Medicine and Health Sciences Commons^™

Microbiome Profiles Of Ligature-Induced Periodontitis In Nonhuman Primates Across The Life Span, Sreenatha Kirakodu, Jin Chen, Janis Gonzalez Martinez, Octavio A. Gonzalez, Jeffrey Ebersole

Dental Medicine Faculty Research

This investigation compared the microbiomes colonizing teeth during the initiation, progression, and resolution of periodontitis in nonhuman primates (Macaca mulatta) at different ages. Subgingival plaque samples were collected at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and following naturally occurring disease resolution at 5 months. Samples were analyzed using 16S amplicon sequencing to identify bacterial profiles across age groups: young ( 3 years of age), adolescent (3 to 7 years), adult (12 to 15 years), and aged (17 to 23 years).-Diversity of the microbiomes was greater in the adult/aged samples than in the young/adolescent samples.-Diversity of the samples …

Acute Tubulointerstitial Nephritis: A Case Report On Rare Adverse Effect Of Pembrolizumab., Sijan Basnet, Rashmi Dhital, Biswaraj Tharu

Reading Hospital Internal Medicine Residency

Pembrolizumab is a novel immune checkpoint inhibitor approved for use in non-small cell lung carcinoma. There have been a few cases that have associated adverse renal outcomes with pembrolizumab. We present a case of acute kidney injury in a patient on pembrolizumab who was noted to have acute tubulointerstitial nephritis on renal biopsy. Pembrolizumab was discontinued and the patient was started on long-term corticosteroids with a taper. Her renal function improved partially with treatment.

Analysis Of A Universal Depression Screening Workflow At An Integrated Healthcare Center, Arthur Roehr

Doctor of Nursing Practice Final Manuscripts

Purpose: Evaluation of an evidence-based protocol that measures the effectiveness of universal depression screening at an integrated healthcare center. At risk patients are those who complete a patient health questionnaire (phq-9) and score ≥ 10 when presenting for a primary care visit. A score of ≥ 10 prompts further evaluation by the primary care provider (PCP) prior to behavioral health care management (BHCM) referral.

Background: In 2016, 16.2 million adults aged 18 or older in the U.S. experienced a major depressive episode (MDE). 65.3% of those received some form of treatment from a healthcare professional (therapy and/or medication). Early identification …

The Current State Of Weight-Cutting In Combat Sports, Oliver R. Barley, Dale W. Chapman, Chris R. Abbiss

Research outputs 2014 to 2021

In combat sports, athletes are divided into categories based on gender and body mass. Athletes attempt to compete against a lighter opponent by losing body mass prior to being weighed (i.e., 'weight-cutting'). The purpose of this narrative review was to explore the current body of literature on weight-cutting and outline gaps for further research. Methods of weight-loss include energy intake restriction, total body fluid reduction and pseudo extreme/abusive medical practice (e.g., diuretics). The influence of weight-cutting on performance is unclear, with studies suggesting a negative or no effect. However, larger weight-cuts (~5% of body mass inh) do impair repeat-effort performance. …

No Place To Be! Common Goods And Homelessness, Patrick Riordan

Journal of Vincentian Social Action

The phenomena of homelessness will be shown to challenge the naïve assumption that our political existence is grounded in a sense of goods we hold in common. And at the same time, a clearer understanding of what is involved in having goods in common will highlight a further dimension of the scandal of homelessness in our societies who are systematically excluded from the enjoyment of negative liberty, an important good in common institutionally secured in liberal democratic states. They are denied their negative liberty, because they are denied the physical space in which they might perform activities essential for personal …

Welcoming The Stranger, St. Vincent De Paul And The Homeless, Robert P. Maloney

Journal of Vincentian Social Action

The theme is examined in three steps: Vincent and the homeless, The Vincentian Family Global Initiative against Homelessness, Blending systemic change and a “culture of encounter” in serving the homeless. Will our worldwide Vincentian Family, working together, have a significant impact on the lives of the homeless, bringing them a sense of security, peace, and a viable future, in the 150 countries where we live and serve? That is the goal of the megaproject we are launching to celebrate the 400th anniversary of the birth of St. Vincent’s charism.

