Medicine and Health Sciences Commons^™

Sickle Cell Anemia, Esther Bassaw

Nursing Student Class Projects (Formerly MSN)

Sickle cell anemia (SCA) is an inherited autosomal recessive disorder of red blood cell caused by an abnormality of hemoglobin called sickle hemoglobin (HbS) (Centers for Disease Control and Prevention (CDC), 2017). African countries carry the highest incident of individuals with the SCA(CDC, 2017). In the United State, approximately 1 in 12 African-Americans carry the trait for SCA, and 1 of every 350 African-American infants born have the disorder (CDC, 2017). Individuals with sickle cell disease exhibit significant morbidity and mortality. Clinical manifestations of SCA are chronic hemolysis and acute vaso-occlusive crisis, which causes severe pain, infections, and chronic organ …

Opiate Addiction And Considerations For Anesthesia, James Saltanovitz

Nursing Student Class Projects (Formerly MSN)

Opiate addiction and awareness are problems and should be of interest to our society, particularly those working in healthcare. This poster provides statistics that provide the reader with information of the depth of the problem in the United States. The poster presents information for the reader to better understand opiate addiction’s pathophysiology, signs, and symptoms. For anesthesia providers there are many different evaluations that can be made to make sure that us at risk or opiate dependent patients are safe while under anesthesia. The poster presents many alternative options to help prevent patients’ from feeling pain, while also keeping them …

Strategies To Combat Drug-Resistant Tuberculosis: Inhalable Microparticles Formulated With Anti-Tubercular Antibiotics And Efflux Pump Inhibitors, Elliott K. Miller

Pharmaceutical Sciences ETDs

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen which can remain dormant within the human body for years (latent tuberculosis), and once active requires extensive multidrug therapies for treatment. Long-term antibiotic(s) exposure have led to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains which require novel treatment approaches to combat Mtb resistance. Mtb may also utilize efflux pumps to expel antibiotics and promote bacterial survival, potentially mediating drug tolerance, which has been hypothesized to contribute to antibiotic resistance. Efflux pump inhibitors (EPIs) such as verapamil (VER) may potentiate effects of first-line anti-tubercular drugs (ATDs) such as rifampicin …

Acceptability Of Active Case Finding With A Seed-And-Recruit Model To Improve Tuberculosis Case Detection And Linkage To Treatment In Cambodia: A Qualitative Study, Sovannary Tuot, Alvin K. J. Teo, Danielle Cazabon, Say Sok, Mengieng Ung, Sangky Ly, Sok Chamreun Choub, Siyan Yi

Background

With support of the national tuberculosis (TB) program, KHANA (a local non-governmental organization in Cambodia) has implemented an innovative approach using a seed-and-recruit model to actively find TB cases in the community. The model engaged community members including TB survivors as seed and newly diagnosed people with TB as recruiters to recruit presumptive TB cases in their social network in a snowball approach for screening and linkage to treatment. This study aimed to explore the acceptability of the active case finding with the seed-and-recruit model in detecting new TB cases and determine the characteristics of successful seeds.

Methods

This …

Standing Javelin Throw, Carley Plentovich, Petra Jkeljic, Chris Tobin

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

No abstract provided.

Safe Sleep In The Nicu., Amy Rudd

Doctor of Nursing Practice Papers

Sleep related infant deaths continue to be an issue in Kentucky with 95% of deaths having at least one sleep related risk factor identified. Evidence from the literature suggests safe sleep practice in the neonatal intensive care unit is inconsistent and nurses may face many barriers when implementing safe sleep. The purpose of this project was to determine current nursing knowledge and practice of safe sleep, as well as how parent education occurs in a local NICU through the use of a survey. The survey was developed and distributed to staff at University of Louisville Hospital NICU nurses to determine …

Analysis Of Unplanned Extubations At A University Neonatal Intensive Care Unit., Elizabeth Turcotte

Doctor of Nursing Practice Papers

Unplanned extubations represent a serious adverse event that occurs within neonatal intensive care units. The current literature on unplanned extubations suggests that the incidence of these events can be reduced in the clinical setting. UEs represent the primary respiratory-related adverse event in the neonatal intensive care unit (NICU) and can result in cardiopulmonary collapse requiring emergent reintubation (Carvalho, Mezzacappa, Calil, & Machado, 2010). Staff members of the University of Louisville’s neonatal intensive care unit collected data surrounding unplanned neonatal extubations from November 2017 through December 2018. These data have been used to target modifiable risk factors temporally associated with unplanned …

Dental Practice Success Vol. 6 No. 2, American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Mapping The Literature Of Dental Hygiene: An Update, Carol L. Watwood, Terry Dean

DLPS Faculty Publications

Objective: This study updates Haaland’s 1999 dental hygiene mapping study. By identifying core journals and estimating database coverage, it characterizes changes in dental hygiene research and aids librarians in collection development and user education.

