Medicine and Health Sciences Commons^™

Development Of Methods To Evaluate The Use Of Medi-551 To Target Cd19 Transmembrane Proteins On B-Cells To Improve Systemic Sclerosis, Natalia Dohman

Honors Thesis

Systemic sclerosis, a subcategory of scleroderma, is a rare autoimmune disease that affects the skin and, in some cases, the internal organs of those diagnosed with the disease. There is currently no cure for this disease, only treatments to slow its progression. It is important to note that each individual diagnosed with scleroderma experience differences in severity and symptoms of the disease and are treated based on their symptoms, not as a whole. Many factors of this disease still remain unknown, such as what causes the disease or stimulates the onset of it. Recent studies have helped determine different treatment …

Commonly Integrated Epigenetic Modifications Of Differentially Expressed Genes Lead To Adaptive Resistance In Cancer., Abdullah Al Emran, Diego M Marzese, Dinoop R Menon, Heinz Hammerlindl, Farzana Ahmed, Erika Richtig, Pascal Duijf, Dave Hoon, Helmut Schaider

Articles, Abstracts, and Reports

Aim: To investigate the integrated epigenetic regulation of acquired drug resistance in cancer. Materials & methods: Our gene expression data of five induced drug-tolerant cell models, one resistant cell line and one publicly available drug-resistant dataset were integrated to identify common differentially expressed genes and pathways. ChIP-seq and DNA methylation by HM450K beadchip were used to study the epigenetic profile of differential expressed genes. Results & conclusion: Integrated transcriptomic analysis identified a common 'viral mimicry' related gene signature in induced drug-tolerant cells and the resistant state. Analysis of the epigenetic regulation revealed a common set of down-regulated genes, which are …

New Dentist News (May 2019), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

New Dentist News (May 2019), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Data Visualization Of Treatment Outcomes For Tuberculosis Patients, Joy Jenkins

Industrial Engineering Undergraduate Honors Theses

Tuberculosis is an infectious disease, and different treatments have been discovered over the years. However, patients may develop various drug resistance levels that affect the likelihood of becoming cured or dying. In this study, we sought to employ data visualization to explore the relationship between treatment trajectory, as indicated by smear and culture results in the follow-up tests and patient outcomes. A large sample of patients have been broken down by demographics including age, gender, and drug resistance status. Sankey diagrams were used to visualize the pathway progression of the patients over time split between two time periods- months 0-6 …

Improving Nicu Referrals To The Missouri Early Intervention Program (First Steps), Luke Prest, Lauren Fenstermann, Ayman Khmour

Posters

First Steps is the statewide early intervention program in Missouri, but a review of referrals from the Truman neonatal intensive care unit revealed that only 24% of eligible patients were being referred. This poster describes efforts to increase awareness among residents and to refer all eligible patients to First Steps upon discharge.

Turf For Teams: Considering Both The Team And I In The Work-Centered Design Of Systems, Vickie Nguyen

Dissertations and Theses (Open Access)

Teams are an inherent part of many work domains, especially in the healthcare environment. Yet, most systems are often built with only the individual user in mind. How can we better incorporate the team, as a user, into the design of a system? By better understanding the team, through their user, task, representational, and functional needs, we can create more useful and helpful systems that match their work domain. For this research project, we utilize the TURF framework and expanded it further by also considering teams as a user, thus, creating the TURF for Teams framework. In addition, we chose …

Does Pediatric Palliative Care Involvement Influence Location Of Death?, Joy Solano, Meghna Singh, Ashley K. Sherman, Jennifer Linebarger

Posters

This study describes the influence of a palliative care team on location of death and location of death discussions with patients/caregivers, and determines whether location of death discussions influence location of death.

With palliative care or a location of death discussion, patients were less likely to die in the PICU and more likely to die at home. Location of death discussions were more likely to occur if a palliative care team was involved.

Viral Whole Genome Sequencing For Antiviral Resistance In A Child With Dock8 Deficiency And Recurrent Hsv-1, Sean Stout, A. L. Greninger, Rangaraj Selvarangan, A. F. Freeman, Brandon D. Newell, Erin Stahl, Dwight Yin

Posters

We present the case of a child with dedicator of cytokinesis 8 (DOCK8) deficiency and chronic, resistant HSV-1 mucocutaneous infections to illustrate the clinical utility of viral whole genome sequencing to detect active and latent HSV resistance mutations.

