical models and in clinical translation.

METHODS: We developed and optimized a DNA vaccine platform to target multiple neoantigens. The polyepitope DNA vaccine platform was first optimized using model antigens in vitro and in vivo. We then identified neoantigens in preclinical breast cancer …

Sacubitril/Valsartan Inhibits Obesity-Associated Diastolic Dysfunction Through Suppression Of Ventricular-Vascular Stiffness, Annayya R. Aroor, Srinivas Mummidi, Juan C. Lopez-Alvarenga, Nitin Das, Javad Habibi, Guanghong Jia, Guido Lastra, Bysani Chandrasekar

School of Medicine Publications

Objective: Cardiac diastolic dysfunction (DD) and arterial stiffness are early manifestations of obesity-associated prediabetes, and both serve as risk factors for the development of heart failure with preserved ejection fraction (HFpEF). Since the incidence of DD and arterial stiffness are increasing worldwide due to exponential growth in obesity, an effective treatment is urgently needed to blunt their development and progression. Here we investigated whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degrading enzyme, and an angiotensin II type 1 receptor blocker (valsartan), suppresses DD and arterial stiffness in an animal model of prediabetes more effectively than valsartan …

American Virtual Institute: The Covid Practicum, Mitchell Stotler

Masters Theses/Capstone Projects

The American Virtual Institute: The COVID Practicum is a practicum experience focused on presenting to Hungarians and other international attendees about American wellness, leadership, and lifestyle. This practicum experience was completed entirely online via Zoom, Google Meets, and Facebook Live over the 2020-2021 academic year.

Dorsal Anterior Cingulate Cortex Encodes The Integrated Incentive Motivational Value Of Cognitive Task Performance, Debbie M Yee, Jennifer L Crawford, Bidhan Lamichhane, Todd S Braver

2020-Current year OA Pubs

Humans can seamlessly combine value signals from diverse motivational incentives, yet it is not well understood how these signals are "bundled" in the brain to modulate cognitive control. The dorsal ACC (dACC) is theorized to integrate motivational value dimensions in the service of goal-directed action, although this hypothesis has yet to receive rigorous confirmation. In the present study, we examined the role of human dACC in motivational incentive integration. Healthy young adult men and women were scanned with fMRI while engaged in an experimental paradigm that quantifies the combined effects of liquid (e.g., juice, neutral, saltwater) and monetary incentives on …

The Effect Of Animated Resources For Learning American Sign Language, Bailey Towns

Honors Projects

American Sign Language (ASL) is a visual language expressed through movements of the hands as well as facial expressions and body language. While Deaf individuals are the primary users of the language, many hearing people learn ASL in order to communicate with Deaf people and promote inclusivity for the Deaf community. When learning ASL, one area of difficulty that they initially encounter is producing signs correctly. The present study addressed this concern by examining two methods for introducing ASL signs to novel learners. Animated ASL programs have been proposed to combat the problems created by static 2D presentations of signs. …

Igg4-Related Disease With Multiorgan Involvement: A Case-Based Review, Nikhil N. Tarte, Chandana Shilpa Ravipati, Jose A. Leon De La Rocha, Elizabeth Rinker, Nirupa J. Patel

School of Medicine Faculty Publications

IgG4-related disease (IgG4-RD) is an immune-mediated multi-organ inflammatory disorder caused by tissue infiltration of lymphocytes with IgG4-secreting plasma cells. Herein, we discuss a case of a patient with IgG4-RD who had involvement of multiple organs: the kidneys, lymph nodes, bone marrow (biopsy performed), lungs, liver, and small intestine (imaging abnormalities). Although several case reports and series of IgG4-RD involving different organ involvement are in the literature, our patient has extensive simultaneous multi-organ involvement. We utilized the four domains (serologic, pathologic, radiologic, and pathologic) as discussed in the new 2019 ACR/EULAR classification criteria to provide a useful framework in considering an …

Educational Tool For Chronic Low Back Pain Interventional Procedures And Modalities, Stacy Dominy

MSN Capstone Projects

Chronic low back pain is a problem for many people. It can be debilitating and those suffering often have a difficult time finding relief. Many times, people rely on potentially dangerous and and addicting medications for pain relief. There is a great need to educate people on the dangers of this route and the potential benefits of interventional procedures and modalities for pain relief. By creating an educational tool backed by evidence-based information, patients can be empowered to make the best choices for their health.

