Medicine and Health Sciences Commons^™

Microfluidic Synthesis Of Plga/Carbon Quantum Dot Microspheres For Vascular Endothelial Growth Factor Delivery, Meisam Omidi, Mohadeseh Hashemi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, vascular endothelial growth factor (VEGF) loaded poly(D,L-lactide-co-glycolide) (PLGA) – carbon quantum dot microspheres were produced using microfluidic platforms. The microcapsules were fabricated in flow-focusing geometry with a biphasic flow to generate solid/oil/water (s–o–w) droplets. To avoid any damage to protein functional and structural stability during the encapsulation process, the VEGF was PEGylated. The produced microspheres were intact and highly monodisperse in size (CV < 5%). Furthermore, microspheres in a size range of 16–36 µm were achieved by adjusting the flow ratio parameter. The encapsulation efficiency, release profile, and bioactivity of the produced microparticles were also studied. The loading efficiency of PEGylated VEGF in the microparticles was varied from 51–69% and more than 90% of PEGylated VEGF was released within 28 days. Furthermore, the release of VEGF was indirectly monitored by carbon quantum dots. The present monodisperse and controllable VEGF loaded microspheres with reproducible manner could be widely used in tissue engineering and therapeutic applications.

Jurisliterature And Transgression, Peter Goodrich

Articles

The jurisliterary profession is the curious enterprise of writing, as a jurist, about law. Many seek to escape into literature, philosophy, critique, psychoanalysis, the couch, but then, in the main, they have abandoned law. Those that persist, who remain jurists, have the propensity to transgress the boundaries of the juridical, the strictures of abstraction and disembodiment, so as to generate accounts of legal sensibility, so as to manifest the polyglottal and visceral potential of transforming the juridical bubble into that most ethical of realms, the poetics of desire. Jurisliterary transgression, at its strongest, returns the materiality of imagination to the …

Comparative Effectiveness Of Dimethyl Fumarate Versus Fingolimod And Teriflunomide Among Ms Patients Switching From First-Generation Platform Therapies In The Us., Daniel Ontaneda, Jacqueline Nicholas, Matthew Carraro, Jia Zhou, Qiang Hou, Jaanai Babb, Katherine Riester, Jason P Mendoza, Terrie Livingston, Mehul Jhaveri

Neuroscience Articles

BACKGROUND: Previous real-world comparative research of MS disease modifying therapies (DMTs) in the overall population has suggested dimethyl fumarate (DMF) to be comparable to fingolimod (FTY) and more efficacious than teriflunomide (TERI) in reducing relapses. However, there is limited comparative evidence in patients switching from platform DMTs in the US. The objective of the study was to compare the annualized relapse rate (ARR) and risk of relapse in MS patients who have switched from a platform therapy to DMF, FTY, or TERI.

METHODS: MS patients (18-65 years old) initiating an oral DMT from June 2013 to March 2015 were identified …

Contextual Interference In Speech Motor Learning Secondary To Similar Phonemes, Katelyn M. Bond

Capstones and Honors Theses

Purpose: The contextual interference (CI) effect is a motor learning phenomenon where learners experience difficulty during training resulting in poor performance; however, improved performance is observed in transfer conditions. Different variables elicit a CI effect, and the purpose of this study is to investigate whether phoneme (or sound) similarity may result in a CI effect during speech motor learning.

Method: The study included twenty-nine participants whose hearing and speech abilities were within the normal range. Participants were randomly assigned to one of two training sessions involving nonwords with either similar or dissimilar phonemes. Each training session included nonword repetition training …

An Application Of The Two-Stage Model Of Motor Learning To Speech Motor Control, Jacob W. Cahn

Capstones and Honors Theses

Purpose: This study used a two-stage model of motor learning (Latash, 2012) to evaluate bad and good variance during a speech learning task. Stage 1 learning involves minimizing bad variance, or overall error, whereas Stage 2 learning involves changes in good variance while ceiling accuracy is maintained. Using two different variables to evaluate speech complexity (manner of articulation and syllable length), two hypotheses were evaluated: 1) A two-stage model exists during speech motor learning and 2) complexity of stimuli will alter the achievement and maintenance of each stage during learning.

