Medicine and Health Sciences Commons^™

Placental Micrornas In Pregnancies With Early Onset Intrauterine Growth Restriction And Preeclampsia: Potential Impact On Gene Expression And Pathophysiology., Zain Awamleh, Gregory B Gloor, Victor K M Han

Paediatrics Publications

BACKGROUND:
A normally developed placenta is integral to a successful pregnancy. Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two common pregnancy related complications that maybe a result of abnormal placental development. Placental microRNAs (miRNAs) have been investigated as potential biomarkers for these complications, as they may play a role in placental development and pathophysiology by influencing gene expression. The purpose of this study is to utilize next-generation sequencing to determine miRNA and gene expression in human placental (chorionic villous) samples from three distinct patient groups with early-onset (EO) PE, IUGR, or PE + IUGR.

METHODS:
Placental tissues were collected …

The Stability Of Retrospective Pre-Injury Symptom Ratings Following Pediatric Concussion., Elizabeth F Teel, Roger L Zemek, Kenneth Tang, Gerard Gioia, Christopher Vaughan, Maegan Sady, Isabelle J Gagnon, Gurinder Sangha

Paediatrics Publications

Objective:
To determine the stability of children's retrospective ratings of pre-injury levels of symptoms over time following concussion.

Methods:
Children and adolescents (n = 3,063) between the ages of 5–17 diagnosed with a concussion by their treating pediatric emergency department (PED) physician within 48 h of injury completed the Post-Concussion Symptom Inventory (PCSI) at the PED and at 1, 2, 4, 8, and 12-weeks post-injury. At each time point, participants retrospectively recalled their pre-injury levels of post-injury symptoms. The PCSI has three age-appropriate versions for children aged 5–7 (PCSI-SR5), 8–12 (PCSI-SR8), and 13–18 (PCSI-SR13). Total scale, subscales (physical, cognitive, …

Risk Of Cancer Death Among White, Black, And Hispanic Populations In South Florida, Paulo S. Pinheiro, Karen E. Callahan, Tulay Koru-Sengul, Justine Ransdell, Layla Bouzoubaa, Clyde P. Brown, Erin Kobetz

Environmental & Global Health Faculty Research

Background: The cancer burden in South Florida, with a population of more than 6 million with a heavily Hispanic and large Afro-Caribbean population, has not been quantified. Methods: We analyzed 2012–2016 cancer mortality data from South Florida for white, Hispanic, and black populations with disaggregation for Cuban, Puerto Rican, South American, African American, and Afro-Caribbean groups. We calculated cancer site-specific and all-sites combined age-adjusted mortality rates, and we used negative binomial regression to determine mortality rate ratios to compare South Florida’s cancer mortality rates with those of the rest of the nation. Results: We analyzed 53,837 cancer deaths. Per 100,000 …

Microrna Regulation Of Epigenetic Modifiers In Breast Cancer, Brock Humphries, Zhishan Wang, Chengfeng Yang

Toxicology and Cancer Biology Faculty Publications

Epigenetics refers to the heritable changes in gene expression without a change in the DNA sequence itself. Two of these major changes include aberrant DNA methylation as well as changes to histone modification patterns. Alterations to the epigenome can drive expression of oncogenes and suppression of tumor suppressors, resulting in tumorigenesis and cancer progression. In addition to modifications of the epigenome, microRNA (miRNA) dysregulation is also a hallmark for cancer initiation and metastasis. Advances in our understanding of cancer biology demonstrate that alterations in the epigenome are not only a major cause of miRNA dysregulation in cancer, but that miRNAs …

Incidence And Cost Of Acute Kidney Injury In Hospitalized Patients With Infective Endocarditis, Victor M. Ortiz-Soriano, Katherine Donaldson, Gaixin Du, Ye Li, Joshua Lambert, Dan Cleland, Alice C. Thornton, Laura C. Fanucchi, Moises A. Huaman, Javier A. Neyra

Internal Medicine Faculty Publications

Acute kidney injury (AKI) is a frequent complication of hospitalized patients with infective endocarditis (IE). Further, AKI in the setting of IE is associated with high morbidity and mortality. We aimed to examine the incidence, clinical parameters, and hospital costs associated with AKI in hospitalized patients with IE in an endemic area with an increasing prevalence of opioid use. This retrospective cohort study included 269 patients admitted to a major referral center in Kentucky with a primary diagnosis of IE from January 2013 to December 2015. Of these, 178 (66.2%) patients had AKI by Kidney Disease Improving Global Outcomes (KDIGO) …

Andrews Recognized By Exercise Is Medicine, Exercise Is Medicine

Andrews Agenda: Campus News

No abstract provided.