Method: Cited references from a three-year (2015–2017) sample of core dental hygiene journals were collected, categorized into five formats, and analyzed by format and publication year according to Bradford’s Law of Scattering. CINAHL Complete, MEDLINE, and EMBASE were surveyed to determine the indexing coverage of cited journals.

Results: The number of cited journal titles increased from 389 in 1999 to 1,675 in 2018. Core Zone 1 …

Ua10/1 Vitality Report, Wku Suzanne Vitale Clinical Education Complex

WKU Administration Documents

Newsletter created by and about the WKU Suzanne Vitale Clinical Education Complex.

• Moore, Mary. LifeWorks Groundbreaking Ceremony Announced
• Hardin, Amy. Sensory Bags Avaiable at WKU Home Football Games
• Kersting, Frank. LifeWorks Job Training & Placement
• Sales, Shannon. Coffee & Conversation: Resources in the SOKY Area for Families with Special Needs
• Hudson, Caroline. Renshaw Early Childhood Care Center Explores the Wonders of Nature Through Play
• Hudson, Caroline. Dating Dos & Don'ts - Circle of Support
• Elkins, Michelle. Building Leadership Skills with a New Kelly Autism Program Group
• Elkins, Michelle. Kelly Autism Program Summer Camp Experience
• Orndorff, Ericka. A Farewell Letter
• Collins, …

The Effect Of High Flow Nasal Cannula Weaning Protocol On Decreasing Length Of Stay In Pediatric Intensive Care., Debbie Farrell

Doctor of Nursing Practice Papers

Background: High-flow nasal cannula (HFNC) is a type of non-invasive respiratory support that has decreased the rate of intubation in infants and children. It is utilized in the PICU and the wards. Due to the increased volume of patients on HFNC, a standard HFNC weaning protocol was created to improve the management of these patients.

Methods: Potential patients were identified through the Virtual Pediatric System (VPS) with the criteria of ages 1 month to 6 years old, admitted to the PICU during the months of January to March of 2018 and 2019, with diagnosis of bronchiolitis and requiring HFNC. Chart …

Implementation And Evaluation Of A Neonatal Chest Tube Simulation Lab For App Competency., Tracey Miller

Doctor of Nursing Practice Papers

Pneumothorax in the neonatal period is a potentially life threatening condition that requires Neonatal Advanced Practice Providers to respond rapidly and competently in order to prevent complications of morbidity and mortality. It has become increasingly difficult to establish initial competency as well as maintain competency in low volume high acuity emergency procedures such as chest tube placement. The purpose of this practice based quality improvement project was to implement a simulation based training program in chest tube placement for the Neonatal Advanced Practice Providers within Norton Children’s Neonatology. The goal was to have all Advanced Practice Providers (APP) be able …

Growing South Dakota (Summer 2019), College Of Agriculture, Food And Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 3 Celebration of Faculty Excellence
[Page] 6 Ag and Biosystems Engineering - Quarter Scale Tractor Team Named Reserve National Champs - Jackrabbit Wrestler Passionate About Sharing the Story of Pork - Mesonet Spray Tool Aids Precision Application Decisions
[Page] 10 Ag Business and Economics -POET Commodity Trading Fund
[Page] 12 Ag Education, Communication and Leadership - Leadership Opportunities Launch Recent Graduate to Career Readiness
[Page] 14 Agronomy, Horticulture & Plant Science - Local Foods Education Center Donates Over 5,000 Pumpkins - Seeding Success - Doug Malo Retires After 43 Years of Teaching - Howard Woodard's 29-Year Career Had a …

Rafi & Patra, Rafi, Patra, Tsos

TSOS Interview Gallery

Rafi and his family have been stuck on the border between Greece and Macedonia for almost four months. They made their way from Afghanistan, received certificates in Greece to help them on their journey, but were then stopped at the border of Macedonia. The Macedonians said that they were no longer allowing Afghans into their country. Now all they can do is wait and hope. In Afghanistan,Rafi was a military man. As a young man, he was a part of the Revolution army, but later was made a soldier for the Government Security of Kabul. During that time, he was …

Spring Into Action: Role Models For Sun Safety., Kelsey A. Grothouse

Doctor of Nursing Practice Papers

Ultraviolet radiation during childhood increases a person's risk for skin cancer later in life. Research has provided support for a multifaceted intervention that targets youth in order to decrease these future risks. The purpose of this paper is to discuss the implementation of an intervention that taught youth athletic football coaches and parent helpers to act as role models and influence sun safe behavior in their youth athletes in order to help reduce the carcinogenic effects of UV radiation in the future. The intervention consisted of a one-hour training session with coaches and parent helpers of a youth football team …

Ua35/8 Reveille, Vol. 27, No. 1, Wku Veterans Upward Bound

WKU Administration Documents

Newsletter created by and about WKU Veterans Upward Bound.

