Medicine and Health Sciences Commons^™

An Uncommon Complication Of A Common Medication: Diffuse Alveolar Hemorrhage Secondary To Supratherapeutic Inr, Nathan Brewster Do, Christopher Lenivy Do, Kareem Godil Md, Andres Zirlinger Md

Department of Medicine

No abstract provided.

Myonuclear Accretion Is A Determinant Of Exercise-Induced Remodeling In Skeletal Muscle., Qingnian Goh, Taejeong Song, Michael J Petrany, Alyssa Aw Cramer, Chengyi Sun, Sakthivel Sadayappan, Se-Jin Lee, Douglas P Millay

Faculty Research 2019

Skeletal muscle adapts to external stimuli such as increased work. Muscle progenitors (MPs) control muscle repair due to severe damage, but the role of MP fusion and associated myonuclear accretion during exercise are unclear. While we previously demonstrated that MP fusion is required for growth using a supra-physiological model (Goh and Millay, 2017), questions remained about the need for myonuclear accrual during muscle adaptation in a physiological setting. Here, we developed an 8 week high-intensity interval training (HIIT) protocol and assessed the importance of MP fusion. In 8 month-old mice, HIIT led to progressive myonuclear accretion throughout the protocol, and …

Fibronectin-Conjugated Thermoresponsive Nanobridges Generate Three Dimensional Human Pluripotent Stem Cell Cultures For Differentiation Towards The Neural Lineages., Linda Harkness, Xiaoli Chen, Zhongfan Jia, Anthony M Davies, Michael Monteiro, Peter Gray, Martin Pera

Faculty Research 2019

Production of 3-dimensional neural progenitor cultures from human pluripotent stem cells offers the potential to generate large numbers of cells. We utilised our nanobridge system to generate 3D hPSC aggregates for differentiation towards the neural lineage, and investigate the ability to passage aggregates while maintaining cells at a stem/progenitor stage. Over 38 days, aggregate cultures exhibited upregulation and maintenance of neural-associated markers and demonstrated up to 10 fold increase in cell number. Aggregates undergoing neural induction in the presence or absence of nanobridges demonstrated no differences in marker expression, proliferation or viability. However, aggregates formed without nanobridges were statistically significantly …

Developing Technologically Advanced Research In Low- And Middle-Income Countries, Isa Abdulkadir, Tina Slusher, Fidelia Bode-Thomas, Sean Riordan, Jean-Baptiste Lepichon, Laila Hassan, Shehu Abdullahi, Akinyemi Ofakunrin, Stephen Oguche, Steven Shapiro, William Ogala

Posters

This poster presents a collaboration between a group of scientists in Nigeria and the USA in developing a genomic research project and the solutions adopted in tackling the ethical implications and partnership equity and ownership of such a project.

Determining Mediators Of Naive T Cell Motility And Dc Association In The Lymph Node, Janie Rae Byrum

Biomedical Sciences ETDs

To become activated and perform effector functions, naive T cells move within lymph nodes to scan dendritic cells presenting antigen. Previous work has shown naive T cell activation is promoted by interleukin 7 in vivo, and it does so by regulating the T cell:dendritic cell interaction. Our work identifies a novel role for IL-7 in mediating naive T cell motility in the lymph node and promoting T cell association with DCs. Additionally, we have developed a method for analyzing microscopy images, regionalized normalized mutual information, to assess intercellular associations between T cells and other cells within the lymph node. Dendritic …

Information And Readiness Build Resilience: The Role Of The Disaster Information Management Research Center, Stacey J. Arnesen, Florence Chang

Collaborative Librarianship

The National Library of Medicine (NLM) established the Disaster Information Management Research Center (DIMRC) in 2008 based on its history of providing health information for disaster preparedness, response, and recovery. The NLM long range plan (Charting a Course for the 21st Century: NLM's Long Range Plan 2006-2016) called for creation of a center to show "a strong commitment to disaster remediation and to provide a platform for demonstrating how libraries and librarians can be part of the solution to this national problem". NLM was urged to "ensure continuous access to health information and effective use of libraries and …

