Medicine and Health Sciences Commons^™

Beware Of Barbiturates: Coma And Hypothermia In A 94-Year-Old Woman Due To Combined Secobarbital And Pentobarbital Toxicity, Andrew L. Koons Do, Amy Wier Do, Kenneth D. Katz Md, Matthew D. Cook Do, Robert D. Cannon Do, Gillian A. Beauchamp Md, Ryan M. Surmaitis Do

Department of Emergency Medicine

No abstract provided.

Mechanistic Studies And Derivative Effects In 1, 3, 4- Oxadiazole Synthesis Via Cyclodehydration Reactions, Evan Huggins

Undergraduate Honors Thesis Projects

In the world of pharmaceutical synthesis, research to combat foreign pathogens is always necessary. Scientists have been exploring different methods in order to synthesize the most effective compounds in antibacterial, anticancer, anti-inflammatory, and many other treatments. A key component within these versatile compounds are 1,3,4-oxadiazoles. Current methods to synthesize these compounds are inefficient. This research seeks to improve oxadiazole synthesis; however, the mechanism of this reaction is unknown. The goal of this project was to study the mechanistic pathway in the discovered, one-pot cyclodehydration synthesis of 1,3,4-oxadiazoles. In the first part of this study, a diacylhydrazine intermediate was proposed. This …

The Promise Of Anti-Idiotype Revisited, Heinz Köhler, Anastas Pashov, Thomas Kieber-Emmons

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The promise of idiotype-based therapeutics has been disappointing forcing a new look at the concept and its potential to generate an effective approach for immunotherapy. Here, the idiotype network theory is revisited with regard to the development of efficacious anti-idiotype vaccines. The experience of polyclonal anti-Idiotype reagents in animal models as well as an understanding of the immune response in humans lends to the proposition that polyclonal anti-Idiotype vaccines will be more effective compared to monoclonal-based anti-Idiotype vaccines. This novel strategy can be adapted in Biotech-standard production of therapeutic antibodies.

Vague Hip Pain In A 9-Year Old Soccer Player, Paolo N. Balmaseda Md, Chelsea Evans Do

Department of Family Medicine

No abstract provided.

Therapeutic Effects Of Yoga On Thyroid Disorders, Shelly Mahowald

Nursing Capstones

No abstract provided.

Incorporation Of Egfr And Ron Receptors Into Nanodiscs, Cristina Flores-Cadengo

Biomedical Engineering ETDs

Understanding the structure-function relationship of membrane receptors is essential to comprehend the crosstalk between key signaling pathways. Aberrant trans-activation between receptors can lead to tumorigenesis. Two of these receptors known to be involved in cancer development are receptor tyrosine kinases (RTKs), RON (Recepteur d'Origine Nantais) and EGFR (Epidermal Growth Factor Receptor). There has been evidence of heterodimerization and crosstalk between these two receptors based on co-immunoprecipitation, however the structural requirements behind these interactions remain unknown. Structural studies could provide insights into these RTKs’ modes of dimerization and structure-function relationship. However, structural studies of full-length membrane proteins are often difficult due …

Steroid Receptor Coactivator-1 Modulates The Function Of Pomc Neurons And Energy Homeostasis, Yongjie Yang, Agatha A Van Der Klaauw, Liangru Zhu, Tessa M Cacciottolo, Yanlin He, Lukas K J Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M Keogh, Elana Henning, Matthew C Banton, Audrey E Hendricks, Elena G Bochukova, Vanisha Mistry, Katherine L Lawler, Lan Liao, Jianming Xu, Stephen O'Rahilly, Qingchun Tong, Uk10k Consortium, Inês Barroso, Bert W O'Malley, I Sadaf Farooqi, Yong Xu

Children’s Nutrition Research Center Staff Publications

Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function …

Value Of Otoacoustic Emissions Testing In Pre-School Hearing Screenings: A Literature Review, Paige Stabrawa, Scott E. Seeman Phd