Use Of Unmanned Aircraft Systems (Uas) And Multispectral Imagery For Quantifying Agricultural Areas Damaged By Wild Pigs, Justin W. Fischer, Kelsey Greiner, Mark W. Lutman, Bryson L. Webber, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Wild pigs (Sus scrofa) cause extensive damage to agricultural crops, resulting in lost production and income. A major challenge associated with assessing damage to crops is locating and quantifying damaged areas within agricultural fields. We evaluated a novel method using multispectral high-resolution aerial imagery, collected from sensors mounted on unmanned aircraft systems (UAS), and feature extraction techniques to detect and map areas of corn fields damaged by wild pigs in southern Missouri, USA. Damaged areas were extracted from orthomosaics using visible and near-infrared band combinations, an object-based classification approach, and hierarchical learning cycles. To validate estimates we also collected ground …

A Comparative Study Of Short-Term Efficacy And Safety For Thyroid Micropapillary Carcinoma Patients After Microwave Ablation Or Surgery., Jianming Li, Yujiang Liu, Ji-Bin Liu, Peipei Yang, Xiangdong Hu, Linxue Qian

Department of Radiology Faculty Papers

Background: Although papillary thyroid microcarcinoma (PTMC) has a high incidence and excellent clinical outcome, debate continues as to the therapeutic approach that would be most appropriate after confirming the diagnosis.

Methods: We retrospectively analyzed the medical records of 311 patients with T1aN0M0 PTMC between January 2013 and September 2018. In all, 168 underwent microwave ablation (MWA), and 143 underwent surgery. MWA was performed using extensive ablation with hydrodissection. The surgery comprised thyroid lobectomy (TL) with unilateral central lymph node dissection (CND). We examined clinical outcomes during mean follow-up periods of 824 ± 452 days for the TL group and 753 …

The Relationship Between Hand And Wrist Musculoskeletal Disorders And Hand Activity And Posture, Warren M. Henry

USF Tampa Graduate Theses and Dissertations

Musculoskeletal disorders are common in many industries such as automotive, manufacturing and line assembly. Risk factors include high frequency or hand repetition, long duration of work activities with short rest periods, unsustainable postures which put strain on the body and muscles, and activities that require significant force to fulfill duties. The current ACGIH TLV for hand activity uses hand activity level (HAL) and normalized peak force (NPF) to assess an individual’s risk of developing an MSD. The purpose of this study is to propose the use of Posture as an alternative to NPF and couple it with HAL to assess …

Script Training For Adults Who Stutter, Courtney M. Rankin

USF Tampa Graduate Theses and Dissertations

Treatment for adulthood stuttering traditionally focuses on some combination of stuttering management and fluency management and may also target emotional and cognitive reactions to stuttering. However, long-term gains are often limited, and there is a need for continued development of approaches for mitigating impacts of stuttering. We know of no evidence-based therapy approaches designed to target functional communication in adults who stutter (AWS), despite widespread interest in improving functional communication in members of this speaker group. Script training is an intervention approach designed to improve accuracy and automaticity in functional communication. Script training was originally designed for use with adults …

The Effect Of Narrative Language Intervention On The Language Skills Of Children With Hearing Loss, Stephanie M. Raymond

USF Tampa Graduate Theses and Dissertations

Children with hearing loss have limited auditory access to their native language and struggle to develop appropriate language skills. These children consistently demonstrate less complex oral language output, smaller vocabulary inventories, and delays in overall communicative proficiency. With the extensive implications hearing loss has on language development, a child with hearing loss requires immediate access to appropriate and effective intervention to address deficits and curb long-term language delays. However, there is a paucity of research investigating the effects of various language intervention programs with children with hearing loss. Much of the existing research focuses on the consequences of a selected …

The "M" Word: Accusations Of Malingering Are Harmful To Patient Care, Joshua S. Ellis

Cooper Rowan Medical Journal

It starts as a small seed of doubt. It can be planted by anyone: the physician, the nurse, a family member, or even the patient. But once the seed gets planted in the minds of those involved in caring for the patient, every word and action from the patient function as water and sunshine, encouraging the seed to grow. The seed of doubt grows into a small tree of criticism which blooms into a collection of judgment and prejudice that prevent the patient from receiving the care that he or she deserves. All of this can happen after a patient …

