Medicine and Health Sciences Commons^™

Primary Prevention Of Cardiovascular Diseases In Uzbekistan, E. R. Urazaliyeva, A. K. Ermatova, D. Y. Ramanova

Central Asian Problems of Modern Science and Education

Every year, an estimated 17 million people globally die of cardiovascular diseases (CVD), particularly heart attacks and strokes. CVDs occur almost equally in men and women. Although heart attacks and strokes are major killers in all parts of the world, 80% of premature deaths from these causes could be avoided by controlling the main risk factors: tobacco, unhealthy diet and physical inactivity. By 2015, the total number of cardiovascular disease (CVD) deaths (mainly coronary heart disease, stroke, and rheumatic heart disease) had increased globally to 17.5 million from 14.4 million in 1990.

Cognitive Impairment In Patients With Parkinson‘S Disease, N. A. Mansurova

Central Asian Problems of Modern Science and Education

The article presents the data of our studies on cognitive impairment in patients with Parkinson's disease (PD): their characteristics and risk factors, features of clinical manifestations

Mammary Tumor And Mastectomy Synergistically Promote Neuroinflammation In A Breast Cancer Survivor Model, Kathryn M. Emmer, William H. Walker Ii, Ning Zhang, A. Courtney Devries

Clinical and Translational Science Institute

Understanding why breast cancer survivors are at an increased risk for cognitive and affective disorders is essential for developing targeted treatment plans and improving quality of life. Microglia priming results in chronic neuroinflammation and can contribute to neuronal degeneration and dysfunction, thereby offering a potential mechanism for altered brain function that persists after tumor removal. This study examined whether mammary tumors alter microglia and augment the inflammatory profile and behavior of mice. To test this, non-metastatic mammary tumor cells (67NR) were injected orthotopically into the mammary glands of BALB/c mice, allowed to grow for 16 days, and then the tumors …

Aortoduodenal Fistula Forms From Primary Aortic Stump Graft In A Two-Time Multi-Visceral Transplant Patient With Presentation Of Gastrointestinal Bleed And Bowel Perforation: A Case Report, Brielle Corrente

Graduate Student Research Symposium

Usually not diagnosed until open laparotomy, aortoduodenalfistulas (ADF) are one of the rarest complications of intestinal transplant surgery. With an incidence rate of only 0.04% at autopsy and only 250 documented cases since the early 1800’s, aortoduodenal fistulas are the most deadly complications of intestinal transplantation with a mortality rate of 100% without surgical intervention. A 39 year old, two-time multi-visceral transplant African American female patient suffered from a primary aortoduodenal fistula formation in a primary modified multi-visceral transplant aortic stump graft site. With emergency open laparotomy repair, revascularization of the secondary multi-visceral transplant was performed, saving the life of …

A Cleaner, Crispr Constitution: Germline Editing And Fundamental Rights, Andrew Cunningham

William & Mary Bill of Rights Journal

No abstract provided.

Ms211: Readme File About Herb Berhstock, Armin Weinberg

Works on Radiation Effects: 1990-2020

This contains information and links to some material about Herb Behrstock who was the UN representative to our project in Kazakhstan and the special UN mission that I participated in. See more at Armin Weinberg, PhD Papers and its finding aid.

The Association Between Blood Pressure And Body Mass Index In School Aged Children, Dana Zahran

Research Horizons Day Posters

No abstract provided.

Evaluation Of Stress Resources In School Age Children By Fifth And Sixth Grade Teachers., Crystal Stephenson

Research Horizons Day Posters

No abstract provided.

Program Coordinators’ Experiences With Introducing Parent-Focused Health Lessons To A Child-Centered Micronutrient Supplementation Program: An Exploration Of Recent Programmatic Changes In Liahona Children’S Foundation, Shannon Barham

Undergraduate Honors Theses

This paper utilizes survey responses from local coordinators of LCF, an international micronutrient supplementation humanitarian organization, to provide insight into the challenges and personal rewards of providing nutrition education to parents of malnourished children. LCF is based in Utah and operates in 19 countries throughout the world. LCF recently introduced a series of health lessons geared toward parents of malnourished children. A survey was sent to LCF workers in 12 countries in order to gather feedback about the health lessons. Qualitative survey responses are explored, and potential suggestions for future changes to the health lessons are proposed. Additionally, data gathered …

Meeting Point: Partner Dancing As Couple's Therapy, Rami Eckhaus

Expressive Therapies Dissertations

This dissertation research explored the experience of partner dancing as a therapeutic process that reflects upon the dynamics and interactions of couples who are in the process of couple's therapy. The research also aimed to gain insight on the ways in which the experience of partner dancing can support these couples' therapeutic processes. Partner dancing is a dance-form that is based on the interaction between two individuals. Such interaction requires the dancing couples to communicate on many levels that may uncover layers of their relational dynamics. In this research, five couples who were undergoing couple's therapy were asked to participate …

Optimization Of Clinical Decision Support Tools For The Care Of Older Adults With Diabetes Mellitus Type Ii, Dorothy Alford

Research Horizons Day Posters

No abstract provided.