AuD Capstone Projects - Communication Sciences and Disorders

Unidentified hearing loss in children can have a potential effect on their speech and language, educational, cognitive, and social development. The goal of early detection is to minimize the effects of hearing loss through the appropriate referral for diagnosis and treatment. Hearing screenings throughout the preschool and school-age years are vital for the detection of a late-onset, late identified, or acquired hearing loss. Three influential organizations known as The American Academy of Audiology (AAA), The American Speech- Language-Hearing Association (ASHA), and The National Center for Hearing Assessment and Management (NCHAM), have considered behavioral pure tone screening as the “gold standard”for …

Severe Anion Gap Metabolic Acidosis Associated With Initiation Of A Very Low-Carbohydrate Diet., Sijan Basnet, Niranjan Tachamo, Salik Nazir, Rashmi Dhital, Asad Jehangir, Anthony Donato

Reading Hospital Internal Medicine Residency

Low carbohydrate diets have been popularized as an effective solution for weight loss. Although rare, life-threatening anion gap metabolic acidosis has been reported in patients on these diets. We present a case of a 31-year-old man with atypical symptoms of chest pain and shortness of breath found to have severe metabolic acidosis after starting low carbohydrate diet for a week.

Influence Of Abnormal Potassium Levels On Mortality Among Hospitalized Heart Failure Patients In The Us: Data From National Inpatient Sample., Sijan Basnet, Rashmi Dhital, Biswaraj Tharu, Sushil Ghimire, Dilli Ram Poudel, Anthony Donato

Reading Hospital Internal Medicine Residency

Abnormalities in serum potassium levels have been associated with variable mortality risk among hospitalized patients with heart failure (HF). We aim to use a large database study to further characterize risk of mortality, demographic factors, and associated comorbidities among heart failure inpatients. Methods: Our sample population was from the US National Inpatient Sample database from the year 2009-2011. The inclusion criteria used to identify patients was those with a diagnosis of heart failure as per ICD-9 classification. Other demographic factors considered in data collection included income, and cardiac risk factors. Taking these factors into consideration, a univariate association of …

Stroke Risk Stratification In Atrial Fibrillation: A Review Of Common Risk Factors., Oreoluwa Oladiran, Ifeanyi Nwosu

Reading Hospital Internal Medicine Residency

Atrial Fibrillation (AF) has become a major global health concern being the most common sustained arrhythmia in clinical practice. Risk factors for AF include congestive heart failure, hypertension, increasing age and diabetes. Many of these factors also increase the risk for thromboembolism and ischemic stroke in AF patients. Great efforts have been made from the latter part of the 20

Aztreonam Lysine Inhalation Solution In Cystic Fibrosis., Claire Elson, Joel Mermis, Deepika Polineni, Christopher M. Oermann

Manuscripts, Articles, Book Chapters and Other Papers

Patients with cystic fibrosis (CF) develop pulmonary disease secondary to airway infection and dysregulated inflammation. Therapeutic innovations such as nebulized antimicrobial therapy targeting specific pathogens have resulted in improvements in quality of life and life expectancy. Aztreonam lysine for inhalation (AZLI) solution was initially approved to improve respiratory symptoms in CF patients with Pseudomonas aeruginosa (PA) in 2010 by the Food and Drug Administration. Since then, research broadening labeling and clinical application has been developed. In this review, we analyze published and ongoing research regarding AZLI therapy in CF. A search of the Cochrane Database of Systematic Reviews and the …

Increased Plasma Levels Of The Th2 Chemokine Ccl18 Associated With Low Cd4+ T Cell Counts In Hiv-1-Infected Patients With A Suppressed Viral Load, Prashant Malhotra, Patrick Haslett, Barbara Sherry, David H. Shepp, Paul Barber, Jonathan Abshier, Upal Roy, Helena Schmidtmayerova

Health & Biomedical Sciences Faculty Publications

The chemokine (C-C motif) chemokine ligand 18 (CCL18) is a structural homolog of CCL3 primarily produced by monocyte-derived cells with an M2 phenotype. Elevated levels of CCL18 have been observed in several diseases associated with malignancies and chronic inflammation. The role of CCL18 in Human Immunodeficiency Virus (HIV-1) infection remains unknown. We analyzed expression levels of T helper cell-mediated (TH2) chemokines CCL18, CCL17, and CCL22 by ELISA in plasma collected from HIV-1-infected and healthy donors. In HIV-1-infected individuals, plasma viral loads were monitored by NucliSense HIV-1 QT assay and T cell counts and expression of the activation marker CD38 were …

Esophageal Necrosis: A Rare Complication Of Diabetic Ketoacidosis – A Case Report, Ricky Buckshaw Do, Ethan S. Stern Do, Robert Andrews Md, Frederic Stelzer Md

Department of Medicine

No abstract provided.