The Effect Of Democracy, Development, Religion And Science On Animal Welfare, Sydney Richardson

Celebration of Learning

This project examined the determinants of animal welfare across five countries: India, New Zealand, Spain, Sweden and the United Stated. The dependent variable of animal welfare was measured based on the Animal Protection Index (API) developed by the World Protection, a global non-profit organization. Democracy, development, religion and science were major areas that were evaluated to determine if there were correlations with the API. Correlation with the API was tested by using the Pearson Correlation Coefficient. A Country’s Freedom House scores were used to evaluate Democracy. Development examined each country’s Human Development Index from the UN’s Human Development Reports and …

Co-Located Retail Clinics And Pharmacies: An Opportunity To Provide More Primary Care., Katherine K. Knapp, Keith Yoshizuka, Debra Sasaki-Hill, Rory Caygill-Walsh

Faculty Publications & Research of the TUC College of Pharmacy

This paper proposes that co-located retail clinics (RCs) and community pharmacies can increase opportunities to provide more accessible, affordable, and patient-friendly primary care services in the United States. RCs are small businesses of about 150-250 square feet with a clientele of about 10-30 patients each day and most frequently staffed by nurse practitioners (NPs). Community pharmacies in the U.S. at ~67,000 far outnumber RCs at ~2800, thereby opening substantial opportunity for growth. Community pharmacies and pharmacists have been working to increase on-site clinical services, but progress has been slowed by the relative isolation from other practitioners. An ideal merged facility …

Modulation Of Osteogenic And Myogenic Differentiation By A Phytoestrogen Formononetin Via P38mapk-Dependent Jak-Stat And Smad-1/5/8 Signaling Pathways In Mouse Myogenic Progenitor Cells, Ilavenil Soundharrajan, Da Hye Kim, Palaniselvam Kuppusamy, Ki Choon Choi

Center for Research on Environmental Disease Faculty Publications

Formononetin (FN), a typical phytoestrogen has attracted substantial attention as a novel agent because of its diverse biological activities including, osteogenic differentiation. However, the molecular mechanisms underlying osteogenic and myogenic differentiation by FN in C2C12 progenitor cells remain unknown. Therefore the objective of the current study was to investigate the action of FN on myogenic and osteogenic differentiation and its impact on signaling pathways in C2C12 cells. FN significantly increased myogenic markers such as Myogenin, myosin heavy chains, and myogenic differentiation 1 (MyoD). In addition, the expression of osteogenic specific genes alkaline phosphatase (ALP), Run-related transcription factor 2(RUNX2), and osteocalcin …

Drug Interactions Between Direct-Acting Oral Anticoagulants And Calcineurin Inhibitors During Solid Organ Transplantation: Considerations For Therapy, Edwin Lam, Babar Bashir, Mark Chaballa, Walter K. Kraft

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Introduction: There is a high incidence of venous thromboembolism (VTE) in solid organ transplant recipients. The safety and efficacy of direct-acting oral anticoagulants (DOAC) have been well established in clinical practice for the prevention and treatment of VTE in broad populations. However, the management of VTE in the setting of solid organ transplantation remains a challenge to clinicians due to limited evidence of DOAC usage with calcineurin inhibitors.

Areas covered: The current literature available on the pharmacokinetic-pharmacodynamic interaction between DOACs and calcineurin inhibitors is presented. A comprehensive review was undertaken using PubMed, Embase, drug product labeling, and drug …

Roche Restarts Redesigned Phase 3 Huntington’S Disease Trial, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Transferrin-Bearing Liposomes Entrapping Plumbagin For Targeted Cancer Therapy, Intouch Sakpakdeejaroen, Sukrut Somani, Partha Laskar, Margaret Mullin, Christine Dufès

School of Medicine Publications

The therapeutic potential of plumbagin, a naphthoquinone extracted from the officinal leadwort with anticancer properties, is hampered by its failure to specifically reach tumours at a therapeutic concentration after intravenous administration, without secondary effects on normal tissues. Its use in clinic is further limited by its poor aqueous solubility, its spontaneous sublimation, and its rapid elimination in vivo. We hypothesize that the entrapment of plumbagin within liposomes grafted with transferrin, whose receptors are overexpressed on many cancer cells, could result in a selective delivery to tumours after intravenous administration. The objectives of this study were therefore to prepare and …

