Medicine and Health Sciences Commons^™

Sensory Primary Cilium Is A Responsive Camp Microdomain In Renal Epithelia, Rinzhin T. Sherpa, Ashraf M. Mohieldin, Rajasekharreddy Pala, Dagmar Wachten, Rennolds S. Ostrom, Surya M. Nauli

Pharmacy Faculty Articles and Research

Primary cilia are hair-like cellular extensions that sense microenvironmental signals surrounding cells. The role of adenylyl cyclases in ciliary function has been of interest because the product of adenylyl cyclase activity, cAMP, is relevant to cilia-related diseases. In the present study, we show that vasopressin receptor type-2 (V2R) is localized to cilia in kidney epithelial cells. Pharmacologic inhibition of V2R with tolvaptan increases ciliary length and mechanosensory function. Genetic knockdown of V2R, however, does not have any effect on ciliary length, although the effect of tolvaptan on ciliary length is dampened. Our study reveals that tolvaptan may have a cilia-specific …

Developing A Rubric To Assess Critical Thinking In A Multidisciplinary Context In Higher Education, Sadia Muzaffar Bhutta, Sahreen Chauhan, Syeda Kauser Ali, Raisa B. Gul, Shanaz Hussein Cassum, Tashmin Khamis

School of Nursing & Midwifery

Critical thinking (CT) is a generic attribute that is greatly valued across academic disciplines in higher education, and around the globe. It is also defined as one of the graduate attributes of higher education for the sample private university where this research was conducted, as it is perceived that CT helps the graduate to become ‘engaged citizens’ in the twenty-first century. Despite the well-documented importance of CT, its assessment remains a challenge. This study addresses this challenge through the systematic development and field-testing of a rubric for assessing critical thinking in a multidisciplinary context in higher education. A multidisciplinary group …

Local In Vivo Measures Of Muscle Lipid And Oxygen Consumption Change In Response To Combined Vitamin D Repletion And Aerobic Training In Older Adults, D. Travis Thomas, David M. Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu

Health and Clinical Sciences Faculty Publications

Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60–80 years with a BMI ranging from 18.5–34.9 and vitamin D status of ≤ 32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D₃) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks …

Support And Mentorship Of Diverse And Disadvantaged Nursing Students, Elle E. Hoselton

Nursing Capstones

No abstract provided.

Development And Evaluation Of A One-Step Multiplex Real-Time Taqman® Rt-Qpcr Assay For The Detection And Genotyping Of Equine G3 And G14 Rotaviruses In Fecal Samples, Mariano Carossino, Maria E. Barrandeguy, Erdal Erol, Yanqiu Li, Udeni B. R. Balasuriya

Veterinary Science Faculty Publications

Background: Equine rotavirus A (ERVA) is the leading cause of diarrhea in neonatal foals and has a negative impact on equine breeding enterprises worldwide. Among ERVA strains infecting foals, the genotypes G3P[12] and G14P[12] are the most prevalent, while infections by strains with other genomic arrangements are infrequent. The identification of circulating strains of ERVA is critical for diagnostic and surveillance purposes, as well as to understand their molecular epidemiology. Current genotyping methods available for ERVA and rotaviruses affecting other animal species rely on Sanger sequencing and are significantly time-consuming, costly and labor intensive. Here, we developed the first one-step …

Evaluating The Correlation Of Diabetes And Gallbladder Disease, Robbi A. Yellow

Nursing Capstones

No abstract provided.