The Emergence Of Population Health In Us Academic Medicine, Marc N. Gourevitch, Lesley H. Curtis, Maureen S. Durkin, Angela Fagerlin, Annetine C. Gelijns, Richard Platt, Belinda M. Reininger, Judith Wylie-Rosett, Katherine Jones, William M. Tierney

School of Medicine Publications

Importance In response to rapidly growing interest in population health, academic medical centers are launching department-level initiatives that focus on this evolving discipline. This trend, with its potential to extend the scope of academic medicine, has not been well characterized.

Objective To describe the emergence of departments of population health at academic medical centers in the United States, including shared areas of focus, opportunities, and challenges.

Design, Setting, and Participants This qualitative study was based on a structured in-person convening of a working group of chairs of population health–oriented departments on November 13 and 14, 2017, complemented by a survey …

The Food Literacy Action Logic Model: A Tertiary Education Sector Innovative Strategy To Support The Charitable Food Sectors Need For Food Literacy Training, Tanya Lawlis, Rosalind Sambell, Amanda Douglas-Watson, Sarah Belton, Amanda Devine

Research outputs 2014 to 2021

Food literacy is seen as a key component in improving the increasing levels of food insecurity. While responsibility for providing training falls on the charitable service organizations, they may not have the capacity to adequately reach those in need. This paper proposes a tertiary education - (university or higher education) led model to support the food literacy training needs of the food charity sector. A cross-sectional study comprised of online surveys and discussions investigated food services offered by Western Australia (WA) and Australian Capital Territory (ACT) agencies, food literacy training needs for staff, volunteers and clients, and challenges to delivering …

Social Vs. Practical Problems In Attaining A Colonoscopy: Different Patient Profiles?, Barbara A. Curbow, Evelyn C. King-Marshall, Nora Mueller, Travis Hyams, Shahnaz Sultan, Thomas J. George Jr

Journal of Health Disparities Research and Practice

Background: Colonoscopy is an effective procedure for identifying precancerous polyps and cancerous lesions, but it is unlike other cancer screening tools in that it requires sedation and thus assistance from at least one other individual. The intent of this paper was to identify logistical problems in completing the colonoscopy and to examine their relationships with sociodemographic characteristics.

Methods: All eligible patients (n = 2500) from two academic-affiliated colonoscopy centers (one free standing, one hospital-based) were invited to participate in an onsite, pre-colonoscopy survey; patients agreeing to participate (n = 1841, RR = 73.6%) received a $5.00 gift card. Multiple correspondence …

Prescription Medication Misuse Among American Indians In The Midwestern Us, Charley S. Lewis, Jordyn Gunville, Ryan Goeckner, Brian Chase, Lauren Clark, Jianghua He, Won S. Choi, Christine M. Daley

Journal of Health Disparities Research and Practice

Background: Prescription medications, particularly opioids, are often abused rather than used as intended by the prescribing physician. This is well-documented, though little data are available on American Indians. Misuse of other prescription medications is far less documented, but does occur and can have wide-spread effects.

Methods: We used a cross-sectional survey of American Indians in the Midwestern US (N=361) to begin to understand misuse of prescription medications, not necessarily to get high, but for any reason. Participants were recruited for this touchscreen computer-based survey at powwows, health fairs, and other community events through a convenience sample. We asked questions …

Cancer Risk Factors And Screening Behavior Among Korean Americans In The Sf Bay Area, Nhayoung Hwang, Hyunju Kim, Eugenia Yoo, Denny Cha, Winston Tseng Phd, Susan L. Ivey Md, Mhsa

Journal of Health Disparities Research and Practice

Background: Korean Americans (KA) have the highest prevalence of death from cancer among Asian American ethnic groups in the U.S. This KA prevalence rate is also substantially higher than that of non-Hispanic whites, yet little is known about their cancer risk factors. This paper is one of the first studies to explore cancer risk factors and screening behaviors of Korean Americans in the San Francisco Bay Area.

