Medicine and Health Sciences Commons^™

Alternative Water Supplies For Arid Areas, Jumaan Alghamdi

NYMC Student Theses and Dissertations

Water is an essential component of growth and life; unfortunately, many countries face growing challenges in providing safe water. This has created a need for alternatives in the ways water can be treated, saved, or reused. In this paper, four alternative water supplies are reviewed: desalination, grey water reuse, harvesting of rainwater, and harvesting of stormwater. These alternatives are examined in terms of their advantages and disadvantages, the waste by-products, other pollution that can be produced by them, and how to handle each one. To accomplish this, brief information about each alternative, what technologies are used for water treatment, and …

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G Denardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M Mcgee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, Francesco M Marincola

Faculty Research 2019

Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes …

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G Denardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M Mcgee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, Francesco M Marincola

Articles, Abstracts, and Reports

Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes …

Community-Based Participatory Research: An Ethical And Practical Model For Academic Public Health And Clinical Research, Cynthia R. Hall

Florida Public Health Review

Community-based participatory research (CBPR) is a strategy for performing health-related research in vulnerable communities that have been exploited by traditional research in the past. CBPR focuses on mutual collaboration between the community and the researchers involved. This form of research is ethically compelled to instill transparency and trust into the research enterprise. CBPR envisions the involvement of the community in all aspects of the research: design, implementation and dissemination of research results. This collaborative process necessitates an analysis of ethical considerations because it implies additional moral principles beyond the traditional ethics enunciated in the Belmont Report, the foundational guideline for …

Effect Of Intraoperative Dexmedetomidine Infusion On Perioperative Opioid Use, Lindsey Holter

Nursing Capstones

No abstract provided.

Epidemiology And Ideology: Why Health Equity Is Problematic In The United States, Cynthia R. Hall

Florida Public Health Review

Health and healthcare are central elements to the achievement of social justice. Braveman and Gruskin are proponents of health equity as a means to realize social justice. They define health equity as the “absence of systemic barriers to health” that are derived from the unequal power, influence, and capital of marginalized groups within societies (2003, p. 254). John Rawls and Norman Daniels have theorized that social justice requires a fair distribution of goods in a society and that good health is of moral importance to this effort, respectively. Thus, having fair access to a healthy life is a crucial element …

Disruption Of Telomere Integrity And Dna Repair Machineries By Kml001 Induces T Cell Senescence, Apoptosis, And Cellular Dysfunctions, Dechao Cao, Juan Zhao, Lan N. Nguyen, Lam N. T. Nguyen, Sushant Khanal, Xindi Dang, Madison Schank, Bal K. Chand Thakuri, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Yue Zou, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

T cells in chronic viral infections are featured by premature aging with accelerated telomere erosion, but the mechanisms underlying telomere attrition remain unclear. Here, we employed human CD4 T cells treated with KML001 (a telomere-targeting drug) as a model to investigate the role of telomere integrity in remodeling T cell senescence. We demonstrated that KML001 could inhibit cell proliferation, cytokine production, and promote apoptosis via disrupting telomere integrity and DNA repair machineries. Specifically, KML001-treated T cells increased dysfunctional telomere-induced foci (TIF), DNA damage marker γH2AX, and topoisomerase cleavage complex (TOPcc) accumulation, leading to telomere attrition. Mechanistically, KML001 compromised telomere integrity …

Leptin Produced By Obesity-Altered Adipose Stem Cells Promotes Metastasis But Not Tumorigenesis Of Triple-Negative Breast Cancer In Orthotopic Xenograft And Patient-Derived Xenograft Models, Rachel A. Sabol, Annie C. Bowles, Alex Côté, Rachel Wise, Benjamen O'Donnell, Margarite D. Matossian, Fokhrul M. Hossain, Hope E. Burks, Luis Del Valle, Lucio Miele, Bridgette M. Collins-Burow, Matthew E. Burow, Bruce A. Bunnell

