Medicine and Health Sciences Commons^™

Cime Newsletter : May 2019, Cime

Centre for Innovation in Medical Education (CIME) Archives

-Clinical Simulation Educators Programme: Moving with the times
-Anaesthesiologist – a key role in the Management of Postpartum Haemorrhage
-Preparing for competence
-New born babies – beautiful but vulnerable
-Enhancing skills to improve patient satisfaction
-Students Educating Students

Using Green Emitting Ph-Responsive Nanogels To Report Environmental Changes Within Hydrogels: A Nanoprobe For Versatile Sensing, Mingning Zhu, Dongdong Lu, Shanglin Wu, Qing Lian, Wenkai Wang, L. Andrew Lyon, Weiguang Wang, Paulo Bártolo, Brian R. Saunders

Engineering Faculty Articles and Research

Remotely reporting the local environment within hydrogels using inexpensive laboratory techniques has excellent potential to improve our understanding of the nanometer-scale changes that cause macroscopic swelling or deswelling. Whilst photoluminescence (PL) spectroscopy is a popular method for such studies this approach commonly requires bespoke and time-consuming synthesis to attach fluorophores which may leave toxic residues. A promising and more versatile alternative is to use a pre-formed nanogel probe that contains a donor/acceptor pair and then “dope” that into the gel during gel assembly. Here, we introduce green-emitting methacrylic acid-based nanogel probe particles and use them to report the local environment …

Clinical Spectrum And Factors Impacting Outcome Of Candida Auris: A Single Center Study From Pakistan, Muneeba Ahsan Sayeed, Joveria Farooqi, Kauser Jabeen, Safia Awan, S Mahmood

Section of Internal Medicine

Background: An outbreak of Candida auris began globally in 2014 including Pakistan and since then it has emerged as a nosocomial multi-drug resistant pathogen. The aim of this study was to assess the clinical spectrum and outcome of patients, from a single center in Pakistan, in whom C. auris was isolated.

Methods: A retrospective study was conducted on 92 patients; ≥16 years with at least one culture positive for C. auris, at the Aga Khan University Hospital Karachi, Pakistan from Sept 2014-Mar 2017.Demographics, clinical history, management and outcome were studied. A logistic regression model was used to identify the risk …

Modeling Changes In Cellular Micro-Environment In Mild To Moderate Head Trauma, Xiangfu Zhang, Subhendra N. Sarkar Phd, Rt

Publications and Research

Our work aims to connect and model multiple small, inter-related tissue injuries as a consequence of mild traumatic brain injuries (mTBI). It has been shown that frontal and temporal lobes are vulnerable regions for brain traumatic injury. A brain injury from a blow or high-speed impact can cause undersurface of the frontal and temporal lobes to deform against the anterior and cranial fossae. This deformation can often trigger damage to the cerebral vasculature, which is ill-understood and can result in chronic damage to larger vessels over time. These physiological injuries can be manifested psychologically; such as patients’ sleep-wake disturbances. The …

How Do Neighbourhood Definitions Influence The Associations Between Built Environment And Physical Activity?, Suzanne Mavoa, Nasser Bagheri, Mohammad Javad Koohsari, Andrew T. Kaczynski, Karen E. Lamb, Koichiro Oka, David O'Sullivan, Karen Witten

Faculty Publications

Researchers investigating relationships between the neighbourhood environment and health first need to decide on the spatial extent of the neighbourhood they are interested in. This decision is an important and ongoing methodological challenge since different methods of defining and delineating neighbourhood boundaries can produce different results. This paper explores this issue in the context of a New Zealand-based study of the relationship between the built environment and multiple measures of physical activity. Geographic information systems were used to measure three built environment attributes—dwelling density, street connectivity, and neighbourhood destination accessibility—using seven different neighbourhood definitions (three administrative unit boundaries, and 500, …

Increasing Adult's Awareness Of The Importance Of End-Of-Life Care Discussions, Taylor Gardner

Capstone Projects and Master's Theses

For many American families, end-of-life care is often not discussed, until advanced illness or injury has fully disrupted everyday life. There are many benefits to discussing end-of-life care prior to any medical complications. Research has shown that individuals who plan their end-of-life processes with a hospice service provider and family members report a higher quality of death than individuals receiving common health care during their final six months of life. In order to make families and friends more comfortable with end-of-life discussions, I will conduct two one-hour educational sessions to students at California State University, Monterey Bay.

