Medicine and Health Sciences Commons^™

An Evaluation Of A Nerve Block Protocol In Patients With Hip Fractures, Jenna Buchman

Doctoral Projects

BACKGROUND/PURPOSE: Pain management for hip fracture patients in the time before surgery is crucial. Literature highlights the success of local, single injection nerve blocks to aid in preoperative pain management. A local hospital implemented a preoperative, single injection nerve block protocol in March 2018. This quality improvement project investigated: (1) organization protocol compliance, and (2) if the preoperative single injection nerve block protocol reduces hip fracture pain, use of systemic opioid analgesics, decreases incidence of adverse opioid effects, and reduces cost of care.

SUBJECTS: Patients ages 18 and older admitted with the primary diagnosis of an operable isolated hip fracture …

Preoperative Patient Reported Outcomes Measurement Information System Scores Assist In Predicting Early Postoperative Success In Lumbar Discectomy, Paul T. Rubery, Jeff Houck, Addisu Mesfin, Robert Molinari, Mark O. Papuga

Faculty Publications - College of Physical Therapy

Study Design. Retrospective review of prospective data.

Objective. Determine whether patient reported outcome (PRO) data collected prior to lumbar discectomy predicts achievement of a minimal important difference (MID) after surgery. Compare ability of PRO and clinical information to predict achievement of MID in short term follow-up after discectomy.

Summary of Background Data. We investigated the ability of patient reported outcomes measurement information system (PROMIS) and clinical factors at the preoperative time point to determine patients achieving MID after surgery.

Methods. PROMIS physical function (PF), pain interference (PI), and depression (D) scores were assessed at evaluation and follow-up for consecutive visits …

Extremely Low Testosterone Due To Relative Energy Deficiency In Sport: A Case Report, Ana Narla, Kimberly Kaiser, Lisa R. Tannock

Orthopaedic Surgery and Sports Medicine Faculty Publications

Objective: Recognize extremely low testosterone due to hypothalamic dysfunction from overtraining syndrome in a male athlete with relative energy deficiency in sport (RED-S).

Methods: Clinical and laboratory information are described.

Results: A 20-year-old male division I collegiate swimmer was found to have strikingly low total, free, and bioavailable testosterone levels with normal sex hormone–binding globulin and inappropriately normal follicle-stimulating hormone and luteinizing hormone. Lab testing ruled out hyperprolactinemia and hypothyroidism as etiologies, and pituitary imaging was normal. A diagnosis of RED-S was made, and the patient worked with the sports medicine team to increase nutrition and modify physical activity. His …

Network Analysis Approaches To Collaborative Information Seeking In Inter-Professional Health Care Teams, J. David Johnson

Communication Faculty Publications

Introduction: It is widely believed that interprofessional health care teams can improve patient care and increase safety; however, intra-team communication has often proven to be problematic. One particularly important aspect of this problem is how teams collaborate to seek the information needed to address the issues they are confronting. Network analysis offers a rich set of concepts for tackling this problem.

Method: Review essay.

Analysis and results: Network analysis approaches offer the promise of more nuanced approaches and diagnostic tools that could address these issues by focusing on its elements: reciprocity, centrality, density, fault lines, multi-team systems, …

Dengue Fever Presenting As Quadriparesis Due To Hypokalaemia: A Rare Presentation, Syed Muhammad Zubair, Syed Ahsan Ali, Saira Furqan

Section of Internal Medicine

Dengue is one of the leading causes of arthropod borne viral haemorrhagic fever. Majority of the times, it clinically manifests as fever, arthralgia and rash; however, we present a case of a young man who presented with progressively increasing weakness of all four limbs. Initial investigations showed low potassium, hence he was managed as hypokalaemic periodic paralysis. With initial history of fever and low platelets, dengue was suspected. Dengue antibody was checked which came out to be positive. Potassium was replaced which led to improvement in power of his limbs. He was discharged in a stable condition with a diagnosis …

Root And Canal Morphology Of Maxillary Premolar Teeth In An Egyptian Subpopulation Using Two Classification Systems: A Cone Beam Computed Tomography Study, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To investigate the number of roots and root canal configurations using two coding systems and the root canal diverging and merging levels in extracted maxillary premolars in an Egyptian subpopulation using cone beam computed tomography (CBCT). Methodology: A total of 700 maxillary premolars were examined using CBCT in an Egyptian subpopulation. The number of roots was identified, and root canal configurations were classified according to Vertucci's classification and a new system for classifying root and canal morphology. In addition, the position where roots bifurcated and the levels where canals merged or diverged were identified. Fisher's exact test and independent …