Investigating Virus Clearance Via Ph Inactivation During Biomanufacturing, Wenbo Xu

Biomedical Engineering Undergraduate Honors Theses

In the processing of biopharmaceuticals, viral clearance and viral safety are important for the development of monoclonal antibodies. Murine xenotropic leukemia virus (XMuLV) is one of the retroviruses, recommended by Food and Drug Administration (FDA) as a model virus for viral clearance via inactivation from therapeutics derived from Chinese hamster ovary cells (CHO). A robust and effective method was investigated to clear or inactivate endogenous viruses by low pH inactivation. The effects of different conductivity and inactivated time on XMuLV clearance was determined. Acetate buffer was prepared with different conductivity, and 2% XMuLV was spiked into acetate buffer. XMuLV virus …

Hyperdominant Left Anterior Descending Artery Presenting As Anterior Wall St Segment Elevation Myocardial Infarction: A Rare Coronary Anomaly, Shahrukh Hashmani Dr., Abid Laghari

Section of Cardiology

We report on a 75 year-old man who presented with severe chest pain for four hours. Physical examination was unremarkable and he was haemodynamically stable. ECG done in the ED showed ST segment elevations along with Q waves in the anterior and inferior leads with T wave inversions. He was rushed to the catheterization lab where the left anterior descending (LAD) artery was 99%occluded in the proximal segment while distal left circumflex showed 50-60% lesion. He underwent primary percutaneous coronary intervention to LAD with drug eluting stent and made an uneventful recovery. The LADwas found to be wrapping around the …

Comparison Of Hip Range Of Motion And Arch Height Index Of Collegiate Female Dancers And Collegiate Females, Philip A. Anloague, Lauren Macnab, Brittany Pease

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Dance requires athleticism and an optimal degree of stiffness and compliance to maximize performance and aesthetics. There is little research published on the utility of hip range of motion (ROM) and arch height index measures (AHI) in the female dance population.

Diffuse Large B-Cell Lymphoma In Kenya: Myc, Bcl2, And The Cell Of Origin, Jonathan Wawire, Shahin Sayed, Zahir Moloo, Aliyah R. Sohani

Pathology, East Africa

Purpose: Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed non-Hodgkin lymphoma in adults in Kenya. Cell of origin (COO) and double expression of MYC and BCL2 are two important prognostic factors for DLBCL. A small subset (5% to 10%) of DLBCL cases show positivity for CD5 and are associated with poor prognosis, whereas CD30 antigen, seen in up to 10% of cases, may be a useful target for therapy. We sought to determine the prevalence of MYC/BCL2 double expression, COO, and proportion of Epstein-Barr virus positivity among patients with DLBCL diagnosed at a tertiary referral laboratory in Kenya. …

Congenital Abnormalities Of The Lower Airways And Lungs, Christopher M. Oermann

Presentations

Participants will be able to: Describe the 5 stages of fetal lung development. Summarize the prenatal identification and management of congenital abnormalities of the lower airways and lung (CALA). Explain the classification of CALAL. Compare the clinical characteristics, pathology, and management of common CALAL. Discuss the long term prognosis of CALAL.

Central Auditory Gain Modulation In The Rehabilitation Of Workers With Tinnitus, Sylvie Hébert, Philippe Fournier, Marc Schönwiesner

Rapports de recherche scientifique

L’acouphène est un son perçu sans qu’il soit provoqué par une source sonore externe. Cette sensation auditive anormale, par exemple des bourdonnements, des tintements ou des sifflements, affecte une seule ou les deux oreilles. Elle peut grandement détériorer la qualité de vie et l’aptitude au travail d’une partie importante des personnes ayant une perte auditive. Dans les deux études décrites dans ce rapport, le modèle récent appelé gain auditif central a été utilisé pour intégrer les données normales et pathologiques dans un même cadre conceptuel. En bref, le « gain auditif central » est un mécanisme normal postulé pour expliquer …

The Scoop, Vol. 6 Issue 2, May 2019, Health Sciences Library

Volume 6

Latest news and events from the Health Sciences Library in our monthly newsletter for May 2019.

Introducing The Clinically Aligned Pain Assessment, Penny Mclain, Theresa Nelson, Mary Waldo

Articles, Abstracts, and Reports

Introduction: The Clinically Aligned Pain Assessment (CAPA) is an innovative way of assessing pain by engaging patients in a brief conversation about their comfort, change in comfort, pain control, functionality, and sleep.

Identification of the Problem: According to the Joint Commission (TJC) and the American Society for Pain Management Nursing (ASPMN) the use of the commonly used numeric rating scale (NRS) can lead to opioid overdose and ineffective treatment.

Purpose of the Study: To compare post-surgical patients’ perceptions of the effectiveness of two pain assessment tools, CAPA and NRS.

