Medicine and Health Sciences Commons^™

Longitudinal Coaching Within A Medical School Curriculum, Amy B. Smith Phd, Kira K. Zwygart Md

Department of Education

No abstract provided.

Overall Survival By Clinical Risk Category For High Dose Interleukin-2 (Hd Il-2) Treated Patients With Metastatic Renal Cell Cancer (Mrcc): Data From The Proclaim, M Fishman, J P Dutcher, J I Clark, A Alva, G P Miletello, B Curti, Neeraj Agarwal, R Hauke, K M Mahoney, H Moon, J Treisman, S S Tykodi, G Daniels, M A Morse, M K K Wong, H Kaufman, N Gregory, D F Mcdermott

Articles, Abstracts, and Reports

BACKGROUND: Prognostic scoring systems are used to estimate the risk of mortality from metastatic renal cell carcinoma (mRCC). Outcomes from different therapies may vary within each risk group. These survival algorithms have been applied to assess outcomes in patients receiving T-cell checkpoint inhibitory immunotherapy and tyrosine kinase inhibitor therapy, but have not been applied extensively to patients receiving high dose interleukin-2 (HD IL-2) immunotherapy.

METHODS: Survival of 810 mRCC patients treated from 2006 to 2017 with high dose IL-2 (aldesleukin) and enrolled in the PROCLAIM

RESULTS: Among the 810 patients, 721 were treatment-naïve (89%) and 59% were intermediate risk. Overall, …

Genomic Inversions And Golga Core Duplicons Underlie Disease Instability At The 15q25 Locus., Flavia A M Maggiolini, Stuart Cantsilieris, Pietro D'Addabbo, Michele Manganelli, Bradley P Coe, Beth L Dumont, Ashley D Sanders, Andy Wing Chun Pang, Mitchell R Vollger, Orazio Palumbo, Pietro Palumbo, Maria Accadia, Massimo Carella, Evan E Eichler, Francesca Antonacci

Faculty Research 2019

Human chromosome 15q25 is involved in several disease-associated structural rearrangements, including microdeletions and chromosomal markers with inverted duplications. Using comparative fluorescence in situ hybridization, strand-sequencing, single-molecule, real-time sequencing and Bionano optical mapping analyses, we investigated the organization of the 15q25 region in human and nonhuman primates. We found that two independent inversions occurred in this region after the fission event that gave rise to phylogenetic chromosomes XIV and XV in humans and great apes. One of these inversions is still polymorphic in the human population today and may confer differential susceptibility to 15q25 microdeletions and inverted duplications. The inversion breakpoints …

Single-Molecule Real-Time (Smrt) Full-Length Rna-Sequencing Reveals Novel And Distinct Mrna Isoforms In Human Bone Marrow Cell Subpopulations., Anne Deslattesmays, Marcel Schmidt, Garrett Graham, Elizabeth Tseng, Primo Baybayan, Robert Sebra, Miloslav Sanda, Jean-Baptiste Mazarati, Anna Riegel, Anton Wellstein

Faculty Research 2019

Hematopoietic cells are continuously replenished from progenitor cells that reside in the bone marrow. To evaluate molecular changes during this process, we analyzed the transcriptomes of freshly harvested human bone marrow progenitor (lineage-negative) and differentiated (lineage-positive) cells by single-molecule real-time (SMRT) full-length RNA-sequencing. This analysis revealed a ~5-fold higher number of transcript isoforms than previously detected and showed a distinct composition of individual transcript isoforms characteristic for bone marrow subpopulations. A detailed analysis of messenger RNA (mRNA) isoforms transcribed from the ANXA1 and EEF1A1 loci confirmed their distinct composition. The expression of proteins predicted from the transcriptome analysis was evaluated …

Ecological Determinants Of Respiratory Health: Examining Associations Between Asthma Emergency Department Visits, Diesel Particulate Matter, And Public Parks And Open Space In Los Angeles, California, Jason A. Douglas, Reginald S. Archer, Serena E. Alexander

Health Sciences and Kinesiology Faculty Articles

Los Angeles County (LAC) low-income communities of color experience uneven asthma rates, evidenced by asthma emergency department visits (AEDV). This has partly been attributed to inequitable exposure to diesel particulate matter (DPM). Promisingly, public parks and open space (PPOS) contribute to DPM mitigation. However, low-income communities of color with limited access to PPOS may be deprived of associated public health benefits. Therefore, this novel study investigates the AEDV, DPM, PPOS nexus to address this public health dilemma and inform public policy in at-risk communities. Optimized Hotspot Analysis was used to examine geographic clustering of AEDVs, DPM, and PPOS at the …

Effect Of Intermittent Fasting In Patients With Type 2 Diabetes, Paul Reynolds

Nursing Capstones

No abstract provided.