• Veterans Administration Community Suicide-Prevention Challenge
• RallyPoint
• PsychArmor Institute
• Explore VA.gov to Learn About Your Benefits
• Stone, Davy. The Director's Desk - Michelle Shutt

Santa Clara Magazine, Volume 60 Number 3, Summer 2019, Santa Clara University

Santa Clara Magazine

16 - PROTECTING THE HEART To grow the campus, we must care for the thing unchanging at its center—its Mission. Take a journey through the restoration of Mission Santa Clara de Asís. By Lander Eicholzer ’19.

22 - A LOBBY FOR JUSTICE What do you do when it is impossible for the innocent to prove their innocence? Change the law. The Northern California Innocence Project teamed up with state lawmakers and others to do just that. By Deborah Lohse.

26 - FINDING CENTER Outgoing Frank Sinatra Chair in the Performing Arts Taye Diggs reflects on celebrating who are you, where …

A High Throughput Assay For The Detection Of Stimulator Of Interferon Genes (Sting) Agonists, Michael J. Ingling

Graduate School of Biomedical Sciences Theses and Dissertations

The innate immune system includes a menagerie of different cell types, each with a different role in the process of monitoring the body for invaders and presenting gathered debris (antigen) to the adaptive immune system. Somatic cells have intracellular receptors for the same purpose. Cancer cells, however, have avoided these methods of detection despite, in many cases, the tumor’s immunogenic traits. Immuno-oncology is a field dedicated to the immunological traits of tumors, more recently finding ways of instigating an immune response against tumors. In this regard, STING, a receptor of cyclic dinucleotides (CDN), has come to the forefront of immuno-oncology. …

Medicare Access And Chip Reauthorization Act And Rural Hospitals, Erica Kelley, Rhea Lipscomb, Jennifer Valdez, Natesh Patil, Alberto Coustasse

Management Faculty Research

The cost of health care within the United States has continued to increase, whereas the quality of patient care has generally decreased in some areas. With the continued use of Medicare's former physician reimbursement algorithm, termed sustainable growth rate, national expenditures within the United States have been expected to increase 5.6% annually. To modernize the delivery and financing of care, Congress has introduced the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA), which has permanently eliminated and replaced the sustainable growth rate. The purpose of this study was to review MACRA and its implementation to determine how it would …

Tnf-Α Differentially Regulates Cell Cycle Genes In Promyelocytic And Granulocytic Hl-60/S4 Cells, Elsie C. Jacobson, Lekha Jain, Mark H. Vickers, Ada L. Olins, Donald E. Olins, Jo K. Perry, Justin M. O'Sullivan

Pharmaceutical Sciences Faculty Publications

Tumor necrosis factor alpha (TNF-α) is a potent cytokine involved in systemic inflammation and immune modulation. Signaling responses that involve TNF-α are context dependent and capable of stimulating pathways promoting both cell death and survival. TNF-α treatment has been investigated as part of a combined therapy for acute myeloid leukemia due to its modifying effects on all-trans retinoic acid (ATRA) mediated differentiation into granulocytes. To investigate the interaction between cellular differentiation and TNF-α, we performed RNA-sequencing on two forms of the human HL-60/S4 promyelocytic leukemia cell line treated with TNF-α. The ATRA-differentiated granulocytic form of HL-60/S4 cells had an enhanced …

Neonatal Nurses’ Knowledge And Assessment Of Necrotizing Enterocolitis (Nec) In The Premature Infant., Kathryn Taylor Van Hoose

Doctor of Nursing Practice Papers

Necrotizing Enterocolitis (NEC) is the most common gastrointestinal emergency seen in the Neonatal Intensive Care Unit (NICU) (Cleveland Clinic, 2015). NEC occurs most frequently in premature infants, accounting for approximately 60 to 80 percent of all cases (Singh et al., 2008). Mortality rates associated with NEC are estimated to be between 20 and 30 percent reaching upwards of 50 percent for patients requiring surgical intervention (Cleveland Clinic, 2015). There is an abundance of research surrounding the pathophysiology, potential causes, and protective factors related to NEC in the premature infant. Comparisons of various interventions such as: feeding practices and protocols, administration …

Decreasing Musculoskeletal Injuries Among Operating Room Personnel Through The Use Of Anti-Fatigue Mats., Hannah Raake

