Medicine and Health Sciences Commons^™

Effects Of Type I Diabetes On Labor Force Participation: A Propensity Score Match, Ore Aina-Badejo

Theses and Dissertations

Type I Diabetes (T1D) is a chronic autoimmune mediated form of insulin resistance that has lasting socioeconomic effects from childhood through old age that may impact labor force participation. Examining this relationship will enhance our understanding of life-long chronic illness beyond individual medical/financial impact by establishing broader socioeconomic implications. This study utilized data from the 2008-2015 data set of the Medical Expenditure Panel Survey (MEPS), to explore the effects of T1D on labor force participation. It was hypothesized that having T1D would decrease both employability and contribution to the labor force. Utilizing methods of propensity score matching and entropy balancing, …

Sleep Apnea In Children, Tanya Al-Talib

School of Dental Medicine - UMC Briefs

Does your child snore? Have you witnessed your child stop breathing while sleeping? Is your child not growth at a normal rate? Does your child feel tired? Does your child have trouble focusing in school? Does your child wet the bed?

All of the above conditions may be related to having sleep problems and or sleep disordered breathing.

Quantitative Clinical And Autoimmune Assessments In Stiff Person Syndrome: Evidence For A Progressive Disorder., Goran Rakocevic, Harry Alexopoulos, Marinos C. Dalakas

Department of Neurology Faculty Papers

BACKGROUND: Stiff Person Syndrome (SPS) is an under-diagnosed disorder that affects mobility and the quality of life of affected patients. The aim of the study is to describe the natural history of SPS, the extent of accumulated disability and the associated clinical and immunological features in patients followed for up to 8 years in a single center.

METHODS: Our collective cohort included 57 SPS patients. Additionally, 32 of these patients were examined every 6 months for a two-year period in a longitudinal study protocol, to assess disease progression using quantitative measures of stiffness and heightened sensitivity.

RESULTS: The most frequent …

Air Quality And Health Burden Of 2017 Northern California Wildfires, Susan O’Neill, Minghui Diao

Faculty Publications, Meteorology and Climate Science

No abstract provided.

Ctcf Governs The Identity And Migration Of Mge-Derived Cortical Interneurons., Adrienne Elbert, Daniel Vogt, Ashley Watson, Michael Levy, Yan Jiang, Emilie Brûlé, Megan E Rowland, John Rubenstein, Nathalie G Bérubé

Paediatrics Publications

The CCCTC-binding factor (CTCF) is a central regulator of chromatin topology recently linked to neurodevelopmental disorders such as intellectual disability, autism, and schizophrenia. The aim of this study was to identify novel roles of CTCF in the developing mouse brain. We provide evidence that CTCF is required for the expression of the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that originate in the medial ganglionic eminence (MGE). Conditional

A Preliminary Randomized Controlled Evaluation Of A Universal Healthy Relationships Promotion Program For Youth, Deinera Exner-Cortens, David Wolfe, Claire Crooks, Debbie G. Chiodo Ms.

Journal Articles

Bullying and mental health problems are pressing concerns for adolescents. Given their burden, we need to find efficacious ways to prevent these experiences. However, existing prevention programs tend to be single-issue and may not focus on the universal capacities required to reduce these problems among youth. To this end, we evaluated the universal, small groups Healthy Relationships Plus (HRP) program, which focuses on the promotion of positive mental health and the reduction of bullying and substance misuse. A sample of 212 youth from Southwestern Ontario were randomly assigned to the HRP or an attention-control condition over an 8-day period during …

Developmental Trajectories And Reference Percentiles For Range Of Motion, Endurance, And Muscle Strength Of Children With Cerebral Palsy., Lynn M Jeffries, Alyssa Laforme Fiss, Sarah Westcott Mccoy, Doreen Bartlett, Lisa Avery, Steven Hanna

Physical Therapy Publications

BACKGROUND: Children with cerebral palsy (CP) frequently present with secondary impairments in spinal alignment and extremity range of motion, endurance for activity, and muscle strength. Creation of developmental trajectories for these impairments will help guide clinical decision-making.

