Medicine and Health Sciences Commons^™

The Role Of Autophagy In Myocardial Ischemia/Reperfusion Injury In Isolated Rat Hearts, Aloysius C. Ibe Ii

PCOM Biomedical Studies Student Scholarship

Autophagy is a housekeeping process used to remove damaged cytoplasmic constituents and protein aggregates. However, a debate persists on whether autophagy is beneficial or detrimental when an ischemic/reperfusion (I/R) insult occurs in the heart. This study tested the effects of autophagy enhancers (rapamycin and trehalose) and an autophagy inhibitor (3-methyladenine) on cardiac function and infarct size after global ischemia (30 minutes) and reperfusion (45 minutes) when given prior to ischemia (pre-treatment) or at the beginning of reperfusion (post-treatment). Rapamycin (25nM) pre-treatment and post-treatment significantly restored final left ventricular developed pressure (LVDP) to 75.4±9.1% and 60±5% of initial baseline respectively (both …

Detection And Concentration Of Plasma Aflatoxin Is Associated With Detection Of Oncogenic Human Papillomavirus In Kenyan Women, Jianjun Zhang, Elkanah Omenge, Philip Tonui, Yan Tong, Titus Manai, Stephen Kiptoo, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen

Obstetrics and Gynaecology, East Africa

Background: Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor.

Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus-uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration.

Results: …

Integration Of Suboptimal Health Status Evaluation As A Criterion For Prediction Of Preeclampsia Is Strongly Recommended For Healthcare Management In Pregnancy: A Prospective Cohort Study In A Ghanaian Population, Enoch Odame Anto, Peter Roberts, David Coall, Cornelius Archer Turpin, Eric Adua, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Background: Normotensive pregnancy may develop into preeclampsia (PE) and other adverse pregnancy complications (APCs), for which the causes are still unknown. Suboptimal health status (SHS), a physical state between health and disease, might contribute to the development and progression of PE. By integration of a routine health measure in this Ghanaian Suboptimal Health Cohort Study, we explored the usefulness of a 25-question item SHS questionnaire (SHSQ-25) for early screening and prediction of normotensive pregnant women (NTN-PW) likely to develop PE. Methods: We assessed the overall health status among a cohort of 593 NTN-PW at baseline (10–20 weeks gestation) and followed …

Testosterone Replacement For Male Military Personnel - A Potential Countermeasure To Reduce Injury And Improve Performance Under Extreme Conditions, Nicolas H. Hart, Robert U. Newton

Research outputs 2014 to 2021

Tactical operators, inclusive of soldiers in the military, are reliant upon their physiological and psychological state in often volatile and extreme life or death situations that require correct decisions and precise actions to ensure operational success with minimal collateral damage. Accordingly, the development of physical and mental resilience are hallmarks of prophylactic and remedial programs designed to ensure military personnel are combat ready, thus optimising their capacity to perform at expert levels, while reducing their risk of injury or the severity of injury sustained...

Exercising Choice And Control: A Qualitative Meta-Synthesis Of Perspectives Of People With A Spinal Cord Injury, Carolyn M. Murray, Gisela Van Kessel, Michelle Guerin, Susan Hillier, Mandy Stanley

Research outputs 2014 to 2021

OBJECTIVE: To systematically search the literature and construct a meta-synthesis of how choice and control are perceived by people with spinal cord injury (SCI).

DATA SOURCES: Medline, Academic Search Premier, CINAHL, Cochrane, EMBASE, HealthSource, ProQuest, PsychInfo, SAGE, and SCOPUS were searched from 1980 until September 2018 including all languages. Reference lists of selected studies were also reviewed.

STUDY SELECTION: Eligible qualitative studies included perspectives about choice of control as reported by people with an SCI. Studies were excluded if they included perspectives from other stakeholder groups. A total of 6706 studies were screened for title and abstract and full text …

Hidradenitis Suppurativa: A Comparison Of Institutional Experience With The Tracking, Sean J. Wallace Md, Andrew Steele Md, Nathan Miller Md, Yee-Cheng Low Md, Robert X. Murphy Jr, Md, Ms

Department of Surgery

No abstract provided.

