Medicine and Health Sciences Commons^™

Arthroscopy Association Of Canada Position Statement On Intra-Articular Injections For Knee Osteoarthritis, Michaela Kopka, Brendan Sheehan, Ryan Degen, Ivan Wong, Laurie Hiemstra, Olufemi Ayeni, Alan Getgood, Cole Beavis, Monika Volesky, Ross Outerbridge, Bogdan Matache

Bone and Joint Institute

No abstract provided.

Understanding The Neural Bases Of Implicit And Statistical Learning, Laura J. Batterink, Ken A. Paller, Paul J. Reber

Brain and Mind Institute Researchers' Publications

© 2019 Cognitive Science Society, Inc. Both implicit learning and statistical learning focus on the ability of learners to pick up on patterns in the environment. It has been suggested that these two lines of research may be combined into a single construct of “implicit statistical learning.” However, by comparing the neural processes that give rise to implicit versus statistical learning, we may determine the extent to which these two learning paradigms do indeed describe the same core mechanisms. In this review, we describe current knowledge about neural mechanisms underlying both implicit learning and statistical learning, highlighting converging findings between …

Macaque Anterior Cingulate Cortex Deactivation Impairs Performance And Alters Lateral Prefrontal Oscillatory Activities In A Rule-Switching Task, Liya Ma, Jason L. Chan, Kevin Johnston, Stephen G. Lomber, Stefan Everling

Brain and Mind Institute Researchers' Publications

© 2019 Ma et al. In primates, both the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC) are key regions of the frontoparietal cognitive control network. To study the role of the dACC and its communication with the dlPFC in cognitive control, we recorded local field potentials (LFPs) from the dlPFC before and during the reversible deactivation of the dACC, in macaque monkeys engaging in uncued switches between 2 stimulus-response rules, namely prosaccade and antisaccade. Cryogenic dACC deactivation impaired response accuracy during maintenance of—but not the initial switching to—the cognitively demanding antisaccade rule, which coincided with a …

Modulation Of The Hoffmann Reflex In The Tibialis Anterior With A Change In Posture., Janelle Unger, Justin W Andrushko, Alison R Oates, Doug W Renshaw, Trevor S Barss, E Paul Zehr, Jonathan P Farthing

Physical Therapy Publications

Hoffmann (H-) reflex amplitudes in plantar flexor soleus muscle are modulated by posture, yet dorsiflexor tibialis anterior (TA) H-reflex parameters have sparingly been studied. The purpose was to investigate modulation of the TA H-reflex when postural demands are increased from sitting to standing. In this study, data from 18 participants (Age: 25 ± 4 years, Height: 170.9 ± 9.5 cm, Weight: 75.9 ± 17.2 kg) allowed comparison of two experimental conditions involving different postures (i.e. sitting and standing). Maximal amplitude of the TA H-reflex (H_max) as a percent of the maximal M-wave amplitude (M_max) …

Evidence-Based Cardiac Monitoring: A Practice Change, Joseph Paul Urbanski

Doctoral Projects

Background: Overuse of cardiac monitoring (CM) in acute care settings contributes to increased healthcare spending and cost of services for patients. Additionally, inappropriate use of CM can contribute to wastefulness of healthcare resources, increases in hospital staff workloads, and can be improved with best evidence-based practice recommendations. A Midwest acute care hospital lacked an evidence-based, systematic method to define care for patients requiring CM.

Objective: The purpose of the project was to pilot an evidence-based CM change initiative, determine feasibility for sustainment, and propose next steps for adoption of the change initiative across non-emergency department, non-intensive care inpatient CM units …

An Investigation Of Problem Gambling And Young Sports Players In An Irish Amateur Sporting Organisation., Maurice Murphy

Dept. of Management & Enterprise Conference Material

The gambling industry is huge in Ireland. The betting firm Paddy Power alone had an operating profit of €163.8million in 2014. The activity has become more popular and accessible in recent years due to its move online. In fact, anybody with a smartphone can gamble wherever they may be. While research within Ireland has been limited, there are some startling statistics related to gambling addiction in Ireland with roughly 7% of gamblers at risk of developing a gambling problem and approximately 30-35% of the gambling industry’s revenues coming from those who have gambling issues. According to the Institute of Public …

The Nutritional Value Of Children's Menus In Chain Restaurants In The United Kingdom And Ireland, Michelle Young, Tara Coppinger, Sue Reeves