Land-Lodging-Labor: The Aesthetic, Ethic, And Political Causes Of Homelessness In Latin America, Emilce Cuda

Journal of Vincentian Social Action

It is impossible to talk about the homeless, understood as a lack of decent housing, without at the same time talking about the lack of work and the concentration of land ownership in one sector of society. “Homeless” in Latin America, and for the Argentine Pope, is the lack of land-lodging-labor. The problem of the three “T’s” in the Spanish Tierra, Techo, Trabajo is the question I will develop from aesthetic-ethical-theological foundations, according to the theological method of the Latin American teaching: See-Judge Act.

Regaining Dignity And Social Inclusion: Street Homelessness In Manila And Strategies From Below, Cynthia Calubaquib, Nicole Tilman

Journal of Vincentian Social Action

Describing the situation of the street homeless in Metro Manila, the underlying causes of their condition and the – unfortunately still inadequate- responses of the government. Second, we review our, and hopefully also the Philippine Church’s, motivation and inspiration to engage in this kind of service. In this paper we have first reflected upon the situation of the street families, as well as our motivations to work toward ending street homelessness. Based on these we have suggested two strategies.

Homelessness And Hospitality On The Ground, A Methodological Proposal For Catholic Social Teaching, Daniel Pilario

Journal of Vincentian Social Action

What resources, perspectives and experiences can we draw from formal Catholic Social Teaching and broader Catholic social thought to help us understand and interpret street homelessness in a global context? This article is intended to be an invitation to share narratives of hospitality on the ground vis-à-vis the problem of homelessness in the global world. Unlike top-down approaches, there are no clear principles to be applied; only concrete stories with all their frictions, ambiguities and difficulties hoping that God’s inspiration can reveal itself on the rough grounds where people walk in fidelity to the Gospel.

"Go Out To The Highways And Hedges" (Cf. Lk 14:23): Peripheral Ecclesiology, The Art Of Accompaniment, And Street Homelessness, Michael M. Canaris

Journal of Vincentian Social Action

The ecclesiological priority of cultivating the art of “walking with” the vulnerable and marginalized as informed by these ecclesiological conversations, especially regarding those “with neither den nor nest” (Mt 8:20), the homeless who can sometimes seem alone in the streets, but are always journeying with the human family (and thus the Church, of which many of our unhoused brothers and sisters are a part) through history. As Vincent puts it, the communal dimension of living the Gospel together “is the wine that cheers and strengthens travelers along this narrow path of Jesus Christ.”

Catholic Social Teaching And Homelessness: The World Tribe Of The Dispossessed, Ethna Regan

Journal of Vincentian Social Action

Homelessness is a complex, global and growing phenomenon, and street homelessness is its most visible aspect. These children, men and women who live on the streets are, in the words of the Jamaican poet Lorna Goodison, “the world tribe of the dispossessed/outside the halls of plenty/ looking in”. This article explores both the specific treatment of homelessness in Catholic social teaching and the ethical principles in Catholic social teaching that can be brought to bear on analysis, advocacy, and action in the area of homelessness.

"Free From Is Not Free For": The Experience Of Depaul Slovensko's Work With Homeless People In A Post-Communist Country, Juraj Barat

Journal of Vincentian Social Action

Depaul Slovensko (Slovakia), a non-profit organization, was established as a response to the unreasonable dying of homeless people on the streets of Bratislava in the winter 2005/2006 and the absence of accommodation for them. The lack of experience, absence of professional social work and the prejudices of a postcommunist, ‘Christian’ society were the context for beginning a new form of work, without precedent in this environment. We learn to be authentic and faithful in the unity of our thoughts, words and deeds. All of this creates tension and we strive to keep these dynamics in balance. We grow, mature and …

Moving From Charity To Justice In Our Work To End Homelessness, Rosanne Haggerty

Journal of Vincentian Social Action

With a growing list of cities, regions-even countries-now reducing and ending forms of homelessness1 the key questions in our field have changed. If the familiar questions have been about resources and policy, the new ones are about purpose, and transformation. Is our purpose to run good programs or to end homelessness? If it’s to end homelessness, are we willing to hold our organizations and communities to that standard? Homelessness, in its raw visibility, confronts our shared beliefs about right and wrong, fairness, care, protection of the vulnerable, the importance of strong community bonds and the dignity of each person.

What The People We Call "Homeless" Have Taught Me, Bruno M. Duffé

Journal of Vincentian Social Action

I think I can say, as far as I can go back to my living memory and as a pastor, that the first thing I learned from “homeless” people we meet in our streets - and that we can sometimes find at the door of our institutions - is the determining importance of the gaze. And I would like to suggest, as a first contribution to our reflection, this intuition that has become for me a conviction and a major theological and ethical assertion: all human encounter begins with a look. Every truly human story finds its origin in the …

Introduction To The Issue, Meghan Clark, Anna F. Rowlands

Journal of Vincentian Social Action

This issue of JoVSA is a continuation of the conversations begun in Rome.1 In this issue are theological and practical reflections from Argentina, the Philippines, France/Rome, Ireland, England, and the United States. Throughout the articles, readers will find robust theological reflection, engagement with persons experiencing homelessness, and critical insights on policies by both government and church agencies. These essays invite all of us to consider more deeply the Catholic social teaching tradition and lived realities of people experiencing homelessness.

Table Of Contents

Journal of Vincentian Social Action

No abstract provided.

Editors

Journal of Vincentian Social Action

No abstract provided.

Cover

Journal of Vincentian Social Action

No abstract provided.

Investigating Neuroinflammation And Demyelination In The Nervous System Of Twitcher Mice By The Use Of Immunohistochemistry, Irene Wilson

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Neuroinflammation and demyelination are the hallmark lesions of the Twitcher mouse—the model of Krabbe Disease. By analyzing hemibrains and sciatic nerves via immunohistochemistry, we supported the microglial hypothesis that early activation of microglial cells, macrophages, and globoid cells in the nervous system of Twitcher mice results in specific cellular polarization states that may contribute to myelin loss. The influx of activated macrophages seen in both the central and peripheral nervous systems at days 21 and 17, respectively, accounted for this polarization. Using selected M1 and M2 markers, YKL-40, and GPNMB and CD206, respectively, we proved that microglial cells and macrophages …

Modulating P300 Acetylation Promotes The Rapid Degradation Of Erbb2 Mrna In Erbb2-Positive Breast Cancer Cells., Jacob Rose

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Histone deacetylase inhibitors (HDACi) are a novel class of drugs that target histone deacetylases, enzymes that by removing acetyl groups from the lysine resides of histones and many other non-histone proteins alter the cell’s chromatin structure and cellular functions, including regulation of protein translation and transcript stability. The mechanism of how these inhibitors destabilize some but not all transcripts remains incompletely understood. Our recent research has demonstrated that treatment of ERBB2-positive breast cancer cells with the HDAC1/2 selective HDACi, FK228 (Romidepsin) promotes rapid decay of various oncogenic mRNA transcripts including ERBB2 mRNA. Most recently we have demonstrated that histone acetyltransferase …

Ada News - 05/20/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Ease Of Caregiving For Children: Re-Validation Of Psychometric Properties Of The Measure For Children With Cerebral Palsy Up To 11 Years Of Age., Mohammed S Alghamdi, Lisa A Chiarello, Lisa Avery, Robert J Palisano

Physical Therapy Publications

PURPOSE: To re-validate stability and hierarchal ordering of items, test-retest reliability, and construct validity of the Ease of Caregiving for Children measure for parents of children with cerebral palsy (CP) up to 11 years of age.

METHODS: Participants were 613 parents of children with CP between 1.5 and 11 years of age. Parents completed Ease of Caregiving for Children and both parents and therapists classified children's levels of gross motor, manual and communication functions.

RESULTS: Rasch analysis indicated acceptable fit of items, stable item calibration, and logical ordering of items by difficulty. Test-retest reliability was good: ICC = 0.69 (95% …

Effect Of Learning To Use A Mobility Aid On Gait And Cognitive Demands In People With Mild To Moderate Alzheimer's Disease: Part I - Cane, Susan W. Hunter, Alison Divine, Humberto Omana, Walter Wittich, Keith D Hill, Andrew M Johnson, Jeffrey D Holmes

Physical Therapy Publications

BACKGROUND: People with Alzheimer's disease (AD) exhibit balance and walking impairments that increase falls risk. Prescription of a mobility aid is done to improve stability, yet also requires increased cognitive resources. Single-point canes require unique motor sequencing for safe use. The effect of learning to use a single-point cane has not been evaluated in people with AD.

OBJECTIVES: In people with AD and healthy adult controls: 1) examine changes in gait while using a cane under various walking conditions; and 2) determine the cognitive and gait costs associated with concurrent cane walking while multi-tasking.

METHODS: Seventeen participants with AD (age …

What's Happening: May 20, 2019, Maine Medical Center

What's Happening

No abstract provided.

Data From: Mapping Of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis In The Lupus-Prone Nzbwf1 Mouse, James Pestka, Abby D. Benninghoff

Browse all Datasets

The dataset contains six files of tabular data with an accompanying README file.

Supplementary file 1: Customized probe annotation file for the Nanostring nCounter Mouse PanCancer Immune Profiling Panel (catalog # 115000142). This file is provided as supporting material for a journal article. Codes for columns are in file.

Supplementary file 2: Microsoft Excel document with output from nSolver for differential expression analyses for pairwise comparisons noted by each named sheet. This data set is supporting material for a journal article. Codes for columns are listed in README.

Supplementary File 3: Microsoft Excel document with output from nSolver for global …

Malignant Hyperthermia Precautions In The Pediatric Patient, Amanda Versteeg

Nursing Capstones

No abstract provided.

Determination Of Anxiolytic And Antidepressant Medicines In New York City Wastewater Samples, Jasmine J. Gayle

Student Theses

Wastewater-based epidemiology (WBE) provides information about a population’s exposure to certain chemical agents, such as drugs of abuse and medicines, by the analysis of human biomarkers, also known as excretion products, in wastewater samples. Although this is a growing field worldwide, mainly in Europe, Oceania, and Asia, limited data from the US are currently available. We developed and validated an analytical method to quantitatively and qualitatively determine the presence of commonly prescribed drugs to treat anxiety (alprazolam, buspirone, clonazepam, lorazepam, and propranolol) and depression (bupropion, citalopram, clomipramine, duloxetine, fluoxetine, imipramine, paroxetine, sertraline, and venlafaxine) in wastewater using liquid chromatography tandem …

A Case-Study Approach To Investigate Transmission, Co-Infection, And Clinical Sequelae During Epidemics Of Dengue And Ebola Virus Disease, Jennifer Elizabeth Giovanni

LSU Doctoral Dissertations

From within their ecologic niches, zoonotic viruses emerge from animal reservoirs into the edges and centers of human habitation to exploit opportunities for unabated transmission within immunologically–naïve populations. Our understanding of where, in whom, and how these viruses emerge is under direct challenge, driving the evolution of modern infectious disease epidemiology within a rapidly-connected global community. The studies presented herein are based on analyses of both aggregate and case-level data, which, we argue, provide unique insight into the complexities of transmission, co-infection, and clinical sequelae occurring within, and arising from, epidemics of emerging zoonotic viruses. In Chapter II, we investigate …

Adductor Canal Block Verus Femoral Nerve Block In Total Knee Arthroplasty, Alexander D. Olson

Nursing Capstones

No abstract provided.

Nutritional Knowledge And Behaviors Of Undergraduate Students, Victoria Inghram

Honors Theses

Poor dietary behavior can lead to various chronic health conditions, such as heart disease and obesity. Because dietary intake takes time to impact health, observing diet knowledge in college students can be beneficial. This study sought to measure whether greater nutritional knowledge would translate to a healthier dietary intake. Nutritional knowledge and behavior were measured and then compared in 257 students in two different undergraduate classes - an introductory nutrition course and a standard biology course - which was the control group. Each class was given the same survey at the beginning and end of the fall semester. Results indicated …