OBJECTIVE: For children in each level of the Gross Motor Function Classification System (GMFCS) this study aimed to: (1) create longitudinal developmental trajectories for range of motion (Spinal Alignment and Range of Motion Measures [SAROMM]), endurance (Early Activity Scale for Endurance [EASE]), and functional strength (Functional Strength Assessment [FSA]); and (2) develop age-specific reference percentiles and amount of change typical over 1 year …

An Artificial Intelligence Approach To Detect Visual Field Progression In Glaucoma Based On Spatial Pattern Analysis., Mengyu Wang, Lucy Q. Shen, Louis R. Pasquale, Paul Petrakos, Sydney Formica, Michael V. Boland, Sarah R. Wellik, Carlos Gustavo De Moraes, Jonathan S. Myers, Osamah Saeedi, Hui Wang, Neda Baniasadi, Dian Li, Jorryt Tichelaar, Peter J. Bex, Tobias Elze

Wills Eye Hospital Papers

Purpose: To detect visual field (VF) progression by analyzing spatial pattern changes.

Methods: We selected 12,217 eyes from 7360 patients with at least five reliable 24-2 VFs and 5 years of follow-up with an interval of at least 6 months. VFs were decomposed into 16 archetype patterns previously derived by artificial intelligence techniques. Linear regressions were applied to the 16 archetype weights of VF series over time. We defined progression as the decrease rate of the normal archetype or any increase rate of the 15 VF defect archetypes to be outside normal limits. The archetype method was compared with mean …

Adolescent Trials Network For Hiv-Aids Scale It Up Program: Protocol For A Rational And Overview, Sylvie Naar, Jeffrey T. Parsons, Bonita F. Stanton

Publications and Research

Background: The past 30 years have witnessed such significant progress in the prevention and treatment of HIV/AIDS that an AIDS-free generation and the end to the global AIDS epidemic are ambitious, but achievable, national and global goals. Despite growing optimism, globally, youth living with HIV are markedly less likely to receive antiretroviral therapy than adults (23% vs 38%). Furthermore, marked health disparities exist regarding HIV infection risk, with young men of color who have sex with men disproportionately affected. A large body of research has identified highly impactful facilitators of and barriers to behavior change. Several efficacious interventions have been …

‘If He Hits Me, Is That Love? I Don’T Think So’: An Ethnographic Investigation Of The Multi-Level Influences Shaping Indigenous Women’S Decision-Making Around Intimate Partner Violence In The Rural Peruvian Andes, Isabella Li Chan

USF Tampa Graduate Theses and Dissertations

This dissertation examines how the intersections of gender, ethnicity, place, and class shape indigenous women’s risks for and experiences of intimate partner violence and related decision-making in Carhuaz province, an underserved, resource-poor setting in the Peruvian Andes. This dissertation applied a mixed-methods, community-based approach to 11 months of ethnographic fieldwork in Peru, which included 82 face-to-face surveys using the World Health Organization’s Multi-Country Study Instrument, 38 semi-structured interviews with survivors, community members, and IPV-related service providers, and 6 participatory action research workshops (n=64).

Through this dissertation, the voices of indigenous women struggling with intimate partner violence illuminate the lived realities …

A State-Level Study Of Opioid Use Disorder Treatment Access And Neonatal Abstinence Syndrome, Elizabeth R. Wolf, Sebastian T. Tong, Roy T. Sabo, Steven H. Woolf, Kassie Abbinanti, James Pecsok, Alex H. Krist

Pediatrics Publications

Background Adult opioid use and neonatal abstinence syndrome (NAS) are growing public health problems in the United States (U.S.). Our objective was to determine how opioid use disorder treatment access impacts the relationship between adult opioid use and NAS.

Methods We conducted a cross-sectional state-level ecologic study using 36 states with available Healthcare Cost and Utilization Project State Inpatient Databases in 2014. Opioid use disorder treatment access was determined by the: 1) proportion of people needing but not receiving substance use treatment, 2) density of buprenorphine-waivered physicians, and 3) proportion of individuals in outpatient treatment programs (OTPs). The incidence of …

Providers’ Perception Of Alert Fatigue After Implementation Of User-Filtered Warnings, Hina Afaq, Sahaana Mukundan, Sadaf Zia, Alisa K. Escano Dr., Rebecca Lear Dr., Casey Washington Dr.

Pharmacotherapy and Outcomes Science Publications

Alert fatigue is a complex problem that many health institutions face when using an electronic health record (EHR). The addition of user-filtered warnings (UFW) is a physicians’ proposed intervention at Inova Health System (IHS), a large 5-hospital health system in Northern Virginia, that allows prescribers to filter out specific drug-drug interactions and pregnancy and lactation medication alerts for a 30-day period. This study aims to determine the impact of UFW on physicians’ perception of alert fatigue and to calculate the reduction of medication alerts. It was hypothesized that the reduction in alerts will significantly impact physicians’ perception of alert fatigue …

Communication Of Deaf People Based On Myoware Muscle Sensor, Mohamad Ataya

Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19

The current project aims to create a product that enhances communication of deaf people. The developed product has the following features:

• a muscle sensor that transcribes sign language into actual letters

• a voice detector that translates speech into actual words

• the ability to receive and send emergency alerts.