Efficacy Of Leukemia Inhibitory Factor As A Therapeutic For Permanent Large Vessel Stroke Differs Among Aged Male And Female Rats, Stephanie M. Davis, Lisa A. Collier, Sarah J. Goodwin, Douglas E. Lukins, David K. Powell, Keith R. Pennypacker

Neurology Faculty Publications

Preclinical studies using rodent models of stroke have had difficulty in translating their results to human patients. One possible factor behind this inability is the lack of studies utilizing aged rodents of both sexes. Previously, this lab showed that leukemia inhibitory factor (LIF) promoted recovery after stroke through antioxidant enzyme upregulation. This study examined whether LIF promotes neuroprotection in aged rats of both sexes. LIF did not reduce tissue damage in aged animals, but LIF-treated female rats showed partial motor skill recovery. The LIF receptor (LIFR) showed membrane localization in young male and aged rats of both sexes after stroke. …

An Analysis Of The Developmental Enrichment Of The Seattle Children's Playgarden, Caitlin Koob

Honors Theses

This paper analyzes the opportunities for developmental enrichment, as provided by the Seattle Children’s PlayGarden, from the perspective of occupational therapy. The PlayGarden, located in Seattle, Washington, is an inclusive playground, preschool, and summer camp that promotes inclusion of children with disabilities. The analysis highlights each area of occupation, as identified in the Occupational Therapy Practice Framework, and discusses the garden’s contribution to facilitate growth in those specific skills (American Occupational Therapy Association [AOTA], 2014). The intentionality of the design and program structure advocates for children to maximize their independence in activities of daily living, despite the play-based approach. …

A265 Lymphocytic Esophagitis: A Single Tertiary Center’S Experience With This Emerging Clinical Entity., C Shams, M Co, M Cappell

Conference Presentation Abstracts

Background: Various disorders can produce esophagitis. Lymphocytic esophagitis (LE) has emerged as another clinical entity responsible for esophagitis symptoms. Although increasingly reported pathologically, the clinical characteristics of LE have not been well characterized. Aims: The present study extends the clinicopathologic characterization of LE by comprehensive analysis of 30 affected patients and identifies specific clinical presentations significantly associated with LE. Methods: Thirty patients were identified from January 2000-December 2016 that satisfied diagnostic criteria for LE by lower esophageal biopsy; (1) high concentration of intraepithelial lymphocytes and (2) few granulocytes (ratio of lymphocytes:granulocytes >50:1). Controls, selected from patients undergoing esophagogastroduodenoscopy (EGD) during …

Exploring A Connection Between Learning And Student Perception Of Place, Katelyn Roberts

Honors Theses

The quality of the physical environment is understood to impact overall health, wellbeing, and capacity to learn and engage in daily life. This pilot study explores how students in the Speech Language and Hearing Sciences program at Western Michigan University view the effects of indoor and outdoor nature spaces at the College of Health and Human Services on the East Campus of Western Michigan University on their learning experience. Results of the study suggest that there are significant relationships between the participant’s perception of interesting qualities in the College of Health and Human Services and feeling a sense of connection …

The Use Of Nature As A Treatment Modality In Occupational Therapy, Lauren Koch

Honors Theses

Nature is inherently therapeutic. Applying the principles of occupational therapy within the natural environment integrates the physical, mental, and socio-emotional health benefits afforded by nature into therapeutic intervention practices. The nature centered context of the outdoors addresses performance skills and patterns, highlighting its use as a therapeutic modality. As such, nature may be used as an effective treatment modality in the practice of occupational therapy due to the benefits that it affords. The incorporation of nature into therapeutic intervention may be based upon the environmental factors, available resources, and function of the natural environment. The goal of this literature review …

Induction Of Ampk Activation By N,N'-Diarylurea Fnd-4b Decreases Growth And Increases Apoptosis In Triple Negative And Estrogen-Receptor Positive Breast Cancers, Jeremy Johnson, Piotr G. Rychahou, Vitaliy M. Sviripa, Heidi L. Weiss, Chunming Liu, David S. Watt, B. Mark Evers

Markey Cancer Center Faculty Publications

Purpose

Triple negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer. AMP-activated protein kinase (AMPK) is a major energy regulator that suppresses tumor growth, and 1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea (FND-4b) is a novel AMPK activator that inhibits growth and induces apoptosis in colon cancer. The purpose of this project was to test the effects of FND-4b on AMPK activation, proliferation, and apoptosis in breast cancer with a particular emphasis on TNBC.