A Practical Understanding Of Preeclampsia For A Nurse In A Third World Setting, Anna Lovin

Senior Honors Theses

Preeclampsia is a disease of pregnancy that affects approximately 3-5% of women with child. It is one of the primary causes of mortality in mothers and babies across the globe. The exact cause, pathogenesis, or disease progression is unknown. Therefore, there is no definition of which patients are at risk for developing preeclampsia and what can work as a preventative measure. In high socioeconomic settings where there is good healthcare, standard treatment is established to manage the symptoms and decrease the progression of preeclampsia to eclampsia. However, in more rural, third-world settings of developing countries, caring for patients with preeclampsia …

Anxiety Is Something To Worry About: The Effects Of A Cognitive Behavioral Therapy And Selective Serotonin Reuptake Inhibitor Intervention Protocol On Generalized Anxiety Disorder, Alesha E. Mcclanahan

Evidence-Based Practice Project Reports

Generalized anxiety disorder (GAD) is highly prevalent in the United States with at least 12% of the population affected (Edmund & Sheppard, 2018). GAD can pose significant distress and debilitation throughout the lifespan (Bystritsky, Khalsa, Cameron, & Schiffman, 2013; Edmund & Sheppard, 2018). Barriers to treatment include adverse effects, inaccessibility, and expense. The purpose of this project was to implement an evidence-based protocol involving combination therapy with self-administered cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitor (SSRI) medication in order to improve patient outcomes through more accessible, affordable, and standardized treatment of GAD. The Neuman Systems Model and Stetler …

Effects Of An Obstructive Sleep Apnea Screening Program On Providers' Adherence, Kelsie A. Tokarczyk

Evidence-Based Practice Project Reports

Obstructive sleep apnea (OSA) is a widely prevalent chronic disease estimated to affect 22 million Americans, with 80 percent of moderate to severe cases undiagnosed (American Sleep Apnea Association [ASAA], 2017). Unmanaged OSA has been associated with numerous detrimental health outcomes including hypertension, chronic heart failure, atrial fibrillation, stroke, and other cardiovascular conditions (ASAA, 2017). The purpose of this evidence-based practice project was to determine if the implementation of a screening protocol would affect providers’ adherence to screening for OSA. The Theory of Planned Change was used as a guide to optimize providers’ adherence to the protocol at a family …

Exploring The Experiences Of Communication Partners Of People With Parkinson's Disease: A Qualitative Study, Jacqueline Bell

Dissertations, Theses, and Projects

The purpose of this phenomenological qualitative study was to explore interactions between persons with Parkinson's disease (PD) and their communication partners. People with PD experience difficulties that can have a profound effect on their ability to communicate. This qualitative study explored the thoughts and feelings of primary communication partners of people with PD. The primary communication partners were interviewed using open-ended questions. The seven participants identified and detailed how declines in communication due to PD have resulted in changes in daily life, including; social participation, daily tasks, and psychosocial well-being. Commonalities that communication partners experienced will aid speech-language pathologists to …

Effects Of Stuttering Frequency, Speaking Rate And Treatment On Speech Naturalness In Adults Who Stutter, Emily Hausman

Honors Theses

Purpose: Individuals who stutter can often exhibit speech patterns that sound unnatural compared to individuals who do not stutter. Unnaturalness can be due to several underlying factors including the presence of stuttering itself and the unintended consequences of treatment approaches that alter speech motor patterns. Understanding factors that impact speech naturalness within the stuttering population can help improve the clinical management of the disorder. The current study investigates the relationship between pause duration, speech rate and stuttering frequency, and listener ratings of speech naturalness in a group of adults who stutter (AWS) before and after participation in a stuttering treatment …

Reliability Of Colour And Hardness Clinical Examinations In Detecting Dentine Caries Severity: A Systematic Review And Meta-Analysis., Larry Hon, Ahmed Mohamed, Edward Lynch

Dental Medicine Faculty Research

Dental caries is the most common human infectious disease and is caused by microorganisms producing acids, resulting in changes in dental tissue hardness and colour. However, the accuracy and reliability of dentine colour and hardness as indicators for carious lesion severity has never been assessed in a systematic review. By applying strict criteria, only seven papers (five randomized control trials and two diagnostic studies) were considered for full text qualitative and quantitative assessment. Only three studies produced high quality evidence and only four articles were considered for meta-analysis, as these provided log10 colony forming units (CFU) data from caries biopsies …

