Medicine and Health Sciences Commons^™

The Oculocardiac Reflex And Depth Of Anesthesia Measured By Brain Wave., Robert W Arnold, Aleah N Bond, Melissa Mccall, Leif Lunoe

Articles, Abstracts, and Reports

BACKGROUND: The oculocardiac reflex (OCR), bradycardia that occurs during strabismus surgery is a type of trigemino-cardiac reflex (TCR) is blocked by anticholinergics and enhanced by opioids and dexmedetomidine. Two recent studies suggest that deeper inhalational anesthesia monitored by BIS protects against OCR; we wondered if our data correlated similarly.

METHODS: In an ongoing, prospective study of OCR/TCR elicited by 10-s, 200 g square-wave traction on extraocular muscles (EOM) from 2009 to 2013, anesthetic depth was estimated in cohorts using either BIS or Narcotrend monitors. The depth of anesthesia was deliberately varied between first and second EOM tested.

RESULTS: From 1992 …

A Case Of Overlooked Popliteal Artery Entrapment Syndrome., Lisa Saa, Peter K Firouzbakht, Mohammad Otahbachi

Articles, Abstracts, and Reports

Popliteal artery entrapment syndrome (PAES) is an uncommon cause of lower extremity claudication that is often overlooked. It most commonly occurs in young athletes without risk factors for peripheral vascular disease. We present a case of a 47-year-old man who went undiagnosed for over 10 years despite multiple orthopedic, chiropractic, and neurosurgery consults. A definitive diagnosis of PAES was confirmed in the catheterization lab by angiography. The patient underwent popliteal artery bypass surgery and his symptoms completely resolved. PAES must be considered in the differential diagnosis of lower extremity pain, especially in younger patients.

Roche Ramps Up Huntington’S Disease Clinical Trial For Early-To Mid-Stage Patients, Considers Ways To Expand Research, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Outcomes Of Catheter Ablation For Atrial Fibrillation In Patients With Hypertrophic Cardiomyopathy, Lohit Garg Md, Syed Rafay Ali Sabzwari Md, Ghulam Akbar Md, Hiwot Ayele Md, Sahil Agrawal Md, Manyoo Agarwal Md, Jeffrey Gordon, Raman Dusaj Md, Talha Nazir Md, Babak Bozorgnia Md, Matthew W. Martinez Md

Department of Medicine

No abstract provided.

Dissecting Features Of Epigenetic Variants Underlying Cardiometabolic Risk Using Full-Resolution Epigenome Profiling In Regulatory Elements., Fiona Allum, Åsa K. Hedman, Xiaojian Shao, Warren A. Cheung, Jinchu Vijay, Frédéric Guénard, Tony Kwan, Marie-Michelle Simon, Bing Ge, Cristiano Moura, Elodie Boulier, Lars Rönnblom, Sasha Bernatsky, Mark Lathrop, Mark I. Mccarthy, Panos Deloukas, André Tchernof, T Pastinen, Marie-Claude Vohl, Elin Grundberg

Manuscripts, Articles, Book Chapters and Other Papers

Sparse profiling of CpG methylation in blood by microarrays has identified epigenetic links to common diseases. Here we apply methylC-capture sequencing (MCC-Seq) in a clinical population of ~200 adipose tissue and matched blood samples (Ntotal~400), providing high-resolution methylation profiling (>1.3 M CpGs) at regulatory elements. We link methylation to cardiometabolic risk through associations to circulating plasma lipid levels and identify lipid-associated CpGs with unique localization patterns in regulatory elements. We show distinct features of tissue-specific versus tissue-independent lipid-linked regulatory regions by contrasting with parallel assessments in ~800 independent adipose tissue and blood samples from the general population. We follow-up …

Pancreatitis, Diabetes And Alcohol Intake: The Interrelationship And Effects On The Human Body, Crystal Marx

Nursing Capstones

No abstract provided.

Vapor Delivery Of Plant Essential Oils Alters Pyrethroid Efficacy And Detoxification Enzyme Activity In Mosquitoes, Scott T. O'Neal, Ellis J. Johnson, Leslie Catherine Rault, Troy D. Anderson

Department of Entomology: Faculty Publications

The use of synthetic insecticides to limit the spread of mosquito-borne disease faces a number of significant challenges, including insecticide resistance, concerns related to the environmental impact of widespread insecticide use, as well as slowed development of new insecticide chemistries. One important alternative to broadcast insecticides is the use of personal protection strategies to limit contact with vector species, including the use of spatial repellents that can employ synthetic pyrethroids or botanical products to effect control. A currently underexplored area of research involves the investigation of botanical products for their potential to serve as insecticide synergists when delivered as a …