Hamstring Fatigue For Anterior Cruciate Ligament (Acl) Rehabilitation, Shiqi Yu

Health and Kinesiology Theses

Persistent quadriceps weakness in individuals with anterior cruciate ligament reconstruction (ACLR) has been attributed to arthrogenic muscle inhibition (AMI), which is partially due to the reciprocal inhibition of the quadriceps with the over-excitation of the hamstrings. The objective of this study was to investigate the effectiveness of the hamstrings fatigue immediately prior to quadriceps strength training on reducing AMI. Eight subjects with ACLR (time since injury: 46.5±23.6 months, age: 21.4±1.4 years) and eight healthy subjects (age: 22.5±2.7 years) with no previous history of knee injury participated. All subjects completed a single session of exercise intervention including 10-mins hamstrings vibration before …

A Simple Mindfulness Practice Can Improve Mental Health, Mary Kate Schutt

Population Health Research Brief Series

Depression, anxiety, and related mental distress are rising at alarming rates in the U.S. This issue brief discusses the impacts of practicing mindfulness on mental health and well-being.

Direct Lung Sampling Indicates That Established Pathogens Dominate Early Infections In Children With Cystic Fibrosis., Peter Jorth, Zarmina Ehsan Md, Amir Rezayat, Ellen Caldwell, Christopher Pope, John J. Brewington, Christopher H. Goss, Dan Benscoter, John P. Clancy, Pradeep K. Singh

Manuscripts, Articles, Book Chapters and Other Papers

Culture and sequencing have produced divergent hypotheses about cystic fibrosis (CF) lung infections. Culturing suggests that CF lungs are uninfected before colonization by a limited group of CF pathogens. Sequencing suggests diverse communities of mostly oral bacteria inhabit lungs early on and diversity decreases as disease progresses. We studied the lung microbiota of CF children using bronchoscopy and sequencing, with measures to reduce contamination. We found no evidence for oral bacterial communities in lung lavages that lacked CF pathogens. Lavage microbial diversity varied widely, but decreases in diversity appeared to be driven by increased CF pathogen abundance, which reduced the …

Empathy, Religious Affiliation, And The Growth Of Osteopathic Medicine, Brianna Cunningham

Senior Honors Theses

A key distinction of Doctors of Osteopathic Medicine (D.O.s) is their recognition of each patient as a whole person rather than just addressing his ailment. This focus previously highlighted physical manipulation over medications; however, the osteopathic profession has evolved significantly over the years. As this field is no longer identified by its original rejection of pharmaceuticals, other original principles of osteopathic medicine have impacted the growth of the field. The data collected from surveyed patients indicated that many osteopathic patients and physicians have religious backgrounds, and there is a widespread emphasis on psychological integration. The increased number of patients is …

Split Tolerance Permits Safe Ad5-Gucy2c-Padre Vaccine-Induced T-Cell Responses In Colon Cancer Patients., Adam E. Snook, Trevor R. Baybutt, Bo Xiang, Tara S. Abraham, John C. Flickinger, Terry Hyslop, Tingting Zhan, Walter K. Kraft, Takami Sato, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Background: The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice. Here, the cancer vaccine Ad5-GUCY2C-PADRE was evaluated in a first-in-man phase I clinical study of patients with early-stage colorectal cancer to assess its safety and immunological efficacy.

Methods: Ten patients with surgically-resected stage I or stage II (pN0) colon cancer received a single intramuscular injection of 1011 viral particles (vp) of Ad5-GUCY2C-PADRE. Safety assessment and immunomonitoring were carried out for 6 months following immunization. This trial employed continual monitoring of both efficacy and toxicity …

An Analysis Of Major Issues For Culturally-Minded Professionals In Women's Health Care, Victoria Clark

Senior Honors Theses

Women's health care professionals, such as general physicians, obstetricians and gynecologists, midwives, nurses, and doulas, in the US need to be aware of cultural issues and disparities. Minorities and migrant women experience cultural challenges and disparities when receiving health care in the US. Without cultural sensitivity, patient care is compromised. Pregnancy and childbirth practices vary widely by culture, and potential differences in perspectives, beliefs, and treatment of these are critical issues for women’s health care professionals to study. Female genital cutting (FGC), obstetric fistulas (OF), and female cancer are also discussed in this paper.