Drug Safety Scientometrics Overview Highlights Public Health Issues, Philippe Gorry, Enrique Seoane-Vazquez

Pharmacy Faculty Articles and Research

"Drug Safety (DS) also known as Pharmacovigilance, is the science of monitoring ADR (Cobert, 2012). Despite that DS has a social welfare function, it has not been the study of any scientometrics analysis... Our goal is to fill this gap by mapping the DS literature. This analysis might highlight some trends, the role of drug regulatory and firms in diffusing information, understand better some DS controversial events, help scholars in mastering pharmacovigilance literature, and it contribute to further development on literature-based discovery of ADR [adverse drug reactions] with the help of natural language processing."

J Mich Dent Assoc September 2019

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA’s 6,200+ members across the state. No publication reaches more Michigan dentists! This issue highlights evidence-based considerations for patients using Cannabis, e-cigarettes from a dental perspective, and reports from the deans at University of Detroit Mercy School of Dentistry and the University of Michigan School of Dentistry.

Clinical Outcome Assessments Toolbox For Radiopharmaceuticals., Charles A Kunos, Jacek Capala, Adam P Dicker, Benjamin Movsas, Susan Percy Ivy, Lori M Minasian

Department of Radiation Oncology Faculty Papers

For nearly 40 years, the U.S. National Cancer Institute (NCI) has funded health-related quality-of-life (HRQOL) and symptom management in oncology clinical trials as a method for including a cancer patient's experience during and after treatment. The NCI's planned scope for HRQOL, symptom and patient-reported outcomes management research is explained as it pertains to radiopharmaceutical clinical development. An effort already underway to support protocol authoring via an NCI Cancer Therapy Evaluation Program (CTEP) Centralized Protocol Writing Service (CPWS) is described as this service aids incorporation of HRQOL, symptom and patient-reported outcomes management research into sponsored protocols.

Effect Of Low-Dose Ketamine Versus Fentanyl On Attenuating The Haemodynamic Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing General Anaesthesia: A Prospective, Double-Blinded, Randomised Controlled Trial, Angela Ongewe, Vitalis Mung’Ayi, Rajpreet Bal

Anaesthesiology, East Africa

Background: The use of drugs to attenuate the haemodynamic response to laryngoscopy and endotracheal intubation is the standard of care during elective surgery. Current evidence is conflicting concerning the best agent and optimal dose for this purpose. In the majority of cases, fentanyl is widely utilized to attenuate haemodynamic responses. Ketamine, an established available drug, has been scarcely studied in this regard at low doses and against varying doses of other common agents.

Objective: To compare the overall occurrence of hypertension and tachycardia immediately pre-intubation (post-induction) until 10 minutes post intubation between the study group receiving fentanyl at 1.0 µg/kg …

Antibiotic Prophylaxis In The Surgical Management Of Miscarriage In Low-Income Countries: A Cost-Effectiveness Analysis Of The Aims Trial, Ilias Goranitis, David M. Lissauer, Arri Coomarasamy, Amie Wilson, Jane Daniels, Lee Middleton, Jonathan Bishop, Catherine A. Hewitt, Andrew D. Week, Chisale Mhango, Ronald Mataya, Iffat Ahmed

Department of Obstetrics & Gynaecology

Background: There is ongoing debate on the clinical benefits of antibiotic prophylaxis for reducing pelvic infection after miscarriage surgery. We aimed to study the cost-effectiveness of antibiotic prophylaxis in the surgical management of miscarriage in low-income countries.
Method: We did an incremental cost-effectiveness analysis using data from 3412 women recruited to the AIMS trial, a randomised, double-blind, placebo-controlled trial designed to evaluate the effectiveness of antibiotic prophylaxis in the surgical management of miscarriage in Malawi, Pakistan, Tanzania, and Uganda. Economic evaluation was done from a health-care-provider perspective on the basis of the outcome of cost per pelvic infection avoided within …

The Association Of Tas1r2 To Dental And Cardiovascular Health, Joseph Keryakos, Annika Van Oosbree, Alyssa Marie Kiesow