Emg Analysis Of Lassimus Dorsi, Middle Trapezius, And Erector Spinae Muscle Activity During Spinal Rotation: A Pilot Study, Katie Holzheimer, Ross Swartz, Keely Hutchens, Joshua Still

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Spinal rotation is a very common movement that occurs multiple times each day during normal daily activities or even during certain sport performances. Since this motion is a contributing factor to back injuries, it will be important for physical therapists to consider this concept with rehabilitation programs for current back injuries as well as prevention of future injuries. The LD has attachments to many areas of the body, including the spine, humerus, scapula, and pelvis, which explains why this muscle also contributes to multiple actions at the trunk and upper extremity. Due to the attachment sites and the …

Cultural Work In Addressing Conflicts And Violence In Traumatized Communities, Eugen Koh

New England Journal of Public Policy

There is a growing appreciation that conflict and violence in many communities have their origins in a history of traumatic experiences. Why this link exists and how it comes about is still unclear. We have no unified psychology of traumatized communities, and little is known about how to address these traumatic origins collectively in these communities. This article proposes a psychodynamic model of collective trauma and a psychoanalytically informed approach to working with traumatized communities to address their issues of conflict and violence. It highlights the impact of collective trauma on the culture of a community, which is its collective …

The Effects Of Eicosapentaenoic Acid (Epa) And Docosahexaenoic Acid (Dha) On Brown Adipogenesis In Stem Cell Culture, Darynne Dahlem

Animal Science Undergraduate Honors Theses

Polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are major maternal dietary supplements due to their positive benefits on neurological tissue growth during the first 12 weeks of gestation. Previous studies show that EPA and DHA inhibit muscle formation but promote adipogenesis. However, no research has addressed the question whether high intake of EPA and DHA affects brown fat development during gestation. The objective of this study was to measure the effect of EPA and DHA supplement on brown adipogenesis and potential pathways related to mitochondrial biosynthesis using fibroblasts as in vitro model. Using Oil-Red-O staining …

Geospatial Analysis Of Rickettsial Species, Amy Frank

Animal Science Undergraduate Honors Theses

Rickettsia species are obligate intracellular, arthropod-borne bacteria with a potential to cause multiple diseases including Rocky Mountain spotted fever (RMSF). Fleas, mites, and ticks serve as vectors for Rickettsia, but ticks are the primary vector of interest. RMSF and other rickettsial diseases have continued to gain importance in both human and veterinary medicine as RMSF is the most common tick-borne disease within the United States according to the Lyme and Tick-Borne Disease Research Center. A statewide citizen science project was utilized to determine the prevalence of Spotted Fever Group (SFG) Rickettsia in Arkansas. This project yielded results in 64 …

The Importance Of Interprofessional Education To Develop Successful Interprofessional Collaborative Teams In Healthcare, Christina Sebastiao

Senior Honors Projects

Many individuals live with chronic illnesses, various disabilities, and other complex needs that require an array of medical services from multiple disciplines within the healthcare field. To address the medical, behavioral and social needs of these patients, there has been an emphasis on providing treatment through interprofessional collaborative teams and interprofessional practice (IPP). These teams consist of multiple health professionals from various disciplines.