Publications

Objective: Obesity in the United Kingdom and the Republic of Ireland is rising, as is the frequency of eating out in restaurants. The aim of this study was to investigate the nutritional quality of children's menus in restaurants. Design: Cross-sectional review of menus aimed at children from 20 popular chain restaurants in the United Kingdom and Ireland. Main Outcome Measures: Total energy, fat, saturated fat, and salt were collected from every food item on the menu in each restaurant. All potential meal combinations were created. A total of 39,266 meals were analysed. Analysis: Meals were compared with UK nutritional guidelines. …

Case Study: Effects Of Psychosocial Factors On A Geriatric Patient With Guillain Barré Syndrome, Keane Evangelista, Mary Pent Hunter, Jessica Phung, Aum Tejani, Lee Anne H. Robotta

San Marcos, Summer 2019

The purpose of this case report is to determine how a change in intrinsic motivation and environmental factors help physical and functional improvements in a 77-year-old male patient with Guillain Barré Syndrome (GBS) in the geriatric population. Interventions to promote this change included patient education about lifestyle choices along with endurance and balance exercises.

Patient psychological state, community access, and general education about interventions/dosing had an effect on the patient's participation in his prescribed HEP. His comorbidities hindered his overall progress over the course of his treatment and should be addressed to improve patient outcomes. Activities that were more salient …

Transmission Dynamics Of Toxoplasma Gondii In Arctic Foxes (Vulpes Lagopus): A Long-Term Mark-Recapture Serologic Study At Karrak Lake, Nunavut, Canada, Emilie Bouchard, Stacey A. Elmore, Ray T. Alisauskas, Gustaf Samelius, Alvin A. Gajadhar, Keaton Schmidt, Sasha Ross, Emily J. Jenkins

United States Department of Agriculture Wildlife Services: Staff Publications

Transmission dynamics of Toxoplasma gondii, a parasite of importance for wildlife and human health, are enigmatic in the Arctic tundra, where free-ranging wild and domestic felid definitive hosts are absent and rarely observed, respectively. Through a multiyear mark-recapture study (2011– 17), serosurveillance was conducted to investigate transmission of T. gondii in Arctic foxes (Vulpes lagopus) in the Karrak Lake region, Nunavut, Canada. Sera from adult foxes and fox pups were tested for antibodies to T. gondii by using serologic methods, including the indirect fluorescent antibody test, direct agglutination test, and modified agglutination test. The overall seroprevalence was 39% in adults …

Validity Of The Short Recovery And Stress Scale In Collegiate Weightlifters, Spencer Kyle Travis, Alec Perkins, Satoshi Mizuguchi, Kevin Breuel, Michael H. Stone, Caleb D. Bazyler

ETSU Faculty Works

Introduction: Monitoring an athlete’s stress and recovery state across sequential training bouts can be used to gauge fitness and fatigue levels (i.e., preparedness). Previous studies have used jumping performance, biochemical markers, and questionnaires to estimate preparedness. However, self-report questionnaires are the most common due to economical and practical means. The Short Recovery and Stress Scale (SRSS) is an 8-item questionnaire ideal for monitoring; however, convergent validity of the SRSS with physiological and performance measures needs to be investigated. Purpose: Thus, the purpose of this study was to determine whether changes in collegiate weightlifter’s training volume-load, biochemical markers, and jumping performance …

Clinical Data: Sources And Types, Regulatory Constraints, Applications., Stanley C Ahalt, Christopher G Chute, Karamarie Fecho, Gustavo Glusman, Jennifer Hadlock, Casey Overby Taylor, Emily R Pfaff, Peter N Robinson, Harold Solbrig, Casey Ta, Nicholas Tatonetti, Chunhua Weng

Faculty Research 2019

Access to clinical data is critical for the advancement of translational research. However, the numerous regulations and policies that surround the use of clinical data, although critical to ensure patient privacy and protect against misuse, often present challenges to data access and sharing. In this article, we provide an overview of clinical data types and associated regulatory constraints and inferential limitations. We highlight several novel approaches that our team has developed for openly exposing clinical data.

