Medicine and Health Sciences Commons^™

Are Family Planning Vouchers Effective In Increasing Use, Improving Equity And Reaching The Underserved? An Evaluation Of A Voucher Program In Pakistan, Moazzam Ali, Syed Khurram Azmat, Hasan Bin Hamza, Md Mizanur Rahman, Waqas Hameed

Community Health Sciences

Background: Low modern contraceptive prevalence rate and high unmet need in Pakistan aggravates the vulnerabilities of unintended pregnancies and births contributing to maternal morbidity and mortality. This research aims to assess the effectiveness of a free, single-purpose voucher approach in increasing the uptake, use and better targeting of modern contraceptives among women from the lowest two wealth quintiles in rural and urban communities of Punjab province, Pakistan.
Methods: A quasi-interventional study with pre- and post-phases was implemented across an intervention (Chakwal) and a control district (Bhakkar) in Punjab province (August 2012-January 2015). To detect a 15% increase in modern contraceptive …

Utilization Of Youtube Videos To Grow Nurse Leader Competencies, Smita Glosson, Adrienne Hartgerink

College of Health Sciences Posters

Purpose: The purpose of this study is to determine the impact of viewing selected inspirational leadership YouTube videos on leadership competency and leader self-efficacy of nurse leaders, by evaluating the difference pre and post intervention. The long-term goal is to provide leadership and succession planning programs and alternative teaching modality to support nurse leader development. Significance: To provide another method to utilize in developing and enhancing future nurse leader competencies. Background: Nurse leaders have responsibility for large spans of control, driving quality metrics, improving financial performance, and operational efficiency. By 2020, it is predicted that 50% of nurse leaders will …

Factors That Influence Response Classifications In Chemotherapy Treated Patient-Derived Xenografts (Pdx)., Joan Malcolm, Timothy M Stearns, Susan Airhart, Joel H. Graber, Carol J Bult

Faculty Research 2019

In this study, we investigated the impact of initial tumor volume, rate of tumor growth, cohort size, study duration, and data analysis method on chemotherapy treatment response classifications in patient-derived xenografts (PDXs). The analyses were conducted on cisplatin treatment response data for 70 PDX models representing ten cancer types with up to 28-day study duration and cohort sizes of 3-10 tumor-bearing mice. The results demonstrated that a 21-day dosing study using a cohort size of eight was necessary to reliably detect responsive models (i.e., tumor volume ratio of treated animals to control between 0.1 and 0.42)-independent of analysis method. A …

Recommendations For Regulating The Environmental Risk Of Shedding For Gene Therapy And Oncolytic Viruses In Canada, Tania M. Bubela, Ron Boch, Sowmya Viswanathan

Office of the Provost

Canadian academic and industry stakeholders are concerned about the inclusion of "virus-like particles or sub-viral particles" in the definition of New Substances Notification Regulations for Organisms (NSNR(O)) which impacts clinical cell and gene therapy and commercialization. The requirement of an independent 120 days Environment and Climate Change Canada (ECCC) review preceding a Health Canada review on quality and environmental concerns places an additional burden on Sponsors submitting clinical trial applications (CTA) and/or New Drug Submissions (NDS). A workshop initiated by CellCAN and BIOTECanada with participants from Environment and Climate Change Canada, Health Canada, the Public Health Agency of Canada and …

Pharmacokinetics Of Ketamine At Dissociative Doses In An Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy., Edwin Lam, Ankit K. Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, Hitoshi Hirose

Department of Pharmacology and Experimental Therapeutics Faculty Papers

PURPOSE: First-line management of severe asthma exacerbations include the use of inhaled short-acting β-agonists, anticholinergics, and systemic corticosteroids. Continuous intravenous ketamine given at dissociative doses may be a pharmacologic option in patients who are intubated with life-threatening severe bronchospasm unresponsive to standard therapy. We describe the case of a 44-year-old man admitted to the intensive care unit for status asthmaticus requiring intubation and mechanical ventilation.