Escaping Death: Naloxone's Chemical Nature And Potential To Combat The Opioid Epidemic, Abigale Miller

Honors Program: Senior Projects (Public)

Naloxone is a life-saving drug with the ability to reverse an opioid overdose. As the opioid epidemic’s death toll rises, we can turn to Naloxone as a tool to combat the crisis. The epidemic, born of corruption, has a wide reach among the people of the United States, with especially firm grasps on middle-aged people, sufferers of chronic pain, white Americans and those living in the eastern portion of the country. Naloxone’s elegant design saves lives by effectively competing for a position on an opioid biding receptor in the brain to almost instantly end an overdose and restore normal breathing. …

"The Tyrant Father": Leslie Stephen And Masculine Influences On Virginia Woolf And Her Novel, To The Lighthouse, Anya Graubard

Honors Program: Senior Projects (Public)

This paper examines the volatile yet nurturing relationship between Virginia Woolf and her father, Leslie Stephen. It specifically considers the effects of three male “tyrants” in Woolf’s childhood, including not only her father but also her two half-brothers, who abused her sexually. Analysis of the dynamics of these relationships provides insight into Woolf’s lifelong battle with mental illness and helps us to understand the complicated relationships she had as an adult with men and women.

In her letters, diaries, and memoir essays, Woolf reveals how she drew from her own experiences of childhood to write her most famous novel, To …

Missing Pieces And Misconceptions: Public Understanding Of Occupational Therapy, Heather Miller-Kuhaneck, Erin Coutts, Brenna Destefano, Andrea Gallo, Caitlin Kaczynski, Giana Marucci, Kristen Mourao, Jennifer Vialonga

Occupational Therapy Faculty Publications

The students of Gamma Nu Chapter of Pi Theta Epsilon at Sacred Heart University completed a qualitative project examining the public perceptions of occupational therapy. This poster is their presentation to the state OT association, ConnOTA.

A Systematic Review Of The Caries Prevalence Among Children Living In Chernobyl Fallout Countries, Michael Wolgin, Nicole Filina, Valentyn Dvornyk, Edward Lynch, Andrej M. Kielbassa

Dental Medicine Faculty Research

The present study analyzed the data concerning the caries prevalence in children born and permanently residing in Chernobyl fallout areas. Setting forth to evaluate if differences regarding the caries prevalence can be observed compared to non-contaminated sites of affected East European countries. Methods used to assess the caries prevalence were limited to DMFT/dmft (decayed, missing and filled teeth) for the primary and the permanent dentitions. The databases PubMed, EMBASE/Ovid, Cochrane Library, Scopus, and eLIBRARY were consulted for the electronic literature search...(Please see text for full abstrast)

Dynamic Prediction Of Survival Data Using Single Or Multiple Longitudinal Markers, Xuehan Ren

Dissertations and Theses (Open Access)

Recurrent events and time-to-event data occur frequently in longitudinal studies. In large clinical trials with survival endpoints, researchers collect a multitude of longitudinal markers. There is a growing need to utilize these rich longitudinal information to build prediction models and assess their prognostic performance. In this dissertation research, I propose a novel approach of integrating longitudinal markers in modeling the recurrent event or terminal event data, and conduct dynamic prediction of event risks. Under joint a model framework, I jointly model a longitudinal outcome and a recurrent event process with the two process correlated via shared latent function. The probability …

Validation Of A New Incremental Swim Test As A Tool For Maximum Oxygen Uptake Analysis In Lifeguards, Brais Ruibal-Lista, José Palacios-Aguilar, José Antonio Prieto, Sergio López-García, José Antonio Cecchini-Estrada, Miguel Santiago-Alonso, Cristian Abelairas-Gómez

International Journal of Aquatic Research and Education

This study was designed to validate an incremental test predicting maximum oxygen uptake for lifeguards. A maximum incremental test was performed in the laboratory (i.e., treadmill run) and in the pool (i.e., swim) by 10 certified lifeguards. The values of maximum oxygen uptake (VO₂Max), maximum heart rate (HRMax), and lactate (LaMax) achieved during both tests were analyzed. The VO₂Max (0.87, p =.001), HRmax (0.85, p = .002) and LaMax (0.67, p