Faculty Work Comprehensive List

Despite brushing and/or flossing their teeth twice daily, many people are still susceptible to dental cavities and tooth decay. This research investigates the genetic and cardiovascular health behind this phenomenon. Two gene variants related to taste pathways, taste 1 receptor member 2 (TAS1R2) and taste 2 receptor member 38 (TAS2R38), were tested on the DNA of 20 students at Northern State University (10 males and 10 females). In concert with genetic screening, tooth impressions were taken of the participants’ upper and lower jaws along with salivary pH, heart rates, and blood pressures. Participants’ cavities and fillings were counted and their …

Andrews Nursing Students Change The World — One Mission Trip At A Time, Shawna Trotman Henry

Lake Union Herald

No abstract provided.

Nutrinews: September, 2019, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Caffeine: Not a Diuretic After All?, Better Strength Better Health

Inflammation, Depression And Non-Adherence Correlates In Persons On Hemodialysis, Kathleen Fulmer

Loma Linda University Electronic Theses, Dissertations & Projects

The hemodialysis patient is at risk for a high inflammatory state as evidenced by the elevation of the pro-inflammatory cytokine, interleukin-6 which has been linked to lower serotonin levels and development of depression. The biological and psychological stress of living with End Stage Renal Disease on hemodialysis increases the risk for depression which is the leading psychological disorder affecting these patients which is also underdiagnosed and under-treated. The phenomenon of depression can manifest itself in the maladaptive behavior of non-adherence which has been associated with increased mortality, morbidity and decreased quality of life for the hemodialysis patient. The purpose of …

Measurements Of The Pharyngeal Airway Using Whole Head 3t Mri And Cbct, Victoria Geren

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study compared pharyngeal airway measurements (volume, linear, area) made using whole head Cone-Beam Computed Tomography (CBCT) and 3T Magnetic Resonance Imaging (MRI) methods.

Methods: Eleven subjects (mean age 15y11m) received whole head CBCT (NewTom5G, AFP Imaging, USA) and 3T MRI (Siemens Medical Solutions, DE). Each subject received both scans within a one-month period of time. CBCT images were made with an 18x16 inch field of view, exposure time of 5.4s, and resolution of 0.3x0.3x0.3mm. 3T MR images were captured as contiguous sagittal images of the whole head with a T1- weighted 3D imaging sequence (Magnetization Prepared …

Clinical Effects Of Oral Hygiene Instruction Via Texting In Orthodontic Patients, Jessica Liu

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This randomized controlled study quantitatively investigated whether providing oral hygiene instruction (OHI), through texting images and videos, affected oral hygiene status in orthodontic patients.

Materials and Methods: Sixty patients between 13-21 years of age, with visible plaque and used a smart phone, were recruited from the Graduate Orthodontic Clinic at Loma Linda University. Once recruited (T1), an initial survey was completed, MBI and OPI were recorded, and OHI was given. Subjects were randomly distributed into either a control or experimental group. The experimental group received OHI texts weekly, whereas the control group did not. After 3 months …

Association Of Nurses’ Sanctification Of Work With Work-Related Outcomes And Patient Satisfaction, Hazel M. Ada

Loma Linda University Electronic Theses, Dissertations & Projects

Nurses working in hospitals face many intrinsic stressors, including widespread job dissatisfaction, burnout, and frustration. These challenges, in turn, may affect patient care. Nursing often attracts individuals who wish to serve others, and some may find the expression of spirituality on the job helpful in finding meaning, satisfaction, and value in their work (Kociszewski, 2004). Sanctification of work (SoW) is a promising facet of spirituality defined by researchers as an individual’s experience of their work as a manifestation of God or sacred qualities that affects their effectiveness and engagement on the job (Walker, Jones, Wuensch, Aziz, and Cope, 2008). In …

Comparison Of Maxillary Sinus Dimensions And Volumes On Cbct And 3t Mr Images, Cara Hodgson

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study compared the height, width, length, and volume of the maxillary sinus in Magnetic Resonance Imaging (MRI) and Cone-Beam Computed Tomography (CBCT).