METHODS: The patient developed severe refractory hypercapnic respiratory failure necessitating additional respiratory support with veno-venous extracorporeal membrane oxygenation (ECMO) therapy. Ketamine treatment was initiated at 0.5 mg/kg/h continuous infusion on the day of admission for …

The Use Of An ‘Acclimatisation’ Heatwave Measure To Compare Temperature-Related Demand For Emergency Services In Australia, Botswana, Netherlands, Pakistan, And Usa, Naomi Van Der Linden, Thomas Longden, John R. Richards, Munawar Khursheed, Wilhelmina M. T. Goddijn, Michiel J. Van Veelen, Uzma R. Khan, M. Christien Van Der Linden

Department of Emergency Medicine

Background: Heatwaves have been linked to increased risk of mortality and morbidity and are projected to increase in frequency and intensity due to climate change. The current study uses emergency department (ED) data from Australia, Botswana, Netherlands, Pakistan, and the United States of America to evaluate the impact of heatwaves on ED attendances, admissions and mortality.
Methods: Routinely collected time series data were obtained from 18 hospitals. Two separate thresholds (≥4 and ≥7) of the acclimatisation excess heat index (EHIaccl) were used to define "hot days". Analyses included descriptive statistics, independent samples T-tests to determine differences in case mix between …

The Effects Of Bacterial Endotoxin Lps On Synaptic Transmission At The Neuromuscular Junction, Robin L. Cooper, Micaiah Mcnabb, Jeremy Nadolski

Biology Faculty Publications

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

Comparative Clinical Outcomes Between Direct Oral Anticoagulants And Warfarin Among Elderly Patients With Non-Valvular Atrial Fibrillation In The Cms Medicare Population, Alpesh Amin, Oluwaseyi Dina, Allison Keshishian, Amol Dhamane, Anagha Nadkarni, Eric Carda, Cristina Russ, Lisa Rosenblatt, Jack Mardekian, Huseyin Yuce, Christine L. Baker

Publications and Research

Atrial fibrillation (AF) prevalence increases with age; > 80% of US adults with AF are aged ≥ 65 years. Compare the risk of stroke/systemic embolism (SE), major bleeding (MB), net clinical outcome (NCO), and major adverse cardiac events (MACE) among elderly non-valvular AF (NVAF) Medicare patients prescribed direct oral anticoagulants (DOACs) vs warfarin. NVAF patients aged ≥ 65 years who initiated DOACs (apixaban, dabigatran, and rivaroxaban) or warfarin were selected from 01JAN2013-31DEC2015 in CMS Medicare data. Propensity score matching was used to balance DOAC and warfarin cohorts. Cox proportional hazards models estimated the risk of stroke/SE, MB, NCO, and MACE. 37,525 …

The Experience Of Non-Spousal Close Intimate Relationships For Women With Breast Cancer: A Journey Of Support, Erin Burke Dooley

Seton Hall University Dissertations and Theses (ETDs)

An estimated 331,530 women will be diagnosed with breast cancer in 2019 ("American Cancer Society," 2019, p. 10). The purpose of this qualitative, phenomenological, descriptive study was to explore the lived experience of non-spousal close/intimate relationships of women with breast cancer. There are very few studies in the literature examining relationships between women with cancer other than those of partner or spouse. This study’s participants consisted of six women, ages 32 to 68. Analysis of these data identified themes reflected along their breast cancer trajectory (1) The journey starts (2) Mid-journey passage, and (3) Journeys end/coming home, as well as …

Investigating The Values Of Guidance And Counseling In Eleganaboi, Augusto Da Costa, Agostinho Dos Santos Goncalves, Sebastiao Pereira, Paulo De Jesus Moreira