Methods: A survey instrument was created using items from the California Health Interview Survey (CHIS) from 2009-2012, which were translated into Korean. A cross-sectional survey assessing the prevalence of cancer risk factors and …

Restricted Access And Delays To Hcv Treatment Among Medicaid Patients In Louisiana, Morris M. Kim, Keanan M. Mcgonigle

Journal of Health Disparities Research and Practice

Background: Many people living with chronic Hepatitis C Virus (HCV) have seen delays in accessing treatment or been denied entirely due to Medicaid restrictions requiring patients to meet certain criteria prior to receiving approval for medication pre-authorization.

Methods: This study identified a cohort of Medicaid-insured patients with chronic HCV infection within New Orleans, LA. Patient medical records were reviewed and information regarding HCV care was gathered. This study sought to determine the degree to which HCV care was delayed for this population and describe common reasons for prior-authorization denials for direct-acting antiviral (DAA) medications.

Results: For this population of Medicaid-insured …

Examining The Impact Of Race And Rurality On Health Differences Among Overweight Youth Accessing Pediatric Endocrinology Care, Kelsee Halpin, Janelle R. Noel-Macdonnell, Yun Yan

Journal of Health Disparities Research and Practice

Methods: This study examines the impact of race and rurality on health differences, including prevalence of prediabetes and type 2 diabetes (T2D), among overweight children accessing pediatric endocrine specialty care. Cross-sectional analysis of overweight/obese youth 10 to 18 years of age receiving pediatric endocrinology consultation for weight gain, hyperglycemia, and/or T2D from 2013 to 2016 at a Midwest tertiary pediatric center.

Results: The 722 patients were 42% white, 25% black, 22% Hispanic; 88% lived in urban areas and 12% in rural areas. Rurality was determined using zip code approximation of Rural-Urban Commuting Area (RUCA) codes. After adjusting for confounders, black …

Nutrient And Food Group Intakes Of Low-Income Pregnant Women By Race/Ethnicity, Alla M. Hill, Danielle L. Nunnery Phd, Rdn, Ldn, Alice Ammerman Drph, Jigna M. Dharod Phd

Journal of Health Disparities Research and Practice

In an exploratory study, a convenience sample of 148 pregnant women was recruited from a WIC clinic in the southeast region of the U.S. to: 1) Examine and compare daily nutrient and food group intakes of WIC pregnant women to national guidelines, and; 2) Determine racial/ethnic differences in nutrient and food group intakes among WIC pregnant women. Women were selected for the study if they were: ≥ 18 y, in 2^nd trimester of pregnancy, and if they spoke English or Spanish as a first language. Upon recruitment, participants were interviewed to collect information on their socio-demographics, including race/ethnicity. Additionally, …

Utilization Of Media-Driven Technology For Health Promotion And Risk Reduction Among American Indian And Alaska Native Young Adults: An Exploratory Study, Todd M. Sabato

Journal of Health Disparities Research and Practice

Across the developmental spectrum, American Indian and Alaska Native (AI/AN) adolescents and young adults experience considerable behavioral and mental health disparities, including substance abuse, depression, and engagement in sexual behaviors which enhance risk of pregnancy and sexually transmitted infections. Health-focused interventions utilizing digital and media technology hold significant promise among tribal communities, as they have the capacity to eliminate geography-based barriers. Utilizing a sample of 210 self-identified AI/AN students attending tribal colleges, this study identified the most effective technologies and intervention strategies, as well as health seeking patterns and preferences, which may impact implementation and sustainable use in tribal settings. …

Five-Year Trend In Diabetes Clinical Care And Self-Management Among Adults With Diabetes In West Virginia: 2010-2014, Ranjita Misra 2934168, Usha Sambamoorthi

Journal of Health Disparities Research and Practice

Objective: To examine the five-year trend in clinical care and diabetes self-management activities among adults living in the Appalachian state of West Virginia.

Methods: This study used a cross-sectional design with data from the Behavioral Risk Factor Surveillance System in 2010 (N=685) and 2014 (N=958), among noninstitutionalized adults with diabetes. Five-year trend in recommended diabetes clinical care, diabetes self-management activities and diabetes education was analyzed after adjusting for sex, education, income, insurance, age, obesity, comorbid hypertension, race and lifestyle behaviors (exercise and smoking).