School of Medicine Faculty Publications

BACKGROUND: Breast cancer is the second leading cause of cancer deaths in the USA. Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer with high rates of metastasis, tumor recurrence, and resistance to therapeutics. Obesity, defined by a high body mass index (BMI), is an established risk factor for breast cancer. Women with a high BMI have increased incidence and mortality of breast cancer; however, the mechanisms(s) by which obesity promotes tumor progression are not well understood. METHODS: In this study, obesity-altered adipose stem cells (obASCs) were used to evaluate obesity-mediated effects of TNBC. Both in vitro …

Simultaneous Determination Of Fourteen Antipsychotic Drugs In Whole Blood By Solid Phase Extraction And Liquid Chromatography Tandem Mass Spectrometry, Theresa M. Dawe

Student Theses

Anti-psychotic drugs are commonly prescribed to patients to treat several mental conditions, such as bipolar, schizophrenia, and manic-depressive disorder. The analysis of anti-psychotic drugs in blood is a common practice in clinical and forensic toxicology, to monitor drug treatment (therapeutic drug monitoring) or to explain the cause of the impairment or intoxication in human performance and in postmortem cases. However, most of the current studies have been performed in plasma, and a limited number in blood. We developed and validated a method to confirm and quantify a panel of commonly prescribed anti-psychotic drugs in whole blood using solid phase extraction …

Men’S Experiences Of Miscarriage: A Passive Phenomenological Analysis Of Online Data, Megan Story Chavez, Valerie Handley, Rebecca Lucero Jones, Brandon Eddy, Von Poll

Couple & Family Therapy Program Faculty Research

Miscarriage is a pervasive health care concern for couples. The impacts of miscarriage on men have not received adequate attention in the literature. The aim of this research was to understand the lived experience of 31 male participants whose partners had miscarried a child. This study analyzed online data using a passive phenomenological methodology. Researchers found four overarching themes including isolation, overwhelmed, protector, and coping. Results found that health professionals might overlook men when a woman experiences a miscarriage. Results suggest that professionals working with these couples could provide greater care by addressing the experiences of both men and women …

View Point On Social Media Use In Interventional Cardiology, Mirvat Alasnag, Mamas Mamas, David Fischman, Salvatore Brugaletta, Jordan Safirstein, Pascal Meier, Vijay Kunadian, Lukasz Koltowski, Sheila Sahni, Chadi Alraies, Michael Gibson

Division of Cardiology Faculty Papers

No abstract provided.

Heart Rate Variability Monitoring During Strength And High-Intensity Interval Training Overload Microcycles, Christoph Schneider, Thimo Wiewelhove, Christian Raeder, Andrew Flatt, Olaf Hoos, Laura Hottenrott, Oliver Schumbera, Michael Kellmann, Tim Meyer, Mark Pfeiffer, Alexander Ferrauti

Health Sciences & Kinesiology: Faculty Publications

Objective: In two independent study arms, we determine the effects of strength training (ST) and high-intensity interval training (HIIT) overload on cardiac autonomic modulation by measuring heart rate (HR) and vagal heart rate variability (HRV).

Methods: In the study, 37 well-trained athletes (ST: 7 female, 12 male; HIIT: 9 female, 9 male) were subjected to orthostatic tests (HR and HRV recordings) each day during a 4-day baseline period, a 6-day overload microcycle, and a 4-day recovery period. Discipline-specific performance was assessed before and 1 and 4 days after training.

Results: Following ST overload, supine HR, and vagal HRV (Ln RMSSD) …

Exome Sequencing Of 20,791 Cases Of Type 2 Diabetes And 24,440 Controls, Jason Flannick, Josep M. Mercader, Christian Fuchsberger, Miriam S. Udler, Anubha Mahajan, Jennifer Wessel, Gil Atzmon, John Blangero, Ravindranath Duggirala, Benjamin Glaser

School of Medicine Publications

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations of rare variants (with minor allele frequencies of less than 0.5%) in 4 genes at exome-wide significance, including a series of more than 30 SLC30A8 alleles that conveys protection against T2D, and in 12 gene sets, including those corresponding to T2D drug targets (P = 6.1 × 10−3) and candidate genes from knockout mice (P = 5.2 × …

