Medicine and Health Sciences Commons^™

Model Hewan Coba Pada Penelitian Diabetes, Fauzul Husna, Franciscus D. Suyatna, Wawaimuli Arozal, Erni H. Purwaningsih

Pharmaceutical Sciences and Research

The animal model has been widely used and contributed vastly to the scientific research over the years. While it can be used as an alternate subject in a study, the selection of the animal is crucial to assess and investigate the influence of the environment and genes on the pathogenesis of a disease. Many factors contribute to the choosing of the animal. They can be ranged from the similarities with the modelled object, easily looked after with less expensive cost, good reproductive performance, ability to produce blood and tissue samples, well-known genetic composition, and the status of the disease can …

Identification And Evaluation Of Antibacterial Compounds From The Vibrio Sp. Associated With The Ascidian Pycnoclavella Diminuta, Abdurraafi’ Maududi Dermawan, Elin Julianti, Masteria Yunovilsa Putra

Pharmaceutical Sciences and Research

This study aims to obtain secondary metabolites that have antibacterial activity from bacteria endophytic of ascidian Pycnoclavella diminuta collected from the coast of Bitung, North Sulawesi, Indonesia. The research was started with screening antibacterial activity of six bacteria isolated from P. diminuta. The active bacteria were selected for identification using standard biological molecular method and further fermentation to produce secondary metabolites. The isolation of secondary metabolites was conducted by various chromatography method and then selected fraction was based on the antibacterial activity from bioautography results. The result showed that the active isolate by coding M2.Tnk.Bt 5.10-3.2 was identified as Vibrio …

Chemical Components Of Ocimum Basilicum L. And Ocimum Tenuiflorum L. Stem Essential Oils And Evaluation Of Their Antioxidant Activities Using Dpph Method, Ni Putu Ermi Hikmawanti, Hariyanti, Nurkamalia, Sahera Nurhidayah

Pharmaceutical Sciences and Research

Ocimum basilicum L. and Ocimum tenuiflorum L. are two types of plants from Ocimum (Lamiaceae). One of their chemical compounds is essential oil. Essential oil might have an antioxidant activities. The part of the plants which are often wasted and never used are stem. This study aimed to analyze the chemical components of O. basilicum L. and O. tenuiflorum L. stem essential oils and evaluate their antioxidant activities. Essential oils were obtained by steam-water distillation. Analysis of chemical component of essential oil was performed using Gas Chromatography-Mass Spectroscopy (GC-MS). Antioxidant activities were evaluated with DPPH method and then the IC50 …

Cytotoxic Activity Of Stem Of Pycnarrhena Cauliflora Through Apoptosis Induction On Human Breast Cancer Cell Line T47d, Masriani, Rudiyansyah, Rini Muharini, Eny Enawaty

Pharmaceutical Sciences and Research

Cytotoxic activities of extracts of Pycnarrhena cauliflora leaves, stems and roots on some human cancer cells have been known. However, the cytotoxicity of stem of Pycnarrhena cauliflora on human breast cancer cell line T47D through an apoptosis induction has not been proven yet. This study was an effort in understanding the cytotoxic activity of stem of Pycnarrhena cauliflora through apoptosis induction. The crude ethanol extract was partitioned between n-hexane and dichloromethane at pH 3, 7 and 9, which was subsequently tested for their cytotoxic activity against human breast cancer cell line T47D by using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT). Flow cytometric …

To Disclose Or Not To Disclose? Self-Disclosure Of Mental Health In The Workplace, Samantha Margaret Reynolds

Dissertations and Theses

When making the decision to disclose a mental illness, individuals may be met with a number of factors that impact disclosure. This study examines the relationship between self-stigma, psychological safety, social support and self-disclosure of mental illness in the workplace. The present study surveyed 756 participants and found a positive relationship between stigma and self-disclosure as well as a positive relationship between social support and self-disclosure. For work outcomes, there was a negative relationship between both job satisfaction and productivity in relation to self-disclosure. This study potentiates the antecedents and consequences of self-disclosure of mental illness and how it impacts …

Social And Psychological Factors Associated With Health Care Transition For Young Adults Living With Sickle Cell Disease, Dora L. Clayton-Jones, Nadine Matthie, Marsha Treadwell, Joshua Field, Amy Mager, Rachel Sawdy, Safiya George Dalmida, Cynthia Leonard, Kathryn L. Koch, Kristin Haglund

College of Nursing Faculty Research and Publications

Introduction: Due to advances in disease management, mortality rates in children with sickle cell disease (SCD) have decreased. However, mortality rates for young adults (YA) increased, and understanding of social and psychological factors is critical. The aim of this study was to explore factors associated with health care transition experiences for YA with SCD.