Methods: Eleven human subjects participated in the study (mean age of 14y7m). One CBCT scan and one MRI scan were performed on each patient. CBCT images were captured with an 18 x16 inch field of view that covered the whole head. Contiguous sagittal MR images of the whole head were produced using a 3.0T imaging system with a T1-weighted 3D imaging sequence and isotropic resolution of 1.0 x1.0 x1.0 mm. Images were imported as …

Accuracy Of Surface Area And Volume Measurements Of Teeth Determined From Cbct, Joseph Hourany

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study compared surface area and volume measurements made from 3D scans of physical teeth and segmented teeth taken from Cone-Beam Computed Tomography (CBCT) scans of a cadaver. Methods: A cadaver specimen was imaged by CBCT and all the teeth were subsequently extracted and cleaned of any tissue. Of all the extracted teeth, sixteen single-rooted teeth were included in this study. The extracted teeth were scanned with a 3M True Definition 3rd Generation intraoral scanner (3M, ESPE) to generate a stereolithography (STL) file to serve as the control for this study and their surface area and volume measurements as …

Biomechanics And Postural Control Characteristics In Low Back Pain Subgroups During Dynamic Task, Amjad Shallan

Loma Linda University Electronic Theses, Dissertations & Projects

Dynamic balance impairments are commonly observed in people with low back pain (LBP). People with LBP have reduced lumbopelvic stability and may exhibit spinal biomechanical and postural control changes during dynamic balance. A limited number of studies are available about the spinal kinematic and postural control changes during dynamic balance in people with nonspecific chronic low back pain (NSCLBP) subgroups. Therefore, the aim of this dissertation was to compare spinal kinematics and postural control between NSCLBP subgroups and healthy individuals during dynamic balance using a modified Star Excursion Balance Test (mSEBT). Eighteen NSCLBP subjects [9 active extension pattern (AEP), 9 …

Reintegration Experiences Of Post-Incarcerated Fathers In Southern California, Sheldon Smith

Loma Linda University Electronic Theses, Dissertations & Projects

The detention of fathers in penal institutions can challenge their involvement in the lives of their children and this experience can impact these relationships as well as the socio-emotional development of their children in the short and long term. Upon release, the reintegration experiences can be difficult, clumsy, and sometimes lost altogether. This present study explored the experiences of nineteen fathers as they sought to reconnect with their children after incarceration. Through the use of grounded theory and qualitative interviews, three major themes emerged from the data, which provided an explanation of participants’ reintegration experiences. These themes were participants’ ideology …

Ratio Of Rme Appliance Expansion To Increase In Arch Perimeter Using Cbct Imaging, Evan Agnetta

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study measured CBCT images to determine if a consistent ratio exists between the quantifiable number of millimeters a cemented rapid palatal expansion appliance is opened and the subsequent increase in the arch perimeter obtained due to lateral expansion of the arch.

Methods: The following measurements: arch perimeter, arch width at first molars, first bicuspids, appliance length, as well as arch depth; were taken from CBCT images of patients who had completed RME therapy. These were obtained both before and after maxillary palatal expansion therapy using a fixed rapid palatal expander. Correlations were calculated for each of …

Examining The Need For Psychosocial Services In Pediatric Non-Accidental Trauma, Samantha Nicole O'Bannon

Loma Linda University Electronic Theses, Dissertations & Projects

Child abuse is a significant issue within our society. In 2014, there were a reported 702,208 cases of child abuse and neglect across the country, with nearly 120,000 suffering from physical abuse. Research has shown the adverse physical and psychological consequences of child maltreatment. Despite what we know about the benefits of early intervention for this population, the degree of implementation of psychosocial interventions, specifically in a hospital setting, remains unclear. In an initial study that utilized archival data from the Loma Linda University Children’s Hospital (LLUCH) Trauma Registry Database, researchers found that the majority of children admitted to the …