Methods: Twelve native English speakers with normal speech and hearing …

Media Exposure And Community Perception Of Alcoholism Among Female Adolescents In South-West Nigeria, Rowland Edet, Julianah Babajide

Department of Sociology: Faculty Publications

Purpose - The purpose of this paper is to investigate the influence of alcohol adverts on female adolescents as well as the perception of the community on alcohol consumption among female adolescents. The authors analyzed respondents’ opinions towards media portrayal of alcoholic beverages. Design/

Methodology/ Approach - The study adopted a descriptive cross-sectional survey. The methodology based upon semi-structured questionnaire among 500 female adolescents and a qualitative methodology using in-depth interviews with parents and alcoholic beverage sellers.

Findings - The study reveals that television was the major source of information on alcoholic beverages among female adolescents in both rural (36.4%) …

Sexual Behaviours Of Adolescents In Creek Town, Cross River State, Nigeria, Kabiru K. Salami, Rowland E. Edet

Department of Sociology: Faculty Publications

Risky sexual behaviors of adolescents in Creek Town have not been fully profiled. This study investigated the sexual behaviors of adolescents and their various dimensions in Creek Town, in Cross River State, Nigeria. This cross-sectional survey design adopted multi-stage sampling procedure to administer a 112-items questionnaire to 422 adolescents, to elicit information on their sexual behaviors and practices. Four focus group discussion sessions were also conducted with in-school and out-of-school adolescents. The mean age of adolescents was 17 years. Majority (65.4%) of the adolescents were sexually active. The mean age at sexual debut was 15 years for both male and …

Comparison Of Quantitative Analysis To Qualitative Analysis For Interpretation Of Lower‑Limb Lymphoscintigraphy, Edward Nganga, Khalid Makhdomi

Imaging & Diagnostic Radiology, East Africa

Qualitative analysis of lymphoscintigrams is subject to wide variability and may miss subtle differences in ilioinguinal uptake between normal and abnormal limbs. This study compared quantitative analysis to qualitative analysis of lower‑limb lymphoscintigraphy in diagnosing lymphedema. Fifty‑two lymphoscintigrams performed using standardized protocol, 99‑metastable technetium nanocolloid intradermal injection at the first interdigital space, were analyzed quantitatively. Fifty‑three normal and 51 abnormal limbs were analyzed. For each limb, a region of interest (ROI) was drawn around the injection site, and ilioinguinal nodes on the 1.5 h static images and the counts in these ROIs were recorded. Percentage ilioinguinal nodes uptake was then …

How Do Teachers Use Comics To Promote Engagement, Equity, And Diversity In Science Classrooms?, Camilla Matuk, Talia Hurwich, Amy Spiegel, Judy Diamond

World of Viruses

Equitable learning opportunities are critical to the goals of science education. However, major curriculum standards are vague on how to achieve equity goals, and educators must often develop their own resources and strategies to achieve equity goals. This study examines how educators used a comic book series designed to interest youth in virology as a way to make science more broadly appealing to their diverse students. We begin with the notion of Pedagogical Design Capacity, which describes a dynamic relationship between teachers and their tools and the ability for teachers to perceive and leverage affordances of artifacts as tools in …

The Effects Of In Utero Levothyroxine Exposure On Anterior-Posterior Craniofacial Development In A Mouse Model, Ashley Rogers Albrecht

MUSC Theses and Dissertations

Introduction: The purpose of this study was to investigate the effects of in utero levothyroxine exposure on anterior-posterior craniofacial development in a mouse model. Methods: In order to determine the effects of in utero levothyroxine exposure on anterior-posterior craniofacial development, a study group (n=19) of C57BL6 mice were exposed to high dose (~667ng per day) levothyroxine during fetal development. Mice were sacrificed day 15 post-natal. Skulls were fixed in a solution of 4% paraformaldehyde, then switched to 70% ethanol in preparation for microCT imaging. Scans were loaded into Dolphin Imaging Software and lateral cephalograms were rendered and analyzed. Results: According …