The Role Of Horticultural Therapy In The Treatment Of Refugees With Post-Traumatic Stress Disorder, Molly Nadeau

Senior Honors Theses

The United Nations High Commissioner for Refugees (UNHCR) cites that there are an unprecedented number of refugees. As of 2017, over 68.5 million people have been forcibly displaced from their homes, with 25.4 million of this group being classified as refugees (United Nations High Commissioner for Refugees, 2018). Often, mental health issues arise from the trauma that they face. Recently, the use of horticultural therapy, which uses gardening and plant-based activities as a form of treatment, has shown mental health improvements in military veterans and active duty soldiers diagnosed with stress related disorders. This paper will describe the role of …

Facing Addiction In College: The Effects On Alcohol, Drugs, And Academics, Alexis Frazier

Honors Theses

The goal of this thesis is to provide a comprehensive overview of collegiate recovery communities (CRCs) and collegiate recovery programs (CRPs) across the U.S for high risk students that suffer from alcohol and drug abuse. After finding the effectiveness of these programs and assessing the students’ needs in college, this research makes a recommendation for Western Michigan University to create a collegiate recovery program. A collegiate recovery program (CRP) is a college or university that provides a supportive environment within the campus culture that reinforces the decision to engage in a lifestyle of recovery from substance use (ARHE, 2019). This …

Initial Evaluation Of Computer-Assisted Radiologic Assessment For Renal Mass Edge Detection As An Indication Of Tumor Roughness To Predict Renal Cancer Subtypes, Rahul Rajendran, Kevan Iffrig, Deepak K. Pruthi, Allison Wheeler, Brian Neuman, Dharam Kaushik, Ahmed M. Mansour, Karen Panetta, Sos Agaian, Michael A. Liss

Publications and Research

Objective. To develop software to assess the potential aggressiveness of an incidentally detected renal mass using images. Methods. Thirty randomly selected patients who underwent nephrectomy for renal cell carcinoma (RCC) had their images independently reviewed by engineers. Tumor “Roughness” was based on image algorithm of tumor topographic features visualized on computed tomography (CT) scans. Univariant and multivariant statistical analyses are utilized for analysis. Results. We investigated 30 subjects that underwent partial or radical nephrectomy. After excluding poor image-rendered images, 27 patients remained (benign cyst = 1, oncocytoma = 2, clear cell RCC = 15, papillary RCC = …

Changing Healthcare Provider And Parent Behaviors In The Pediatric Post‐Anesthesia‐Care‐Unit To Reduce Child Pain: Nurse And Parent Training In Postoperative Stress (Np‐Tips), Brooke N. Jenkins, Michelle Fortier, Robert S. Stevenson, Mai Makhlouf, Paulina Lim, Remy Converse, Zeev N. Kain

Psychology Faculty Articles and Research

Background

Children who undergo surgery experience significant pain in the post anesthesia care unit. Nurse and parent behaviors in the post anesthesia care unit directly impact child postoperative pain. Therefore, we have developed and evaluated (Phase 1) and then tested (Phase 2) the feasibility of a new intervention (Nurse and Parent Training in Postoperative Stress) to alter parent and nurse behaviors in a way consistent with reducing child postoperative pain.

Methods

In Phase 1, a multidisciplinary team of experts (physicians, nurses, and psychologists) developed an empirically‐based intervention which was then evaluated by experienced nurses (N = 8) and parents …

Uptake And Persistence Of Bacterial Magnetite Magnetosomes In A Mammalian Cell Line: Implications For Medical And Biotechnological Applications., Jefferson Cypriano, Jacques Werckmann, Gabriele Vargas, Adrana Lopes Dos Santos, Karen T. Silva, Pedro Leao, Fernando P. Almeida, Dennis A. Bazylinski, Marcos Farina, Ulysses Lins, Fernanda Abreu

Life Sciences Faculty Research

Magnetotactic bacteria biomineralize intracellular magnetic nanocrystals surrounded by a lipid bilayer called magnetosomes. Due to their unique characteristics, magnetite magnetosomes are promising tools in Biomedicine. However, the uptake, persistence, and accumulation of magnetosomes within mammalian cells have not been well studied. Here, the endocytic pathway of magnetite magnetosomes and their effects on human cervix epithelial (HeLa) cells were studied by electron microscopy and high spatial resolution nano-analysis techniques. Transmission electron microscopy of HeLa cells after incubation with purified magnetosomes showed the presence of magnetic nanoparticles inside or outside endosomes within the cell, which suggests different modes of internalization, and that …

A Background Of The Opioid Epidemic And Its Relationship To The Medicaid Expansion, Er Yearn Jang