“What I Hadn’T Realized Is How Difficult It Is, You Know?”: Examining The Protective Factors And Barriers To Breastfeeding In The Uk, Cheyenne R. Wagi

USF Tampa Graduate Theses and Dissertations

The international recommendation for breastfeeding is that a baby should be exclusively breastfed for six months. Breastfeeding should be continued for up to two years and beyond with complementary foods (WHO, 2016). The United Kingdom exhibits some of the lowest breastfeeding rates in the world (HSCIC, 2012). The percentage of mothers who breastfed in the United Kingdom falls below 34% at six months, with only 1% of mothers breastfeeding exclusively at this point (HSCIC, 2012:31). This study sought to examine the protective factors and barriers for breastfeeding in the UK. Mums (n=28), their partners (n=6), and facilitators at breastfeeding support …

Cucurbitacin D Reprograms Glucose Metabolic Network In Prostate Cancer, Mohammed Sikander, Shabnam Malik, Neeraj Chauhan, Parvez Khan, Sonam Kumari, Vivek Kumar Kashyap, Sheema Khan, Aditya Ganju, Fathi T. Halaweish, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc D) effectively inhibits glucose uptake and lactate production in metastatic PrCa cells via modulating glucose metabolism. This metabolic shift by Cuc D was correlated with decreased expression of GLUT1 by its direct binding as suggested by its proficient molecular docking (binding energy -8.5 kcal/mol). Cuc D treatment also …

Immunology And Immunotherapeutics Php/Bps 415, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Dysphagia Practice Patterns Of Virginia Speech-Language Pathologists, Molly Kathleen Dailey

Theses & Honors Papers

Currently, there are a variety of screening tools, clinical, and instrumental assessments used by speech-language pathologists (SLPs) to diagnose dysphagia and plan for treatment. Anecdotal reports and empirical evidence suggest that dysphagia assessment and treatment practice patterns vary considerably across patient populations, work settings, and clinicians. Understanding the SLP assessment and treatment practices across settings and factors that may influence their decisions will help inform future directions in dysphagia education, training, and clinical practice components. These findings will enable the provision of quality care that will ultimately lead to positive patient health outcomes. Thus, this survey study was designed to …

Prefrontal Corticotropin-Releasing Factor (Crf) Neurons Act Locally To Modulate Frontostriatal Cognition And Circuit Function., Sofiya Hupalo, Andrea J Martin, Rebecca K Green, David M Devilbiss, Craig W Berridge

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The PFC and extended frontostriatal circuitry support higher cognitive processes that guide goal-directed behavior. PFC-dependent cognitive dysfunction is a core feature of multiple psychiatric disorders. Unfortunately, a major limiting factor in the development of treatments for PFC cognitive dysfunction is our limited understanding of the neural mechanisms underlying PFC-dependent cognition. We recently demonstrated that activation of corticotropin-releasing factor (CRF) receptors in the caudal dorsomedial PFC (dmPFC) impairs higher cognitive function, as measured in a working memory task. Currently, there remains much unknown about CRF-dependent regulation of cognition, including the source of CRF for cognition-modulating receptors and the output pathways modulated …

Vascular Risk Reduction In Type Ii Diabetes Mellitus: Addition Of A Fibrate To A Statin, Angela Halvorson

Nursing Capstones

No abstract provided.

A Woman With A Lung Infiltrate And Brain Abscesses: Case Discussion From The University Of Louisville Hospital, Veronica Corcino, Viswanathan Nagarajan, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Vaping Is An Urgent Threat To Public Health, Elliott M. Reichardt, Julie R. Guichon

Sociology & Anthropology Faculty publications

No abstract provided.

The Deadly Influenza Virus And Its Changing Forms, Kayce Boggess

D.U.Quark

The influenza virus has plagued humans for centuries. Recently antiviral medications, which shorten the duration of the flu, have been introduced into society. These medications along with vaccinations, which try to give the body immunity before the virus strikes, help to stop the flu before it attacks the host. The virus, however, replicates using host cells and can slightly change itself with each replication, which over time could lead to a strain immune to the current antiviral medication and vaccines. However, using more preventative measures could help slow the changing strains of the flu virus. Using vaccines to stop the …

Combined Congenic Mapping And Nuclease-Based Gene Targeting For Studying Allele-Specific Effects Of Tnfrsf9 Within The Idd9.3 Autoimmune Diabetes Locus., Matthew H Forsberg, Bardees Foda, David V. Serreze, Yi-Guang Chen