Doctor of Nursing Practice Papers

Work-related musculoskeletal disorders (WRMDs) are a common occurrence among operating room (OR) personnel due to certain job requirements including standing in a static position for long periods of time. The American Association of Operating Room Nurses (AORN) ergonomic guidelines support interventions (anti-fatigue mats, shoe in-soles, etc.) aimed at decreasing the rates of WRMDs among OR personnel. A 3-month pre- and post-intervention trial was established at one Southern Indiana hospital to assess the efficacy of anti-fatigue mats in the OR theatre. Two anti-fatigue mats were placed in each OR, cardiovascular operating room (CVOR), and endoscopy room for use with each case. …

Long-Term Rent Assistance Program Evaluation Final Report, Natalie Royal Kenton, Kayla Albrecht Mcmenamin, Joseph B Rinaldi

View All

No abstract provided.

Fighting Independent Risk Assessment Of Talc And Glyphosate: Whose Benefit Is It Anyway?, Alfredo Morabia

Publications and Research

No abstract provided.

Characterization Of Human Dutpase, Shawna Marie Rotoli

Graduate School of Biomedical Sciences Theses and Dissertations

Deoxyuridine nucleotidyl transferase (dUTPase) is an enzyme found in all organisms that have thymine as a component of DNA. It catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate thus precluding the buildup of dUTP pools as well as providing the substrate, dUMP, for the de novo synthesis of thymidylate. In Homo sapiens, there are four isoforms: mitochondrial (mDut), nuclear (nDut), variant 3 and variant 4. This work is largely focused on nDut. Using structural and MS analyses of recombinant dUTPase constructs, an intermolecular disulfide bridge between cysteine-3 of each nDut monomer was discovered. It was found that these two …

Occupational Therapy In Prisons, Amber Carmean, Amanda Boman, Katie Kowalski, Joselyn Walsworth

Community Based

This study investigates the needs of incarcerated individuals upon reintegration into the community. In this article, we use thematic analysis to dissect two prison documentaries in order to best assess the needs of these individuals to inform occupational therapy intervention. Occupational therapy seeks to empower individuals while analyzing needs and how the individuals can be best supported. Our analysis shows that there are many needs that go unaddressed prior to community reintegration leading to a higher chance of recidivism recurring. Through better understanding the needs of individuals, occupational therapy can become better informed on how intervention can benefit this specific …

Prevalence And Risk Factors Associated With Long-Term Opioid Use After Injury Among Previously Opioid-Free Workers, Zoe Durand, Sarah Nechuta, Shanthi Kreishnaswami, Eric L. Hurwitz, Melissa Mcpheeters

Peer Reviewed Articles

Importance Using opioids for acute pain can lead to long-term use and associated morbidity and mortality. Injury has been documented as a gateway to long-term opioid use in some populations, but data are limited for injured workers.

Objective To evaluate the prevalence and risk factors of long-term opioid use after injury among workers in Tennessee who were opioid free at the time of injury.

Design, Setting, and Participants This cohort study identified injured workers aged 15 to 99 years who reported only 1 injury to the Tennessee Bureau of Workers’ Compensation from March 2013 to December 2015 and had no …

Infuse!_Volume 3_Number 1_ 2019, College Of Nursing

Infuse! College of Nursing Magazine

No abstract provided.

Chromium: Rise And Shine In Peritoneal Dialysis Patients?, Guido Filler, Christopher Mcintyre

Paediatrics Publications

Some trace elements are altered with chronic kidney disease. Selenium, zinc, and manganese tend to be wasted, and there is growing evidence that selenium deficiency is associated with mortality on dialysis. Other trace elements accumulate, such as chromium, cobalt, lead, molybdenum, and vanadium. The highest chromium levels are found in dialysis patients. The dialysis modality may further affect these levels, especially in hemodialysis patients, where even small contaminations in the dialysis feed water may lead to a concentration gradient that increases the concentration of certain trace elements. Chromium levels in peritoneal dialysis (PD) patients have been understudied. A single cross-sectional …

The Effect Of Wrist Position On Finger Tendon Loads Following Pulley Sectioning And Operative Reconstruction, Mohammad M. Haddara, B. Byers, Shrikant Chinchalkar, Louis M. Ferreira, Nina Suh

Bone and Joint Institute

© 2019 The Authors Purpose: Postoperative rehabilitation is important for maximizing patient outcomes after surgical pulley reconstruction. The purpose of this study was to identify the optimal wrist position in which rehabilitation should be undertaken to decrease the load on surgically reconstructed pulleys. Methods: We tested 14 digits composed of the index, middle, and ring fingers from 5 cadaveric specimens in a novel in vitro finger motion simulator designed to achieve full finger flexion and extension actively. Servo-motors were used to generate motion through tendons under load or position control while measuring tendon forces, joint range of motion, and tendon …