Nursing Students' Knowledge Of Alcohol - Interactive Medications, Andrew Coop

Honors Projects

In 2018, nearly 57% of American adults reported drinking alcohol in the past month, and 41.5% of current drinkers reported taking alcohol-interactive (AI) medications. Consuming alcohol and medications concurrently may result in adverse effects. The purpose of this study was to determine the effectiveness of a one-hour lecture about AI medications in a class of undergraduate nursing students (N = 48) at a small Midwestern university. The Jarvis Nursing Knowledge of Alcohol-Interactive Medications survey was distributed on August 27, 2018, and again on November 19, 2018. A significant increase was found between pretest and posttest on correct identification of …

Contribution Of Retrotransposons To Breast Cancer Malignancy, Isaac D. Raplee

USF Tampa Graduate Theses and Dissertations

The components contributing to cancer progression, especially the transition from early to invasive are unknown. Consequently, the biological reasons are unclear as to why some patients diagnosed with atypia and ductal carcinoma in situ (DCIS) never progress into invasive breast cancer. The “one gene at a time” approach does not sufficiently predict progression. To elucidate the early stage progression to invasive ductal cancer, expression signature of transcripts and transposable elements in micropunched samples of formalin-fixed, paraffin embedded (FFPE) tissue was conducted. A bioinformatics pipeline to analyze poor quality, short reads (>36 nts) from RNA-Seq data was created to compare …

Patients With Refractory Out-Of-Cardiac Arrest And Sustained Ventricular Fibrillation As Candidates For Extracorporeal Cardiopulmonary Resuscitation - Prospective Multi-Center Observational Study., Takahiro Nakashima, Teruo Noguchi, Yoshio Tahara, Kunihiro Nishimura, Soshiro Ogata, Satoshi Yasuda, Daisuke Onozuka, Naoto Morimura, Ken Nagao, David F. Gaieski, Yasufumi Asai, Hiroyuki Yokota, Satoshi Nara, Mamoru Hase, Takahiro Atsumi, Tetsuya Sakamoto

Department of Emergency Medicine Faculty Papers

BACKGROUND: We investigated whether patients with out-of-hospital cardiac arrest (OHCA) and sustained ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT) or conversion to pulseless electrical activity/asystole (PEA/asystole) benefit more from extracorporeal cardiopulmonary resuscitation (ECPR). Methods and Results: We analyzed data from the Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan, which was a prospective, multicenter, observational study with 22 institutions in the ECPR group and 17 institutions in the conventional CPR (CCPR) group. Patients were divided into 4 groups by cardiac rhythm and CPR group. The primary endpoint was favorable neurological outcome, defined as Cerebral Performance Category 1 …

Neural Indices Of Vowel Discrimination In Monolingual And Bilingual Infants And Children, Yan H. Yu, Carol Tessel, Henry Han, Luca Campanelli, Nancy Vidal, Jennifer Gerometta, Karen Garrido-Nag, Hia Datta, Valerie L. Shafer

Publications and Research

Objectives: To examine maturation of neural discriminative responses to an English vowel contrast from infancy to 4 years of age and to determine how biological factors (age and sex) and an experiential factor (amount of Spanish versus English input) modulate neural discrimination of speech.

Design: Event-related potential (ERP) mismatch responses (MMRs) were used as indices of discrimination of the American English vowels [ε] versus [I] in infants and children between 3 months and 47 months of age. A total of 168 longitudinal and cross-sectional data sets were collected from 98 children (Bilingual Spanish–English: 47 male and 31 female …

Overcoming The Overwhelming, Abigail Mae Riitano

Akesis

This piece was inspired by a CPC prompt that required reflection on where we feel we are currently as medical students and how it compares to our expectations before starting medical school. I believe this relates to the theme "always forward" as I reflected on my expectations and realized that I need to give my positive perspectives room to grow.