Methodology: An IRB approved, prospective observational study was conducted. Patients undergoing …

Home Care Instruction For Eye Surgery – Using Health Literacy Best Practices, Jennifer Reynolds

Articles, Abstracts, and Reports

Background Information: Health literacy is a well-established best practice that nurses can use to provide home care instructions post hospital stay. It is an excellent place to start, especially given the intensity of care, complexity of medications and importance of patient adherence. Nurses provide extensive information in a condensed period of time about how to take acre at home. With the anxiety of surgery, potential side effects of anesthesia and the time limitations of an outpatient setting, there is greater risk for patients being unprepared when they leave our care. Patients report this as an overwhelming experience, sometimes with little …

Comparative Effectiveness Of Drugs Used To Constrict The Patent Ductus Arteriosus: A Secondary Analysis Of The Pda-Tolerate Trial (Nct01958320)., Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C Hassinger, Susan W Aucott, Madoka Hayashi, Anne Marie Heuchan, William A Carey, Matthew Derrick, Ilene Sue Wolf, Amy Kimball, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize, Ronald I Clyman

Articles, Abstracts, and Reports

OBJECTIVE: To evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns < 28 weeks.

METHODS: We performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320). Infants with moderate-to-large PDAs were randomized 1:1 at 8.1 ± 2.1 days to either Drug treatment (n = 104) or Conservative management (n = 98). Drug treatments were assigned by center rather than within center (acetaminophen: 5 centers, 27 infants; ibuprofen: 7 centers, 38 infants; indomethacin: 7 centers, 39 infants).

RESULTS: Indomethacin produced the greatest constriction (compared with spontaneous constriction during Conservative management): RR (95% CI) = 3.21 (2.05-5.01)), followed by ibuprofen …

Understanding A Physician’S Role In Combating The Anti-Vaccination Movement: A Retrospective Analysis Using 2014-2019 Data, Alisa C. Kim

PCOM Capstone Projects

Childhood vaccination has been one of public health’s greatest achievements in its history. Just over the past 20 years, immunizations averted more than 21 million hospitalizations and 732,000 deaths in the US (Skinner, 2017). However, healthcare professionals, public health advocates, and researchers are still witnessing an unceasing tension between the anti-vaccination movement and pro-vaccination organizations. Since the invention of the first vaccines, individuals from various religious sects, cultural backgrounds, and ethnic groups have been questioning the efficacy of vaccines, the possible health risks and side effects that may be introduced, and the morality behind the act of vaccinating. With questionable …

The Perceptions, Attitudes, And Knowledge Of Primary Care Providers Regarding Childhood Obesity Treatment, Akshita Taneja

PCOM Capstone Projects

Childhood obesity is a persistent problem in the United States and can result in many health problems in adulthood. Primary Care Providers (PCPs) play a crucial role in treating obesity by providing family-based behavioral weight management counseling and by educating patients and their families about the health concerns associated with obesity. Despite the significant role that PCPs play within treating childhood obesity, little is known about PCPs’ perceptions of their efficacy in treating this condition. Through individual semi-structured interviews, this study’s aims were to obtain a greater understanding of PCPs’: 1) perceptions of the education and training they received to …

Neuroenhancement: Is Society Ready?, Jennifer Dang

PCOM Capstone Projects

Humans were always able to discover and invent solutions to our species limitations, from the discovery of vaccines and irradiation of diseases to the invention of personal computers that could fit in our pockets. Concerning the idea of scientific and technological advancements, it is never the question of whether or not scientists could discover these achievements, but it is always the question of whether or not science should create or discover something. In regards to the topic of neuroenhancement, experts have been unable to unanimously determine if, as a society, we are morally responsible enough to handle such an advancement. …

Reducing Re-Hospitalizations Of Patients With Heart Failure At A Skilled Nursing Facility, Louis D'Onofrio Jr.

The Eleanor Mann School of Nursing DNP Capstone Projects

The purpose of this project was to introduce the quality improvement (QI) process to reduce re-hospitalization rates in a skilled nursing facility (SNF) in Stratford, Connecticut for patients having a diagnosis of heart failure (HF). After reviewing the data from the nursing facility for re-hospitalization rates over a three-month period, it was discovered that 22% of patients at the SNF were re-hospitalized within 30 days. Of this population of patients, 22.9% had a diagnosis or complication of HF, which is associated with the highest re-hospitalization rates. This QI project focused on HF education customized towards nursing and nursing assistant staff …

Ethical Art Waste: Examining Resource Management In The Art Studio, Amanda Peavey

Expressive Therapies Capstone Theses

This paper highlights the lack of education about production and disposal of art materials within the field of art therapy. Failure to educate clinicians creates ethical problems when hazardous materials are used in sessions unknowingly. This paper is grounded in environmental studies and chemical management to supplement the art therapy field’s lack of research and commentary. The literature is dedicated to educating the reader about the hazardous nature of materials, issues surrounding regulations of chemicals involved in production, and consumerism in relation to waste processing. The research data was collected from a community engagement project: an educational presentation was offered …