The N-Glycan Structures Of The Antigenic Variants Of Chlorovirus Pbcv-1 Major Capsid Protein Help To Identify The Virus-Encoded Glycosyltransferases, Immacolata Speciale, Garry A. Duncan, Luca Unione, Irina Agarkova, Domenico Garozzo, Jesus Jimenez-Barbero, Sicheng Lin, Todd L. Lowary, Antonio Molinaro, Eric Noel, Maria Elena Laugieri, Michela Tonetti, James L. Van Etten, Cristina De Castro

James Van Etten Publications

The chlorovirus Paramecium bursaria chlorella virus 1 (PBCV-1) is a large dsDNA virus that infects the microalga Chlorella variabilis NC64A. Unlike most other viruses, PBCV-1 encodes most, if not all, of the machinery required to glycosylate its major capsid protein (MCP). The structures of the four N-linked glycans from the PBCV-1 MCP consist of nonasaccharides, and similar glycans are not found elsewhere in the three domains of life. Here, we identified the roles of three virus-encoded glycosyltransferases (GTs) that have four distinct GT activities in glycan synthesis. Two of the three GTs were previously annotated as GTs but the third …

Alternative Care Models For Management Of Diabetes, Sarah Tsai

Presentations

Describes effort to improve A1C in teens using motivational interviewing vs. traditional patient/provider interaction in real-world clinic setting.

Lipids, Reactive Oxygen Species, And Health, Heather Bowen

DNP Research Projects

Cardiovascular disease (CVD) is the leading cause of death in the United States. Coronary artery disease (CAD), where plaque builds up to create atherosclerosis, puts patients at risk for heart attack or stroke. Mitochondrial Reactive Oxygen Species (ROS) have been implicated as a source of oxidative stress that can lead to the development of CAD, and diets high in fat potentiate this occurrence. As certain fats are heated and experience chemical and physical degradation, they cause an increased risk of obesity, diabetes, various forms of cancer, and CVD. This research study, based on CREATION Health ideals, aimed to evaluate the …

Untethered Lecture Capture: A Qualitative Investigation Of College Student Experiences, Lorretta Krautscheid, Samuel Williams, Benjamin Kahn, Katherine Adams

Faculty Publications - College of Nursing

Untethered Lecture Capture (ULC), a technology-enhanced teaching strategy, permits faculty to be freely mobile in the classroom (untethered) while simultaneously teaching and creating audiovisual media assets (lecture capture). Faculty, representing nine disciplines, implemented ULC in undergraduate courses. Qualitative content analysis resulted in three themes. Undergraduate participants (n¼23) reported ULC supports accessibility and education affordances, enhancing personalized, self-paced learning, and equal opportunities for academic success. Untethered faculty teach on our turf, teaching among rather than talking at students, enhancing time-on-task, in-class focus, and learner socialization. Understanding and retention were perceived as improved when multimedia instruction principles were integrated in the classroom.

Intraoperative Finding Of Vascular Malformation During Carpal Tunnel Release: A Case Report, Mark S. Anderson, Moheb S. Moneim

UNM Orthopaedic Research Journal

Carpal tunnel release is a common surgical procedure performed by hand surgeons. The procedure is typically straightforward; however, uncommon causes of median nerve compression encountered intraoperatively may add complexity. We describe a 67-year-old man with carpal tunnel syndrome and an intraoperative finding of a compressive vascular malformation during a mini-open carpal tunnel release. A space-occupying malformation of a persistent median artery was bisecting the nerve and thought to be responsible for the patient’s symptoms. The compression was relieved through extended carpal tunnel release without requiring removal of the vascular malformation. The patient’s symptoms improved postoperatively. Hand surgeons undertaking this procedure …

Chronic Volar Lunate Dislocation Resulting In Carpal Tunnel Syndrome: A Case Report, Travis D. Blood, Amanda J. Fantry, Nathan T. Morrell