Not Now, Psoas., Kelly Mcguirl

Akesis

My psoas is always tight.

Sometimes I’m too intense.

My psoas reminds me with a collegial cramp.

Usually on my dominant side.

I notice, but push through, telling my psoas to shut the hell up, I’m busy.

When it’s quiet,

I notice and allow the guidance.

I soften and submit to a gentleness of mind and muscle.

The ease that comes is an honest breeze that carries me through.

A Home Death On Peaks Island, Chuck Radis

Akesis

I believe that those who die, particularly those like my patient Martha, can teach the living a great deal about “Always Forward.” All too often I find that the immediate family of the deceased becomes stuck in grief, unable to move beyond their loss. My patient Martha, by allowing her children to participate directly in bathing her after she passed was very wise in anticipating how powerful grief can be. She wanted the healing to take place even on the day she passed. And I have to think that her insistence that I come by the house the night she …

Preventive Health Service Use Among Rural Women, Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, Nathan Paluso Mph, Jaclyn Janis Bsn, Rn

Access / Insurance

Preventive health services and screenings are an important component in the continuum of care provided to individuals across all ages. Yet, research has shown that rural residents generally use fewer preventive health services and screenings. This study used the National Health Interview Survey to examine receipt of preventive health services (cholesterol check, fasting blood sugar test, mammogram, pap smear, and receipt of the HPV vaccine) by rural and urban women over the age of 18. Findings indicate that rural women were less likely than their urban peers to receive preventive health services, and that some of the differences may be …

The Effect Of Exercise On Postmenopausal Women With Osteoporosis, Mckenzie Brown

Nursing Capstones

No abstract provided.

Facile Fabrication Of Superhydrophobic And Superolephilic Materials For Effective Oil Absorbtion And Oil-Water Separation, Ali Tawfeeq Abdulhussein

Theses and Dissertations

Surfaces that have a water contact angle (WCA) above 150° and a negligible difference between the receding and advancing contact angles are superhydrophobic, meaning that a simple, minimal tilt will cause water droplets to roll off the surfaces. Superhydrophobic surfaces are found in nature and can possess several fascinating properties, including the ability to self-clean. A typical superhydrophobic surface has micro/nanostructure roughness and low surface energy, which combine to give it its unusual anti-wetting properties. Because of their unique capabilities, superhydrophobic surfaces have interested scientists in research and industry fields for years. In recent decades, researchers have developed a number …

05-07-2019 Hsc Committee Meeting Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Process Improvement For Follow-Up Radiology Report Recommendations Of Lung Nodules., Philip S. Lim, Doron Schneider, Jonathan Sternlieb, Michel Taupin, Nicholas Sich, Joan Diaz, Eileen Jameson, Bryan Frambes, Sharon Taylor

Abington Jefferson Health Papers

In the modern healthcare system, there are still wide gaps of communication of imaging results to physician and patient stakeholders and tracking of whether follow-up has occurred. Patients are also unaware of the significance of findings in radiology reports. With the increase in use of cross-sectional imaging such as CT, patients are not only being diagnosed with primary urgent findings but also with incidental findings such as lung nodules; however, they are not being told of their imaging findings nor what actions to take to mitigate their risks. In addition, patients at high risk for developing lung cancer often obtain …

Meditation As An Intervention To Help College Students Cope With Stress, Marissa Bottos

Evidence-Based Practice Project Reports

According to the American College Health Association (ACHA) (2017), in a survey of 31,463 students, 31.7% stated that stress negatively impacts their academic performance (lower grades, dropped course, etc.). Additionally, 45.1% of the students stated they have more than average stress levels. The purpose of this evidence-based practice (EBP) project was to determine if mindfulness meditation was effective in helping college students cope with stress. Based on current evidence, Jon Kabat-Zinn’s online application for mindfulness meditation is supported as an effective way to help college students cope with stress (Regehr et al. 2013; Yusufov et al. 2018; Cavanagh et al. …