To ensure IPP teams are efficient and effective in the workplace, the application of interprofessional education (IPE) is key. The goal of IPE is to increase competency in interdisciplinary collaborative skills in students and future practitioners. In …

The Characterization Of A New Metabolite From A Trichodesmium Bloom, Kelly M. Mcmanus

Senior Honors Projects

Our laboratory has been investigating blooms of Trichodesmium, a genus of ecologically important, nitrogen-fixing cyanobacteria, collected from Padre Island in the Gulf of Mexico. Trichodesmium species are an underexplored biological source of cyanobacteria – a taxa that has been shown to produce chemically diverse secondary metabolites. With our focus on the isolation and structure characterization of new bioactive marine natural products, our research group has discovered over 25 new-to-science compounds over the past three years from these blooms. UV and mass spectrometry-guided isolation of Trichodesmium chromatography fractions were utilized to isolate a new metabolite. Isolation of this metabolite was …

The Effects Of Gesture On Early Language Production, Gabrielle Zeyl

Senior Honors Projects

Over the last decade, baby sign language (adapted signs for simple words like milk or mom) has become a trending parenting fad. Although significant research is still lacking on the subject, there is evidence suggesting that the use of early gestures is beneficial in promoting spoken language in typically developing children. Given developmental support for early gesture, this project aims to investigate the use of manual gestures to support speech sound production for a young child with speech and language delay. This project is two-fold. Part one included an extensive literature review of existing research on baby sign, gesture and …

Fostering Meaning Making In Grieving Adults With Intellectual And Developmental Disabilities, Teresa Graziano

Senior Honors Projects

No abstract provided.

Addressing Barriers To Preventative Health Care For Transgender Populations: A Systems Approach To Improving Access To Gynecological Care, Meghan N. Flynn

Master's Theses

The current study addresses the lack of research exploring the individual and systemic barriers to accessing gynecological care for transgender populations. An integrated mixed-methods needs assessment was designed to explore the individual and systemic barriers to gynecological health care for transgender and gender diverse populations. Participants of the study included established community providers known to serve the transgender community through advocacy or research efforts, as well as clinical psychologists and medical professionals working in gynecological settings. The study includes a brief quantitative survey, which measured “Perceptions of Inclusivity Importance” among key stakeholders. Following the survey, participants were invited to engage …

Development And Validation Of A Tool To Measure Patient Assessment Of Clinical Compassion, Brian W. Roberts, Michael B. Roberts, Jady Yao

PCOM Scholarly Works

Importance: Clinician compassion is a vital element of health care quality. Currently, there appears to be no validated and feasible method for health care organizations to measure patient assessment of clinician compassion on a large scale. Objective: To develop and validate a tool for measuring patient assessment of clinician compassion that can be used in conjunction with the Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CG-CAHPS) survey. Design, Setting, and Participants: This prospective cohort study took place from June 1 to August 30, 2018, at a US academic health care system among a pilot cohort consisting of …

Aortic Valve Opening And Closure: The Clover Dynamics., Emmanuel Lansac, Hou-Sen Lim, Yu Shomura, Khee Hiang Lim, Nolan T Rice, Isabelle Di Centa, Pouya Youssefi, Wolfgang Goetz, Carlos M G Duran

Articles, Abstracts, and Reports

Background: Systolic aortic root expansion is reported to facilitate valve opening, but the precise dynamics remain unknown. A sonometric study with a high data sampling rate (200 to 800 Hz) was conducted in an acute ovine model to better understand the timing, mechanisms, and shape of aortic valve opening and closure.

Methods: Eighteen piezoelectric crystals were implanted in 8 sheep at each annular base, commissures, sinus of Valsalva, sinotubular junction, nodulus of Arantius, and ascending aorta (AA). Geometric changes were time related to pressures and flows.

Results: The aortic root was hemodynamically divided into left ventricular (LV) and aortic compartments …

Experience With Acute Diaphragmatic Trauma And Multiple Rib Fractures Using Routine Thoracoscopy., Ledford Powell, Jacob Chai, Aaliyah Shaikh, Almaas Shaikh

Articles, Abstracts, and Reports

Background: Diaphragmatic injury is mostly caused by blunt or penetrating traumas. It is an uncommon diagnosis and therefore carries the risk of being misdiagnosed or delayed in diagnosis. In our institution, we perform routine thoracoscopy for the management of patients with traumatic rib fractures. We have noted several cases of occult diaphragmatic injuries and hypothesize that these injuries may be more of a penetrating injury from rib fractures as opposed to the high velocity blunt trauma typically associated with diaphragmatic injuries.