UNM Orthopaedic Research Journal

Lunate dislocations are rare injuries caused by highenergy trauma disrupting the ligamentous restraints that connect the lunate to the carpus. We describe a case of missed volar lunate dislocation 10 years after the initial injury. The patient presented to our clinic with symptoms of carpal tunnel syndrome after falling on an outstretched arm. He had increasing paresthesias in his median nerve territory and underwent a proximal row carpectomy with release of the transverse carpal ligament. At 2 years postoperatively, successful outcomes were noted with an 80° arc of motion of the carpus and complete resolution of carpal tunnel symptoms. Although …

Ipsilateral Femoral Neck And Shaft Fractures With A Floating Knee Injury: A Case Report, Matthew T. Philippi, Scott M. Sandilands, Paul J. Goodwyn, Samer Kakish

UNM Orthopaedic Research Journal

Isolated ipsilateral fractures of the femoral neck and shaft are rare injuries. Similarly, a floating knee (ie, ipsilateral fractures of the femur and tibia) is uncommon. We describe a 34-year-old man with ipsilateral fractures of the femoral neck and shaft with an ipsilateral floating knee after a motorcycle collision. He was treated with operative fixation, and was walking without assistive devices at his most recent follow-up appointment in February 2019. We believe this to be a unique combination of injuries not yet described in studies.

Intraoperative Finding Of Flexor Carpi Radialis Avulsion During Closed Distal Radius Fracture: A Case Report, Camille Aubin-Lemay, Deana Mercer

UNM Orthopaedic Research Journal

Distal radius fractures are a common reason for orthopaedic consultations in emergency departments and outpatient orthopaedic clinics. Ruptures of the extensor pollicis longus tendon have been regularly described in conjunction with distal radius fractures, whereas only five cases of flexor tendon injuries have been reported. We describe a patient with acute rupture of the flexor tendon identified during operative fixation of the distal radius fracture. The tendon avulsion was repaired at the same time as fracture fixation; unfortunately, the patient was lost to follow-up. This case highlights the importance of a careful physical examination in treating high-energy traumatic injuries and …

Diagnosis Of Leprosy Using Sural Nerve Biopsy Findings: A Case Report, Bridgette M. Love, Deana Mercer, Amber West, Karen S. Santacruz, Elizabeth A. Mikola

UNM Orthopaedic Research Journal

Leprosy, also known as Hansen disease, is an uncommon chronic disease caused by the slowly growing acid-fast bacilli, Mycobacterium leprae. Leprosy has tropism for peripheral nerves and skin and can also be found in the upper respiratory tract, eyes, and nasal mucosa. When left untreated, there can be considerable nerve damage resulting in paralysis, blindness, and the crippling of hands and feet. Although infrequent in the United States, leprosy has been diagnosed in patients exposed to armadillos, an animal reservoir. We describe an 80-year-old man who presented with a 6-year history of chronic erythematous, macular rash, and progressive symmetric sensory …

Multiple Pterygium Syndrome With Severe Knee Flexion Contracture: A Case Report, Jory Wasserburger, Garrett Waller, Scott Plaster, David M. Bennett

UNM Orthopaedic Research Journal

Multiple pterygium syndrome, a subgroup of arthrogryposis multiplex congenita, is characterized by the webbing of different parts of the body. We describe a child who developed 140° flexion contractures of the popliteal fossa, which complicated mobility, skin care, and general hygiene. After seeking multiple opinions, the parents elected to proceed with through-knee amputation of both knees. At 6 month follow-up, the child had been fitted with bilateral prostheses and was able to ambulate with assistance. The findings of the current case suggest that in extreme cases of multiple pterygium syndrome, through-knee amputations may represent a predictable and functional treatment option …

Leukocytoclastic Vasculitis In A 66-Year-Old Woman After Fusion Of The Second Right Metatarsocuneiform Joint Using Titanium Plate And Screws: A Case Report, Sarah K. Brown, Christopher Kurnik, Emily M. Altman, Richard A. Miller

UNM Orthopaedic Research Journal

Metallic orthopaedic implants are known to instigate cutaneous reactions; however, the mechanism by which this occurs is not fully understood. Contact dermatitis after implantation of stainless steel fracture plates was first described in 1966, and similar reactions to various implants have been documented subsequently. Leukocytoclastic vasculitis (LCV) is an inflammatory condition of small dermal blood vessels resulting from neutrophil invasion, degranulation, and cell death caused by a type III hypersensitivity reaction. No studies have reported use of titanium orthopaedic implants resulting in LCV. We describe a 66-year-old woman who developed LCV after the fusion of her second right metatarsocuneiform joint …