P62-Mediated Selective Autophagy Endows Virus-Transformed Cells With Insusceptibility To Dna Damage Under Oxidative Stress, Ling Wang, Mary E. A. Howell, Aryianna Sparks Wallace, Caroline Hawkins, Camri A. Nicksic, Carissa Kohne, Kenton H. Hall, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning

ETSU Faculty Works

DNA damage response (DDR) and selective autophagy both can be activated by reactive oxygen/nitrogen species (ROS/RNS), and both are of paramount importance in cancer development. The selective autophagy receptor and ubiquitin (Ub) sensor p62 plays a key role in their crosstalk. ROS production has been well documented in latent infection of oncogenic viruses including Epstein-Barr Virus (EBV). However, p62-mediated selective autophagy and its interplay with DDR have not been investigated in these settings. In this study, we provide evidence that considerable levels of p62-mediated selective autophagy are spontaneously induced, and correlate with ROS-Keap1-NRF2 pathway activity, in virus-transformed cells. Inhibition of …

A Multi-Component Education, Skill, And Resource Evidence-Based Practice Intervention For The Alzheimer’S Caregiver, Cheryl Garmon

DNP Final Reports

Abstract

Dementia caregiving is expensive, stressful, and consumes all facets of the caregiver’s (CGs) life. The purpose of this project is to introduce the evidence-based practice (EBP) interventions most helpful in decreasing stress and burden in those who are in-home caregivers for Alzheimer’s disease and related dementias (ADRD) individuals.

The three primary intervention domains of the EBP studies that results in a positive impact are; providing education about the terminal course of the disease, introducing communication and caregiving skills, and furnishing resource and social network information.

The methodology included a convenient and voluntary population of CGs who sought service at …

Parameterizing And Validating Existing Algorithms For Identifying Out-Of-Bed Time Using Hip-Worn Accelerometer Data From Older Women, John Belletierre, Yiliang Zhang, Vincent Berardi, Kelsie M. Full, Jacqueline Kerr, Michael J. Lamonte, Kelly R. Evenson, Melbourne Hovell, Andrea Z. Lacroix, Chongzhi Di

Psychology Faculty Articles and Research

Objective: To parameterize and validate two existing algorithms for identifying out-of-bed time using 24-hour hip-worn accelerometer data from older women. Approach: Overall, 628 women (80±6 years old) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to 7 days and concurrently completed sleep-logs. Trained staff used a validated visual analysis protocol to measure in-bed periods on accelerometer tracings (criterion). The Tracy and McVeigh algorithms were adapted for optimal use in older adults. A training set of 314 women was used to choose two key thresholds by maximizing the sum of sensitivity and specificity for each algorithm and data (vertical axis, VA, …

Trna Methylation Is A Global Determinant Of Bacterial Multi-Drug Resistance., Isao Masuda, Ryuma Matsubara, Thomas Christian, Enrique R. Rojas, Srujana S. Yadavalli, Lisheng Zhang, Mark Goulian, Leonard J. Foster, Kerwyn Casey Huang, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Gram-negative bacteria are intrinsically resistant to drugs because of their double-membrane envelope structure that acts as a permeability barrier and as an anchor for efflux pumps. Antibiotics are blocked and expelled from cells and cannot reach high-enough intracellular concentrations to exert a therapeutic effect. Efforts to target one membrane protein at a time have been ineffective. Here, we show that m ¹ G37-tRNA methylation determines the synthesis of a multitude of membrane proteins via its control of translation at proline codons near the start of open reading frames. Decreases in m ¹ G37 levels in Escherichia coli and Salmonella impair …

An Incidental Diagnosis Of Aids-Related Disseminated Kaposi’S Sarcoma, Kathryn Kass Md, Amy Slenker Md

Department of Medicine

No abstract provided.