Predicting Functional Responses In Agro-Ecosystems From Animal Movement Data To Improve Management Of Invasive Pests, Mark Q. Wilber, Sarah M. Chinn, James C. Beasley, Raoul K. Bourghton, Ryan K. Brooks, Stephen S. Ditchkoff, Justin W. Fischer, Steve B. Hartley, Lindsey K. Holmstrom, John C. Kilgo, Jesse S. Lewis, Ryan S. Miller, Nathan P. Snow, Kurt C. Vercauteren, Samantha M. Wisely, Colleen T. Webb, Kim M. Peen

United States Department of Agriculture Wildlife Services: Staff Publications

Functional responses describe how changing resource availability affects consumer resource use, thus providing a mechanistic approach to prediction of the invasibility and potential damage of invasive alien species (IAS). However, functional responses can be context dependent, varying with resource characteristics and availability, consumer attributes, and environmental variables. Identifying context dependencies can allow invasion and damage risk to be predicted across different ecoregions. Understanding how ecological factors shape the functional response in agro-ecosystems can improve predictions of hotspots of highest impact and inform strategies to mitigate damage across locations with varying crop types and availability. We linked heterogeneous movement data across …

Meta-Analysis A Myriad Of Data - Is It Helpful?, James Harrop

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

The Development Of Face Morphing Task To Assess Self Other Differentiation, Esen Karan

Dissertations, Theses, and Capstone Projects

Self-Other Differentiation (SOD) refers to a developmental process of acquiring a consolidated, integrated, and individuated sense of self. SOD develops at a) perceptual (e.g., facial perception) and b) representational (e.g., traits, mental states, and beliefs) levels. Impairments in representational SOD (R-SOD) are associated with many forms of psychopathology, particularly borderline personality disorder (BPD) and narcissistic personality disorder (NPD). Few studies to date have examined the perceptual aspects of SOD (P-SOD), which are hypothesized to develop from infancy onwards in tandem and in interaction with R-SOD. Given that the human face is one of the key characteristics that humans use to …

Clinical Characteristics And Neuroanatomical Predictors Of Acute Antidepressant Outcome For Patients With Comorbid Depression And Mild Cognitive Impairment, Jeffrey N. Motter

Dissertations, Theses, and Capstone Projects

Background: Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. The classification of cognitive impairment severity continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Previous studies have found associations between treatment outcome and both cortical thickness and white matter hyperintensities (WMH), though report inconsistent directionality and affected regions. In this study, we examined baseline clinical characteristics and neuroanatomical features as prognostic indicators for older adults with comorbid DEP and CI participating in an open antidepressant trial. EMCI is hypothesized to have greater …

Exploration Of The Inhibitory Properties Of The Nucleoside Antibiotic Salicyl-Ams And Analogues Targeting Siderophore Biosynthesis In Mycobacterium Tuberculosis, Glennon Bythrow

Dissertations, Theses, and Capstone Projects

Mycobacterium tuberculosis (Mtb) is a resilient, obligate bacterial pathogen responsible for pulmonary tuberculosis disease (TB), that has upheld a significant impact on global public health throughout history. The World Health Organization (WHO) approximates nearly 10 million new TB cases arose in 2017 alone, accounting for 1.6 million deaths. There has been a notable rise in TB cases produced by multidrug‑resistant (MDR) and extensively drug-resistant (XDR) strains of Mtb. This, along with the intrinsic resistance of Mtb to many standard drugs and poor patient compliance, is deeply impacting global control of TB. Among the several strategies currently in …

The Social Cost Of Pain: Rejection Sensitivity, Social Rejection, And Cannabis Use In Young Adults, Naomi Dambreville

Dissertations, Theses, and Capstone Projects

Cannabis has been implicated in relieving distress and social pain, an important area of research in young adult samples, given the saliency of peer and social networks to addiction. Cannabis, via opioid pathways, has been shown to reduce, or potentially buffer, the effects of social pain and rejection. Thus, cannabis may be protective against the painful feelings of social stress, particularly for heavier or more frequent users. However, findings are not wholly positive, as other research indicates cannabis may blunt affective responses and impair social processing. The effects of cannabis use in young adults are understudied, as well as its …