A Methodology For Rapid Deployment Of Shared Cohort Discovery System With Integrated Ehr To Enable Federated Health Data Governance, Muhammad Asim Khan

Theses and Dissertations

This dissertation is an effort to address the Information Quality (IQ) issues in the federated healthcare networks. As the Electronic health records (EHR) systems technology evolves, the importance of data sharing in federated research has increased. However time consuming and technical difficulties in deploying federated data networks, along with the issue of disparate EHR systems in use of data federating entities aggravate the IQ challenges. Healthcare data mapping across federated database schemas and consistent clinical criteria for phenotype identification requires better data governance in the federated data networks. This research provides the methodology for the rapid deployment of Federated Healthcare …

Six-Month Outcome Of Transient Ischemic Attack And Its Mimics, Alireza Sadighi, Vida Abedi, Alia C. Stanciu, Nada El Andary, Mihai Banciu, Neil Holland, Ramin Zand

Faculty Journal Articles

Background and Objective: Although the risk of recurrent cerebral ischemia is higher after a transient ischemic attack (TIA), there is limited data on the outcome of TIA mimics. The goal of this study is to compare the 6-month outcome of patients with negative and positive diffusion-weighted imaging (DWI) TIAs (DWI-neg TIA vs. DWI-pos TIA) and also TIA mimics.

Methods: We prospectively studied consecutive patients with an initial diagnosis of TIA in our tertiary stroke centers in a 2-year period. Every included patient had an initial magnetic resonance (MR) with DWI and one-, three-, and six-month follow-up visits. The primary outcome …

The Use Of Aerosolized Ribavirin In Respiratory Syncytial Virus Lower Respiratory Tract Infections In Adult Immunocompromised Patients: A Systematic Review, Lisa M. Avery, Charles Hoffmann, Karen M. Whalen

Pharmacy Faculty/Staff Publications

Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug costs remain a challenge for patient management. The purpose of this systematic review is to summarize the efficacy and adverse event profile of RBV AER for the treatment of hospitalized RSV LRTI in immunocompromised adult patients. Methods: A Medline/PubMed, Embase, Google Scholar, Clinicaltrials.gov, and Cochrane Library database search was conducted from 1966 to January 2019 for the use of RBV AER. Search strategy: [(ribavirin OR ICN1229) AND …

Sport Participation And Specialization Characteristics Among Pediatric Soccer Athletes, Tamara Valovich Mcleod, Michael Israel, Melissa A. Christino, Jane S. Chung, Scott D. Mckay, Pamela J. Lang, David R. Bell, Charles M. Chan, Allison Crepeau, Elizabeth Davis, Amanda L. Fletcher, Jessica Laniak, Kelsie Mccaffrey, Donna M. Pacicca, Mark Riederer, Katherine Rizzone, Jeremy K. Rush, Tracy Zaslow

Manuscripts, Articles, Book Chapters and Other Papers

© The Author(s) 2019.

Background: Soccer is an increasingly popular sport for children and adolescents in the United States. Little is known about participation patterns related to sport specialization.

Purpose: To investigate soccer participation levels and sport specialization characteristics among youth soccer athletes.

Study Design: Cross-sectional study. Methods: Adolescent athletes aged between 12 and 18 years completed an online survey addressing participant demographics, sports and soccer participation history, and level of specialization. Descriptive analyses characterized participation, while chi-square and Kruskal-Wallis tests assessed the influence of specialization, sex, and grade on survey variables.

Results: Overall, 83.7% of 746 respondents participated in …

Glycine Supplementation Extends Lifespan Of Male And Female Mice, Richard A. Miller, David E. Harrison, C. Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G. Ryazanov, Jessica Snyder, Timothy M. Stearns, Douglas E. Vaughan, Randy Strong

Publications and Research

Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%–6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycinesupplemented females were lighter than controls, but there was no effect on weight in males. End‐of‐life necropsies suggested that glycine‐treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine‐supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI‐1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late‐life diseases.

Kinase Suppressor Of Ras 1 And Exo70 Promote Fatty Acid-Stimulated Neurotensin Secretion Through Erk1/2 Signaling, Stephanie Rock, Xian Li, Jun Song, Courtney M. Townsend, Heidi L. Weiss, Piotr G. Rychahou, Tianyan Gao, Jing Li, B. Mark Evers

Markey Cancer Center Faculty Publications

Neurotensin is a peptide hormone released from enteroendocrine cells in the small intestine in response to fat ingestion. Although the mechanisms regulating neurotensin secretion are still incompletely understood, our recent findings implicate a role for extracellular signal–regulated kinase 1 and 2 as positive regulators of free fatty acid-stimulated neurotensin secretion. Previous studies have shown that kinase suppressor of Ras 1 acts as a molecular scaffold of the Raf/MEK/extracellular signal–regulated kinase 1 and 2 kinase cascade and regulates intensity and duration of extracellular signal–regulated kinase 1 and 2 signaling. Here, we demonstrate that inhibition of kinase suppressor of Ras 1 attenuates …