Effects Of Single And Integrated Water, Sanitation, Handwashing, And Nutrition Interventions On Child Soil-Transmitted Helminth And Giardia Infections: A Cluster-Randomized Controlled Trial In Rural Kenya, Amy J. Pickering, Sammy M. Njenga, Lauren Steinbaum, Jenna Swarthout, Audrie Lin, Benjamin F. Arnold, Christine P. Stewart, Holly N. Dentz, Maryanne Mureithi, Benard Chieng, Marlene Wolfe, Ryan Mahoney, Jimmy Kihara, Kendra Byrd, Gouthami Rao, Theodora Meerkerk, Priscah Cheruiyot, Marina Papaiakovou, Nils Pilotte, Steven A. Williams, John M. Colford Jr., Clair Null

Biological Sciences: Faculty Publications

Helminth and protozoan infections affect more than 1 billion children globally. Improving water quality, sanitation, handwashing, and nutrition could be more sustainable control strategies for parasite infections than mass drug administration, while providing other quality of life benefits.

Is Intimate Partner Violence A Risk Factor For Cardiovascular Disease In Women? A Review Of The Preponderance Of The Evidence, Rose Eva Constantino, Alona D. Angosta, Andrew Thomas Reyes, Brayden Kameg, Linden Wu, Jordan Cobb, Vivian Hui, Daisy Palompon, Reema Safadi, Mayada Daibes, Elizabeth Schlenk

Nursing Faculty Research

This paper examines the relationship between intimate partner violence (IPV) experience in women and cardiovascular disease (CVD), and determines if there is a preponderance of literature evidence. Research is reviewed dealing with the different biopsychosocial factors affecting the relationship between IPV and CVD. As a result of our review, we propose a framework on the biopsychosocial pathway of IPV as a risk factor of CVD of women. Our proposed framework portrays how IPV experiences contribute to long-term biopsychosocial changes that increase the risk of CVD among female victims of IPV. These biopsychosocial changes include chronic inflammation and hypothalamus-pituitary-adrenal axis dysfunction, …

Liver Cancer: A Leading Cause Of Cancer Death In The United States And The Role Of The 1945–1965 Birth Cohort By Ethnicity, Paulo S. Pinheiro, Karen E. Callahan, Patricia D. Jones, Cyllene Morris, Justine M. Ransdell, Deukwoo Kwon, Clyde Perry Brown, Erin N. Kobetz

Environmental & Global Health Faculty Research

No abstract provided.

Competitive Frontoparietal Interactions Mediate Implicit Inferences, Martijn E. Wokke, Tony Ro

Publications and Research

Frequent experience with regularities in our environment allows us to use predictive information to guide our decision process. However, contingencies in our environment are not always explicitly present and sometimes need to be inferred. Heretofore, it remained unknown how predictive information guides decision-making when explicit knowledge is absent and how the brain shapes such implicit inferences. In the present experiment, 17 human participants (9 females) performed a discrimination task in which a target stimulus was preceded by a predictive cue. Critically, participants had no explicit knowledge that some of the cues signaled an upcoming target, allowing us to investigate how …

A Prospective, Multi-Center, Randomized Comparison Of Iron Isomaltoside 1000 Versus Iron Sucrose In Patients With Iron Deficiency Anemia; The Ferwon-Ida Trial., Michael Auerbach, David Henry, Richard J. Derman, Maureen M. Achebe, Lars L. Thomsen, John Glaspy

Global Health Articles

Iron deficiency anemia (IDA) is prevalent, and intravenous iron, especially if given in a single dose, may result in better adherence compared with oral iron. The present trial (FERWON-IDA) is part of the FERWON program with iron isomaltoside 1000/ferric derisomaltose (IIM), evaluating safety and efficacy of high dose IIM in IDA patients of mixed etiologies. This was a randomized, open-label, comparative, multi-center trial conducted in the USA. The IDA patients were randomized 2:1 to a single dose of 1000 mg IIM, or iron sucrose (IS) administered as 200 mg intravenous injections, up to five times. The co-primary endpoints were adjudicated …

Association Of Early Interventions With Birth Outcomes And Child Linear Growth In Low-Income And Middle-Income Countries: Bayesian Network Meta-Analyses Of Randomized Clinical Trials, Jay J. Park H., Mei Lan Fang, Ofir Harari, Louis Dron, Ellie G. Siden, Reham Majzoub, Virginia Jeziorska, Kristian Thorlund, Edward J. Mills, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Importance:
The first 1000 days of life represent a critical window for child development. Pregnancy, exclusive breastfeeding (EBF) period (0-6 months), and complementary feeding (CF) period (6-24 months) have different growth requirements, so separate considerations for intervention strategies are needed. No synthesis to date has attempted to quantify the associations of interventions under multiple domains of micronutrient and balanced energy protein and food supplements, deworming, maternal education, water sanitation, and hygiene across these 3 life periods with birth and growth outcomes.
Objective:
To determine the magnitude of association of interventions with birth and growth outcomes based on randomized clinical trials …