Faculty Research 2019

Rodent complex trait genetic studies involving a cross between two inbred strains are usually followed by congenic mapping to refine the loci responsible for the phenotype. However, progressing from a chromosomal region to the actual causal gene remains challenging because multiple polymorphic genes are often closely linked. The goal of this study was to develop a strategy that allows candidate gene testing by allele-specific expression without prior knowledge of the credible causal variant. Tnfrsf9 (encoding CD137) is a candidate gene for the Idd9.3 type 1 diabetes (T1D) susceptibility locus in the nonobese diabetic (NOD) mouse model. A C57BL/10Sn (B10)-derived diabetes …

02-05-19 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Exercises For Older Adults With Knee And Hip Pain, Neil E. Peterson, Kay D. Osterloh, M. Nichole Graff

Faculty Publications

Half of all older adults report knee and/or hip pain. Obesity and sedentary lifestyle contribute to the incidence and prevalence of painful knee and hip conditions. Weight loss should be a priority in overweight or obese patients. Improving joint function over time requires a balance of rest and usage. Practitioners should assess joint disorders and recommend exercises for reducing knee and hip pain with patients when appropriate. Instruction should include a combination of 1) stretching and flexibility, 2) strength training, and 3) endurance conditioning exercises. Even small improvements in exercise can make meaningful improvements in pain, movement, endurance, and quality …

The Infuence Of The Host Microbiome On 3,4- Methylenedioxymethamphetamine (Mdma)-Induced Hyperthermia And Vice Versa, Emily A. Ridge, Sudhan Pachhain, Sayantan Roy Choudhury, Sara R. Bodnar, Ray A. Larsen, Vipaporn Phuntumart, Jon E. Sprague

Forensic Science Faculty Publications

Hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) can be life-threatening. Here, we investigate the role of the gut microbiome and TGR5 bile acid receptors in MDMA-mediated hyperthermia. Fourteen days prior to treatment with MDMA, male Sprague-Dawley rats were provided water or water treated with antibiotics. Animals that had received antibiotics displayed a reduction in gut bacteria and an attenuated hyperthermic response to MDMA. MDMA treated animals showed increased uncoupling protein 1 (UCP1)and TGR5 expression levels in brown adipose tissue and skeletal muscle while increased expression of UCP3 was observed only in skeletal muscle. Antibiotics prior to MDMA administration significantly blunted …

Association Of Cohort And Individual Substance Use With Risk Of Transitioning To Drug Use, Drug Use Disorder, And Remission From Disorder: Findings From The World Mental Health Surveys, Louisa Degenhardt, Chrianna Bharat, Meyer D. Glantz, Nancy A. Sampson, Ali Al-Hamzawi, Jordi Alonso, Laura H. Andrade, Brendan Bunting, Alfredo Cia, Giovanni De Girolamo, Peter De Jonge, Koen Demyttenaere, Oye Gureje, Josep Maria Haro, Meredith G. Harris, Yanling He, Hristo Hinkoy, Aimee Nasser Karam, Elie G. Karam, Andrzej Kiejna, Viviane Kovess-Masfety, Victor Lasebikan, Sing Lee, Daphna Levinson, Maria Elena Medina-Mora, Zeina Mneimneh, Fernando Navarro-Mateu, Marina Piazza, Jose Posada-Villa, Kate Scott, Dan J. Stein, Hisateru Tachimori, Nathan L. Tintle, Yolanda Torres, Ronald C. Kessler

Faculty Work Comprehensive List

Importance: Limited empirical research has examined the extent to which cohort-level prevalence of substance use is associated with the onset of drug use and transitioning into greater involvement with drug use.

Objective: To use cross-national data to examine time-space variation in cohort-level drug use to assess its associations with onset and transitions across stages of drug use, abuse, dependence, and remission.

Design, Setting, and Participants: The World Health Organization World Mental Health Surveys carried out cross-sectional general population surveys in 25 countries using a consistent research protocol and assessment instrument. Adults from representative household samples were interviewed face-to-face in the …

Racial Disparities In A State Based Workers' Compensation System, Caroline Kristine Smith

Dissertations and Theses

Racial, ethnic, and linguistic minority workers suffer higher rates of work-related injuries and illnesses in the United States compared to their White counterparts. Explanations for these higher rates include potential socioeconomic causes (education, income, and wealth) and occupational segregation into more dangerous occupations. What is less studied are the post-injury sequelae for minority workers, which is their experiences in the workers' compensation system, as well as their health and return to paid employment. What is known comes primarily from qualitative literature, which includes themes of racial discrimination (from employers, health care providers, and workers' compensation employees), a lack of information …

Can Assisted Reproductive Technologies Help Conserve 300 Million Years Of Evolution? A First Attempt At Developing These Technologies For Male Reptiles, Sean M. Perry

LSU Doctoral Dissertations

Biodiversity loss is the most critical environmental problem threatening ecosystem, animal, and human health today. Increases in extinction rates have been observed over the past 50 years, with reptile losses occurring twelve times faster than traditional extinction rates. This demonstrated biodiversity loss is secondary to climate change, habitat destruction, infectious disease, invasive species, poaching, and unsustainable trade. Approximately 20% of all reptiles are threatened with extinction and population declines are approaching rates similar to the current amphibian extinction crisis. Preventing the extinction of reptiles will require humans to acknowledge these losses and develop plans to preserve these evolutionary sentinel species. …

Elevated Tsh And Obesity: Cause Or Consequence?, Ashley Rose

Nursing Capstones

No abstract provided.