Mental Health Disparities For Latino Immigrants & Its Impact On Psychological Well-Being, Ana Do Rosario Sousa

Counseling Psychology | Master's Theses

In the present study, the researcher sought to examine the factors associated with Latino immigrants and the barriers/challenges that are faced in mental health. The main question that the researcher focuses on in the present study is: What are some of the mental health challenges for Latino immigrants & how do these disparities further impact psychological well-being? Furthermore, the research focuses on highlighting the variables that are increasingly damaging to the minority population of Latinos in the United States. These variables include lack of health insurance, stigma, acculturation issues, legal issues, and biopsychosocial factors, such as socioeconomic class. In multiple …

Supporting Marin County Youth Suffering From Anxiety And Depression, Victoria L. Grajeda

Counseling Psychology | Master's Theses

This toolkit was created to help shed light on the impact a stressful high school environment can have on today’s youth, and provide teachers, students, and parents with up-to-date information on what resources are available within the county of Marin. When working with adolescents, it is important to consider environmental threats to their mental health (i.e., lack of sleep) in order to make proper referrals and treatment plans. A study done by Kelley, Lockley, Kelley, & Evans (2017) implemented a 10:00 a.m. start time at an urban school in England. By delaying school start times, Kelley et al., found that …

Dietary Restriction Enhances Circadian Amplitude And Delays Visual Decline By A Clock-Driven Increase In Phototransduction, Geoff Meyerhof

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Aging is accompanied by a progressive loss of circadian rhythms. Lifespan-extending dietary paradigms such as dietary restriction (DR) enhance circadian amplitude and appear to extend lifespan in a clock-dependent fashion. However, the mechanisms by which DR amplifies circadian rhythms and why circadian rhythms decline with age have yet to be fully elucidated. Here we find that DR amplifies circadian amplitude by enhancing light sensitivity in the eye. We performed a circadian mRNA microarray in flies (Drosophila melanogaster) reared on DR or a high nutrient diet and found that DR increases the number of circadian transcripts and selectively amplifies the …

2019 May 21 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Preclinical Rationale For Entinostat In Embryonal Rhabdomyosarcoma., Narendra Bharathy, Noah E Berlow, Eric Wang, Jinu Abraham, Teagan P Settelmeyer, Jody E Hooper, Matthew N Svalina, Zia Bajwa, Martin W Goros, Brian S Hernandez, Johannes E Wolff, Ranadip Pal, Angela M Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C Goodwin, Peter Ordentlich, James G. Keck, Douglas S Hawkins, Erin R Rudzinski, Atiya Mansoor, Theodore J Perkins, Christopher R Vakoc, Joel E Michalek, Charles Keller

Faculty Research 2019

BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years. We previously identified the class I-specific histone deacetylase inhibitor, entinostat (ENT), as a pharmacological agent that transcriptionally suppresses the PAX3:FOXO1 tumor-initiating fusion gene found in alveolar rhabdomyosarcoma (aRMS), and we further investigated the mechanism by which ENT suppresses PAX3:FOXO1 oncogene and demonstrated the preclinical efficacy of ENT in RMS orthotopic allograft and patient-derived xenograft (PDX) models. In this study, we investigated whether ENT also has antitumor activity in fusion-negative eRMS orthotopic allografts and …

Intraoperative Lidocaine Infusions For Postoperative Pain Management, Sarah Solberg

Nursing Capstones

No abstract provided.

Hermansky-Pudlak Syndrome 1 And 2 Have Differential Effects On Lung Fibroblast Behavior, Karina Cuevas-Mora, Dominic Sales, Hoora Shaghaghi, Ross Summer, Freddy Romero

Center for Translational Medicine Posters

Objective

To determine whether mitochondrial function and/or the proteasome system is altered in fibroblasts from the HPS mouse lung.