Jurnal Kajian Bimbingan dan Konseling

Eleganaboi was a traditional ceremony in Luro society which contained essential elements of local wisdom. This study aimed to investigating the values of guidance and counseling in Eleganaboi. To investigate the values of guidance and counseling, we use phenomenology qualitative descriptive method. To collect the data, we implemented observation and interview. The observations were carried out during a cultural ceremony in the Luro community. Furthermore, interview was conducted on four traditional leaders. Edicts and transcendental reduction were used to analyze data. The results show eleven fundamental values of guidance and counseling in Eleganaboi. Those values are: gratitude; genuine; humble; honest; …

Keefektifan Teknik Drama Segitiga Karpman Untuk Meningkatkan Keterampilan Empati Siswa Sekolah Menengah Pertama, Leny Latifah

Jurnal Kajian Bimbingan dan Konseling

Empathic skills encourage an individual to look into the problems more clearly and objectively. Without empathy, it is difficult to know what others are experiencing because it is not possible to feel and understand the conditions of others. The particular study aimed to determine the effectiveness of Karpman drama triangle technique to increase junior high school students’ empathy skill. The research subjects were six students of eighth grade in Sekolah Menengah Pertama Negeri 1 Turen, Malang. The particular research was Quasi-Experiment using the pretest and posttest design. The instruments were student empathy scale; experimental guidelines; and observation guidelines. The study …

Proteomic Alterations Of Hdl In Youth With Type 1 Diabetes And Their Associations With Glycemic Control: A Case-Control Study, Evgenia Gourgari, Junfeng Ma, Martin P. Playford, Nehal N. Mehta, Radoslav Goldman, Alan T. Remaley, Scott M. Gordon

Saha Cardiovascular Research Center Faculty Publications

Background: Patients with type 1 diabetes (T1DM) typically have normal or even elevated plasma high density lipoprotein (HDL) cholesterol concentrations; however, HDL protein composition can be altered without a change in cholesterol content. Alteration of the HDL proteome can result in dysfunctional HDL particles with reduced ability to protect against cardiovascular disease (CVD). The objective of this study was to compare the HDL proteomes of youth with T1DM and healthy controls (HC) and to evaluate the influence of glycemic control on HDL protein composition.

Methods: This was a cross-sectional case–control study. Blood samples were obtained from patients with T1DM and …

Duration Of Bisphosphonate Therapy For The Treatment Of Osteoporosis, Monica Schonteich

Nursing Capstones

No abstract provided.

Perbedaan Kinerja Guru Bimbingan Dan Konseling Dalam Menyelenggarakan Konseling Individual Ditinjau Dari Latar Belakang Pendidikan Dan Pengalaman Bekerja, Muya Barida, Alif Muarifah

Jurnal Kajian Bimbingan dan Konseling

The particular study aimed to determine the differences performance between school counselors in organizing individual counseling services in schools in terms of educational background and work experience. The research approach was descriptive survey through a descriptive comparative study design. The subjects were school counselor in Daerah Istimewa Yogyakarta, especially at Bantul Regency. The data analysis technique used two way ANOVA. Based on the statistical tests, the educational background and work experience did not significantly affect the performance of school counselors in providing individual counseling services in schools.

The Use Of Life Story Interventions Between Older Adult With Dementia And Caregivers: A State Of The Science, Katelyn Mater

Honors Theses

Objective

To synthesize the research findings of storytelling techniques in healthcare settings for adults 50 and older with a diagnosis of dementia.

Data Sources

Data was gathered using the databases CINAHL, Clinicalkey, Pubmed, OVID, Proquest, and Web of Science using the search terms “storytelling/story-telling” and “caregiver”. Articles chosen for this review ranged from 2003-2018.

