Interleukin 1 Alpha Administration Is Neuroprotective And Neuro-Restorative Following Experimental Ischemic Stroke, Kathleen E. Salmeron, Michael E. Maniskas, Danielle N. Edwards, Raymond Wong, Ivana Rajkovic, Amanda L. Trout, Abir A. Rahman, Samantha Hamilton, Justin F. Fraser, Emmanuel Pinteaux, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Stroke remains a leading cause of death and disability worldwide despite recent treatment breakthroughs. A primary event in stroke pathogenesis is the development of a potent and deleterious local and peripheral inflammatory response regulated by the pro-inflammatory cytokine interleukin-1 (IL-1). While the role of IL-1β (main released isoform) has been well studied in stroke, the role of the IL-1α isoform remains largely unknown. With increasing utilization of intravenous tissue plasminogen activator (t-PA) or thrombectomy to pharmacologically or mechanically remove ischemic stroke causing blood clots, respectively, there is interest in pairing successful cerebrovascular recanalization with neurotherapeutic pharmacological interventions (Fraser et …

Hospital-Based Palliative Care Programs: Perspectives Regarding Conceptualization And Accreditation, Karen L. Walker

Nursing Theses and Dissertations

Palliative care has been shown to improve symptoms and increase quality of life in people with a life-limiting illness. Despite growth in hospital-based palliative care programs throughout the United States, only 91 hospitals have obtained The Joint Commission’s Advanced Palliative Certification. The purpose of this descriptive study was to identify how programs that do not have The Joint Commission’s Advanced Palliative Care Certification defined and conceptualized palliative care. An additional focus was to identify the barriers these programs perceived or experienced that prevented them from obtaining the advanced palliative care certification. This research program began with an evolutionary concept analysis …

Chronic Environmental Exposure To Metal Mixtures In Tribal Populations And Potential Immune System Effects, Jennifer J. Ong

Biomedical Sciences ETDs

Hardrock mining in the United States (US) has left a legacy of mixed metal mine waste sites. Wastes may contain multiple metals of health concern, including arsenic, cadmium, lead, mercury, and uranium, among others. Mining waste sites are disproportionately located on or contiguous to the watersheds of tribal lands. Due to proximity, and because of reliance on natural resources to maintain traditional diets and customs, Native American communities’ contact with multiple metals is often increased. Two impacted communities are the Cheyenne River Sioux Tribe (CRST) and Navajo Nation. Both tribes have expressed concerns that metals in mine waste adversely affect …

Characteristics Of Medial-Lateral Postural Control While Exposed To The External Perturbation In Step Initiation, Yun-Ju Lee, Jing Nong Liang, Bing Chen, Alexander S. Aruin

Physical Therapy Faculty Research

Controllability of posture in the medial-lateral direction is critical for balance maintenance, particularly in step initiation. The objective of the current study was to examine the effects of external perturbation and landing orientation on medial-lateral control stability in step initiation. Eleven young healthy participants stood on the force platform and waited for the instruction of taking a step while experiencing a pendulum perturbation applied at the lateral side of the right shoulder. Eight experimental conditions were conducted by two levels of step side (right or left), two levels of perturbation (with or without), and two levels of landing orientation (forward …

Plasma Cell Leukemia Mimicking Hairy Cell Leukemia: Extended Role Of Immunophenotyping In Correct Diagnosis, Ayesha Majeed Memon, Natasha Ali

Department of Pathology and Laboratory Medicine

No abstract provided.

The Best Is The Enemy Of The Good, David B. Gillette

All Faculty Scholarship

When I began my residency, I wanted to deepen my clinical expertise so I could better serve the growing population of older adults. I thought my perfectionism would be an asset in this process and help me be successful. As a high achiever, I focused on meeting internal and external expectations, not on growth. What I did not think of was how to better myself as a person—or that I even needed to do so. I did not know that perfectionism can be a weakness that affects not only me but also those around me.