Senior Honors Theses

Despite the recent increase in public awareness of the opioid epidemic, the background of this epidemic is still disappointingly unknown to the public. The opioid epidemic is a national crisis which impacts, not only individuals’ wellbeing but the economy of the United States. The federal government sought to mitigate it through the enactment of the Patient Protection and Affordable Care Act. The Medicaid expansion, which was built into this law, sparked controversy; controversy which has yet to be solved to this day. Going forward, the knowledge we gather from examining the connection between this epidemic and the Medicaid expansion will …

The Impact Of Power Training On Balance And Visual Feedback Removal, Juliana Bouton

Senior Honors Theses

Because power training has been known to augment stability, the purpose of this study was to assess whether the removal of visual input affects lower limb muscle power production in young women who are resistance trained to the same degree it affects the untrained. This provided insight as far as the need for resistance training protocols in a largely untrained visually impaired population. To study this, fourteen college-aged female participants (18-23 years) performed a seated double-leg press on a leg sled machine, isolating power production of the lower limbs. After establishing baselines, which involved finding an average of power produced …

A Review Of The Treatment And Prevention Options For Medial Tibial Stress Syndrome, Samantha Yamasaki

Senior Honors Theses

Medial Tibial Stress Syndrome (MTSS) is a chronic lower-limb injury that effects a large population of athletes and exercisers. There is no definitive knowledge on what causes this injury, making prevention and treatment difficult. The purpose of this thesis is to identify the prevention and treatment methods for MTSS that seem the most promising. The risk factors of MTSS and possible preventative methods are first presented. Following this is an overview of both traditional and cutting-edge treatment options. One of the major conclusions reached in this thesis is that prevention of MTSS is often easier than treating it after onset. …

Management Of Cancer-Associated Anemia With Erythropoiesis-Stimulating Agents: Asco/Ash Clinical Practice Guideline Update., Julia Bohlius, Kari Bohlke, Roberto Castelli, Benjamin Djulbegovic, Maryam B Lustberg, Massimo Martino, Giannis Mountzios, Namrata Peswani, Laura Porter, Tiffany N. Tanaka, Gianluca Trifirò, Hushan Yang, Alejandro Lazo-Langner

Department of Medical Oncology Faculty Papers

PURPOSE: To update the American Society of Clinical Oncology (ASCO)/American Society of Hematology (ASH) recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer.

METHODS: PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs in patients with cancer published from January 31, 2010, through May 14, 2018. For biosimilar ESAs, the literature search was expanded to include meta-analyses and RCTs in patients with cancer or chronic kidney disease and cohort studies in patients with cancer due to limited RCT evidence in the cancer setting. ASCO and ASH convened an Expert Panel to …

The Criminogenic And Psychological Effects Of Police Stops On Adolescent Black And Latino Boys, Juan Del Toro, Tracey Lloyd, Kim S. Buchanan, Summer Joi Robins, Lucy Zhang Bencharit, Meredith Gamson Smiedt, Kavita S. Reddy, Enrique Rodriguez Pouget, Erin M. Kerrison, Philip Atiba Goff

Publications and Research

Proactive policing, the strategic targeting of people or places to prevent crimes,is a well-studied tactic that is ubiquitous in modern law enforcement. A 2017 National Academies of Sciences report reviewed existing literature, entrenched in deterrence theory, and found evidence that proactive policing strategies can reduce crime. The existing literature, however, does not explore what the short and long-term effects of police contact are for young people who are subjected to high rates of contact with law enforcement as a result of proactive policing. Using four waves of longitudinal survey data from a sample of predominantly black and Latino boys in …

Chronic Urticaria Associated With Helicobacter Pylori., Rajesh Essrani Md, Matthew Sullivan Do, Hiral N. Shah Md

Department of Medicine

A 31-year-old male presented with a complaint of chronic pruritus with diffuse urticarial wheals for the past seven months. He underwent extensive workup and was found to have positive Helicobacter pylori (H. pylori) stool antigen test. He was treated with bismuth subsalicylate, metronidazole, tetracycline, and omeprazole for two weeks. Pruritus and urticarial wheals disappeared in four weeks after therapy was started.