Data Extraction

Inclusion criteria were: 1). primary research articles, 2). written in English 3). research focused on the use of story-telling between healthcare providers and 4). participants were adults 55 and older with a dementia diagnosis. A total of 9 studies have been selected for further …

Pengembangan Skala Keyakinan Irasional Dalam Penulisan Skripsi, Diniy Hidayatur Rahman

Jurnal Kajian Bimbingan dan Konseling

Previous studies have shown that irrational beliefs contribute significantly to the procrastination, including the thesis-writing procrastination. Unfortunately, there are no scales that specifically can measure the beliefs in the thesis writing context. Therefore, this study aimed to develop and validate a scale called the Skala Keyakinan Irasional dalam Penyusunan Skripsi (SKI-S). The scale was developed based on irrational belief construct proposed by Albert Ellis in the context of thesis writing. To achieve the aim, the study applied a research and development design involving four steps: (1) defining the construct; (2) developing the measurement model; (3) carrying out confirmatory factor analysis; …

Analisis Kebutuhan Bimbingan Pribadi Sosial Berbasis Context, Experience, And Reality (Cer) Untuk Meningkatkan Karakter Kebajikan Siswa Sekolah Menengah Pertama, Im Hambali

Jurnal Kajian Bimbingan dan Konseling

The general objective of the study is to describe the needs of junior high school counselor toward CER-based socio-personal guidance service in order to improve the virtue of junior high school students. During the conduct of the study, the researcher implemented the survey design in order to attain the description data. The results of the study show that the counselors need CER-based media for improving the virtue of the junior high school students. Therefore, the counselor should search, find, create and even design the CER-based service media.

Respiratory Infections And Risk For Development Of Narcolepsy: Analysis Of The Truven Health Marketscan Database (2008 To 2010) With Additional Assessment Of Incidence And Prevalence, Darren Scheer

USF Tampa Graduate Theses and Dissertations

Background and Significance: Narcolepsy is a chronic neurological disorder. These patients experience various psychiatric and physical comorbid diseases and mortality at an increased rate compared to the general population. Additionally, patients with narcolepsy experience approximately a doubling of various annual healthcare related facility visits, transactions, and costs comparatively. Narcolepsy with cataplexy is generally believed to be more prevalent than narcolepsy without cataplexy. However, incidence and prevalence estimates of narcolepsy (with or without cataplexy) vary widely with few large epidemiological studies conducted worldwide and none in the U.S evaluating these proportions in both children and adults utilizing a large health care …

Does The Theory Of Reasoned Action Inform The Willingness Of Individuals Undergoing Genetic Testing To Seek Disclosure Of Incidental Findings Related To The Risk For Alzheimer Disease?, Alisa M. Forrest

Theses & Dissertations

Background: In recent years, researchers have increasingly employed genetic testing as a means for understanding and treating diseases like Alzheimer disease, a common progressive disease affecting cognition and behavior. Genetic studies hold the potential for major breakthroughs in treatment of diseases like Alzheimer disease. However, with the increase in the use of genomewide association, microarray, and whole genome sequencing comes the potential for a greater number of incidental findings in genetic research—findings not central to the aim of a study but nonetheless informative about a participant’s health. Although many studies have documented the ethical implications around disclosure of such findings …

Genomics And Transcriptomics Approaches To Understanding Drug Resistance Mechanisms In The Malaria Parasite Plasmodium Falciparum, Justin Allan Gibbons

USF Tampa Graduate Theses and Dissertations

The malaria parasite Plasmodium falciparum is responsible for about 500,000 deaths a year and is evolving resistance to the front-line treatment of artemisinin-based combination therapy. Resistance is currently confined to South East Asia, however millions of lives will be at risk if resistance spreads to Africa. Understanding the mechanism of resistance to artemisinins would aid containment strategies to prevent the spread of artemisinin resistance. There is also an urgent need to accelerate drug discovery since drug resistance has already been documented to all existing antimalarials. Here, I report on our efforts to understand the function of the gene k13, the …

Blood-Based Molecular Biomarkers For Alzheimer's Disease, Henrik Zetterberg, Samantha C. Burnham