At Risk Alcohol Consumption With Smoking By National Background: Results From The Hispanic Community Health Study/Study Of Latinos, Frank C. Bandiera, Eliseo J. Pérez-Stable, Folefac Atem, Raul Caetano, Denise C. Vidot, Marc D. Gellman, Elena L. Navas-Nacher, Jianwen Cai, Gregory Talavera, Neil Schneiderman, Robert Kaplan

United States Food and Drug Administration: Publications

Introduction: Tobacco smoking and binge or excess drinking are unhealthy behaviors that frequently co-occur. Studies of Hispanics/Latinos have mostly been of Mexican Americans although there are substantial differences in smoking and drinking by heritage background. Associated with co-use by 5 subpopulations.

Methods: Cross-sectional data of 16,412 Hispanics/Latinos from Miami, the Bronx, Chicago and San Diego collected between 2008 and 2011 as part of the HCHS/SOL were analyzed. Smoking and alcohol consumption and demographic data were measured by self-report. Prevalence of smoking and alcohol consumption and co-use were reported. Logistic regression models examined the odds of co-use of smoking and binge …

Comparing Methods For Clinical Investigator Site Inspection Selection: A Comparison Of Site Selection Methods Of Investigators In Clinical Trials, Nicholas Hein, Elena Rantou, Paul Schuette

United States Food and Drug Administration: Publications

Background During the past two decades, the number and complexity of clinical trials have risen dramatically increasing the difficulty of choosing sites for inspection. FDA’s resources are limited and so sites should be chosen with care.

Purpose To determine if data mining techniques and/or unsupervised statistical monitoring can assist with the process of identifying potential clinical sites for inspection.

Methods Five summary-level clinical site datasets from four new drug applications (NDA) and one biologics license application (BLA), where the FDA had performed or had planned site inspections, were used. The num- ber of sites inspected and the results of the …

Cdek: Clinical Drug Experience Knowledgebase, Rebekah H Griesenauer, Constantino Schillebeeckx, Michael S Kinch

2010-2019 OA Pubs

The Clinical Drug Experience Knowledgebase (CDEK) is a database and web platform of active pharmaceutical ingredients with evidence of clinical testing as well as the organizations involved in their research and development. CDEK was curated by disambiguating intervention and organization names from ClinicalTrials.gov and cross-referencing these entries with other prominent drug databases. Approximately 43% of active pharmaceutical ingredients in the CDEK database were sourced from ClinicalTrials.gov and cannot be found in any other prominent compound-oriented database. The contents of CDEK are structured around three pillars: active pharmaceutical ingredients (n = 22 292), clinical trials (n = 127 223) and organizations …

Novel Amphiphilic Cyclobutene And Cyclobutane Cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium Avium Subsp. Paratuberculosis Growth, Denise K. Zinniel, Wantanee Sittiwong, Darrell D. Marshall, Govardhan Rathnaiah, Isin T. Sakallioglu, Robert Powers, Patrick H. Dussault, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Mycobacterium avium subspecies paratuberculosis (Map) is the etiologic agent of Johne’s disease in ruminants and has been associated with Crohn’s disease in humans. An effective control of Map by either vaccines or chemoprophylaxis is a paramount need for veterinary and possibly human medicine. Given the importance of fatty acids in the biosynthesis of mycolic acids and the mycobacterial cell wall, we tested novel amphiphilic C₁₀ and C₁₈ cyclobutene and cyclobutane fatty acid derivatives for Map inhibition. Microdilution minimal inhibitory concentrations (MIC) with 5 or 7 week endpoints were measured in Middlebrook 7H9 base broth media. We compared the …

Investigation Of Congestive Heart Failure In Beef Cattle In A Feedyard At A Moderate Altitude In Western Nebraska, Rodney A. Moxley, David R. Smith, Dale M. Grotelueschen, Tom Edwards, David Steffen

School of Veterinary and Biomedical Sciences: Faculty Publications

Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500– 3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009–2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8–4.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: …

Thymic Expression Of Il-4 And Il-15 After Systemic Inflammatory Or Infectious Th1 Disease Processes Induce The Acquisition Of"Innate" Characteristics During Cd8 + T Cell Development, Natalia S. Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L. Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A. Young, Maria Cecilia Rodriguez-Galan

United States Public Health Resources

Innate CD8 + T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in the thymus and depend on IL-4 and IL-15 for their development. Even though innate CD8 + T cells exist in the thymus of WT mice in low numbers, they are highly enriched in KO mice that lack certain kinases, leading to an increase in IL-4 production by thymic NKT cells. Our work describes that in C57BL/6 WT mice undergoing a Th1 biased infectious disease, …

Phytochemical Investigation And Drug Interaction Potential Of Cyanotis Vaga, Ibrahim Almarabi

Electronic Theses and Dissertations

Cyanotis. vaga (Lour.) Schult, & Schult. f. (C. vaga) previously called Tradescantia vaga and Cyanotis barbata, is a perennial herb. It is native to Eastern Asia and Tropical Africa. It has been reported that its decoction reduces fever and enhances well-being. Recently, C. vaga has been used widely for its anabolic effects, due to its richness of ecdysteroids. Even though C. vaga is a commedicinal plant (dietary supplement), there are no reports about its effect on the drug metabolizing enzyme Cytochromes P450 to predict its interaction with concomitantly used medications. In this study, eight ecdysteroids were isolated …

Cheminformatic Approach For Deconvolution Of Active Compounds In A Complex Mixture - Phytoserms In Licorice, Manal Mohammad Alhusban

Electronic Theses and Dissertations

ABSTRACT After the validation of our in silico models by using the previous knowledge in this area the alerting phytochemicals from two Glycyrrhiza species (G. glabra and G. uralensis) were clustered. Exhaustive computational mining of licorice metabolome against selected endocrinal and metabolic targets led to the discovery of a unique class of compounds which belong to the dihydrostilbenoids (DHS) class appended with prenyl groups at various positions. To the best of our knowledge this interesting group of compounds has not been studied for their estrogenic activities or PXR activation. In addition some of the bis-prenylated DHS have been reported to …

Comparative Characteristics Of Antibacterial Activity Of Plants Growing In The Central Part Of The Republic Of Tajikistan., Saidbeg Satorov, F. Mirzoeva, Sh. Satorov, M. Vakhidova, Vyacheslav Dushenkov

Publications and Research

Objective: To evaluate the spectrum of antibacterial activity of plants growing in the central part of the Republic of Tajikistan.
Methods: The antibacterial properties of 18 plant species from the 14 families were studied. The extract samples on dry filter discs were prepared according to the method developed at Rutgers University. Screens-to-Nature (STN) and disc diffusion (DD) methods were used to assess antimicrobial properties of the extracts. The antimicrobial activity of plant extracts was determined against four types of pathogenic standard museum strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, as well as …

การตรวจสอบความใช้ได้ของวิธีการวิเคราะห์คัดกรองสารเสพติดในน้ำวุ้นลูกตาด้วยเทคนิคการสกัด Quechers และตรวจด้วย Lc-Ms/Ms, บัณฑิตา บุญเฉลียว

Chulalongkorn University Theses and Dissertations (Chula ETD)

น้ำวุ้นลูกตาถูกนำมาใช้เป็นตัวอย่างทางเลือก เนื่องจากทนต่อการเปลี่ยนแปลงหลังการเสียชีวิต รวมถึงมีส่วนประกอบที่เป็นเซลล์น้อยจึงสามารถนำมาเตรียมตัวอย่างได้ง่าย การเตรียมตัวอย่างทางนิติพิษวิทยาสามารถเตรียมได้หลายวิธี เช่น Solid Phase Extraction (SPE) และLiquid-Liquid Extraction (LLE) แต่มีข้อเสียคือใช้เวลาในการเตรียมนาน มีค่าใช้จ่ายสูงและใช้สารที่เป็นอันตรายในปริมาณมาก เทคนิค modified QuEChERS ถูกนำมาพัฒนาให้เข้ากับงานทางนิติพิษวิทยา ซึ่งเทคนิคนี้ใช้เวลาในการเตรียมน้อย ทำได้ง่าย ค่าใช้จ่ายถูก มีประสิทธิภาพ มีความทนทานและมีความปลอดภัย เครื่องมือตรวจวเคราะห์ Liquid Chromatography -tandem mass spectrometry (LC-MS/MS) สามารถวิเคราะห์สารประกอบได้หลากหลาย มีความจำเพาะสูงและการเตรียมตัวอย่างเพียงเล็กน้อยก็สามารถนำไปวิเคราะห์ได้ งานวิจัยนี้มีวัตถุประสงค์เพื่อตรวจสอบความใช้ได้ของวิธีการวิเคราะห์คัดกรองสารเสพติดในน้ำวุ้นลูกตาด้วยเทคนิค modified QuEChERS และตรวจด้วย LC-MS/MS ทำการทดสอบความใช้ได้ (validation) ทั้งหมด 6 พารามิเตอร์ โดยนำน้ำวุ้นลูกตามา spike สารเสพติดลงไปทั้งหมด 24 ชนิด จากนั้นนำไปสกัดด้วยเทคนิค modified QuEChERS และตรวจวิเคราะห์ด้วย LC-MS/MS หลังจากนั้นนำเทคนิคที่ผ่านการทดสอบแล้วไปทดสอบกับตัวอย่างน้ำวุ้นลูกตาจริงทั้งหมด 10 ตัวอย่าง และเปรียบเทียบผลที่ได้กับการทดสอบในตัวอย่างเลือด ผลการศึกษาความใช้ได้พบว่า การทดสอบความใช้ได้ทั้ง 6พารามิเตอร์มีค่าอยู่ในช่วงที่ยอมรับได้ทั้งหมด และผลการทดสอบ selectivity ไม่พบการรบกวนของสารอื่น ๆ ในการทดสอบและเมื่อเปรียบเทียบผลการทดสอบตัวอย่างน้ำวุ้นลูกตากับตัวอย่างเลือดก็ให้ผลไม่แตกต่างกัน

Prevalence Of Enteric Helminths And Protozoa And Identification Of Hookworm, Threadworm And Giardia Spp. In Cats In Bangkok And Vicinity, Thailand, Wanarit Jitsamai

Chulalongkorn University Theses and Dissertations (Chula ETD)

A total of 835 fecal samples collected from client-owned and community cats between 2014 and 2016 were subjected to wet fecal smear and/or PBS-ethyl acetate and/or ZnSO4 centrifugal flotation. Ancylostoma spp. was the most common, 28.5%, followed by 6.7% Toxocara spp., 5.3% Cystoisospora spp., 4.4% Platynosomum fastosum, 2.5% Taenia taeniaeformis, 1.7% Strongyloides spp., 1.4% Spirometra spp., 1.3% Dipylidium caninum, 0.1% Eucoleus aerophilus and 0.1% Opisthorchis-like trematode egg. For retroviruses, FeLV and FIV were positive 7.1% (19/269) and 5.2% (14/269), respectively, without association with endoparasitic infection. Based on Giardia copro-antigen detection test, 3.9% (9/233) of tested cats were positive. From multivariable …

การเปรียบเทียบการเกิดภาวะเอียงของกระดูกเชิงกรานขณะวิ่งที่ระดับความหนักปานกลางในกลุ่มนักวิ่งมือใหม่และนักวิ่งสันทนาการเพศหญิง, หทัยภัทร ทิพยุทธ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อศึกษาผลของการวิ่งที่ระดับความหนักปานกลางต่อระยะเวลาการเกิดภาวะเอียงของกระดูกเชิงกราน (pelvic drop) ในนักวิ่งมือใหม่ และนักวิ่งสันทนาการเพศหญิง และศึกษาความสัมพันธ์ระหว่างแนวการเอียงของกระดูกเชิงกราน (pelvic alignment)กับอัตราการเต้นของหัวใจ (heart rate; HR), การใช้ออกซิเจน (VO2 uptake), ค่าความรู้สึกเหนื่อย (Rating of Perceived Exertion; RPE), ค่าความรู้สึกล้าของขา (Rating of Perceived Exertion for legs; RPElegs) และความล้าของกล้ามเนื้อ Gluteus medius และ Gluteus maximus กลุ่มตัวอย่างในงานวิจัยครั้งนี้อายุระหว่าง 18 - 35 ปี เป็นนักวิ่งมือใหม่ (ประสบการณ์น้อยกว่า 1 ปี) 27 คน และนักวิ่งสันทนาการ (ประสบการณ์ 2 - 4 ปี) 27 คน ซึ่งทั้งสองกลุ่มได้รับการทดสอบประสิทธิภาพการใช้ออกซิเจนสูงสุด (VO2max) และวิ่งบนลู่วิ่ง 30 นาที ที่ระดับความหนักปานกลางที่อัตราเร็วที่เลือกเอง (นักวิ่งมือใหม่; 5.87 ± 0.62 กม./ชม. vs. นักวิ่งสันทนาการเพศหญิง; 6.44 ± 0.58 กม./ชม.) โดยอยู่ในช่วงอัตราการเต้นหัวใจที่ 40 - 59% ของอัตราการเต้นหัวใจสำรองสูงสุด (heart rate reserve; HRR) ขณะทดสอบบนลู่วิ่ง 30 นาที นักวิ่งทั้งสองกลุ่มจะถูกบันทึกค่าอัตราการเต้นของหัวใจ, การใช้ออกซิเจน, ค่าความรู้สึกเหนื่อย, ค่าความรู้สึกล้าของขา และวัดการทำงานของกล้ามเนื้อ (muscle activity) จากสัญญาณไฟฟ้า (electromyography; EMG) ที่กล้ามเนื้อ Gluteus medius และ Gluteus maximus ทุก ๆ …

Development Of A Biosafety Level-2 Facility For Irradiation Of Biological Cells Using Mev Ions, Jay D. Diaz, Naresh T. Deoli, Deborah Rogers, Armin De Vera, Karen M. Smith, Robin Schmeider-Broussard, Harry J. Whitlow

Louisiana Accelerator Center

The development of a facility for irradiation of murice and primate tissue presents several challenges. First, extremely low fluences (10⁶-10¹¹ ions cm⁻²) are required to deliver doses of 1 mGy - 50 Gy using MeV proton. Second,the tissues, particularly from non-human primate, may be infectious to humans. Third, protection of irradiated tissue samples from contamination by mold and bacteria is critical. Here we present an ultra-low flux irradiation facility and associated fluence control for biological cell and tissue irradiation under sterile biosafety level 2 (BSL-2) conditions suitable for use with low energy (1-3.4 MeV) protons. The operation is demonstrated using …

Proceedings Of The 2019 Undergraduate Research Conference, Ryan C. Winters, Courtney A. Suire, Dillard University, Grambling State University, Louisiana State University, Loyola University New Orleans, Mcneese State University, Nicholls State University, Northwestern State University Of Louisiana, Southeastern Louisiana University, Southern University And A&M College, University Of Louisiana At Lafayette

Advance: Student Research Experience

Proceedings of the 2019 Undergraduate Research Conference, University of Louisiana at Lafayette, November 22-23, 2019

Predictive Relationship Between Socio-Demographics, Medication, And Treatment Completion Among Persons Experiencing Homelessness Treated For Tuberculosis, Sophia Ajoku

Walden Dissertations and Doctoral Studies

Approximately 80% of people who contract tuberculosis (TB) in the United States are first infected with untreated latent tuberculosis infection (LTBI). LTBI is an ongoing public health concern in people who experience homelessness. Because of the transient nature of this population, it is often difficult for them to adhere to and complete treatment for LTBI. In this quantitative, correlational of a cross-sectional study, secondary data was from a public health clinic in southern U.S. The theoretical framework used for the study was the social ecological framework. Multiple logistic regression was used to determine if a statistically significant predictive relationship existed …

Improving Care For Transgender Veterans Through Staff Education, Stephanie C. Henrickson

Walden Dissertations and Doctoral Studies

The VHA Directive 1341 (2018a): Providing Health Care for Transgender and Intersex Veterans, outlines care for transgender patients. Staff members at the project site lacked knowledge of the directive and available resources, making their care of transgender veterans inefficient. The purpose of the project was to implement staff education about the directive and resources to increase transgender patient visits and access to care. The practice-€focused question asked whether the development and implementation of staff education about the national directive and transgender services would affect the number of transgender patient visits in a 2-€month period. The Iowa and Community Readiness Models …

Exploring Healthcare Transitions And Health Equity: An Integrative Review, Susan Ann Jordan

Walden Dissertations and Doctoral Studies

Compared to their typically developing peers, adolescents, and emerging adults with special healthcare needs (AEA-SHCN) disproportionately experience healthcare transition (HCT) disparities and poor access to adult care. Theoretical models that describe how access gaps develop and strategies to address unmet HCT needs are not well understood. While HCT researchers describe both system and patient healthcare barriers, a comprehensive approach that discovers how these factors interact and interfere remains misunderstood. An integrative review (IR) was conducted to understand the multiplicity of these factors. An intersectional theory (IT) provided further clarity on how key findings influence patient HCT experiences. Several themes were …

Staff Education On Metabolic Syndrome In Patients Taking Antipsychotic Medications, Juliana Ifeoma Omile

Walden Dissertations and Doctoral Studies

Second-generation antipsychotics (SGAs) are prescribed for treatment of psychosis. A major side effect of SGAs is an increased risk of metabolic syndrome (MetS) with symptoms of hypertension, hyperlipidemia, hyperglycemia, and truncal obesity. A clinic in the northeastern United States was not screening patients for MetS when being treated with SGAs. The purpose of this project was to educate staff on MetS risk factors, signs, symptoms, and patient management with a goal to improve their knowledge of MetS. Lewin's change theory provided a conceptual framework for the project. The project question explored the development and evaluation of an educational module on …

Diagnosis And Rehabilitation Of Multiple Hip Pathologies In A Division I Football Player: A Case Study, Kelsey E. Sanders

Electronic Theses and Dissertations

Objective: To present a diagnosis and rehabilitation plan for femoroacetabular impingement (FAI), labral tear, and sports hernia in a Division I college football player. Background: A 21-year-old NCAA Division I college football player experienced a rare combination diagnosis of hip FAI, labral tear and sports hernia. Overlapping signs and symptoms proved difficult to conclude a diagnosis. The patient underwent three months of conservative treatment with no relief before electing to undergo surgery. Differential Diagnosis: Hip flexor strain, osteitis pubis. Treatment: A combination of conservative treatment such as activity modification, anti-inflammatories, therapeutic modalities, injections, and rehabilitation were unsuccessful in relieving symptoms …

Implementation Of A Transcultural Nursing Education Program To Improve Nurses' Cultural Competence, Ann Marie Elizabeth Edwards

Walden Dissertations and Doctoral Studies

The exponential growth of culturally diverse populations in the United States has led to a multicultural patient population while the nursing workforce remains predominantly White. At the project site, managers identified that staff nurses struggled to deliver culturally competent care. The purpose of this project was to improve the cultural competence of registered nurses (RNs) through a transcultural nursing education program. Leininger's transcultural nursing theory guided the project. Sources of evidence used to develop a face-to-face educational program included peer-reviewed journals, credible websites, and the Inventory for Assessing the Process of Cultural Competence Among Healthcare Professionals-R tool. Aggregate pretest and …