I am not alone in …

Outpatient Facility-Based Order Variation In Combined Imaging., Adam C. Powell, Yan Wang, Gary L. Smith, James W. Long, Uday U. Deshmukh, David P. Friedman, Christopher G. Roth, Baskaran Sundaram

Department of Radiology Faculty Papers

OBJECTIVE: Combined computed tomography (CT) occurs when one anatomical area is simultaneously imaged both without and with contrast, or two overlapping anatomical areas are imaged concurrently. While this has been studied in a Traditional Medicare population, it has not been studied in other populations subject to prior authorization. This study explores between-facility variation in ordering and receiving orders to render combined CT in a mixed commercial and Medicare Advantage population.

METHODS: Orders for CT abdomen (without/with contrast), CT thorax (without/with contrast), and concurrent CT brain and sinus authorized by a prior authorization company from 2013-2017, pertaining to patients with commercial …

Transdermal Lidocaine For Perioperative Pain: A Systematic Review Of The Literature., Jordan Smoker, Alexa Cohen, Mohammad R Rasouli, Eric S. Schwenk

Department of Anesthesiology Faculty Papers

PURPOSE OF REVIEW: The purpose of this review is to provide a summary of the perioperative studies that have examined transdermal lidocaine (lidocaine patch) as an analgesic and put the evidence in context of the likely overall benefit of transdermal lidocaine in the perioperative period.

RECENT FINDINGS: Several randomized controlled trials have been published in the past 4 years that concluded transdermal lidocaine can reduce acute pain associated with laparoscopic trocar or cannula insertion. Transdermal lidocaine may reduce short-term pain after surgery in selected surgery types and has a low risk of toxicity but its overall clinical utility in the …

Pharmacological Interventions For Painful Sickle Cell Vaso-Occlusive Crises In Adults., Tess E. Cooper, Ian R. Hambleton, Samir K. Ballas, Brydee A. Johnston, Philip J. Wiffen

Cardeza Foundation for Hematologic Research

BACKGROUND: Sickle cell disease (SCD) is a group of inherited disorders of haemoglobin (Hb) structure in a person who has inherited two mutant globin genes (one from each parent), at least one of which is always the sickle mutation. It is estimated that between 5% and 7% of the world's population are carriers of the mutant Hb gene, and SCD is the most commonly inherited blood disorder. SCD is characterized by distorted sickle-shaped red blood cells. Manifestations of the disease are attributed to either haemolysis (premature red cell destruction) or vaso-occlusion (obstruction of blood flow, the most common manifestation). Shortened …

The Role Of Atypical Protein Kinase C In Colorectal Cancer Cells Carcinogenesis, S M Anisul Islam

USF Tampa Graduate Theses and Dissertations

Colorectal cancer (CRC) is the third most common malignancy and the fourth most common cause of cancer-related death worldwide. CRC is a life-threatening disease due to therapy-resistant cancerous cells. The exact mechanisms of cell growth, survival, metastasis and inter & intracellular signaling pathways involved in CRC are still a significant challenge. Moreover, the treatment of metastatic CRC considered palliative for many years aimed for an improved life, with little hope of a cure, highlighting the need for developing novel targeted therapy for CRC. Hence, investigating new molecular mechanism(s) that lead to colorectal carcinogenesis may give insight into the therapeutic target. …

Pathological Comparisons Of The Hippocampal Changes In The Transient And Permanent Middle Cerebral Artery Occlusion Rat Models, Fawad Ali Shah, Tao Li, Lina Tariq Al Kury, Alam Zeb, Shehla Khatoon, Gongping Liu, Xifei Yang, Fang Liu, Huo Yao, Arif Ullah Khan, Phil Ok Koh, Yuhua Jiang, Shupeng Li

All Works

© Copyright © 2019 Shah, Li, Kury, Zeb, Khatoon, Liu, Yang, Liu, Yao, Khan, Koh, Jiang and Li. Ischemic strokes are categorized by permanent or transient obstruction of blood flow, which impedes delivery of oxygen and essential nutrients to brain. In the last decade, the therapeutic window for tPA has increased from 3 to 5–6 h, and a new technique, involving the mechanical removal of the clot (endovascular thrombectomy) to allow reperfusion of the injured area, is being used more often. This last therapeutic approach can be done until 24 h after stroke onset. Due to this fact, more acute …

Availability Of Pain Medications For Npo Patients, Anna Augustin Do, Kyle Borodunovich Do, Sean Quinonez Do, Furqan Haq, My Myers Md

Family Medicine

In recent years, the opioid epidemic has been a key catalyst in changing the medical standards for treating both acute and chronic pain. Instead of relying heavily on narcotics for pain management, practitioners are not encouraged to adapt a non-pharmacologic, non-opioid approach to analgesia. While many guidelines have been set to standardize outpatient pain management, the rules surrounding inpatient analgesia are limited or lacking.