Effects Of Altered Gravity On The Central Nervous System Of Drosophila Melanogaster, Amber M. Paul, Siddhita Mhatre, Janani Iyer, Jhony A. Zavaleta, Ravikumar Hosamani

Publications

A comprehensive understanding of the effects of spaceflight and altered gravity on human physiology is necessary for continued human space exploration and long-term space habitation. Spaceflight includes multiple factors such as microgravity, hyper gravity, ionizing radiation, physiological stress, and disrupted circadian rhythms and these have been shown to contribute to pathophysiological responses that target immunity, bone and muscle integrity, cardiovascular and nervous systems. In terrestrial conditions, some of these factors can lead to cancer and neuroimmunological disorders. In this study, we used a well-established spaceflight model organism, Drosophila melanogaster, to assess spaceflight-associated changes in the nervous system. We hypothesize that …

The Validity Of Microblogs As A Source For Idiopathic Pulmonary Fibrosis Patient-Reported Outcomes, Kim Tran

Theses and Dissertations

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease which affects an estimated five million patients worldwide. Characterized by progressive respiratory failure and a median patient survival time of three to five years, this disease affects 150,000 patients in the United States (US) and results in 40,000 deaths annually. While the US mortality rate for IPF is similar to breast cancer, idiopathic pulmonary fibrosis remains characterized as a rare disease. Lack of awareness and information for lesser known diseases such as IPF can affect factors ranging from proper diagnosis to the advancement of the drug development pipeline. One platform which …

The Role Of Inhibition Of Apoptosis In Acute Leukemias And Myelodysplastic Syndrome., Amanda Mcbride, Sarah Houtmann, Lindsay Wilde, Carlos Vigil, Christine M. Eischen, Margaret Kasner, Neil Palmisiano

Department of Medical Oncology Faculty Papers

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.

Oxytocin Receptor Gene (Oxtr) And Father Support Interact To Predict Depressive Symptoms Postpartum, Parambir Bhatti, Taylor Delaney, Michael Poulin, Jennifer Hahn-Holbrook

Psychology Faculty Articles and Research

Postpartum depression (PPD) is a debilitating mental illness affecting approximately 13% of mothers after birth. Both genetic and psychosocial factors contribute to PPD risk, but very little is known about how these factors interact. We tested whether the rs53576 polymorphism in the oxytocin receptor (OXTR) gene accounts for variation in the impact of low social support as a risk factor for depression among mothers during the perinatal period. New mothers (N = 220) provided saliva or blood DNA samples and completed surveys assessing PPD symptoms and perceived social support. In a significant interaction, social support from the …

Safety Oriented, Low-Cost Peritonsillar Abscess Needle Aspiration Model For Emergency Medicine Simulation, Anne Mai Bs, Julie A. Fritzges Do, Gavin C. Barr Jr. Md, Marna R. Greenberg Do, Mph, Facep, Smeet Bhimani Do

Department of Emergency Medicine

No abstract provided.

Effects Of External Memory Aid Assessment And Treatment On Everyday Task Performance Of Individuals With Mild Neurocognitive Disorder, Alyssa M. Lanzi

USF Tampa Graduate Theses and Dissertations

Individuals with mild neurocognitive disorder complete many activities of daily living independently; however, they may require the use of compensatory strategies while performing everyday tasks. Compensatory strategies, such as external memory aids, incorporate a strengths-based approach to enhance the functional needs of individuals. Although external memory aids have a strong evidence-base, limited assessment tools and interventions are available to facilitate the development of individualized treatment plans that promote sustained strategy use. To better support the everyday needs of individuals with mild neurocognitive disorder and to inform clinicians who are developing interventions, the current dissertation includes four paper that examine a …

Effects Of Implementing A Health Team Communication Redesign On Hospital Readmissions Within 30 Days, Kristi Opper, Joseph Beiler, Olga Yakusheva, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Background and Rationale

Poor communication between health team members can interfere with timely, coordinated preparation for hospital discharge. Research on daily bedside interprofessional health team rounds and nursing bedside shift handoff reports provides evidence that these strategies can improve communication.

Aims

To improve health team communication and collaboration about hospital discharge; improve patient experience of discharge measured by patient‐reported quality of discharge teaching, readiness for discharge, and postdischarge coping difficulty; and reduce readmissions and emergency department (ED) visits postdischarge.