Age-Related Cognitive Impairment In Apparently Healthy Older Adults, Jake Sage

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Significant increases in age-related cognitive impairment (ARCI) associated with aging have been observed among older adults, negatively affecting measures of Quality of Life (QOL). Purpose: To examine the effects of a 12-week aerobic and cognitive training intervention on cognitive function in apparently healthy older adults. Methods: Six participants (40-75 years) were randomly placed into one of three training groups: 1) aerobic, cognitive, and flexibility (AER/COG); 2) aerobic and flexibility (AER); or 3) cognitive and flexibility (COG). There was a complete physical and cognitive assessment administered before and after the 12-week intervention. Individuals were assigned to 36 one hour …

Employees Who Are Deaf Or Hard Of Hearing: Perceptions Of Workplace Accommodations, Cassandra Lempka

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

The purpose of this paper is to measure the effectiveness of existing employment accommodations required by the Americans with Disabilities Act for employees who are Deaf or hard of hearing. Participants completed an online survey in which they identified with one of four levels of hearing loss and selected from descriptions of workplace accommodations. Each selection was ranked according to perceived importance and satisfaction. Accommodations that showed any significance of importance were endorsed by 18% or less of the respondents. The most important accommodations were computer assisted note-taking (18%) and flashing alarms (11%). Participants reported high satisfaction with most of …

Exploring The Cochlear Implant Controversy: The Role Of And Experience With Deaf Culture For Parents Of Pediatric Cochlear Implant Users, Tia Kilgore

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

This project examined the relationships between pediatric cochlear implantation and Deaf Culture. More specifically, this research investigated how/if parents are educated about or exposed to Deaf Culture during the cochlear implant candidacy evaluation process, and what type of interactions (if any) the child or caregiver had with members of the Deaf community after the child received a cochlear implant. A short survey was distributed to caregivers of pediatric cochlear implantees. While the responses were varied, a majority of caregivers responded that Deaf culture was not an active piece of the CI candidacy process. Additionally, interactions with members of the Deaf …

Can Your Dog Hear You? Perceptions About Canine Hearing Loss And Noise Exposure, Nakita Jarmon

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

This research study was designed to explore dog owners’ views on how often they expose their dogs to loud noises and whether or not the owners believe noise exposure affects their dogs’ hearing. Many humans are not aware that dogs, too, can suffer from hearing loss. To determine dog owners’ perceptions of the amount of noise exposure their dogs face and if their hearing is affected as a result, I created a survey for dog owners in Colorado. The results indicated that many dog owners do not believe they expose their dogs to loud noises. A majority of individuals were …

Nhs England Always Events® Program: Developing A National Model For Co-Production, Claire Marshall, Angela Zambeaux, Esther Ainley, David Mcnally, Jenny King Miss, Lorraine Wolfenden, Helen Lee

Patient Experience Journal

NHS England, the Institute for Healthcare Improvement, Picker and NHS Improvement started the work described in this article to strengthen how patients, carers and staff working together in co-design and co-production can make a real difference in improving experience of care. Always Events®, which is an improvement methodology for the co-design and consistent implementation of those aspects of patient experience that matter most to patients in a health care setting, was chosen. The approach has been to first test the methodology with three organizations then to spread to a substantial proportion of acute health care providers, with concurrent scale-up within …

Interprofessional Collaboration To Improve And Sustain Patient Experience Outcomes In An Ambulatory Setting, Natalie Sanchez, Kimberly Hermis

Patient Experience Journal

Patient experience is an important factor across diverse healthcare delivery settings. Despite enhanced attention to and advances in patient experience, many of the published initiatives focus on in-hospital care and opportunities have been identified to continue to strategically address patient experience in the ambulatory setting. This quality improvement initiative presents the development of an interprofessional approach to patient experience in a freestanding ambulatory oncology center. The objective of this initiative was to improve and sustain patient experience, as reflected in the Consumer Assessment of Healthcare Providers and Systems (CAHPS) scores via Press Ganey. This approach consisted of redesigning a previously …

Twelve Principles To Support Caregiver Engagement In Health Care Systems And Health Research, Kerry Kuluski, Kristina M. Kokorelias, Allie Peckham, Jodeme Goldhar, John Petrie, Carole Anne Alloway

Patient Experience Journal

Family and friend caregivers (i.e., unpaid carers) play a critical role in meeting the needs of people across various ages and illness circumstances. Caregiver experiences and expertise, which are currently overlooked, should be considered in practice (such as designing and evaluating services) and when designing and conducting research. In order to improve the quality of health care we need to understand how best to meaningfully engage caregivers in research, policy and program development to fill this important gap. Our study aimed to determine principles to support caregiver engagement in practice and research. A pan Canadian meeting brought together 48 stakeholders …