Genomic Data Analysis Workflows For Tumors From Patient-Derived Xenografts (Pdxs): Challenges And Guidelines., Xing Yi Woo, Anuj Srivastava, Joel H Graber, Vinod Yadav, Vishal Kumar Sarsani, Allen K. Simons, Glen L Beane, Stephen C. Grubb, Guruprasad Ananda, Rangjiao Liu, Grace Stafford, Jeffrey Chuang, Susan Airhart, Radha Krishna Murthy Karuturi, Joshy George, Carol J Bult

Faculty Research 2019

BACKGROUND: Patient-derived xenograft (PDX) models are in vivo models of human cancer that have been used for translational cancer research and therapy selection for individual patients. The Jackson Laboratory (JAX) PDX resource comprises 455 models originating from 34 different primary sites (as of 05/08/2019). The models undergo rigorous quality control and are genomically characterized to identify somatic mutations, copy number alterations, and transcriptional profiles. Bioinformatics workflows for analyzing genomic data obtained from human tumors engrafted in a mouse host (i.e., Patient-Derived Xenografts; PDXs) must address challenges such as discriminating between mouse and human sequence reads and accurately identifying somatic mutations …

Drug Safety Africa: An Overview Of Safety Pharmacology & Toxicology In South Africa., Brian D Guth, Anne F Grobler, Kendall S Frazier, Andrea Greiter-Wilke, Danuta Herzyk, Tertius A Hough, Asrar Ali Khan, Michael Markert, James D Smith, Karen L. Svenson, Sara Wells, Michael K Pugsley

Faculty Research 2019

This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20-22, 2018 at the North-West University campus. There were 134 attendees (including 26 speakers and 34 students) from the pharmaceutical industry, academia, regulatory agencies as well as 6 exhibitors. These meeting proceedings are designed to inform the content that was presented in terms of Safety Pharmacology (SP) and Toxicology methods and models that are used by the pharmaceutical industry to characterize the safety profile of novel small chemical or biological molecules. The first part of this report includes an …

Automatic Feature Discrimination Of Non-Nutritive Suck Dynamics Among Extremely Preterm Infants., Mckenzie Ann Ochoa

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Prematurity is the leading cause of death in the first month of life. Neonates are forced to engage the extrauterine environment with an underdeveloped nervous systems, with limited connectivity between orofacial sensorimotor anatomy, brainstem pattern-generating circuits, and sensory-driven thalamocortical inputs to layer IV of the neocortex. This is correlated with an inability to produce the complex neuromotor behaviors of oral feeding. The NTrainer System is an assessment and treatment tool that promotes ororhythmic motor patterning in preterm infants though pulsed orocutaneous stimulation to improve NNS.

This report represents an interim analysis of NNS development among 42 extremely preterm infants enrolled …

The Innovator - Summer 2019, Allison Litera

Faculty Affairs & Research Newsletters - The Innovator

Newsletter published by the Offices of Faculty Affairs & Research.

Co-Crystal Structure Of The Fusobacterium Ulcerans Ztp Riboswitch Using An X-Ray Free-Electron Laser., Christopher Jones, Brandon Tran, Chelsie Conrad, Jason Stagno, Robert Trachman, Pontus Fischer, Alke Meents, Adrian Ferré-D'Amaré

School of Medicine and Health Sciences Student Works

Riboswitches are conformationally dynamic RNAs that regulate gene expression by binding specific small molecules. ZTP riboswitches bind the purine-biosynthetic intermediate 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate (ZMP) and its triphosphorylated form (ZTP). Ligand binding to this riboswitch ultimately upregulates genes involved in folate and purine metabolism. Using an X-ray free-electron laser (XFEL), the room-temperature structure of the Fusobacterium ulcerans ZTP riboswitch bound to ZMP has now been determined at 4.1 Å resolution. This model, which was refined against a data set from ∼750 diffraction images (each from a single crystal), was found to be consistent with that previously obtained from data collected at …

The Impact Of Technology On Fine Motor Development In Children, Erin Taylor

MOT Student Capstones

Fine motor skills involve the coordination and refinement of small muscles that control the hand, fingers, and thumb. Children need to develop these skills along with dexterity and strength in order to complete important tasks including writing, self-feeding, getting dressed, and playing. With the abundance of technology and touchscreen devices available, there is evidence that children are spending more than the recommended time using a device and engaging in screen time. While there is evidence that the use of technology in children has increased, there is little research on the possible impact of this increased use on the development of …

The Use Of Music As A Therapeutic Tool To Increase Positive Outcomes In Individuals With Neurological Disorders, Kelly Swaringen

MOT Student Capstones

The overall concept of this study is to explore and gather evidence to support the positive impact that music can have on individuals with neurological impairments or disorders in areas including communication, cognition/memory, psychosocial skills, and motor skills. The goal is to examine how music can be a powerful tool in increasing patient outcomes and how occupational therapy (OT) practitioners can utilize music as a tool in their own practice setting. As OT practitioners, our overarching goal is to facilitate functional and effective participation in occupation while promoting emotional well-being and high quality of life. We have the unique privilege …