Results: A significant increase in percentage of adults with 2 or more A1C tests was …

Native American Weight Loss Movement: Pilot Test Of A Culturally Tailored Weight Loss Program For American Indians, Christine M. Daley, Jason W. Hale, Shelley Bointy, Kelly Berryhill, Joseph Lemaster, Byron J. Gajewski

Journal of Health Disparities Research and Practice

American Indians (AIs) have higher rates of obesity than other racial/ethnic groups, placing them at heightened risk for cardiovascular diseases, diabetes, and certain cancers. Culturally appropriate weight loss interventions may be the key to reducing risk. The most successful program used in AI communities has been the Diabetes Prevention Program (DPP), which limits enrollment to individuals with a clinical diagnosis of pre-diabetes. The purpose of this pilot project was to modify and culturally tailor a weight loss intervention to AI communities in Kansas to improve weight loss related behaviors among those who do not qualify for the DPP. The Native …

Drugs And Mental Health, Peyton Mcclellan

Show Your Stripes Research and Creative Showcase

My study focuses on drug abuse as it relates to mental health. One study was conducted where people were asked about all the prescribed medications they were on for a month or longer, and the correlation between mental health disorders and opioid use was much more direct for those who were on them for longer. Another study found that it became common for adolescents to self- medicate, and that these adolescents believed that they were curing their own mental health issues by doing so. In my study, I found several factors to contribute to this correlation.

The Efficacy Of Vision Training In Collegiate Baseball Hitting Performance, Connor Tupper

Celebration of Research

There has been a surge of research on vision training and its implications in a sports setting over the past decade. A large body of research is available on the implementation of ophthalmology-based vision training exercises for athletes and performance on a standardized task that tests eye-hand coordination through a sport-specific skill. However, there remains a gap in the literature on the implications of vision training for on-field performance. To help fill this gap, the present study examines the efficacy of a vision training on hitting performance through a pitching simulation that approaches game-like with the Northwestern College Varsity Baseball …

Efficacy Of Curos Caps In Infection Reduction, Betsy Bolt, Cherish Shuka, Kassidy De Jong, Megan Young

Celebration of Research

The current practice for accessing a central line or intravenous access point is by sterilizing the hub site manually with an alcohol swab. However, using an alcohol impregnated port protector cap is more effective at both sterilizing the site and reducing the incidence of bloodstream infections. The overall decrease in the incidence of infection shortens the length of hospital stay and lowers treatment costs. The purpose of this literature review is to help provide evidence to Spencer Hospital in Spencer, Iowa regarding the best standard of care for patients with central lines and intravenous access devices.

The Prevalence Of Lower Extremity Non-Contact Injuries In Athletic Populations In Relation To Measured Ankle Dorsiflexion, Logan Richard, Rick Loutsch, Zachary Riddle

Celebration of Research

Context: Ankle dorsiflexion is the degree to which the dorsal aspect of the foot can be brought closer in relation to the shin. Restricted ankle dorsiflexion can cause altered biomechanics and loading patterns, which can lead to injury from over-compensation in movement patterns. Limited ankle dorsiflexion alters frontal and sagittal plane biomechanics and has been hypothesized to contribute to common lower extremity injuries. The weight-bearing lunge test is a simple clinical evaluation test that can measure the range of ankle dorsiflexion. Objective: The purpose of this study was to determine if there was a correlation between restricted range of motion …

Compassion Fatigue, Abigail Wanninger, Courtney Riley, Karli Hofer, Maddie Swift

Celebration of Research

A literature review was conducted between the months of August 2018 and November 2018 to determine supportive measures that can be used to decrease the incidence of compassion fatigue in acute care rural nurses. Twelve articles were reviewed focusing on supportive measure to decrease compassion fatigue and measures to increase compassion satisfaction. The purpose of this literature review was to propose measures for the Spencer Hospital in Spencer, Iowa to implement in order to protect their nurses from compassion fatigue as well as to raise awareness of compassion fatigue among the nurses. Results showed that supportive measures such as meaningful …