Materials and methods

(i) Estrogen-receptor positive breast cancer (ER+BC; MCF-7, and T-47D), TNBC (MDA-MB-231 and HCC-1806), and breast cancer stem cells were treated with FND-4b for 24h. …

Isolated Bicuspid Pulmonic Valve: “Forgotten Valve” And A Rare Anomaly, Ghulam Akbar Md, Fnu Vikram Md, Lohit Garg Md, Larry E. Jacobs Md, Matthew W. Martinez Md

Department of Medicine

No abstract provided.

Traumatic Tricuspid Regurgitation: When To Operate, Ghulam Akbar Md, Lohit Garg Md, Syed Rafay Ali Sabzwari, Fnu Vikram Md, Raman Dusaj Md

Department of Medicine

No abstract provided.

Yielding To The Necessities Of A Great Public Industry: Denial And Concealment Of The Harmful Health Effects Of Coal Mining, Caitlyn Greene, Patrick Charles Mcginley

William & Mary Environmental Law and Policy Review

In the mid-nineteenth century, coal mined in Central Appalachia began to flow into industrial markets. Those mines and the coal they produced provided jobs, put food on family tables in coalfield households, and even provided housing for hundreds of thousands of coal miners and their families. The bounty from America’s expanding coalfields fueled the Industrial Revolution and powered the nation’s steel mills, factories,steamboats, and railroads. It powered America’s defense through two World Wars and later military conflicts. Coal-fired power plants generated more than half of the electricity used in the United States in the latter quarter of the twentieth century. …

The Myth Of "It's All In Your Head"

DePaul Magazine

Researchers at DePaul's Center for Community Research are mapping the brain to uncover the causes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Psychologist Leonard Jason has been carrying out community-based epidemiology prevalence studies that show that about one million Americans, many of them from ethnic minorities, are afflicted with the condition.

Association Of Slco1b1 *14 Allele With Poor Response To Methotrexate In Juvenile Idiopathic Arthritis Patients, Laura B. Ramsey, Halima Moncrieffe, Chelsey Smith, Marc Sudman, Miranda C. Marion, Carl D. Langefeld, Mara L. Becker, Susan D. Thompson

Manuscripts, Articles, Book Chapters and Other Papers

Objective: Variants in the SLCO1B1 gene, encoding a hepatic methotrexate (MTX) transporter, affect clearance of high-dose MTX. We tested whether in the *14 and *15 alleles of SLCO1B1 influenced the response to low-dose MTX in juvenile idiopathic arthritis (JIA) patients.

Methods: The study included 310 JIA patients genotyped for three single nucleotide polymorphisms (SNPs) in SLCO1B1 (rs4149056, rs2306283, and rs11045819). A patient's SLCO1B1 diplotype was determined by combining the SNPs into the *1a, *1b, *4, *5, *14, and *15 alleles. Number of active joints at follow-up (visit closest to 6 months of treatment and prior …

Hematological Profile And Gametocyte Carriage In Malaria Patients From Southern Pakistan, Najia Karim Ghanchi, Mohammad Hassaan Khan, Muhammad Abdullah Arain, Mustafa Bin Ali Zubairi, Ahmed Raheem Buksh, Muhammad A. Khan, Mohammad A. Beg

Department of Pathology and Laboratory Medicine

Background: Malarial infection is a major cause of concern, both worldwide and in Pakistan. Gametocytes are the sexual forms of the parasite that are essential for transmission. They fuse inside the mosquito to develop sporozoites. Gametocytes of the plasmodium parasites, which cause the infection, differentiate into male and female gametocytes. These gametocytes constitute the sexual stage of the malaria parasite and are essential in transmission of the disease from human to vector Anopheles. Gametocytes are affected by factors such as host immunity, drug treatment, reticulocytemia, anemia, low levels of asexual parasitemia and stress to the parasite. The aim of this …