Ion Gresser 1928-2019, Jan Vilcek, Howard A. Young

United States Public Health Resources

Ion Gresser, a virologist who transformed understanding of the roles of interferons, may be best remembered for showing that in mice, interferon-α (IFN-α) can produce acute and chronic disease. At the time Gresser began these studies, interferon was considered to be a selective antiviral substance, harmless to uninfected cells and organisms, and there was no indication that cytokines would play a role in pathogenesis. That belief was shattered with the 1975 Nature publication with the simple title “Lethality of interferon preparations for newborn mice.” Gresser subsequently demonstrated that antibodies to IFN-α can protect young mice from death caused by infection …

Community Involvement And Leadership In Nonmetropolitan Nebraska: Rural Poll Research Report 19-1, Rebecca Vogt, Cheryl A. Burkhart-Kriesel, Randolph Cantrell, Bradley Lubben, L. J. Mcelravy, Timothy Meyer, Jason L. Weigle

Rural Futures Institute: Publications

Community leadership and involvement are important parts of community development. Rural communities rely on volunteers for many community development activities as well as local leadership positions. In smaller communities in particular, community members often take on multiple roles. Given these challenges, how involved are rural Nebraskans in community and political activities? How do they feel about the leadership in their community? How often do they have social interactions with others during a typical month? This paper provides a detailed analysis of these questions. This report details 1,776 responses to the 2019 Nebraska Rural Poll, the 24th annual effort to understand …

Sensory Integration In Classrooms: Improving Attention In School-Aged Children, Abbey Mccormick

MOT Student Capstones

The overall concept of this capstone project is to gather evidence supporting the positive effects of sensory integration in relation to attention in school-aged children, including children diagnosed with attention deficit disorder and those with no forn1al diagnosis. The goal of this project is to provide teachers and support staff, including occupational therapists, in a school system with training to implement sensory activities throughout the school day to improve students' attention. Occupational therapy can play a unique role in school systems by providing teachers and other staff with the tools and education to understand the importance of sensory integration and …

Can Alternate-Day Statin Regimen Minimize Its Adverse Effects On Muscle And Tendon?: A Systematic Review, Zehra Abdul Muhammad, Tashfeen Ahmad, Naveed Baloch

Section of Orthopaedic Surgery

Objective: To review evidence-based data with respect to safety and efficacy of alternate-day statin therapy in dyslipidaemia compared to the standard daily dose.
Methods: The literature review was conducted at Aga Khan University Hospital, Karachi from July, 2016 to August, 2017. Electronic database search was carried out to compile available literature using PubMed, Excerpta Medica database and Google Scholar. The most relevant evidence-based research articles published over 10 years were selected. The latest search was dated August 03, 2017.
Results: A total of 2,074 articles were initially located. Alternate day statin regimen was reported in 53% of articles. Adverse effects …

Effect Of Pregnancy On Growth Of Intracranial Meningiomas, Ayesha Quddusi, Muhammad Shahzad Shamim, Quratulain Virani

Section of Neurosurgery

Meningiomas are the most common benign primary intracranial tumours in adults. Their rapid growth during pregnancy has been well reported. Moreover, the relationship of increased progesterone expression during pregnancy and extensive tumour growth has been debated. In this review, we discuss not only the effect of progesterone on meningiomal growth but also other mechanisms involved in gestational meningiomas.

Divergent Trends In Life Expectancy Across The Rural-Urban Gradient And Association With Specific Racial Proportions In The Contiguous Usa 2000-2005, Yun Jian, Lucas Neas, Lynne C. Messer, Christine L. Gray, Jyotsna S. Jagai, Kristen M. Rappazzo, Danelle T. Lobdell

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objectives: To estimate county-level adult life expectancy for Whites, Black/African Americans (Black), American Indian/Alaska Native (AIAN) and Asian/Pacific Islander (Asian) populations and assess the difference across racial groups in the relationship among life expectancy, rurality and specific race proportion.

Methods: We used individual-level death data to estimate county-level life expectancy at age 25 (e25) for Whites, Black, AIAN and Asian in the contiguous USA for 2000–2005. Race–sex-stratified models were used to examine the associations among e25, rurality and specific race proportion, adjusted for socioeconomic variables.

