Medicine and Health Sciences Commons^™

The Fall Of The Gladiators: Wives’ Tales Of Concussion Reporting And (Possible) Progressive Neurodegenerative Disease In Nfl Players, Caroline E. Faure Edd; Atc, Madeline P. Casanova Mpe

The Qualitative Report

This study aims to uncover and describe stories of progressive cognitive, emotional, and behavioral decline in NFL players, as told by those who may know them best: their wives. The goal of the study was to simply explore and understand this new phenomenon with a group of individuals who had not yet been asked to voice their experiences. For this qualitative study, we conducted interviews with 20 wives of current and retired NFL players. Through thematic analysis of the wives’ narratives, we identified four themes that help to describe the wives’ attitudes and experiences. These were (a) Husbands’ Willingness to …

Enhanced A1 Adenosine Receptor-Induced Vascular Contractions In Mesenteric Artery And Aorta Of In L-Name Mouse Model Of Hypertension, Vishal R. Yadav, Bunyen Teng, S. Jamal Mustafa

Clinical and Translational Science Institute

L-NAME-induced hypertension is commonly used to study endothelial dysfunction and related vascular effects. It has been reported that genetic deletion of A1 adenosine receptor (AR) reduces blood pressure (BP) increases in mice and thus, suggesting the involvement of A1AR. Thus, we sought to determine whether A1AR-induced vascular responses were altered in this mouse model of hypertension. L-NAME (1 mg/ml) was given in the drinking water for 28 days to mice. The BP was monitored using non-invasive tail-cuff system. Muscle tension studies were performed using DMT for mesenteric arteries (MAs) and organ bath for aorta. Protein expression was analyzed by western …

Occupational Therapy Programming Facilitates Goal Attainment In A Community Work Rehabilitation Setting, Tina M. Deangelis, Kimberly Mollo, Carolyn Giordano, Michaela Scotten, Brianna Fecondo

Department of Occupational Therapy Faculty Papers

An occupational therapy program for participants with mental health challenges, a history of serious mental illness, recovering from substance use disorders, on parole/probation, and/or experiencing homelessness was implemented in a community work rehabilitation setting. The impact of occupational therapy interventions focused on stress and anger management, sleep hygiene, anxiety and depression management, relapse prevention for addiction, vocational and academic skill building, money management, healthy eating, and relationship and leisure skill development. Participant satisfaction and performance scores regarding individual goal setting and attainment was collected and analyzed via retrospective review of pre/post outcome scores (n = 44) obtained through the Canadian …

Star-Related Lipid Transfer Protein 10 (Stard10): A Novel Key Player In Alcohol-Induced Breast Cancer Progression, Andrea Floris, Jia Luo, Jacqueline A. Frank, Jennifer Zhou, Sandro Orrù, Michela Biancolella, Sabina Pucci, Augusto Orlandi, Paolo Campagna, Antonella Balzano, Komal Ramani, Maria Lauda Tomasi

Pharmacology and Nutritional Sciences Faculty Publications

Background: Ethanol abuse promotes breast cancer development, metastasis and recurrence stimulating mammary tumorigenesis by mechanisms that remain unclear. Normally, 35% of breast cancer is Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-positive that predisposes to poor prognosis and relapse, while ethanol drinking leads to invasion of their ERBB2 positive cells triggering the phosphorylation status of mitogen-activated protein kinase. StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Interestingly, STARD10 has been described to be highly expressed in 35–40% of ERBB2-positive breast …

Individual-Level Antibody Dynamics Reveal Potential Drivers Of Influenza A Seasonality In Wild Pig Populations, Kim M. Pepin, Kerri Pedersen, Xiu-Feng Wan, Fred L. Cunningham, Colleen T. Webb, Mark Q. Wilber

United States Department of Agriculture Wildlife Services: Staff Publications

Swine are important in the ecology of influenza A virus (IAV) globally. Understanding the ecological role of wild pigs in IAV ecology has been limited because surveillance in wild pigs is often for antibodies (serosurveillance) rather than IAVs, as in humans and domestic swine. As IAV antibodies can persist long after an infection, serosurveillance data are not necessarily indicative of current infection risk. However, antibody responses to IAV infections cause a predictable antibody response, thus time of infection can be inferred from antibody levels in serological samples, enabling identification of risk factors of infection at estimated times of infection. Recent …

Comparison Of Treatment Regimens In Organophosphate And Carbamate Poisoning In A Tertiary Care Hospital-A Retrospective Analysis, Girish P. Thunga Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Introduction Organophosphate consumption is a most common form of poisoning in Asian countries such as India and Srilanka. These compounds being highly lipid soluble they can easily distribute in the tissues and can cross the blood brain barrier and result in various complications. There is an increased rate of morbidity and mortality associated with these compounds. Eventhough, ATR is the most widely used antidote, treatment with PAM and GPR are also noteworthy. However, there are no clear studies stating benefits of individual or combination of regimens with respect to the outcomes. This study is carried out to compare the efficacy …

Role Of N-Acetylcysteine In Management Of Rodenticide Poisoning: A Retrospective Analysis, Girish P. Thunga Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