Methods: A retrospective review of medical records was performed on all patients admitted to our facility with rib fractures …

Predator Journals: An Urgent And Global Problem., Karsten Wiechert, Jeffrey C Wang, Jens R Chapman

Articles, Abstracts, and Reports

No abstract provided.

Erratum. Sodium-Glucose Cotransporter 2 Inhibition And Diabetic Kidney Disease. Diabetes 2019;68:248-257., Radica Alicic, Joshua J Neumiller, Emily J Cox, Brad P Dieter, Katherine Tuttle

Articles, Abstracts, and Reports

No abstract provided.

Management Of Acute Traumatic Central Cord Syndrome: A Narrative Review., Srikanth N Divi, Gregory D Schroeder, John J Mangan, Madeline Tadley, Wyatt L Ramey, Jetan H Badhiwala, Michael G Fehlings, F Cumhur Oner, Frank Kandziora, Lorin M Benneker, Emiliano N Vialle, Shanmuganathan Rajasekaran, Jens R Chapman, Alexander R Vaccaro

Articles, Abstracts, and Reports

Study Design: Narrative review.

Objectives: To provide an updated overview of the management of acute traumatic central cord syndrome (ATCCS).

Methods: A comprehensive narrative review of the literature was done to identify evidence-based treatment strategies for patients diagnosed with ATCCS.

Results: ATCCS is the most commonly encountered subtype of incomplete spinal cord injury and is characterized by worse sensory and motor function in the upper extremities compared with the lower extremities. It is most commonly seen in the setting of trauma such as motor vehicles or falls in elderly patients. The operative management of this injury has been historically variable …

Mental Health Advocacy Internship, Hannah Cogburn

The Eleanor Mann School of Nursing Undergraduate Honors Theses

While statistics indicate an increased need for mental health treatment in the United States, the stigmatization surrounding mental illness prevents many from seeking help. During my internship, I worked with multiple mental health advocacy groups in Northwest Arkansas, including Mental Health America and Judicial Equality for Mental Illness, to bring about beneficial change for mental health consumers. These groups have been successful in bringing additional treatment centers to our area and raising community awareness for the importance of mental health. Through my internship, I learned how to organize public awareness events, how to advocate politically, and how to meet the …

The Perception Of Iron-Deficient Anemia In Bolgatanga, Ghana Among Women Of Childbearing Age, Sydney Albrecht

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Objective: To understand the perception of anemia among the women of childbearing age in Bolgatanga, Ghana, and to correlate the reasoning with the high incidence of anemia in the area.

Method: This research was a qualitative study consisting of 67 interviews over the course of the three weeks that were spent in Bolgatanga. 50 of these interviews were women of childbearing age (15-49), 6 were health professionals, and 11 were women older than the age range provided. Interviews were taken from the maternity clinics nearby as well as from women in a rural area that was a 10-minute taxi ride …

Prospective Evaluation Of A Population Pharmacokinetic Model Of Pantoprazole For Obese Children, Alenka Chapron, Susan M. Abdel-Rahman, Valentina Shakhnovich

Posters

We previously developed a population pharmacokinetic (popPK) model of pantoprazole for obese children. Our objective was to evaluate the predictive performance of this model in an independent cohort of normal weight, overweight and obese children.