Results: Lower e25 was found in the central USA for AIANs and …

Evaluation Of Kidney Injury Molecule-1 As A Disease Progression Biomarker In Diabetic Nephropathy, Fatima Abid Khan, Syeda Sadia Fatima, Ghulam Mustafa Khan, Sana Shahid

Department of Biological & Biomedical Sciences

Background & Objective: Kidney Injury Molecule-1 (KIM-1) is a peptide whose release into circulation is specific to tubular injury. This study aimed to estimate levels of kidney injury molecule-1 in diabetic patients with and without kidney disease. And evaluate the role of KIM-1 as an early screening marker of progressive kidney injury.
Methods: This follow-up study included n=85 subjects from the diabetic clinic of Jinnah Post Graduate Medical Center (JPMC) in collaboration with Aga Khan University from November 2016 till September 2017. They were divided as: i) Group A1 (n=30) participants with diabetes for <5 years without microalbuminuria ii) Group A2 (n= 30) subjects with diabetes for 6-10 years with microalbuminuria; iii) Group B (n=25) subjects as healthy control group. All study participants were followed for 6 months and their blood glucose, urea, creatinine, electrolytes, albuminuria and serum KIM-1 were assayed.
Results: High KIM-1 at baseline was …

Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin

Honors Projects

A 3D printed hand and arm prosthetic was created from the idea of adding bionic elements while keeping the cost low. It was designed based on existing models, desired functions, and materials available. A tilt sensor keeps the hand level, two motors move the wrist in two different directions, a limit switch signals the fingers to open and close, and another motor helps open and close the fingers. All sensors and motors were built on a circuit board, programmed using an Arduino, and powered by a battery. Other supporting materials include metal brackets, screws, guitar strings, elastic bands, small clamps, …

Visual And Treatment Outcomes Of Tubercular Uveitis: A Prospective Case Series From A Referral Hospital In Pakistan, Muhammad Ishaq Ghauri, Nousheen Iqbal, Syeda Urooj Riaz, Muhammad Irfan, Ajeet Kumar, Muhamad Shariq Mukarram

Section of Pulmonary & Critical Care

Objective: Pakistan is the fifth highest TB burden country. Tuberculous uveitis (TbU) is a form of extrapulmonary TB, that is not uncommon in high burden country but very limited data is available on its outcome. The aim of the study is to assess the outcome of TbU with anti-tuberculous treatment (ATT).

Results: A prospective study was conducted at Jinnah Medical College Hospital (JMCH) Karachi, Pakistan from July to December 2017. Patients with suspected TbU were started on standard ATT chemotherapy for 12 months. Their response was assessed via slit lamp examination and visual acuity at 1, 3, 6 and 12 …

Reproductive Risk Factors Of Thyroid Cancer Among Females: A Hospital Based Case Control Study, Aseela S Ms, Athirarani M. R Ms, Sasikala

Manipal Journal of Nursing and Health Sciences

Introduction: The most frequent endocrine malignancy seen in adults is thyroid cancer. The incidence of thyroid cancers are increasing all over the world. It is one of the cancers in women diagnosed at a younger age. The objective of the study was to identify reproductive risk factors of thyroid cancer among females. Material and methods: The research design used was a hospital-based-case-control study. The samples were 86 cases and 172 controls recruited from the surgical outpatient department of Medical college hospital, Thiruvananthapuram. Cases were patients who had undergone thyroidectomy and histopathological examination confirmed of thyroid cancer and controls were patients …

Jefferson Digital Commons Quarterly Report: April-June 2019, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• CREATE Day Presentations
• Dissertations
• From the Archives
• Grand Rounds and Lectures
• House Staff Quality Improvement and Patient Safety Posters
• JCIPE Student Hotspotting Posters
• Journals and Newsletters
• MPH Capstone Presentations
• Posters
• Sigma Xi Research Day
• What People are Saying About the Jefferson Digital Commons

When An Infected Meniscus Portends A Perforated Viscus, Michelle Hannon, Stephen Zachariah, Neha Bansal Etherington, Anusha Govind, Devin Weber, Bryan Hess

Division of Infectious Diseases and Environmental Medicine Faculty Papers

A 59-year-old woman with a status of post–renal transplant 7 years prior for autosomal dominant polycystic kidney disease on tacrolimus and mycophenolate mofetil presented with subacute left knee and right wrist pain. She received local steroid injections to both areas as an outpatient without improvement in her symptoms. She had recently traveled to India, her home country, to visit relatives. Aspiration of the knee revealed 4+ acid fast bacilli on smear, and she was taken for surgical debridement. She was started on empiric antibiotics for presumed infection with rapidly growing mycobacteria. Her course was complicated by acute onset abdominal pain …