Femoral Vein Transposition Arteriovenous Fistula Is A Feasible Option In "Selected" Patients As Hemodialysis Access, Zia Ur Rehman, Asfia Arham, Ziad Sophie

Section of Cardiothoracic Surgery

Introduction: Lower extremity hemodialysis access is offered to the patients who have severe central venous stenosis. Femoral vein transposition arteriovenous fistula (FV tAVF) is an alternative to lower leg arteriovenous prosthetic grafts. Its safety and patency is under observation.
Materials and Methods: This is a retrospective review of patients who had FV tAVF between January 2011 and March 2016. Preoperative clinical findings, intraoperative findings, postoperative complications, and patency of the AVF were noted and analyzed.
Results: There were 7 patients who underwent FV tAVF during this study period. Most patients were female (6 : 1), with mean …

Understanding Constipation: A Cross-Sectional Study From A Developing Country Setting, Minaz Mawani, Abdul Azeem, Sakina Gheewala, Nazish Butt, Shahab Abid

Section of Gastroenterology

A cross-sectional study was conducted in the Gastroenterology Clinics of The Aga Khan Hospital and Jinnah Postgraduate Medical Centre in Karachi. All patients complaining of constipation were included. Patients with alarm features were excluded. Interviews were conducted by trained doctors using a structured Rome III based pre-tested questionnaire and Bristol Stool Form Scale. Out of 396 participants, 186 (47.0%) had FC and 209 (52.7%) had IBS-C. Based upon Bristol Stool Form Scale, only 214 (54%) reported to have slow transit constipation (BSS <2). A higher proportion of women reported severe form of constipation as compared to men (81.5%, n=150 vs. 65.1%, n=138 p<0.001). However, a higher percentage of men reported using medications to treat their symptoms (71.2%, n=151 vs. 57.1%, n=105 p=0.003). Proper understanding of patient's symptoms is essential for optimizing individual patient management.

Premedical Programs Newsletter, March-April 2019, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs. This issue contains information about the Miami Valley Hospital Healthcare Symposium; Mental Health First Aid; Healthy Minds survey; summer fellowship opportunities; and professional school acceptance announcements.

Two Weeks Of Ischemic Conditioning Improves Walking Speed And Reduces Neuromuscular Fatigability In Chronic Stroke Survivors, Matthew J. Durand, Timothy F. Boerger, Jennifer Nguyen, Saad Z. Alqahtani, Michael T. Wright, Brian D. Schmit, David D. Gutterman, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

This pilot study examined whether ischemic conditioning (IC), a noninvasive, cost-effective, and easy-to-administer intervention, could improve gait speed and paretic leg muscle function in stroke survivors. We hypothesized that 2 wk of IC training would increase self-selected walking speed, increase paretic muscle strength, and reduce neuromuscular fatigability in chronic stroke survivors. Twenty-two chronic stroke survivors received either IC or IC Sham on their paretic leg every other day for 2 wk (7 total sessions). IC involved 5-min bouts of ischemia, repeated five times, using a cuff inflated to 225 mmHg on the paretic thigh. For IC Sham, the cuff inflation …

Design And Assessment Of Myoelectric Games For Prosthesis Training Of Upper Limb Amputees, Meeralakshmi Radhakrishnan, Asim Smailagic, Brian French, Daniel P. Siewiorek, Rajesh Krishna Balan

Research Collection School Of Computing and Information Systems

In this paper, we present the design and evaluation of our system, which provides an engaging game-based pre-prosthesis training environment for upper limb transradial amputees. We believe that patients who train using such a training tool will demonstrate significantly higher improvement in functional performance tests using a myoelectric prosthesis than when conventional pre-prosthesis training protocols are used. We re-designed two simple games to be playable using three muscle contractions which are appropriate to pre-prosthesis exercises and are detected by an EMG-based arm sleeve. Through user studies conducted with 16 non-amputee subjects, we show that the proposed games are enjoyable, fun …

A Multicenter Evaluation Of A New Eus Core Biopsy Needle: Experience In 200 Patients., Douglas G. Adler, V. Raman Muthusamy, Dean S. Ehrlich, Gulshan Parasher, Nirav C. Thosani, Ann Chen, Jonathan M. Buscaglia, Anoop Appannagari, Eduardo Quintero, Harry Aslanian, Linda Jo Taylor, Ali Siddiqui

Division of Gastroenterology and Hepatology Faculty Papers

Background and Objectives: We present a multicenter study of a new endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle (Acquire, Boston Scientific, Natick, MA). The aim of the study was to analyze the needle's clinical performance when sampling solid lesions and to assess the safety of this device.