Diagnostic Accuracy Of Diffusion Weighted Mri In Differentiating Benign And Malignant Meningiomas, Din Muhammad Sohu, Saba Sohail, Rehana Shaikh

Department of Radiology

Objective: To determine the diagnostic accuracy of DWI in differentiating benign and malignant meningiomas keeping histopathology as gold standard.
Methods: This was a descriptive analytical study conducted at Radiology Department, DUHS/Dr. Ruth K. M. Pfau Civil Hospital Karachi, from August 2016 to March 2018.It included152 patients clinically suspected of meningioma on conventional neuroimaging. Imaging features of DWI were compared with histopathology findings. The diagnostic accuracy of DWI was calculated in terms of sensitivity, specificity, accuracy, PPV and NPV using histopathology as gold standard.
Results: There were 59 male and 93 female patients with mean age of 55.38±9.8 years. Mean duration …

Food Pantry Evaluation And Assessment At The Dominican University Of California, Damian Cortez

Senior Theses

Food security continues to be a relevant and prevalent problem in the US that affects millions of people per year (1). In 2016, 12.3% of American households were food insecure. Although the percentage of food insecure households is experiencing a downward trend since the great recession in 2007, the current percentage is still higher than the percent of food insecure households before the recession (1).

Research shows that food insecurity is an indicator for negative health, academic, and social outcomes among elementary children leading to poor mathematical and reading performance, weight gain, and poor social development (2). The negative health …

Development And Psychometric Analysis Of The Roy Adaptation Modes Scale (Rams) To Measure Coping And Adaptation, Sandra A. Russo

Dissertations, Theses, and Capstone Projects

Peoples’ lives are often interrupted or changed by experiencing a serious illness. It is important to study and understand the various coping processes that people have in adapting to illness. The purpose of this study was to develop an instrument to measure a person’s coping response to illness-related stimuli using the Roy Adaptation Model (RAM) as its structure and framework. This study is quantitative descriptive design to develop the validity and reliability of a new instrument the Roy Adaptation Modes Scale (RAMS). A review of RAM based measurement instruments found no instrument that measured all four adaptive modes that is …

American Sign-Language (Asl) For Audiologists, Colette Vossler-Welch

Dissertations, Theses, and Capstone Projects

The goal of this project is to provide a means for Audiologists, Speech-Language-pathologists and related personnel to improve their ability to communicate and connect with culturally Deaf individuals through the use of video-animated sign-language interpretations. Arguments for or against the bilingual approach of using ASL and the spoken language with regards to Deaf education will be discussed through both a personal memoir and a review of current literature. This study will also shed light upon the history of the American Deaf population, American Sign-Language (ASL) and will conclude with a training module in ASL. The training module will be available …

Heterocycle Synthesis From Quinols, Jing Wu

Dissertations, Theses, and Capstone Projects

Three cascade reactions that provide access to various heterocyclic skeletons from quinols were developed. Various substituted 1-hydroxyacridones, 4-hydroxycarbazoles and 4-hydroxy-indolin-3-ones were readily synthesized in moderate to excellent yields. The common sequential transformation involves carbamation/Michael addition/mixed Claisen condensation/decarboxylative aromatization which were realized in one-pot reactions in the synthesis of acridones and indolin-3-ones, or two-step reactions in the synthesis of carbazoles. A side reaction from oxidative dearomatization of phenols, affording iodo diaryl ethers in one step from commercial phenols, albeit in low yields, revealed an intricate mechanistic pathway. The synthesis of jaboticabin was realized in nine linear steps from commercial phloroglucinol and …

Effects Of Primary And Secondary Cigarette Smoke On Auditory Function: A Systematic Review, Hilary Mcmanus

Dissertations, Theses, and Capstone Projects

Objective: The goal of this paper was to systematically review literature in order to investigate the effects of active and passive cigarette smoke on auditory function when assessing outcome measures including pure tone audiometry, otoacoustic emissions, high-frequency audiometry, and auditory evoked potentials.

Methods: A comprehensive search using the Medline Complete database was conducted to identify relevant studies published after 2005. Inclusion criteria included the use of pure tone audiometry, high-frequency audiometry, otoacoustic emissions, and/or auditory evoked potentials to examine the effect of primary or secondary cigarette smoke. Studies involving noise exposure or other confounding factors were excluded.

Results: A total …