New Targeted Treatments For Fragile X Syndrome, Dragana Protic, Maria J. Salcedo-Arellano, Jeanne Barbara Dy, Laura A. Potter, Randi J. Hagerman

Ateneo School of Medicine and Public Health Publications

Fragile X Syndrome (FXS) is the most common cause of inherited intellectual disability with prevalence rates estimated to be 1:5,000 in males and 1:8,000 in females. The increase of >200 Cytosine Guanine Guanine (CGG) repeats in the 5' untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene results in transcriptional silencing on the FMR1 gene with a subsequent reduction or absence of fragile X mental retardation protein (FMRP), an RNA binding protein involved in the maturation and elimination of synapses. In addition to intellectual disability, common features of FXS are behavioral problems, autism, language deficits and atypical physical …

La Lambda-Cyhalothrine Comme Insecticide En Milieu Agricole : Étude De La Toxicocinétique De Biomarqueurs Pour Le Suivi De L’Exposition Des Travailleurs, Michèle Bouchard, Jonathan Côté, Rania Khemiri

Rapports de recherche scientifique

Les insecticides pyréthrinoïdes sont une famille de pesticides largement utilisés au Québec pour lutter contre les insectes nuisibles dans les cultures maraîchères. Parmi ces insecticides, on compte la lambda-cyhalothrine. Malgré l’utilisation abondante de ce pyréthrinoïde, il existe peu de données sur le comportement biologique de cette molécule chez l’humain. Il devient donc essentiel de développer des outils pour bien évaluer l’exposition des travailleurs à ces pesticides lors d’épandages ou de travaux dans des zones traitées. La surveillance biologique, par la mesure de produits excrétés dans l’urine (appelés métabolites), est considérée comme une approche privilégiée pour évaluer les doses réellement absorbées …

Public Opinion Report Of Nutrition Education And Nutrition-Related Behaviors, Kristen Hicks-Roof, Robert J. Zeglin, Daniel Manson, Corinne A. Labyak

Florida Public Health Review

Objectives: Sources of obtaining credible evidence-based nutrition knowledge appears to be more and more limited as nutrition information becomes widespread. The purpose of this study was to determine sources of nutrition information and corresponding nutrition-related behaviors among Florida residents. Study Design: A cross-sectional study.

Methods: A telephone survey was conducted using probability sampling with residents of Florida in October 2017.Results: A total of 611 respondents completed the survey from 45 different counties across Florida. A significant relationship was established between age and primary source of obtaining nutrition information. Young, middle age and elderly adults preferred media, registered dietitians and physicians/nurses …

A Heartfulness Meditation Intervention In University Students Using Mixed Methodology, Dipta Amatya

Health and Kinesiology Theses

Objective: This is a mixed methods study in which Heartfulness meditation was introduced to university students. The objective of this study was to demonstrate a link between Heartfulness meditation and mental health as well as a link between Heartfulness meditation and Emotional Intelligence. The study also explored the experiences of the students after the meditation practice.

Background: College students have greater levels of stress and psychopathology now than at any other time in the nation’s history. Increases in mental distress can lead to serious mental health disorders in the future so there is a need for self-care skills for students …

Exploring Help-Seeking Intentions Of Homeless Veterans Attending A Stand Down Event, Tara Vaughn

Nursing Theses and Dissertations

Lack of help-seeking behavior among homeless veterans results in higher burden of disease and lower quality of life. No studies have been conducted involving help- seeking intentions of homeless veterans within the veteran stand down population. Pender’s Revised Health Promotion Model was used to guide this descriptive correlational study with the aim of exploring the extent selected personal characteristics and experiences and behavior-specific factors affect help-seeking intentions among homeless veterans attending a stand down event.