Pparg Signaling In The Nucleus Accumbens Regulates Mesolimbic Dopamine Activity, Tony Jung, Roger Hudson, Hanna Szkudlarek, Walter Rushlow, Steve Laviolette

Western Research Forum

Background: The mesolimbic dopamine system consists of dopamine neuron projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc). The NAc regulates VTA dopamine release through inhibitory GABA projections to the VTA. Hyperactive mesolimbic dopamine signaling is implicated in anxiety. Cannabidiol, a compound found in cannabis, demonstrates promising therapeutic potential for anxiety through the regulation of the mesolimbic dopamine system. Previous studies have revealed that cannabidiol infusions into the NAc decreases mesolimbic dopamine activity - potentially through the inhibitory GABA signaling to the VTA. However, the receptor mechanism in the NAc through which CBD produces its effects is …

An Essay Comparing And Contrasting Different Medical Issue On Opposite Ends Of The Spectrum Of Health Care, Cecilie Elliot, Kaitlyn Mccleese

The Omnipedia Review

In healthcare, there are a plethora of issues that vary in diagnosis and treatment and are present in many different cultures and age groups. We reviewed the topics of sleep paralysis and childhood cataracts, and found that there is a correlation between impoverished cultures who struggle with a lack of resources and adequate medical care that affects both of these topics. In countries where there is less development, the technology is not available to educate or treat patients.

Culture shapes the lifestyles of different group of individuals worldwide. From belief systems to available resources, culture often increases the effects of …

Marketing Channel Effectiveness Of New Medications/Medical Technology, Hadley Mccormick

Celebration of Learning

This research project will study what marketing platforms/channels are most effective in the dissemination of new medical product news. Many people like myself have an illness/disease that requires daily medication, or require the daily use of a medical device. Due to the increasing influence of Direct to Consumer advertising of pharmaceuticals and the constant development of new medications and devices, patients may now more often go to the doctor with perceptions of what they should do to manage their illness/disease. This study aims to look at how the developers of these medications/medical devices promote their products currently and how certain …

Perceptions Of Health Practices And Interactions With The Us Healthcare System Among Bhutanese Refugees: A Qualitative Approach, Amy E. Szajna

Journal of Refugee & Global Health

Purpose

The aim of this pilot study was to explore health practices of Bhutanese refugees and their interactions with the US healthcare system and providers.

Methodology

Researchers conducted 12 in-depth interviews and 7 patient-provider observation units as part of this descriptive qualitative study.

Results

Participants identified individual definitions of health and behaviors they value to maintain health. They identified significant trust and faith in their healthcare provider and valued provider-directed suggestions. Participants cited concerns with patient-provider communication resulting from limited English proficiency and frequent changes in primary care providers.

Discussion

This study is useful to inform further research and potential …

Cross-Cultural Lessons On Anger And Social Connectedness, Miranda Worthen

Faculty Publications

I first started thinking about anger and its role in the experiences of people who have fought in wars when I was in Sierra Leone, about a year after the cease-fire ended the civil war. I was working as a research assistant on a study with girls who had been child soldiers and who had given birth to children during the war. We were living in a community in the west, on the border with Guinea. At first, we met only a few young women. We listened to their stories—about the war, and about what life had been like for …

M6a Mrna Demethylase Fto Regulates Melanoma Tumorigenicity And Response To Anti-Pd-1 Blockade, Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E. Aplin, Zhike Lu, Seungmin Hwang, Chuan He, Yu-Ying He

Department of Cancer Biology Faculty Papers

Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N⁶-methyladenosine (m⁶A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade immunotherapy. FTO level is increased in human melanoma and enhances melanoma tumorigenesis in mice. FTO is induced by metabolic starvation stress through the autophagy and NF-κB pathway. Knockdown of FTO increases m⁶A methylation in the critical protumorigenic melanoma cell-intrinsic genes including PD-1 (PDCD1), CXCR4, and SOX10, leading to increased RNA decay through the m⁶A reader YTHDF2. Knockdown of …