Lewy Body Dementia Association's Research Centers Of Excellence Program: Inaugural Meeting Proceedings., Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. Mckeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly, John Duda, Stephen Gomperts, Neill Graff-Radford, Samantha Holden, Lawrence Honig, Daniel Huddleston, Carol Lippa, Irene Litvan, Carol Manning, Karen Marder, Charbel Moussa, Chiadi Onyike, Fernando Pagan, Alexander Pantelyat, Victoria Pelak, Kathleen Poston, Joseph Quinn, Irene Richard, Liana S. Rosenthal, Marwan Sabbagh, Douglas Scharre, Sharon Sha, Holly Shill, Yasar Torres-Yaghi, Tina Christie, Todd Graham, Ian Richards, Mike Koehler, Brad Boeve

Department of Neurology Faculty Papers

The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator's meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), and to create a clinical trials-ready network. Four working groups (WG) were created to pursue the LBDA RCOE aims: (1) increase access to high-quality clinical care, (2) increase access to support for people living with LBD and their caregivers, (3) increase knowledge of LBD among medical and allied (or …

Rotating Shifts Vs. Fixed Schedules, Sara Vallett, Ba, Bsn, Rn, Dilek Reisoglu, Bs, Bsn, Rn

College of Nursing Posters

Purpose

• This EBP project seeks to examine the literature and nurses’ perceptions related to rotating shifts, especially the impact of quick returns on nurses and possible solutions.
• Nurses struggle to manage rotating shifts with quick turnaround between shifts. Quick returns defined as returning to work a different shift within 24 hrs

PICO question: What effect does rotating shifts with (quick returns) have on clinical nurses?

Adult Vaccination Rates In The Mentally Ill Population: An Outpatient Improvement Project, Leslie W. Miles, Nathalia Williams, Karlen Beth Luthy, Lacey Eden

Faculty Publications

Background: Adults who suffer with severe and persistent mental illness (SPMI) rarely access medical care to receive preventive vaccines. Aims: To increase the rate of vaccines among the SPMI population in an outpatient community mental health center (CMHC). Methods: A review of the literature identified a gap between the general population and SPMI clients in receiving preventive vaccinations. An initial mixed-method convenience survey of SPMI clients (n = 392) provided information on current vaccination status, demographics, beliefs, and interest in receiving vaccines. A vaccination program was developed to address identified barriers and increase vaccination rates. Postintervention data were collected …

Employment Opportunities And Experiences Among Recent Master’S-Level Global Health Graduates, William Cherniak, Elahe Nizami, Quentin Eichbaum, Jessica Evert, Ashti Doobay-Persaud, Sharon Rudy, Ginny Defrank, Tom Hall, Adam Hoverman

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objectives: To examine the job search, employment experiences, and job availability of recent global health-focused master’s level graduates. Methods: An online survey was conducted from October to December 2016 based out of Washington, DC. The study sample includes students graduating with master’s degrees in global health, public health with a global health concentration or global medicine from eight U.S. universities. Results: Out of 256 potential respondents, 152 (59%) completed the survey, with 102/152 (67%) employed. Of unemployed graduates, 38% were currently in another educational training program. Out of 91 employed respondents, 62 (68%) reported they had limitations or gaps in …

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Save the Date for graduating acute and primary care nurse practitioner students in the School of Nursing poster presentation

Breaking The Transportation Barrier: Enhancing Access To Cancer Treatment Through Technology And Philanthropy, Rebecca Cammy, Msw, Lcsw, Jodi Sandos, Msw, Lcsw, Stephanie Chapman, Bs

Department of Medical Oncology Posters

Cancer patients face many obstacles and challenges after being diagnosed with cancer. Thomas Jefferson University Hospitals’ Sidney Kimmel Cancer Center (SKCC) has effectively eliminated transportation as a barrier to care for patients receiving cancer treatments such as chemotherapy and radiation. SKCC dedicates a full-time patient navigator to assess and connect patients with appropriate transportation resources based on location, insurance coverage, and mobility. The utilization of patient-focused transportation platforms, such as Uber Health, RoundTrip, and Ride Health have streamlined the process, while SKCC philanthropic funds have assisted with associated financial costs. As a result of these resources, oncology patients who would …