Method: This was a qualitative descriptive study. A 45-minute semistructured interview was conducted with 13 YA (M = 21.5 years, SD = 1.73).

Results: Results suggest that social and psychological factors and self-management experiences influence health care transition. Eight themes emerged: “need for accessible support”; “early …

Incidence Of Initial Renal Replacement Therapy Over The Course Of Kidney Disease In Children., Derek K. Ng, Matthew B. Matheson, Bradley A. Warady, Susan R. Mendley, Susan L. Furth, Alvaro Muñoz

Manuscripts, Articles, Book Chapters and Other Papers

The Chronic Kidney Disease in Children Study, a prospective cohort study with data collected from 2003 to 2018, provided the first opportunity to characterize the incidence of renal replacement therapy (RRT) initiation over the life course of pediatric kidney diseases. In the current analysis, parametric generalized gamma models were fitted and extrapolated for RRT overall and by specific treatment modality (dialysis or preemptive kidney transplant). Children were stratified by type of diagnosis: nonglomerular (mostly congenital; n = 650), glomerular-hemolytic uremic syndrome (HUS; n = 49), or glomerular-non-HUS (heterogeneous childhood onset; n = 216). Estimated durations of time to RRT after …

What's Happening: December 30, 2019, Maine Medical Center

What's Happening

No abstract provided.

Mers-Cov Infection In South Korea And Strategies For Possible Future Outbreak: Narrative Review, Chulwoo Park

Faculty Publications

Although there were some positive viewpoints from international press and academia that the Republic of Korea (hereafter South Korea) successfully controlled the Middle East Respiratory Syndrome (MERS) outbreak in 2015, the domestic point of view towards the MERS response in South Korea was critical. As people in the world’s 11th largest economy, South Koreans criticized the failure of hospitals’ initial response to the MERS index case and the lack of a proper control strategy for secondary and tertiary cases. To contain the MERS outbreak, South Korea implemented mainly three MERS control and intervention strategies: quarantine and isolation system, temporary closure …

Recanalization After Radio-Frequency Ablation (Rfa) In Limb Varices At Dr. Cipto Mangunkusumo And Fatmawati General Hospitals From 2015- 2017, Rudi Hermansyah, Dedy Pratama, Witra Irfan

The New Ropanasuri Journal of Surgery

Introduction. Ligation in upper location and stripping of the varicose veins, enfacing high incidence of failure, recanalization. Endovascular surgery is a modality used to treat limb varicose. However, the recanalization following the procedure was never evaluated.

Method. We ran a cohort study on subjects with reflux of the great saphenous vein treated by RFA. Following the RFA procedure, the evaluation proceeded using ultrasound within the first three weeks.

Results. A total of 77 subjects were analysed for recanalization post-RFA. Recanalization was found in one subject (1.3%), partial recanalization in 6 subjects (7.79%), and no recanalization in 70 …

Biology Of Glycocalyx: The Essential Role In Maintaining Epithelial Barrier: A Mini-Review, Toar J.M. Lalisang

The New Ropanasuri Journal of Surgery

No abstract provided.

Open Surgery With Intraoperative Enteroscopy In Jejunoileal Massive Bleeding In Pediatric Patient: An Evidence-Based Case Report, Rini Y. Husni, Kshetra Rinaldhy

The New Ropanasuri Journal of Surgery

Introduction. A case report of surgical exploratory laparotomy with intraoperative enteroscopy (IOE) as a treatment in massive jejunoileal bleeding in children.

Method. We conducted a literature search on databases such as Cochrane, PubMed, ScienceDirect, and Google Scholar. Abstract and title screening was done based on exclusion criteria, inclusion criteria, and double filtering. The selected article then reviewed using critical appraisal tools based on its validity, importance, and applicability. Selected articles were benchmark to the discussion.

Results. The application of open surgery with IOE as the final treatment that can be recommended in the critical or life-threatening condition …

Efek Asi Eksklusif Terhadap Stunting Pada Anak Usia 6-59 Bulan Di Kabupaten Bogor Tahun 2019, Hardya Gustada Hikmahrachim, Rinawati Rohsiswatmo, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Stunting, atau perawakan pendek, berhubungan erat dengan hambatan kemampuan kognitif dan kualitas hidup. Prevalensi stunting di Indonesia mencapai 30,8% tahun 2018. Stunting dipengaruhi pemenuhan nutrisi di awal kehidupan, salah satunya melalui ASI eksklusif. Meskipun cakupan ASI eksklusif di Indonesia sudah 74,5%, hubungan stunting dengan ASI eksklusif seringkali tidak konsisten akibat keberagaman kuantitas dan kualitas ASI. Penelitian ini ingin mengetahui efek ASI eksklusif terhadap stunting di Kabupaten Bogor, sebagai salah satu daerah tinggi stunting di Indonesia. Penelitian dengan desain potong lintang ini dilaksanakan di Puskesmas Kecamatan Ciampea, Kabupaten Bogor, pada Februari sampai April 2019. Kriteria inklusi adalah balita usia 6-59 bulan …

Pulmonary Resection In Complicated Primary Pediatric Pulmonary Tuberculosis: An Evidence-Based Case Report, Hendra Wibowo, Suprayitno Wardoyo, Dhama Shinta

The New Ropanasuri Journal of Surgery

Introduction. Paediatric pulmonary tuberculosis incidence was increasing, with many undetected cases. Antituberculosis regiments are known to be the treatment of choice for tuberculosis. Even though pulmonary resection for pulmonary tuberculosis has reduced in daily practice, it remains continues to play an important role in several advanced conditions and complications. Currently, there are no specific practical guidelines concerning surgical indications and approaches for pulmonary tuberculosis. We report a case with complicated primary paediatric pulmonary tuberculosis underwent resection and looking for the literature of the best evidence.

Method. A case report completed with a discussion based on the best evidence. …

A Rare Presentation Of A Giant Epidermal Cyst Of The Parietooccipital Region: A Case Reports, David Kereh, Septiman Septiman

The New Ropanasuri Journal of Surgery

Introduction. Epidermal cysts are common benign cutaneous cysts. An epidermal cyst may be classified as a giant epidermal cyst if it exceeds 5 cm. Giant epidermal cysts with a diameter of 5 cm or more are rare but have been reported. The epidermal cyst rarely discloses malignancy. Although rare, a case of malignant change of benign epidermal cyst is possible. We describe here a rare case of a giant epidermal cyst of the parietooccipital region in a 35-year-old man.

Case Illustration. A 35-year-old man was admitted to the hospital with a huge swelling over the scalp for the …

Comparison Of External Root Resorption In Orthodontic Treatment Between Self-Ligating And Conventional Bracket Systems, Nuriah Bohari, Noor Airin Koah, Rohana Ahmad

Journal of Dentistry Indonesia

The relationship between orthodontic bracket systems and external root resorption has remained debatable. Objective: This study compared the magnitude and pattern of the external root resorption of maxillary incisors as induced by self-ligating and conventional bracket systems via cone beam computed tomography and medical imaging programs. Methods: Eight participants were recruited for each bracket system. Their maxillary incisors were scanned at the beginning (T0) and 18 months into treatment (T1). Three-dimensional models of the four maxillary incisors at T0 and T1 were reconstructed using the Mimics program. The difference in root length between T0 and T1 models represented external root …

Violent Conflict And Breastfeeding: The Case Of Iraq, Vidya Diwakar, Michael A. Malcolm, George Naufal

Economics & Finance Faculty Publications

Background: This study explores the relationship between armed conflict and breastfeeding practices of Iraqi mothers. To date, the relationship between violent conflict and breastfeeding is surprisingly understudied. Especially in the Middle East, which is conflict-prone and has a young population, research on war and household behavior is critical for promoting recovery and sustainable development. Methods: This study employs a unique pairing of the Iraq Body Count Database and the 2006 and 2011 Multiple Indicator Cluster Surveys for Iraq. We use probit models to explore the association between armed conflict and several breastfeeding outcomes – whether a child was ever breastfed, …

Social Ecological Factors Affecting Substance Abuse In Ghana (West Africa) Using Photovoice, Ahmed Kabore, Evans Afriyie-Gyawu, James Awuah, Andrew R. Hansen, Ashley Walker, Melissa Hester, Moussa Aziz Wonadé Sié, Dhruv Medarametla, Nicolas Meda

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Introduction: substance abuse is an important public health issue affecting West Africa; however, there is currently a dearth of literature on the actions needed to address it. The aim of this study was to assess the risks and protective factors of substance abuse in Ghana, West Africa, using the photovoice method.

Methods: this study recruited and trained 10 participants in recovery from substance abuse and undergoing treatment in the greater Accra region of Ghana on the photovoice methodology. Each participant received a disposable camera to take pictures that represented the risk and protective factors pertinent to substance abuse …

Intervention For Cognitive Reserve Enhancement In Delaying The Onset Of Alzheimer's Symptomatic Expression (Increase), A Randomized Controlled Trial: Rationale, Study Design, And Protocol, Daniela C. Moga, Brooke F. Beech, Erin L. Abner, Frederick A. Schmitt, Riham H. El Khouli, Ashley I. Martinez, Lynne Eckmann, Mark Huffmyer, Rosmy George, Gregory A. Jicha

Pharmacy Practice and Science Faculty Publications

BACKGROUND: The course of Alzheimer's disease (AD) includes a 10-20-year preclinical period with progressive accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles in the absence of symptomatic cognitive or functional decline. The duration of this preclinical stage in part depends on the rate of pathologic progression, which is offset by compensatory mechanisms, referred to as cognitive reserve (CR). Comorbid medical conditions, psychosocial stressors, and inappropriate medication use may lower CR, hastening the onset of symptomatic AD. Here, we describe a randomized controlled trial (RCT) designed to test the efficacy of a medication therapy management (MTM) intervention to reduce inappropriate …

Medical Conditions And Oral Diseases In Elderly Thai Dental Patients In Lower Northern Thailand, Ruchadaporn Kaomongkolgit, Pissacha Daroonpan, Weeraya Tantanapornkul, Jadesada Palasuk, Ronnayut Chansamat

Journal of Dentistry Indonesia

The World Health Organization (WHO) aims to strengthen oral health promotion and disease prevention around the globe. The prevalence and association of systemic diseases and oral diseases has been reported. Objectives: The objectives of this study were to investigate prevalence of medical conditions and oral diseases in elderly Thai dental patients. Methods: Three hundred dental records of patient aged 60 years old and older were retrospectively reviewed. Data were analyzed using Pearson’s Chi-square and Fisher›s exact test with the significant level at p < 0.05. Results: All of them were Thai of 142 males (47.3%) and 158 females (52.7%). Their age ranged …

Hazards Of Short- And Long-Term Administration Of Glucocorticoids On The Periodontium In Rats: A Histological And Electron Microscopic Study, Tahani Abd El Karim Hagag, Elham Fathy, Mahmoud Fathy Mahmoud, Zeinab Salem

Journal of Dentistry Indonesia

The administration of glucocorticoids is proven to cause serious adverse events. Objectives: This study was conducted to compare the possible hazards of the short- and long-term administration of glucocorticoids on the periodontium in rats, using histological examination and scanning electron microscopy. Methods: Fifteen adult male albino rats were included in the study and divided into the 3 groups. Group I served as a control, group II received 7 mg/kg dexamethasone intramuscularly once a week for 5 wk, and group III received 7 mg/kg dexamethasone intramuscularly once a week for 10 wk. The mandibles were dissected and examined histologically as well …

Orthodontic Camouflage Treatment Of A High-Angle Severe Skeletal Class Ii Discrepancy, Deryana Marshadhianti, Miesje Karmiati Purwanegara

Journal of Dentistry Indonesia

Proper orthodontic treatment in adult patients with severe skeletal Class II discrepancy can be challenging. Recently, miniscrew implants have been used as a strategy to treat skeletal Class II patients. Objective: This report illustrates a skeletal Class II malocclusion management combining straight wire technique and miniscrew implant anchorage. Case report: The patient was a 21-years- old Indonesian female with Class II skeletal discrepancy, a retrognathic mandible, a high mandibular plane angle, and a mouth breathing habit due to a history of allergic rhinitis. Anchorage control is important in the sagittal and vertical directions. Miniscrew implants were placed in the …

Oral Manifestations Of Renal Osteodystrophy In A Patient With Systemic Lupus Erythematosus With Chronic Renal Failure And Secondary Hyperparathyroidism: A Case Report, Inthivorn Riyachan, Ajiravudh Subarnbhesaj, Wilairat Sarideechaigul, Poramaporn Klanrit

Journal of Dentistry Indonesia

Systemic lupus erythematosus (SLE) is one of the chronic autoimmune diseases that leads to multiple manifestations in several organ systems, including chronic renal failure (CRF). Renal osteodystrophy (ROD) is one of the most common complications of CRF associated with secondary hyperparathyroidism (HPT). A combination of CRF and HPT can result in broad-spectrum disorders in the metabolism of minerals such as calcium, phosphorus, and vitamin D, which can affect bone turnover, mineralization, and volume. Radiographic alterations of ROD are considered as one of the earliest signs of CRF. Objective: To describe the oral manifestations in both the maxilla and mandible of …

Antimicrobial Efficacy Of Myrmecodia Pendens Extract And Fraction Combination Against Enterococcus Faecalis Atcc 29212, Faisal Kuswandani, Mieke H. Satari, Ani M. Maskoen

Journal of Dentistry Indonesia

Enterococcus faecalis can withstand harsh environmental conditions in the root canal and cause a secondary infection. Myrmecodia pendens is an herbal medicine rich in polyphenol compounds that have antibacterial, antioxidant, and anticancer properties. Objectives: To analyze the effects of M. pendens fraction combination on the sensitivity of E. faecalis. Methods: The minimum inhibitory concentration (MIC) was determined using a serial microdilution method, and the minimum bactericidal concentration (MBC) was determined by adding the test sample to sterile Mueler Hinton agar medium. Results: The MIC of combination 1 (hexane-ethyl acetate, HE) was 0.049 mg/mL, whereas those of combinations 2 (hexane-water, HA) …

The Papoose Board: Parents’ Perceptions And Attitudes Of Its Usage In Their Child’S Dental Treatment, Ilham Wan Mokhtar, Aida Syazana Mohd Suhaimi, Mas Suryalis Ahmad, Izyan Hazwani Baharuddin, Nur Iryani Izzaty Andytan

Journal of Dentistry Indonesia

Parental perception and attitudes are important parameters in deciding the most suitable behavioral management technique for their children’s dental treatment. Objective: This study sought to evaluate parents’ perceptions, attitudes, and concern in using a papoose board (PB) on their child during dental treatment as a behavioral management technique in dentistry, as well as determine the sociodemographic factors associated with parents’ willingness to use the PB for their children’s dental care. Methods: One hundred parents from three locations with at least one healthy child aged between 4 and 7 years old were randomly identified. A self-made video (duration of 94 s) …

Primary Amelanotic Melanoma Of The Maxillary Gingiva: A Case Report, Wipasinee Sungkhao, Poramaporn Klanrit, Suthin Jinaporntham, Ajiravudh Subarnbhesaj

Journal of Dentistry Indonesia

Malignant melanoma arising in the oral cavity is particularly rare. The clinical presentations of malignant melanoma can range from a benign-looking pigmented macule or nodule to a non-pigmented neoplasm which can be categorized into primary or metastatic lesions. Less than 2% of all melanomas show no pigmentation and could lead to misdiagnosis. Objective: To present a benign looking but life-threatening malignancy of melanotic melanoma. Case report: A 59-year-old female patient was referred to a regional hospital for further treatment of a localized gingival swelling with no ulceration at the anterior maxilla. An incisional biopsy was performed, with initial histopathologic …

Hubungan Wilayah Tempat Tinggal Dengan Pemberian Asi Ekslusif Pada Anak 0-5 Bulan Di Indonesia (Analisis Data Survei Demografi Kesehatan Indonesia) Tahun 2017, Andi Karnila, Krisnawati Bantas

Jurnal Epidemiologi Kesehatan Indonesia

ASI ekslusif dapat mencegah morbiditas dan mortalitas pada anak. Wilayah tempat tinggal perkotaan dan pedesaan memiliki keterkaitan dengan praktek pemberian ASI ekslusif. Penelitian ini bertujuan untuk menganalisis hubungan antara wilayah tempat tinggal dengan praktek pemberian ASI ekslusif pada anak 0-5 bulan di Indonesia. Desain studi penelitian yaitu cross sectional menggunakan data sekunder Survei Demografi Kesehatan Indonesia. Penelitian ini dilaksanakan diseluruh provinsi di Indonesia. Variabel dalam penelitian ini terdiri dari ASI ekslusif sebagai variabel dependen, wilayah tempat tinggal sebagai variabel independen dan variabel perancu yang terdiri dari umur ibu, pendidikan ibu, paritas, kondisi depresi ibu, status bekerja, status ekonomi, status pernikahan, …

Pemberantasan Sarang Nyamuk 3m Plus Terhadap Kejadian Demam Berdarah Dengue Di Puskesmas Payung Sekaki Kota Pekanbaru; Studi Kasus Kontrol, Tyagita Widya Sari, Retno Putri

Jurnal Epidemiologi Kesehatan Indonesia

Demam Berdarah Dengue (DBD) adalah penyakit menular yang disebabkan oleh virus Dengue dan ditularkan melalui gigitan nyamuk Aedes aegypti. Dinas Kesehatan Provinsi Riau melaporkan jumlah kasus DBD sebanyak 277 dan Case Fatality Rate (CFR) DBD sebesar 1,4% pada tahun 2016, di mana kasus terbanyak berasal dari Kota Pekanbaru yaitu 58 kasus dengan CFR sebesar 0%. Adapun, CFR DBD di wilayah kerja Puskesmas Payung Sekaki meningkat dari 0% pada tahun 2015 menjadi 0,7% pada tahun 2016. DBD merupakan penyakit berbasis lingkungan yang dapat dicegah dengan melakukan tindakan pengendalian vektor, antara lain dengan pemberantasan sarang nyamuk (PSN) dan tindakan pencegahan lainnya. Akan …

Pengaruh Inisiasi Menyusu Dini Terhadap Kematian Neonatal Pada Bayi Berat Lahir >2500 Gram Dan Pada Bayi Berat Lahir Rendah Di Indonesia, Ana Maina Rezky, Asri C. Adisasmita

Jurnal Epidemiologi Kesehatan Indonesia

Kematian balita banyak terjadi pada masa neonatal. Inisiasi menyusu dini merupakan salah satu bentuk perawatan esensial saat lahir dan sebagai kunci awal dalam meningkatkan kelangsungan hidup bayi neonatal. Penelitian ini bertujuan mengetahui pengaruh inisiasi menyusu dini terhadap kematian neonatal pada bayi berat lahir > 2500 gram dan pada bayi berat lahir rendah di Indonesia. Penelitian ini menggunakan data yang bersumber dari Survei Demografi dan Kesehatan Indonesia tahun 2012. Data yang dikumpulkan dalam SDKI diperoleh melalui wawancara responden menggunakan kuesioner. Metode pengambilan sampel yang digunakan dalam SDKI yakni pertama melakukan pemilihan sejumlah primary sample unit (PSU) secara probability proportional to size (PPS), …

Association Of Obesity And Negative Acid-Fast Bacilli Finding Among Pulmonary Tuberculosis Patients With Type 2 Diabetes Mellitus, Nadya Magfira, Md Ikhsan Mokoagow, Ida Ayu Kshanti, Helda Helda

Jurnal Epidemiologi Kesehatan Indonesia

non-diabetes mellitus population. However, it’s effect on PTB in type 2 diabetes mellitus (T2DM) patient is unclear. The study aims to determine the association between obesity and PTB in patient with T2DM. A cross sectional study was held in in-patient, The Department of Internal Medi cine, Fatmawati General Hospital from January 2015 to December 2017. This study includes patient with T2DM who had been diagnosed with PTB and age > 18 years old. In this study negative Acid-fast-bacilli (AFB) founding defined as patient’s sputum is negative by smear microscopy, while obesity define as body mass index > 24.9 kg/m2. From 363 PTB …