A convenience sample of 86 homeless veterans (mean age 56) was recruited from a 3-day veteran stand down event in Northern California. Each participant was …

Abcb1 Snp Predicts Outcome In Patients With Acute Myeloid Leukemia Treated With Gemtuzumab Ozogamicin: A Report From Children's Oncology Group Aaml0531 Trial., Roya Rafiee, Lata Chauhan, Todd A. Alonzo, Yi-Cheng Wang, Ahlam Elmasry, Michael R. Loken, Jessica Pollard, Richard Aplenc, Susana Raimondi, Betsy A. Hirsch, Irwin D. Bernstein, A S. Gamis, Soheil Meshinchi, Jatinder K. Lamba

Manuscripts, Articles, Book Chapters and Other Papers

Gemtuzumab-ozogamicin (GO), a humanized-anti-CD33 antibody linked with the toxin-calicheamicin-γ is a reemerging and promising drug for AML. Calicheamicin a key element of GO, induces DNA-damage and cell-death once the linked CD33-antibody facilitates its uptake. Calicheamicin efflux by the drug-transporter PgP-1 have been implicated in GO response thus in this study, we evaluated impact of ABCB1-SNPs on GO response. Genomic-DNA samples from 942 patients randomized to receive standard therapy with or without addition of GO (COG-AAML0531) were genotyped for ABCB1-SNPs. Our most interesting results show that for rs1045642, patients with minor-T-allele (CT/TT) had better outcome as compared to patients with CC …

Altered Detrusor Contractility And Voiding Patterns In Mice Lacking The Mechanosensitive Trek-1 Channel., Ricardo H. Pineda, Joseph Hypolite, Sanghee Lee, Alonso Carrasco, Nao Iguchi, Randall B. Meacham, Anna P. Malykhina

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Previously published results from our laboratory identified a mechano-gated two-pore domain potassium channel, TREK-1, as a main mechanosensor in the smooth muscle of the human urinary bladder. One of the limitations of in vitro experiments on isolated human detrusor included inability to evaluate in vivo effects of TREK-1 on voiding function, as the channel is also expressed in the nervous system, and may modulate micturition via neural pathways. Therefore, in the present study, we aimed to assess the role of TREK-1 channel in bladder function and voiding patterns in vivo by using TREK-1 knockout (KO) mice.

METHODS: Adult C57BL/6 …

Anesthetic Implications For Patients With Friedreich’S Ataxia, Clara Hoss

Nursing Capstones

No abstract provided.

Aortic Valve Calcium Score Indexed To Transaortic Valve Gradient: A Novel Hemodynamic And Anatomic Index For Patients With Low Gradient Aortic Stenosis., Ramy Mando, George S Hanzel, Francis Shannon, Ashish Chaddha, Craig Tucker, Michael Gallagher, Robert D Safian, Amr E Abbas

Conference Presentation Abstracts

Background Aortic valve calcium score (AVCS) is a marker for aortic stenosis (AS) severity. We sought to evaluate the effect of aortic valve (AV) variables of flow defined by stroke volume index (SVI), area (AVA), and gradient (MG) on AVCS and study the role of AVCS/MG ratio in patients with low gradient AS.

Methods We retrospectively studied patients undergoing transcatheter aortic valve replacement (TAVR) for severe AS (defined by Echo, Cath, and multimodality team consensus) at our institution from January 1, 2014 through September 1, 2018. AVCS was compared among patient groups defined by their MG (low < or high ≥40 mmHg), echocardiographic SVI (low < or normal ≥35 mL/m2), and AVA (< 0.8 or ≥0.8 cm2) using a three-way factorial ANOVA. The AVCS/MG ratio was developed and compared to AVCS and AVCS/cm2 (annular area) to identify severe AS in patients with low gradient. AVCS/MG was developed based on AVSC (AU) 2000 in males, and 1600 in females/ 40 mmHg (50 and 30, retrospectively)

Results Our analysis …

Mechanisms Of Hepatocellular Carcinoma Progression, Olorunseun O. Ogunwobi, Trisheena Harricharaan, Jeannette Huaman, Anna Galuza, Oluwatoyin Odumuwagun, Yin Tan, Grace X. Ma, Minhhuyen T. Nguyen

Publications and Research

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib …