Medicine and Health Sciences Commons^™

‘Navigating’ The Huntington’S Disease Community Towards Crucial Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Outcomes In Patients With Gunshot Wounds To The Brain., Leigh Anna Robinson, Lauren M Turco, Bryce Robinson, Joshua G Corsa, Michael Mount, Amy V Hamrick, John Berne, Dalier R Mederos, Allison G Mcnickle, Paul J Chestovich, Jason Weinberger, Areg Grigorian, Jeffry Nahmias, Jane K Lee, Kevin L Chow, Erik J Olson, Jose L Pascual, Rachele Solomon, Danielle A Pigneri, Husayn A Ladhani, Joanne Fraifogl, Jeffrey Claridge, Terry Curry, Todd W Costantini, Manasnun Kongwibulwut, Haytham Kaafarani, Janika San Roman, Craig Schreiber, Anna Goldenberg-Sandau, Parker Hu, Patrick Bosarge, Rindi Uhlich, Nicole Lunardi, Farooq Usmani, Joseph Victor Sakran, Jessica M Babcock, Juan Carlos Quispe, Lawrence Lottenberg, Donna Cabral, Grace Chang, Jhoanna Gulmatico, Jonathan J Parks, Rishi Rattan, Jennifer Massetti, Onaona Gurney, Brandon Bruns, Alison A Smith, Chrissy Guidry, Matthew E Kutcher, Melissa S Logan, Michelle Y Kincaid, Chance Spalding, Matthew Noorbaksh, Frances H Philp, Benjamin Cragun, Robert D Winfield

Trauma and Acute Care Articles

INTRODUCTION: Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for survival or organ donation. Therefore, we sought to determine the rates of survival and organ donation, as well as identify factors associated with both outcomes in patients with GSWB undergoing CPR.

METHODS: We performed a retrospective, multicenter study at 25 US trauma centers including dates between June 1, 2011 and December 31, 2017. Patients were included if they suffered isolated GSWB and required CPR at …

Treatment And Outcome Improvement With Implementation Of A System-Wide Comprehensive Plan Of Care For Management Of Isolated Hip Fractures, C. Michael Lecroy, Adam Kaufman, Christina Mcquiston, Harold Michael Frisch, Martha Hoskyns, Sean Snyder, Terrie Smith, Jaclyn Gosnell, Michael J. Schurr, William Shillinglaw

Orthopedic Surgery

No abstract provided.

Outcomes In Patients With Gunshot Wounds To The Brain, Leigh Anna Robinson, Lauren M. Turco, Bryce Robinson, Joshua G. Corsa, Michael Mount, Amy V. Hamrick, John Berne, Dalier R. Mederos, Allison G. Mcnickle, Paul J. Chestovich, Jason Weinberger, Areg Grigorian, Jeffry Nahmias, Jane K. Lee, Kevin L. Chow, Erik J. Olson, Jose L. Pascual, Rachele Solomon, Danielle A. Pigneri, Husayn A. Ladhani, Joanne Fraifogl, Terry Curry, Todd W. Costantini, Manasnun Kongwibulwut, Haytham Kaafarani, Janika San Roman, Craig Schreiber, Anna Goldenberg-Sandau, Parker Hu, Patrick Bosarge, Rindi Uhlich

School of Medicine Faculty Research

Introduction: Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for survival or organ donation. Therefore, we sought to determine the rates of survival and organ donation, as well as identify factors associated with both outcomes in patients with GSWB undergoing CPR. Methods: We performed a retrospective, multicenter study at 25 US trauma centers including dates between June 1, 2011 and December 31, 2017. Patients were included if they suffered isolated GSWB and required CPR at …

Volume Changes After Traumatic Spinal Cord Injury In Animal Studies - A Systematic Review, Mahdi Sharif-Alhoseini, Fariba Vahedi, Mahmoud Omidbeigi, Marzieh Sharifi, Zahra Hassannejad, Shayan Abdollah Zadegan, Motahareh Rezvan, Mona Mokhatab, Kiavash Sajadi, Aida Shakouri-Motlagh, Farhad Shokraneh, Alexander R. Vaccaro, Vafa Rahimi Movaghar

Department of Orthopaedic Surgery Faculty Papers

There are limited data on the lesion volume changes following spinal cord injury (SCI). In this study, a meta-analysis was performed to evaluate the volume size changes of the injured spinal cord over time among animal studies in traumatic SCI. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive electronic search of English literature of PubMed and EMBASE databases from 1946 to 2015 concerning the time-dependent changes in the volume of the spinal cord following mechanical traumatic SCI. A hand-search was also performed for non-interventional, non-molecular, and non-review studies. Quality appraisal, data extraction, …

Creutzfeldt Jakob Disease: Progressive Neurological Decline, Christine Fayad Md, Scott J. Anderson, H. Alex Akhondi Md

Internal Medicine

No abstract provided.

Utilizing The Community-Based Research Approach To Examine Mental Health And Support Services Issues Related To Hiv-Associated Neurocognitive Disorder, Renato M. Liboro

Psychology Faculty Research

Human immunodeficiency virus (HIV)-associated neurocognitive disorder is an emergent public health problem known to HIV researchers and scientists, but unfortunately, is a concern that still needs to be better recognized by people living with HIV and HIV service providers. Research studies have reported that between 30 to 50% of people living with HIV who have access to combination antiretroviral therapy are and will be affected by this disorder. This raises the need to find more appropriate research approaches for examining issues that will significantly impact people living with HIV experiencing or at risk of developing neurocognitive impairments. People living with …

Healthy Older Adults’ Motivation And Knowledge Related To Food And Meals, Kai Victor Hansen

The Qualitative Report

The population over 60 years old is growing rapidly in Norway and in many other countries, and researchers often focus on elderly people and various diseases. This article examines the healthy elderly who are active in their daily lives to understand their motivation and knowledge about food and meals. The method used was CurroCus® group interviews, or fast focus groups. Nine CurroCus® groups were conducted, lasting for 37 to 56 minutes (average = 45 minutes). Altogether, 76 persons participated, ranging in age from 60 to 87 years; participants were predominantly female (>80%). The article discusses two areas: motivation and …

How Unstructured Data From The Data Warehouse Can Be Used With Machine Learning And Visualization To Develop Novel Medical Technologies, Alfred A. Cecchetti

Faculty Research Day

Machine Learning (ML) can accurately classify and accurately predict disease as well as other medical events.

Device Programming, especially smartphone applications, can provide new ways to acquire, transport, store, process, and secure personalized patient data to deliver meaningful results.

Telehealth In Critical Care: Quality And Cost Outcomes, Michael Robbie, Stephanie Cole, Bukola Abodunde, Alberto Coustasse

Faculty Research Day

The purpose of this study was to assess the potential for the implementation of telehealth in the ICU to determine its impact on quality of care and overall healthcare costs. The primary hypothesis of this study was that telehealth would be linked with lower ICU LOS and hospital mortality rates among critically ill patients.

Post-Implementation Analysis Of The Impact Of Intravenous Automation Systems On Health-System Pharmacy Operations, Craig Kimble, Ken Maxik, Chris Booth, Michael Rudolph, Kim Broedel-Zaugg

Faculty Research Day

We have all seen the reports on the news about issues related to IV rooms and IV room compounding. Many health-system pharmacies have implemented, or are considering some form of intravenous (IV) automation and/ or compounding system in their clean rooms to reduce pharmacy errors and improve accuracy, productivity, and workflow. Manufacturers tout that automated systems, used appropriately, aid in reducing errors from reaching patients. Additionally, IV admixture automation is one of the most recent areas where technology has been added to pharmacy workflow.

A Public Health Approach To Uncovering The Health-Related Needs Of Library Patrons, Jennifer R. Banas, Michelle Oh

Faculty Research and Creative Activities Symposium

As libraries are re-envisioned and reborn as community centers and resource providers, what is their role in understanding and positively contributing to a given neighborhood’s social determinants of health (SDOH), particularly among vulnerable populations? To answer this question the Teen Services department of Chicago Public Library, a licensed professional counselor, and a NEIU team made up of a faculty researcher, an academic librarian, undergraduate students majoring in community health, collaborated to conduct a needs assessment. The aims of the needs assessment was as follows: 1) To uncover the most common health-related needs among community teens as perceived by Teen Services …

Patient Communication With Their General Practice Physicians: Does Age Matter?, William K. Willis, Marcy Butler, Ashish Chandra

Faculty Research Day

We examine the difference in outcomes between various age groups and their communication with their General Practitioner.

Machine Learning To Quantitate Neutrophil Netosis, L. Elsherif, N. Sciaky, C. A. Metts, M. Modasshir, I. Rekleitis, C. A. Burris, J. A. Walker, N. Ramadan, T. L. Leisner, S. P. Holly, M. Cowles, K. I. Ataga, J. N. Cooper, L. V. Parise

Pharmaceutical Sciences

No abstract provided.

Faith Healing: An Unregulated Health Domain, Farhan Mushtaq

MSJ Capstone Projects

Despite Pakistan having adopted modern forms of treatment as part of its official healthcare regime, many non-traditional treatment types are still prevalent in the country - faith healing being one of them. It has a wide acceptance among the masses, be it country’s cities or rural areas.

There are many factors that have forced people to seek alternative forms of treatment: inadequate healthcare facilities, weak healthcare legislation, and religious misconceptions surrounding health-related concerns.

This capstone project is focused on highlighting the flaws in Pakistan’s healthcare regulations that have failed to devise a robust mechanism to curtail the practice. It includes …

Coronavirus And Journalism In Pakistan, Syed Osama Ali

MSJ Capstone Projects

The lockdown caused by the Coronavirus pandemic in 2019 made the reporting process extremely challenging for journalists. In this dire situation, Pakistani journalists like other journalists around the world, ensured the implementation of Coronavirus SOPs while fulfilling their duty as journalists and reporting problems they faced in the process, this is my subject of writing.

The Transcription Factor Pu.1 Mediates Enhancer-Promoter Looping That Is Required For Il-1 Erna And Mrna Transcription In Mouse Melanoma And Macrophage Cell Lines, Soon-Duck Ha, Woohyun Cho, Rodney P. Dekoter, Sung Ouk Kim

Paediatrics Publications

The DNA-binding protein PU.1 is a myeloid lineage– determining and pioneering transcription factor due to its ability to bind “closed” genomic sites and maintain “open” chromatin state for myeloid lineage–specific genes. The precise mechanism of PU.1 in cell type–specific programming is yet to be elucidated. The melanoma cell line B16BL6, although it is nonmyeloid lineage, expressed Toll-like receptors and activated the transcription factor NF-B upon stimulation by the bacterial cell wall component lipopolysaccharide. However, it did not produce cytokines, such as IL-1 mRNA. Ectopic PU.1 expression induced remodeling of a novel distal enhancer (located 10 kbp upstream of the IL-1 …

Service-Learning Research For Development: An Option For The Poor In Practice Through Social Analysis And Community Engagement, Thomas M. Kelly, Kate L. Nolt

Jesuit Higher Education: A Journal

A group of faculty, staff and students from Creighton University conducted a research project using a strengths-based approach to create a community health needs assessment (CNHA) in the fall of 2017. The instruments, including a survey to determine health status, a focus group questionnaire, an environmental scan and an individual interview instrument, were developed to help shift the paradigm from which many international medical missions are conducted with Creighton’s community partner in the Dominican Republic, the Centro de Educación para la Salud Integral (CESI). In the process of creating, developing, implementing, assessing and reformulating this strength-based CHNA, researchers encountered both …

A Bayesian Mixture Model For The Analysis Of Allelic Expression In Single Cells., Kwangbom Choi, Narayanan Raghupathy, Gary Churchill

Faculty Research 2019

Allele-specific expression (ASE) at single-cell resolution is a critical tool for understanding the stochastic and dynamic features of gene expression. However, low read coverage and high biological variability present challenges for analyzing ASE. We demonstrate that discarding multi-mapping reads leads to higher variability in estimates of allelic proportions, an increased frequency of sampling zeros, and can lead to spurious findings of dynamic and monoallelic gene expression. Here, we report a method for ASE analysis from single-cell RNA-Seq data that accurately classifies allelic expression states and improves estimation of allelic proportions by pooling information across cells. We further demonstrate that combining …

Physical And Chemical Stability Of Dexamethasone Sodium Phosphate In Intravenous Admixtures Used To Prevent Chemotherapy-Induced Nausea And Vomiting, Ina Buga, Joy Uzoma, Kristin Reindel, Kateryna Rashid, Tuong Diep, Pamela Mccartan, Fang Zhao

Pharmacy Faculty/Staff Publications

Purpose: Dilute intravenous (IV) admixtures of dexamethasone sodium phosphate (DSP) are becoming increasingly used in antiemetic regimens to prevent chemotherapy-induced nausea and vomiting (CINV). Based on its chemical structure and previous studies, DSP is known to be susceptible to hydrolysis and oxidation under certain conditions. There are limited data to directly support the selection of IV diluents, storage conditions, and beyond-use dates for the dilute IV solutions of DSP used in the antiemetic regimens. This study was designed to investigate these parameters. Methods: A stability-indicating high-performance liquid chromatography (HPLC) method was first developed for the analysis of DSP. Commercially available …

Developing An Ignatian Pedagogy For Occupational Therapy Education In China: The Lived Experience Of The First Two Entry Level Otd, Jesuit Trained Clinicians, Angela Patterson, Alfred G. Bracciano

Jesuit Higher Education: A Journal

This paper explores the lived experience of the initial two Chinese professionals, competitively selected by a Traditional Chinese Medicine University, to attend and graduate from the Creighton University entry-level Doctor of Occupational Therapy (OTD) program. The process and challenges facing implementation of an international collaborative relationship between a Jesuit university and a public higher education institution in China is considered along with the challenges facing international students immersed in Jesuit health care education. Highlights of differences between Eastern and Western higher education are suggested in the discussion. A review of Jesuit education in China provides the historical background and context …

Hiv Prevention Via Mobile Messaging For Men Who Have Sex With Men (M-Cubed): Protocol For A Randomized Controlled Trial, Patrick Sean Sullivan, Ryan J. Zahn, Sarah Wiatrek, Cristian J. Chandler, Sabina Hirshfield, Rob Stephenson, Jose A. Bauermeister, Mary Ann Chiasson, Martin J. Downing, Deborah J. Gelaude, Aaron J. Siegler, Keith Horvath, Erin Rogers, Ana Alas, Evelyn J. Olansky, Heather Saul, Eli S. Rosenberg, Gordon Mansergh

Publications and Research

Background:

Men who have sex with men (MSM) continue to be the predominately impacted risk group in the United States HIV epidemic and are a priority group for risk reduction in national strategic goals for HIV prevention. Modeling studies have demonstrated that a comprehensive package of status-tailored HIV prevention and care interventions have the potential to substantially reduce new infections among MSM. However, uptake of basic prevention services, including HIV testing, sexually transmitted infection (STI) testing, condom distribution, condom-compatible lubricant distribution, and preexposure prophylaxis (PrEP), is suboptimal. Further, stronger public health strategies are needed to promote engagement in HIV care …

The Community Structure Of Functional Brain Networks Exhibits Scale-Specific Patterns Of Inter- And Intra-Subject Variability, Richard F Betzel, Maxwell A Bertolero, Evan M Gordon, Caterina Gratton, Nico U F Dosenbach, Danielle S Bassett

2010-2019 OA Pubs

The network organization of the human brain varies across individuals, changes with development and aging, and differs in disease. Discovering the major dimensions along which this variability is displayed remains a central goal of both neuroscience and clinical medicine. Such efforts can be usefully framed within the context of the brain's modular network organization, which can be assessed quantitatively using computational techniques and extended for the purposes of multi-scale analysis, dimensionality reduction, and biomarker generation. Although the concept of modularity and its utility in describing brain network organization is clear, principled methods for comparing multi-scale communities across individuals and time …

Cordycepin Inhibits Human Ovarian Cancer By Inducing Autophagy And Apoptosis Through Dickkopf-Related Protein 1/Β-Catenin Signaling, Hyun-Jin Jang, Kyeong Eun Yang, In-Hu Hwang, Yang Hoon Huh, Dae Joon Kim, Hwa-Seung Yoo, Soo Jung Park, Ik-Soon Jang

School of Medicine Publications

Cordycepin, the major active component from Cordyceps militaris, has been reported to significantly inhibit some types of cancer; however, its effects on ovarian cancer are still not well understood. In this study, we treated human ovarian cancer cells with different doses of cordycepin and found that it dose-dependently reduced ovarian cancer cell viability, based on Cell counting kit-8 reagent. Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited β-catenin signaling. Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas β-catenin overexpression abolished the effects of cordycepin on cell death and proliferation. Furthermore, we found …

Assessment Of Particulate Matter Toxicity And Physicochemistry At The Claim 28 Uranium Mine Site In Blue Gap, Az, Jessica G.S. Begay

Biomedical Sciences ETDs

Particulate matter (PM) inhalation is known to have adverse effects on the respiratory and cardiovascular systems. Community concerns in the southwestern US have been expressed in regions of extensive open-pit hard-rock (especially uranium) mining that windblown dusts may pose an excess health risk. To address these concerns, we have undertaken a campaign to detail: (1) the amount and composition of the PM_2.5 in the region, (2) meteorological characteristics, such as wind speed and direction, and (3) and immunological and physiological responses of mice after PM_2.5 exposures.

For toxicity studies, C57BL/6 and apolipoprotein E-null (ApoE^-/-, a vascular …

November 2019, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Molluscum Contagiosum Infection With Features Of Primary Cutaneous Anaplastic Large Cell Lymphoma., Doaa Shalabi, John Ringe, Jason B. Lee, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

CD30+ T cell pseudolymphomas (CD30+ PSL) are a group of benign inflammatory cutaneous disorders that can develop in settings of viral infections or drug reactions. Owing to their histological similarities to malignant lymphomas, these benign infiltrates are occasionally misdiagnosed as malignant, causing significant concerns for patients and physicians. Herein, we report a patient with CD30+ PSL associated with molluscum contagiosum whose initial biopsy revealed atypical large CD30-expressing cells, leading to a misdiagnosis of primary cutaneous anaplastic large cell lymphoma and referral to our cutaneous lymphoma clinic. We report this case to demonstrate that reactive CD30+ infiltrate associated with molluscum contagiosum …

Characterization Of Mucosal Dysbiosis Of Early Colonic Neoplasia., Bo-Young Hong, Takayasu Ideta, Bruno S Lemos, Yuichi Igarashi, Yuliana Tan, Michael Disiena, Allen Mo, John W Birk, Faripour Forouhar, Thomas J Devers, George M. Weinstock, Daniel W Rosenberg

Faculty Research 2019

Aberrant crypt foci (ACF) are the earliest morphologically identifiable lesions in the colon that can be detected by high-definition chromoendoscopy with contrast dye spray. Although frequently associated with synchronous adenomas, their role in colorectal tumor development, particularly in the proximal colon, is still not clear. The goal of this study was to evaluate the profile of colon-adherent bacteria associated with proximal ACF and to investigate their relationship to the presence and subtype of synchronous polyps present throughout the colon. Forty-five subjects undergoing a screening or surveillance colonoscopy were included in this retrospective study. Bacterial cells adherent to the epithelia of …

Transcriptional Profiling Predicts Running Promotes Cerebrovascular Remodeling In Young But Not Midlife Mice., Kate E Foley, Hongtian Stanley Yang, Leah C. Graham, Gareth R Howell

Faculty Research 2019

BACKGROUND: The incidence of dementia and cognitive decline is increasing with no therapy or cure. One of the reasons treatment remains elusive is because there are various pathologies that contribute to age-related cognitive decline. Specifically, with Alzheimer's disease, targeting to reduce amyloid beta plaques and phosphorylated tau aggregates in clinical trials has not yielded results to slow symptomology, suggesting a new approach is needed. Interestingly, exercise has been proposed as a potential therapeutic intervention to improve brain health and reduce the risk for dementia, however the benefits throughout aging are not well understood.

RESULTS: To better understand the effects of …

Screening Tools For Hiv-Associated Neurocognitive Disorders Among Adults Living With Hiv In Sub-Saharan Africa: A Scoping Review, Patrick N. Mwangala, Charles R. Newton, Melanie Abas, Amina Abubakar

Institute for Human Development, East Africa

Background: People living with HIV are at risk of developing HIV-associated neurocognitive disorders (HAND) which adversely affects their quality of life. Routine screening of HAND in HIV care is recommended to identify clinically important changes in cognitive functioning and allow for early interventions. However, HAND detection in routine clinical practice has never been reported in sub-Saharan Africa (SSA), partly due to a lack of adequately standardized screening tools. This review was conducted to identify the commonly used screening tools for HAND in SSA and document their psychometric properties and diagnostic accuracy.
Methods: We searched Ovid Medline, PsycINFO and Web of …