Research outputs 2014 to 2021

A major barrier to the effective conduct of clinical trials of new drug candidates against Alzheimer's disease (AD) and to identifying patients for receiving future disease-modifying treatments is the limited capacity of the current health system to find and diagnose patients with early AD pathology. This may be related in part to the limited capacity of the current health systems to select those people likely to have AD pathology in order to confirm the diagnosis with available cerebrospinal fluid and imaging biomarkers at memory clinics. In the current narrative review, we summarize the literature on candidate blood tests for AD …

Forgotten Children & Bonds That Heal: The Critical Nature Of Attachment, August Ashbaker

Lesley University Community of Scholars Day

Human attachment is one of the most critical factors in proper neurological and physiological development. Attachment is built through the mutuality of emotional impact, as well as the regular reception of physical touch. Infants and children who have been deprived of these vital necessities through the lacking initiatives of their caregivers—through neglect—display visible signs of its physiological, cognitive, emotional, and behavioral impact. Research has found neglect to be the highest risk factor for permanent damage to brain development in comparison to other forms of complex trauma (i.e. chronic caregiver interpersonal trauma in childhood); it is also the most prevalent …

Risk Factors For Vte In Orthopedic Surgery, Kellie Musick

Nurse Presentations

Describes a project to halt the rising incidence of venous thromboembolism in pediatric surgery patients and the underuse of sequential compression devices in the operating room.

Acquiring Blood Pressures On High Risk Sepsis Patients In The Ed, Mckenna Scharlau, Jacob Schneider

Nurse Presentations

Describes a project to improve use of the Sepsis Tool in the Emergency Department and to improve documentation of blood pressure measurements in high risk sepsis patients under three years of age.

Vte Risk Factors: Scd Education And Compliance, Kaly Hayden, Shari Gardner, Baleigh Haag, Alex Wofford

Nurse Presentations

Describes a project to increase the use of sequential compression devices in post-operative patients to prevent venous thromboembolism.

Minimizing Unplanned Extubations In The Intensive Care Nursery, Lindsay Barrosse, Blaire Collins, Cassidy Horton, Jodie Seitzer, Brittney Hunter, Jenny Mckee

Nurse Presentations

Describes a project to ensure compliance with a standardized process for endotracheal tube management in the intensive care nursery in order to reduce the number of unplanned extubations and their consequent adverse effects.

In The Pocket With Kangaroo Education, Brett Butler, Carly Creekmore, Skylar Suppes

Nurse Presentations

Describes a quality improvement project to deliver timely kangaroo care education that empowers parents.

Timely Interventions In Patients Developing Sepsis Within The Picu, Lindsey Bloom, Ashley Bramel, Kelsey Cumpton, Christopher Damrat, Emily Lingo, Grace Sexton, Breton Struble

Nurse Presentations

Describes a project to increase the number of sepsis interventions completed within one hour in the pediatric intensive care unit, and to improve the documentation (COW Cards) of rapid interventions.

Sepsis: Identification & Recognition, Shelbi Ethington, Lakisha Irwin, Jodi Cramer, Victoria Roell, Mindy Von Elling

Nurse Presentations

Describes educational interventions to increase confidence of pediatric nurses on a medical/surgical unit in their recognition and treatment of sepsis.

Pathological Changes In Microvascular Morphology, Density, Size And Responses Following Comorbid Cerebral Injury, Zareen Amtul, Jun Yang, Ting-Yim Lee, David F. Cechetto

Anatomy and Cell Biology Publications

Aberrations in brain microcirculation and the associated increase in blood-brain-barrier (BBB) permeability in addition to neuroinflammation and Aβ deposition observed in Alzheimer’s disease (AD) and ischemia have gained considerable attention recently. However, the role of microvascular homeostasis as a pathogenic substrate to disturbed microperfusion as well as an overlapping etiologic mechanism between AD and ischemia has not been thoroughly explored. In this study, we employ temporal histopathology of cerebral vasculature in a rat model of β-amyloid (Aβ) toxicity and endothelin-1 induced-ischemia (ET1) to investigate the panorama of cerebral pathology and the protein expression on d1, d7, and d28 post-injury. The …