Methods

A two‐sample pre‐ and postintervention design provided baseline data for redesign of health team communication processes and comparison data for …

Next-Generation Solutions For Indian Health Care: Strengthening The Impact Of Allied Health, Narasimman Swaminathan, Karen A. Grimmer, Steve Milanese

Internet Journal of Allied Health Sciences and Practice

The contributions of allied health professionals to patient care is well recognized in developed countries. In developed countries, allied health providers can reach the general public easily and cater to the health care needs of the society. However, medical dominance in developing countries often curtails the autonomy of allied health professionals. The Public Health Foundation of India prepared a report in 2012 on allied health professionals in India. This report explained the role of the AHP in improving the health status of the country. The objective of this commentary is to provide a possible opportunity for better integrating the allied …

Food Allergy In Youth, Stefanie Abrahams

Internet Journal of Allied Health Sciences and Practice

No abstract provided.

The Irresponsible Persons: The Imposition And Execution Of The Mandatory Treatment Measures On Criminal Procedure Of Kosovo, Mujë Ukaj

International Journal on Responsibility

According to the Code of Criminal Procedures of Kosovo, the treatment of irresponsible persons is carried out in a special criminal procedure only with regard to the determination of innocence, respectively irresponsibility and the imposition of compulsory psychiatric treatment, while the further treatment is transferred to the competent court for the abolition of legality action and then begins with the execution of the measure imposed on the psychiatric institution. In comparative criminal law, security measures are mainly part of the criminal sanction system, but there are also exceptions. The treatment of irresponsible persons in Kosovo's criminal legislation was built based …

Talking To Children About Their Terminal Disease And Ultimate Death, Alyssa Nesbitt

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Kreicbergs U, Valdimarsdóttir U, Onelöv E, Henter J, Steineck G. Talking about death with children who have severe malignant disease. New Eng J Med. 2004;351(12):1175-1186. doi: 10.1056/nejmoa040366.

Outcomes Of Robotic-Assisted Laparoscopic Prostatectomy Versus Open Prostatectomy In Surgical Intervention Of Localized Prostate Cancer, Hojun Lee, Brandon Ahlgren

Clinical Research in Practice: The Journal of Team Hippocrates

An informed consent conversation regarding robotic-assisted laparoscopic prostatectomy versus open prostatectomy in patients with localized prostate cancer.

Evidence Doesn’T Change Prescribing Patterns…So What Does?, Ali Rida, Anthony Brooks

Clinical Research in Practice: The Journal of Team Hippocrates

The authors write in support of critical analysis of clinical research, as a corrective to the physician's urge to "do something" even when no evidence of benefit exists.

Asking Before Accessing, Jennifer Baumert, Carly Hornig

Posters and Presentations: State of the Art Nursing Conference

No abstract provided.

Embracing Technology As The Extension Of Nursing Practice To Enhance The Patient Experience, Liz Raabe, Brandon Fleharty

Posters and Presentations: State of the Art Nursing Conference

No abstract provided.

Temporary Fracture Stabilization Device, Steven J. Lawrence

Orthopaedic Surgery and Sports Medicine Faculty Patents

A temporary fracture stabilization device includes a first intramedullary fixation rod, a second intramedullary fixation rod, a first extramedullary connector, a second extramedullary connector and a fastener. A field kit for temporary fracture stabilization is also disclosed.

Ethanolamine Regulates Cqsr Quorum-Sensing Signaling In Vibrio Cholerae, Samit Watve, Kelsey Barrasso, Sarah A. Jung, Kristen J. Davis, Lisa A. Hawver, Atul Khataokar, Ryan G. Palaganas, Matthew B. Neiditch, Lark Perez, Wai-Leung Ng

College of Science & Mathematics Departmental Research

The pathogen that causes cholera, Vibrio cholerae, uses the cell-cell communication process known as quorum sensing (QS) to regulate virulence factor production and biofilm formation in response to changes in population density and complexity. QS is mediated through the detection of extracellular chemical signals called autoinducers. Four histidine kinases, LuxPQ, CqsS, CqsR and VpsS, have been identified as receptors to activate the key QS regulator LuxO at low cell density. At high cell density, detection of autoinducers by these receptors leads to deactivation of LuxO, resulting in population-wide gene expression changes. While the cognate autoinducers that regulate the activity of …

Endovascular Coiling Versus Neurosurgical Clipping For Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, Syed Ijlal Ahmed, Gohar Javed, Syeda Beenish Bareeqa, Syeda Sana Samar, Ali Shah, Arwa Giani, Zainab Azam, Abeer Tasleem, Syed Hasham Humayun

Section of Neurosurgery

Background: Aneurysmal subarachnoid hemorrhage is a frequently devastating condition with a reported incidence of between 10 and 15 people per 100,000 in the United States. Currently, according to the best of our knowledge, there are not enough meta-analyses available in the medical literature of the last five years which compare the risks and benefits of endovascular coiling with neurosurgical clipping.
Methods: Twenty-two studies were selected out of the short-listed studies. The studies were selected on the basis of relevance to the topic, sample size, sampling technique, and randomization. Data were analyzed on Revman software.
Results: Mortality was found to be …