Methods: We performed a multicenter retrospective study of patients undergoing EUS-FNB during July 1-November 15, 2016.

Results: Two hundred patients (121 males and 79 females) underwent EUS-FNB of solid lesions with the Acquire needle. Lesions included solid pancreatic masses (n = 109), adenopathy (n = 45), submucosal lesions (n = 34), cholangiocarcinoma (n = …

A Word From The Writing Team (March 2019), Jennifer Wilson, Ms, Els, Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Key to Great Writing: Rewriting
• 3-Minute Thesis Competition (3MT)
• Upcoming Workshops

Diagnosis Of B-Cell Lymphoproliferative Disorder Through Concomitant Management Of Medication-Related Osteonecrosis Of The Jaw: A Case Report, Robert Diecidue, Allen F. Champion, Ruifeng Zhou, James G. Buckley

Department of Oral and Maxillofacial Surgery Faculty Papers

No abstract provided.

Know Thy Student: Using A Graduate Student Learning Assessment Questionnaire, Melinda Hermanns, Danice B. Greer

Nursing Faculty Publications and Presentations

Background: Creating an online learning environment for today’s adult learner that is engaging and conducive to meeting the various needs can be a challenge for any educator, new or seasoned. Understanding the students’ perspectives of what they need from faculty to be successful is underexplored. Therefore, the purpose of this study was to describe the students’ perspectives of their learning needs and motivation as reported in a faculty developed Graduate Student Learning Assessment Questionnaire (GSLAQ).

Methods: A cross-sectional descriptive survey design was employed and consisted of 120 non-traditional adult learners in graduate nursing school. The demographics are as follows: 100 …

Engaging Older Adults With Parkinson’S Disease In Physical Activity Using Technology: A Feasibility Study, Melinda Hermanns, Barbara K. Haas

Nursing Faculty Publications and Presentations

Parkinson’s disease (PD), a progressive neurodegenerative disorder, presents unique and daily challenges. Living with PD may limit one’s physical activity and negatively affect quality of life (QOL). No studies were identified that utilized online technology to promote health in this population. The purposes of this study were to (a) assess the feasibility of an intervention that requires wearing a physical activity tracker and participating in an online support group, and (b) examine the effect of this intervention on the self-efficacy for physical activity and QOL of older adults with PD. A 12-week longitudinal pretest/posttest design was used to assess physical …

Stress-Induced Epinephrine Enhances Lactate Dehydrogenase A And Promotes Breast Cancer Stem-Like Cells, Bai Cui, Yuanyuan Luo, Pengfei Tian, Fei Peng, Jinxin Lu, Yongliang Yang, Qitong Su, Bing Liu, Jiachuan Yu, Xi Luo, Liu Yin, Wei Cheng, Fan An, Bin He, Dapeng Liang, Sijin Wu, Peng Chu, Luyao Song, Xinyu Liu, Huandong Luo, Binhua P. Zhou

Molecular and Cellular Biochemistry Faculty Publications

Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress–induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A–dependent (LDHA-dependent) metabolic rewiring. Chronic stress–induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC. The SLUG promoter was then activated by MYC, which promoted development of breast cancer stem-like traits. Using a drug screen that targeted LDHA, we found that a chronic stress–induced cancer stem-like phenotype could be reversed by vitamin C. These findings demonstrated the critical importance of psychological …

Inspire : Vol 2, Issue 3, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Message From the Chair
• Department of Medicine Strategic Planning Retreat
• Life Notes by Dr. Saad Shafqat
• Department of Medicine at National and International Forums
• What Are Academics Around the World Reading This Month?
• Featured Faculty Profile
• Dr. Syedah Saira Bukhari; “Choose to be kind.”
• Events Around the Corner
• Publications

Application Of Tasman Technique For Congenital Absence Of Nasal Cartilage: A Case Report, Dominick Gadaleta, Ryan N. Heffelfinger

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

No abstract provided.

Prevalence Of Anaemia And Associated Factors Among Oraon Females Of North 24 Parganas, West Bengal, India, Tanaya Kundu Chowdhury, Subrata K. Roy

Journal Articles

Low haemoglobin level or anaemia is a health problem worldwide especially in developing countries like India. Anaemia is generally higher among indigenous groups compared to general population globally and females are specifically more prone to anaemia. However, studies are inadequate on indigenous groups of India. The aims of the study are to determine the prevalence of anaemia among the female Oraons of North 24 Parganas and to study the association between anaemia and concomitants like socio-demographic and food habit variables. Data have been collected on demographic, socio-economic and food habit variables using well-tested questionnaire from 309 Oraon females living in …

Adult-Onset Still’S Disease Triggered By Pregnancy, Saleem Abdulkarim, Fredrick Otieno, Sayed Karar

Internal Medicine, East Africa

Adult-onset Still’s disease (AOSD) is an inflammatory disorder with arthritis, quotidian fever, evanescent rash, elevated white cell count, elevated ferritin, and abnormal liver function tests. The diagnosis requires the exclusion of other inflammatory, infectious, and malignant conditions. Onset of AOSD, though rare, has been known to occur in pregnancy. We present a 28-year-old woman diagnosed with AOSD at 3 months gestation.

Effect Of Conditioning Regimen Dose Reduction In Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation., Claudio G. Brunstein, Marcelo C. Pasquini, Soyoung Kim, Mingwei Fei, Kehinde Adekola, Ibrahim A. Ahmed, Mahmoud Aljurf, Vaibhav Agrawal, Jeffrey J. Auletta, Minoo Battiwalla, Nelli Bejanyan, Joseph Bubalo, Jan Cerny, Lynette Chee, Stefan O. Ciurea, Cesar Freytes, Shahinaz M. Gadalla, Robert Peter Gale, Siddhartha Ganguly, Shahrukh K. Hashmi, Peiman Hematti, Gerhard Hildebrandt, Leona A. Holmberg, Oscar B. Lahoud, Heather Landau, Hillard M. Lazarus, Marcos De Lima, Vikram Mathews, Richard Maziarz, Taiga Nishihori, Maxim Norkin, Richard Olsson, Ran Reshef, Seth Rotz, Bipin Savani, Harry C. Schouten, Sachiko Seo, Baldeep M. Wirk, Jean Yared, Shin Mineishi, John Rogosheske, Miguel-Angel Perales

Manuscripts, Articles, Book Chapters and Other Papers

Data are limited on whether to adjust high-dose chemotherapy before autologous hematopoietic cell transplant (autoHCT) in obese patients. This study explores the effects of dose adjustment on the outcomes of obese patients, defined as body mass index (BMI) ≥ 30 kg/m2. Dose adjustment was defined as a reduction in standard dosing ≥20%, based on ideal, reported dosing and actual weights. We included 2 groups of US patients who had received autoHCT between 2008 and 2014. Specifically, we included patients with multiple myeloma (MM, n = 1696) treated with high-dose melphalan and patients with Hodgkin or non-Hodgkin lymphomas (n = 781) …

Prevalence Of Bacteremia And Bacterial Meningitis In Febrile Neonates And Infants In The Second Month Of Life: A Systematic Review And Meta-Analysis., Eric A. Biondi, Brian R. Lee, Shawn L. Ralston, Jared M. Winikor, Justin F. Lynn, Angela Dixon, Russell Mcculloh

Manuscripts, Articles, Book Chapters and Other Papers

Importance: Febrile neonates (persons in the first month of life) are believed to be at higher risk for bacteremia or bacterial meningitis than infants in their second month of life. However, the true prevalence is unclear.

Objective: To determine modern rates of bacteremia and bacterial meningitis in febrile neonates and infants in the second month of life presenting to an ambulatory setting.

Data Sources: A comprehensive, no-limit search was conducted in PubMed using previously published search terms in February 2015 and repeated in September 2016.

Study Selection: Abstracts and full texts were reviewed independently by several investigators. Studies were included …

Neutralizing Antibody Against Enterovirus D68 In Children And Adults Before 2014 Outbreak, Kansas City, Missouri, Usa, Christopher J. Harrison, William C. Weldon, Barbara A. Pahud, Mary Anne Jackson, M. Steven Oberste, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

© 2019, Centers for Disease Control and Prevention (CDC). All rights reserved. We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012-2013. Neutralizing antibodies against Fermon and the dominant 2014 Missouri isolate were universally detected. Titers increased with age. Widespread circulation of enterovirus D68 occurred before the 2014 outbreak. Research is needed to determine a surrogate of protection.