Achilles Tendon Ruptures In Two Male Athletes In Ncaa Division I: Report Of Two Cases, Lisa Hardy, Michele Bliss, Garyn Worrall, James Slauterbeck

UNM Orthopaedic Research Journal

Major tendon ruptures are rare, with an Achilles tendon rupture (ATR) being the most frequent type. Reported cases most commonly involve male recreational athletes who have increased body mass indexes and are between ages 30 and 50 years. We describe two male athletes in Division I of the National Collegiate Athletic Association who underwent surgical repair for treating an ATR associated with running-related activities. In contrast to other cases, both patients had normal body mass indexes. These two cases identify high-level athletes who underwent operative Achilles tendon repair and returned to their sport at a similar level or high level …

Inclusion Body Myositis In A Middle-Aged Woman With Knee Pain And Weakness: A Case Report, Jacob Christensen, Christopher A. Mcgrew

UNM Orthopaedic Research Journal

Weakness and osteoarthritis are common concerns for orthopaedic and primary care physicians when caring for aging adults. We describe a 58-year-old woman with a history of Sjogren syndrome and knee osteoarthritis. She presented to our clinic for injection of viscosupplementation in her left knee, and review of her medical records revealed right hand weakness at 7 years after the onset of symptoms. Findings of muscle biopsy and multiple electromyograms revealed inclusion body myositis, primarily affecting the deep finger flexors and quadriceps muscles. On the basis of this diagnosis, physical therapy and supportive care were recommended. The results of the current …

An Uncommon Presentation Of Coxa Saltans: A Case Report, Christopher S. Bossart, Christopher A. Mcgrew, Rebecca A. Dutton

UNM Orthopaedic Research Journal

Coxa saltans, or “snapping hip,” refers to various conditions that produce a palpable or audible snapping of the hip after movement. We present an uncommon case of coxa saltans in a patient with a snapping proximal hamstring tendon. Findings of dynamic ultrasound evaluation were used to confirm the source of snapping, characterized by a lateral subluxation of the conjoint tendon over the ischial tuberosity. Our patient was treated nonoperatively, and we observed mild improvement of her symptoms. Few cases of similar pathological findings have been described, with varying causes of tendon instability. The results of the current case may help …

Use Of Titanium Mesh Cage In Treating A Subtrochanteric Defect: A Case Report, Lucas D. Winter, James A. Dollahite, Rick Gehlert

UNM Orthopaedic Research Journal

Titanium mesh cages have been used during fixation of segmental defects in long bones; however, use in the subtrochanteric region of the proximal femur is a novel application. We describe a 38-year-old, 330-lb man with a highly comminuted fracture about the right femur after a gunshot wound. Immediate treatment involved use of a cement spacer. Findings of follow-up imaging showed about 26° external rotational deformity and 2-cm limb shortening. To correct the rotational abnormality and limb length discrepancy, a cylindrical titanium mesh cage and custom-made femur locking plate with a cancellous bone autograft were used. Subsequently, successful bridging was obtained …

Understanding And Improving Patient Satisfaction In Orthopaedic Surgical Procedures: A Review, Paul J. Johnson

UNM Orthopaedic Research Journal

Orthopaedic surgeons and their hospitals are being evaluated and reimbursed according to their ability to provide patient satisfaction. It behooves physicians to learn how patient satisfaction is evaluated, how patient satisfaction may be improved, and how improvements in patient satisfaction may positively influence patient outcomes both subjectively and objectively. The purpose of this review is to illuminate how evaluation works, how patient factors may affect or correlate with increased satisfaction, and how physicians can improve actions to enhance patient satisfaction. Notably, studies have found that improved care coordination, nursing follow-up, provider listening skills, providing realistic yet positive expectations, and sitting …

Complete Great Toe Sesamoid Excision: A Case Series, James A. Dollahite, Benjamin D. Packard, Richard A. Miller

UNM Orthopaedic Research Journal

Background: Hallux sesamoids notably contribute to the biomechanics of the great toe. Although frequently ignored or forgotten, injury to the hallux sesamoids can be debilitating. Conservative management remains the initial approach for symptomatic sesamoid disorders, but surgical excision is an option. We performed a retrospective case series to examine the preoperative characteristics and postsurgical outcomes of patients who underwent great toe sesamoidectomy.

Methods: We reviewed medical records of patients who underwent great toe sesamoidectomy performed by a single surgeon (RAM) during a 10-year period (26 patients, 28 procedures). Data collected included smoking status, prior first ray surgical treatment, highlevel athlete …