Does Family Communication Matter? Exploring Knowledge Of Breast Cancer Genetics In Cancer Families, Deborah Himes, Sarah H. Davis, Jane Lassetter Phd, Rn, Neil E. Peterson, Margaret F. Clayton, Wendy C. Birmingham, Anita Y. Kinney

Faculty Publications

Purpose: Knowledge of breast cancer genetics is critical for those at increased hereditary risk who must make decisions about breast cancer screening options. This descriptive study explored theory-based relationships among cognitive and emotional variables related to knowledge of breast cancer genetics in cancer families. Methods: Participants included first-degree relatives of women with breast cancer who had received genetic counseling and testing. Study participants themselves did not have breast cancer and had not received genetic counseling or testing. Data were collected by telephone interviews and surveys. Variables analyzed included numeracy, health literacy, cancer-related distress, age, education, and the reported amount of …

Identification Of Coordinately Regulated Microrna-Gene Networks That Differ In Baboons Discordant For Ldl-Cholesterol, Genesio M. Karere, Jeremy P. Glenn, Shifra Birnbaum, Roy Garcia, Jane F. Vandeberg, Laura A. Cox

School of Medicine Publications

Rationale

Plasma low-density lipoprotein cholesterol (plasma LDL-C), vascular endothelial cells and peripheral blood mononuclear cells (PBMCs), particularly monocytes, play key roles in initiating atherosclerosis, the primary cause of cardiovascular disease (CVD). Although the mechanisms underlying development of atherosclerosis are not well understood, LDL-C is known to influence expression of endothelial microRNAs (miRNAs) and gene-targets of miRNAs to promote cell senescence. However, the impact of LDL-C on expression of PBMC miRNAs and miRNA targeted genes in response to an atherogenic diet is not known. In this study, we used unbiased methods to identify coordinately responsive PBMC miRNA- gene networks that differ …

Empiric Antibiotic Use For Infectious Conjunctivitis Provides Little Clinical Benefit, Matthew M. Rolain

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Rose PW, Harnden A, Brueggemann AB, et al. Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet. 2005;366(9479):37-43. doi: 10.1016/S0140-6736(05)66709-8.

Bisphosphonates Can Be Safely Given To Patients With Hypercalcemia And Renal Insufficiency Secondary To Multiple Myeloma, Matthew J. Miller

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Itou K, Fukuyama T, Sasabuchi Y, et al. Safety and efficacy of oral rehydration therapy until 2 h before surgery: a multicenter randomized controlled trial. Journal of Anesthesia. 2012;26(1):20-27. doi: 10.1007/s00540-011-1261-x.

Social Inequity Is A Life And Death Situation For Our Patients, Stephanie Clough, Mira Hamame, Elizabeth Bavers

Clinical Research in Practice: The Journal of Team Hippocrates

Advocating for change in the economic structure of health care in the United States is a moral imperative.

Nurse Practitioner And Pharmacist Collaboration In Rural Congregate Housing Facility, Kendra Babcock Pharmd

Theses and Dissertations

A Certified Nurse Practitioner (CNP) expanded her clinical services to include a project called Senior Transitions (ST). The CNP visited assisted living facilities in the area and conducted rounds on each of the facility’s patients participating in the ST program. The CNP had collaborated with pharmacists in her prior practice setting and wanted to continue doing so in her new practice setting. A pharmacy resident was assigned to participate in co-visits with the CNP at a local assisted-living facility and consulted on any medication-related questions regarding long-term care facility patients which were followed by the practitioner. While conducting co-visits and …

Safety And Efficacy Of Very High Dose Furosemide Continuous Infusions, Jessica Wilczynski, Pharmd, Matthew Decaro, Md, Facc, Facp, Gregary Marhefka, Md, Facc, Facp, Brandi Thoma, Pharmd, Bcps, Bccp, Susan Varghese, Pharmd, Bcps, Ryan Watson, Md, Ilya Danelich, Pharmd, Bcps, Bccp

Division of Cardiology Posters

• Fluid overload is treated with loop diuretics in patients with heart failure and in patients with acute kidney injury1,2
• There are sparse data regarding use of very high dose continuous loop diuretic infusions. In some studies, very high doses were only used in outlying patients (maximum160 mg/hour)3, 4
• The use of very high dose furosemide continuous infusions at Thomas Jefferson University Hospital is a rare practice. These infusions range in dose from 40-240 mg/hour, with no limitation on the duration
• The purpose of this study is to examine the efficacy and safety of very high dose furosemide continuous infusions