Introducing A Mobile Health Care Platform In An Underserved Rural Population: Reducing Assimilations Gaps On Adoption And Use Via Nudges, Joseph Hodges

USF Tampa Graduate Theses and Dissertations

Rural communities are often overlooked when it comes to offering cutting edge consumer healthcare technologies. Mobile applications usually exclude populations in rural demographics due to the infrastructure requirements and available technology in the region. The population studied is a low income rural health plan in southwest Georgia. They are uniquely considered as they have the highest healthcare costs in the U.S. and are compared to healthcare costs among higher income populations like Vail, Colorado. Innovations, such as mobile healthcare applications, have the capacity to offset some of these costs, but even if adoption occurs, this does not guarantee use will …

Perceived Discrimination And Cardiovascular Outcomes In Blacks: A Secondary Data Analysis Of The Heart Score Study, Marilyn Aluoch

USF Tampa Graduate Theses and Dissertations

Despite the consistent reduction in morbidity and mortality associated with cardiovascular disease (CVD) over the last four decades, CVD remains the leading cause of death globally. In the United States, Blacks are disproportionately affected by CVD compared to Whites. Blacks are also more likely to report incidence of perceived discrimination. Perceived discrimination has been linked to cardiovascular risk factors such as smoking, hypertension (HTN), hyperlipidemia, and obesity. However, the relationship between perceived discrimination and cardiovascular outcomes such as stroke, myocardial infarction, acute ischemic syndrome, coronary revascularization, and cardiac death remains unclear. The primary goal of this study was to examine …

Research Roles And Methods In Nursing Nur 650, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Responsible Conduct Of Nursing And Healthcare Research Nur 649, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Psychological Stress And Cellular Aging In Cancer: A Meta-Analysis, Joanna Kruk, Basil Aboul-Enein, Joshua Bernstein, Magdalena Gronostaj

Health & Wellness Department Faculty Publications and Research

Background. Epidemiological evidence continues to accumulate on the effect of psychosocial and behavioral factors in relation to cancer risk, progression, and mortality. Material and Methods. This article presents the current evidence on the relationship between psychological stress and the risk of cancer and cellular aging process. Ten databases were searched to identify publications up to September 2019. References from retrieved articles were also reviewed. We included nine review papers and 26 cohort or case-control studies based on inclusion/exclusion criteria. Results. Results of previously published review articles did not show consistent evidence for the association between cancer risk …

Pink Tooth Of Mummery In The Maxillary Left Canine After Fixed Partial Denture (Fpd) Preparation, Eger V. Korolevsky, Takashi Komabayashi, Denise Foran

Dental Medicine Faculty Publications

Pink tooth of Mummery is typically found after trauma. However, this case report describes an unusual occurrence of pink tooth in a 67-year-old Caucasian male after fixed partial denture (FPD) tooth preparation. Pink tooth in this case may be due to one or more factors: tooth reduction and heat generation during tooth preparation; heat generation during polymerization of provisional material; and hyperocclusion of a provisional FPD. This case highlights the importance of choosing the appropriate materials and techniques to avoid pulpal complications after dental prosthesis work.