The Effect Of The Coaching Program In Health Behaviors Modification On Hba1c Of Persons With Pre-Diabetes(ผลของโปรแกรมการสอนแนะในการปรับเปลี่ยนพฤติกรรมสุขภาพต่อระดับน้ำตาลเฉลี่ยสะสมในเลือดของผู้ที่มีภาวะก่อนเป็นเบาหวาน), Jintipa Sirikunwiwat, Rungrawee Navicharern

Journal of Nursing Research, Innovation, and Health

Purpose: To study the effect of the coaching program in health behaviors modification of persons with pre-diabetes.Design: Quasi-experimental researchMethods: The subjects were 60 persons with prediabetes in out-patient clinic, Medicine Department of Phrachomklao hospital, Phetchaburi province. Thirty persons with prediabetes per group were matched by sex, age and use of Metformin. The control group received the normal nursing care whereas the experimental group received the coaching program in health behaviors modification. The research instrument were the coaching program in health behaviors modification based on the concept of Haas (1992), The data were collected by demographic data, HbA1C level and health …

The Effect Of Group Experiential Learning For Parents On Aggressive Behaviors Of Children With Attention - Deficit /Hyperactivity Disorder(ผลของโปรแกรมการเรียนรู้โดยประสบการณ์แบบกลุ่มของบิดามารดาต่อพฤติกรรมก้าวร้าวของเด็กสมาธิสั้น), Jirapan Saboonma, Branom Rodcumdee, Sunisa Suktrakul

Journal of Nursing Research, Innovation, and Health

Purposes: to compare aggressive behaviors of children with ADHD before and after using the group experiential learning for parents program and to compare aggressive behavior of children with ADHD using the group experiential learning for parents program and those who received regular caring activities.Design: Quasi-experimental researchMethods: Forty children with ADHD receiving services in outpatient department Rajanukul Institute, who met the inclusion criteria, were paired up and then randomly assigned to experimental group and control group; 20 subjects in each group. The experimental group received the group experiential learning for parents program for 6 weeks whereas the control group received regular …

Is There An Association Between Placental Inflammatory Lesions And Vaginal Microbiota In Preterm Labour? A Case Control Study, David Ogechi Atandi

Master of Medicine in Anatomic Pathology

Background: Preterm birth continues to be a significant contributor to neonatal mortality and morbidity despite diverse unique interventional strategies. There is need for better understanding of differences and influences of the now characterized vaginal microbiome on terminal inflammatory effects in the uterine microenvironment in term and preterm labour to improve on current strategies. How the existence of a postulated placenta microbiome also affects this understanding should be considered. Objectives: The aim of this study was to explore the association between the maternal vaginal microbiota and placental inflammatory lesions in preterm labour and to determine the presence of a placenta microbiome …

Comparison Of Post-Activation Potentiation Methods On Power And Sprint Acceleration, Aaron Piper

Electronic Theses and Dissertations

Post-activation potentiation (PAP) is a stimulus used to enhance performance by performing specific interventions prior to subsequent explosive movements. The purpose of this study was to determine the effect of different PAP methods on power and sprint acceleration in resistance trained, college-aged men and women. A total of 13 subjects participated in the study. After determining back squat 1 repetition max, subjects returned for testing on separate days to complete one of four interventions (dynamic resistance, weighted plyometric, isometric, or control) in a randomized order. A standardized warmup was given, followed by a baseline countermovement jump (CMJ) and 20-meter sprint. …

The Effects Of Participation In A Grief Choir On Perceived Grief, Coping, Energy, Social Support, And Health Among Bereaved Adults: A Mixed Methods Randomized Control Study, Lauren Dimaio

Crossroads of Music and Wellness

The purpose of this study was to test the effects of participation in a grief choir vs. verbal grief group on bereaved persons’ perceived grief, coping, energy, social support and health and to examine the experiences of those participating in both groups. In this mixed-methods study, the results from qualitative phenomenological focus groups were used to explain and interpret the findings of the Randomized Control Trial (RCT). Findings demonstrated that the grief choir may have been as effective as the verbal grief group when impacting the participants’ experience of grief.

Interdisciplinary Aspects Of Cultural Engagement In Older Adults: Who/What/Why/When/How, Penny Roberts

Crossroads of Music and Wellness

The population of the United States is aging. Caring for older adults requires a variety of approaches and collaboration among professionals. One approach, cultural engagement, involves experiences rooted in cultural activities, such as choir singing, group music, art- and craft-making, drama involvement, etc. Cultural engagement provides opportunities to address aging-associated issues that will not interfere with medication or other treatments. The concept of cultural engagement has been successfully applied to a number of fields including chronic disease management, addictive behaviors, and pain control.