Type 2 Diabetes - A Change For A Better Life, Hilary Greene

MSN Capstone Projects

Cardiovascular disease has been known to be the leading cause of mortality in patients with type 2 diabetes. With diabetes on the rise in the United States, it is important to assess changes in these patients to decrease the risk of developing cardiovascular disease or a major cardiovascular event such as a myocardial infarction, stroke, or death. If able to address healthy alternatives to patients to reduce the risks of major cardiovascular events such as a myocardial infarction or stroke, it could potentially save many lives. As a nurse educator, it is important to provide patients with the education they …

Effects Of Palliative Care On Nurses’ Knowledge And Attitudes, Daniel Kerr

MSN Capstone Projects

Heart failure (HF) is a chronic, progressive disease that affects 6 million Americans (Ng & Wong, 2017). During the course of the disease, patients have worsening symptoms and need increasing levels of care from both medical staff and home caregivers. Often, these caregivers are family members or friends who spend a significant amount of their free time assisting the patient, leading to significant stress and burden on the caregivers. Recent changes in recommendations from the American Heart Association (AHA) include Palliative Care (PC) consultation for patients diagnosed with advanced stage heart failure, but many physicians have not included a PC …

Treatment Of Acute Bronchitis In Active Duty Military Members Benchmark Project, Nicole Williams

MSN Capstone Projects

Antibiotic resistant infections are a growing problem in the United States and the world. The main cause of this is antibiotic prescriptions, which can not only cause antibiotic resistance but adverse events. Decreasing the amount of antibiotics prescribed for inappropriate conditions can help to decrease the rates of antibiotic resistant infections and the problems these infections can cause. One illness that is treated frequently with antibiotics, against recommendations, is acute bronchitis. Acute bronchitis is a self-limiting viral infection, characterized by cough. By decreasing the number of providers who are prescribing antibiotics for acute bronchitis, the clinic can help to prevent …

Reducing Unnecessary Telemetry Utilization In A Community Hospital: A Value Enhancing Project, Deanna Blanchard, Md, Cpe, Facs

Master of Science in Healthcare Quality and Safety Capstone Presentations

Health care expenditures are growing at an unsustainable rate with one third of those expenditures directly attributed to overtreatment and waste. Waste associated with unnecessary telemetry utilization includes physical waste in garbage, process defects in false alarms, time in patient flow, motion in tasks, excessive work, and excessive cost. The American Heart Association (AHA) has published guidelines establishing best practices for telemetry use. American Board of Internal Medicine Foundation (ABIMF) and the Society of Hospital Medicine in the Choosing Wisely® campaign have deemed inappropriate telemetry use as a wasteful practice. A multidisciplinary task force was created at Hospital A to …

Insects Provide Unique Systems To Investigate How Early-Life Experience Alters The Brain And Behavior, Rebecca R. Westwick, Clare C. Rittschof

Entomology Faculty Publications

Early-life experiences have strong and long-lasting consequences for behavior in a surprising diversity of animals. Determining which environmental inputs cause behavioral change, how this information becomes neurobiologically encoded, and the functional consequences of these changes remain fundamental puzzles relevant to diverse fields from evolutionary biology to the health sciences. Here we explore how insects provide unique opportunities for comparative study of developmental behavioral plasticity. Insects have sophisticated behavior and cognitive abilities, and they are frequently studied in their natural environments, which provides an ecological and adaptive perspective that is often more limited in lab-based vertebrate models. A range of cues, …

Intraluminal Endovascular Coil Migration: A Rare Complication Post-Embolization Of The Gastroduodenal Artery For A Previously Bleeding Duodenal Ulcer, Yassin Naga, Mahendran Jayaraj, Yousif Elmofti, Annie Hong, Gordon Ohning

School of Medicine Faculty Research

Transarterial angiographic embolization is a highly effective, safe treatment for non-variceal upper gastrointestinal bleeding refractory to endoscopic intervention. However, intraluminal coil migration is a possible complication. Coil migration, while usually a self-limiting process, can lead to significant rebleeding. In our case, a patient presented with a life-threatening duodenal ulcer hemorrhage, likely precipitated by intraluminal endovascular coil migration after a recent gastro-duodenal artery embolization. He was successfully managed without endoscopic coil removal and had no additional gastrointestinal bleeding. It is important for endoscopists to be aware of this complication and weigh the risks and benefits of coil removal.

The Association Of Education In A New Society And Social Support From The Education With The Health Of North Korean Defectors: A Cross-Sectional Study, Jihyun Lee, Yui Park, Dong Hun Han, Ji Won Yoo, Wenlian Zhou, Pearl Kim, Jay J. Shen

School of Medicine Faculty Research

Background: The number of North Korean defectors (NKDs) escaping to South Korea has increased. The health status of NKDs is an essential factor for a successful settlement into South Korean society. However, no studies have been conducted on the health status of NKDs in terms of education and social support. The aim of this study was to determine the associations of education and social support with the self-rated health status among NKDs. Methods: This study utilized data gained from face-to-face interviews with 126 NKDs. A multivariable logistic regression and path analysis were performed to assess the effects of education in …