Functional Localization Of The Frontal Eye Fields In The Common Marmoset Using Microstimulation, Janahan Selvanayagam, Kevin D. Johnston, David J. Schaeffer, Lauren K. Hayrynen, Stefan Everling

Brain and Mind Institute Researchers' Publications

Copyright © 2019 the authors. The frontal eye field (FEF) is a critical region for the deployment of overt and covert spatial attention. Although investigations in the macaque continue to provide insight into the neural underpinnings of the FEF, due to its location within a sulcus, the macaque FEF is virtually inaccessible to electrophysiological techniques such as high-density and laminar recordings. With a largely lissencephalic cortex, the common marmoset (Callithrix jacchus) is a promising alternative primate model for studying FEF microcircuitry. Putative homologies have been established with the macaque FEF on the basis of cytoarchitecture and connectivity; however, physiological investigation …

Comparison Of Functional And Patient-Reported Outcomes Between Direct Anterior And Lateral Surgical Approach One-Year After Total Hip Arthroplasty In A Canadian Population: A Cross-Sectional Study., Susan W. Hunter, Pavlos Bobos, Lyndsay Somerville, James Howard, Edward Vasarhelyi, Brent Lanting

Physical Therapy Publications

Background: From a clinical perspective, it is important to understand the outcomes that occur after total hip arthroplasty (THA) and do these vary with surgical approach. The objective of the study was to compare physical performance-based and patient-report outcomes between the Direct Anterior (DA) and Direct Lateral (DL) surgical approach at one-year after THA surgery.

Methods: We evaluated patients attending their one-year follow-up assessment after primary elective unilateral THA surgery for osteoarthritis of the hip. The Activities-specific Balance Confidence Scale, Falls Risk in Older People in a Community Setting, Timed Up and Go Test, 30-Second Chair Stand Test, Step Test, …

Impact Of A Web-Based Instructional Module Of Alzheimer’S Disease Within Seven Content Knowledge Domains, Joyce Haynie

Dissertations

Abstract

Alzheimer’s Disease (AD) has been classified as the most common form of dementia. Primary health care providers are usually the first clinicians to whom individuals present with symptoms of dementia. By 2050, it is expected that as many as 13.8 million Americans will be living with AD, and millions more will be placed in the challenging role of providing care for these individuals. However, studies continue to show that dementia is often underdiagnosed and under detected. The purpose of the study was to systematically inquire about the impact of AD education on level of knowledge about AD among primary …

Diseases Of The Aorta, Maria Mazalkova

Faculty Works: AHS (2004-2023)

Aortic diseases are very common, however , for many years they might be undiscovered. It is very important to raise awareness of aortic diseases in order to provide a highest quality patient care through education, research and treatment.

The Firre Locus Produces A Trans-Acting Rna Molecule That Functions In Hematopoiesis., Jordan P Lewandowski, James C Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M Goldstein, Abigail F Groff, Nydia P Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A Flavell, Jeannie T Lee, Chiara Gerhardinger, Amy J Wagers, John L Rinn

Faculty Research 2019

RNA has been classically known to play central roles in biology, including maintaining telomeres, protein synthesis, and in sex chromosome compensation. While thousands of long noncoding RNAs (lncRNAs) have been identified, attributing RNA-based roles to lncRNA loci requires assessing whether phenotype(s) could be due to DNA regulatory elements, transcription, or the lncRNA. Here, we use the conserved X chromosome lncRNA locus Firre, as a model to discriminate between DNA- and RNA-mediated effects in vivo. We demonstrate that (i) Firre mutant mice have cell-specific hematopoietic phenotypes, and (ii) upon exposure to lipopolysaccharide, mice overexpressing Firre exhibit increased levels of pro-inflammatory cytokines …

Suicide Among Persons Who Entered Same-Sex And Opposite-Sex Marriage In Denmark And Sweden, 1989–2016: A Binational, Register-Based Cohort Study, Annette Erlangsen, Sven Drefahl, Ann Haas, Charlotte Bjorkenstam, Merete Nordentoft, Gunnar Andersson

Publications and Research

Background

People belonging to sexual minority groups have higher levels of suicidality than heterosexuals. However, findings regarding suicide death are sparse. Using unique national data from two countries, we investigated whether individuals entering a same-sex marriage (SSM), a proxy group of sexual minority individuals, had higher suicide rates than those entering opposite-sex marriage (OSM).

Methods

A cohort study of all males and females who entered an SSM (n=28 649) or OSM (n=3 918 617) in Denmark and Sweden during 1989–2016 was conducted. Incidence rate ratios (IRRs) for suicide were calculated using adjusted Poisson regression models.

Results

In total, 97 suicides …

Tracking The Implementation Of A New Telepsychiatry Inpatient Consultation-Liaison Service At A Separate Campus Of A Large Tertiary Care Health Network, Michael S. Yoon Bs, Katherine B. Martin Md, Rory L. Marraccini Md, Edward R. Norris Md, Fapa, Fapm

Department of Psychiatry

No abstract provided.

Association Of Receiving Multiple, Concurrent Fracture-Associated Drugs With Hip Fracture Risk, Rebecca T. Emeny, Chiang-Hua Chang, Jonathan Skinner, James A. O'Malley, Jeremy Smith, Gouri Chakraborti, Clifford J. Rosen, Nancy E. Morden

Dartmouth Scholarship

Importance: Many prescription drugs increase fracture risk, which raises concern for patients receiving 2 or more such drugs concurrently. Logic suggests that risk will increase with each additional drug, but the risk of taking multiple fracture-associated drugs (FADs) is unknown.

Objective: To estimate hip fracture risk associated with concurrent exposure to multiple FADs.

Design, Setting, and Participants: This cohort study used a 20% random sample of Medicare fee-for-service administrative data for age-eligible Medicare beneficiaries from 2004 to 2014. Sex-stratified Cox regression models estimated hip fracture risk associated with current receipt of 1, 2, or 3 or more of 21 FADs …

Prognostic Value Of Neutrophil-Lymphocyte Ratio In Patients With Severe Alcoholic Hepatitis., Yazan Abu Omar, Tejinder Randhawa, Bashar Attar, Rohit Agrawal, Yuchen Wang, Rayli Pichardo, Muhammad B Majeed, Sanjay A Patel

Ambulatory and Primary Care Articles

Background Prednisolone is considered the cornerstone treatment for severe alcoholic hepatitis (AH). However, its use is limited by the increased risk of infection in an already immunocompromised patient population. Among patients with severe AH, there exists a group of non-responders who do not benefit from prednisolone therapy. Day-4 Lille score is a widely employed prognostic model used to identify this non-responder subgroup. The present study evaluates the prognostic ability of the inflammatory marker, the neutrophil-lymphocyte ratio (NLR), as a stand-alone model and in conjunction with the day-4 Lille score. Methods We retrospectively reviewed the electronic medical records of patients diagnosed …

Cs-Cash Pilot Grant: Improving Agricultural Worker Health & Safety Awareness Through Multimodal, Case-Based Physician Assistant Education, Carey Wheelhouse, Mia Hyde, Annie Wildermuth, Wayne Mathews

Posters and Presentations: Physician Assistant

The University of Nebraska Medical Center Division of Physician Assistant Education intends to improve health outcomes of patients in Midwest agricultural communities through didactic, clinical, and case-based instruction of Physician Assistant (PA) students.

Aims

1. Increase PA student awareness of agricultural health and safety issues
2. Increase PA student medical knowledge on respiratory health, chemical exposure, and noise-induced hearing loss
3. Enhance PA student communication skills with agricultural patients
4. Increase patient health care access in agricultural environments

UNMC PA students will undergo learning specific to agricultural-related respiratory health issues, chemical exposures, and hearing loss, including preventative health education and communication with agricultural patient …

Health-Promoting Behaviors And Subjective Well-Being Among High School Students, Nicholas David W. Smith

USF Tampa Graduate Theses and Dissertations

In positive psychology, a greater emphasis is placed on the presence of indicators of both physical and mental health. This study examined the relationship between 12 health-promoting behaviors and subjective well-being (SWB; e.g., happiness) in a sample of 450 high school aged youth from five high schools in two states. Participants reported on their dietary habits, physical activity, abstinence from tobacco products, abstinence from alcohol, and sleep hygiene (i.e., 8 unique components) as well as a multidimensional assessment of SWB (i.e., life satisfaction, positive affect, and negative affect). It was hypothesized that increased engagement in each of the health-promoting behaviors …

Tracking The Implementation Of A New Telepsychiatry Inpatient Consultation-Liaison Service At A Separate Campus Of A Large Tertiary Care Health Network, Michael S. Yoon Bs, Katherine B. Martin Md, Rory L. Marraccini Md, Edward R. Norris Md, Fapa, Fapm

USF-LVHN SELECT

No abstract provided.