INTRODUCTION: Rodenticide consumption is a very common form of poisoning, either accidental or intentional, and is mainly reported in the rural parts of India. Rodenticides generally comprise of Superwarfarins, Thallium, Barium Carbonate, Aluminium phosphide (AIP) and Zinc phosphide. They are quite inexpensive and highly toxic chemicals. Annually, around 50,000 cases are reported [1]. The agents present in rodenticides are hepatotoxic in nature and the outcome is often fatal. Therefore, it has always been a concern in major public health, especially in Asian countries. Absence of a definite antidote often results in high mortality rate among the patients. Recent studies suggest …

Dipeptidyl Peptidase-4 Inhibitors Induced Inflammatory Bowel Disease In Type 2 Diabetes Patients: A Case Control Study In A South-Indian Tertiary Care Hospital, Sonal M. Sekhar Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Over the past few years, the use of dipeptidyl peptidase-4 (DPP-4) inhibitors in management of type 2 diabetes have increased as second to third line treatment. A recent study reported that the use of DPP-4 inhibitors may be associated with an increased risk of Inflammatory bowel disease (IBD). However, a meta-analysis showed conflicting results. Objectives:  To find association between DPP-4 inhibitors use and development of IBD in type 2 diabetic patients.  To find association between duration of DPP-4 inhibitors and development of IBD in type 2 diabetic patients.  To find association between duration of type 2 …

A Study On Identifying And Resolving Problems Associated With Administration Of Drugs Via Nasogastric Tube, Sreedharan Nair Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Administration of drugs via the nasogastric tube (NGT) has become very common in ICU patients. Many drug formulations are administered in the crushed form through the tube and this procedure is increasingly done by the nurses. Although crushing of solid dosage forms permits the ease of administration, there are several dosage forms that should not be broken or crushed as it can result in various problems like decreased or increased bioavailability, drug interactions or interaction with the tube itself. Objectives: To assess the problems encountered when medications are being administered by nasogastric tube in a tertiary care hospital and …

Use Of Statins In Ischemic Stroke Patients With Carotid Artery Stenosis: A Prospective Cohort Study In A Tertiary Healthcare Facility, Sonal M. Sekhar Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Stroke is one of the leading causes of adult disability. Carotid artery stenosis (CAS) is a result of systemic atherosclerotic disease. Therefore, any risk factor predisposing a patient to progressive atherosclerosis can potentially manifest itself as stenosis of the carotid artery with resultant ischemic stroke and/or transient ischemic attack (TIA) like symptoms. An aggressive medical cardiovascular risk reduction approach, centered on the use of a statin when CAS is present, is the current standard of care. Therefore, the purpose of this study was to investigate the effect of statin use in ischemic stroke patients with and without CAS on …

Comparison Of Various Cardiovascular Risk Scores To Assess Cardiovascular Risk In People Living With Hiv On Haart In Kasturba Hospital Manipal, Rajesh Radhakrishnan Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Intoduction: The risk of cardiovascular diseases in people living with HIV is greater than in normal individuals Objectives: 1. To Assess the cardiovascular risks in people living with HIV with HAART using standard cardiovascular risk scores. 2. To compare the pattern of cardiovascular disease risk associated with HIV seropositive patients with HAART. Methodology: Patients diagnosed with HIV with HAART with one or other cardiovascular diseases will be enrolled. The data related to various cardiovascular diseases, the duration of cardiovascular disease with onset of HIV infection with HAART. The enrolled patients will be evaluated by using various validated cardiovascular risk scores …

Use Of Surfactants For The Treatment Of Neonatal Respiratory Distress Syndrome, Rajesh V Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Respiratory Distress Syndrome (RDS) is breathing disorder that affects the newborns especially preterm neonates, extremely low birth weight and very low birth weight neonates. This is due to lack of surfactant production in the lungs of a premature baby. Surfactant therapy and oxygen support improves the condition of the neonate with RDS. Use antenatal steroid prevents the occurrence of RDS/reduces the severity of RDS. This study is necessary to assess which surfactant is better, risk factors associated with RDS and comorbidities of neonates present along with RDS. Objectives: The objectives of the studies are to compare the surfactants used …

Retrospective Study To Evaluate Prescription Pattern And Cost Of Illness In Patients With Rheumatoid Arthritis In A Tertiary Care Hospital Setting, Rajesh V Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Rheumatoid Arthritis (RA) is a chronic disease associated with poor quality of life of patients, lifelong dependency on medications and long-term disease suffering which leads to both physical and financial disability in terms of cost. RA flare and complications lead to hospitalization and demand in-patient care and these costs impose a significant burden on the patients especially those from a poor socioeconomic background in a developing society like India where the country reserves only 1.4% of the income for healthcare. Objective: The objective of this study is to find the cost of illness associated with hospitalized patients suffering from …

Drug Utilization Review Of Anticancer Drugs With Otherdrugs In Breast Cancer Patients, Mahadev Rao Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: To study the prescribing pattern of chemotherapeutic drugs in Breast Cancer patients and to survey the prevalence of exigent drug-drug interactions (DDIs) between chemotherapeutic drugs and non-chemotherapeutic drugs and evaluate the risk factors associated with these drug-drug interactions in India. Methods: All discharged patients’ data in the Department of Oncology were collected from September 2019 to March 2020 with the help of Hospital Information System and inpatient file of the breast cancer patients collected from the Medical Records Department. Drugs were screened for interactions by Micromedex solutions database and Epocrates database. Descriptive statistics were generated and was used to …

Assessment Of Pattern, Risk Factors And Treatment Of Iron Deficiency And Megaloblastic Anemia In Adult And Pediatric Population In A Tertiary Care Hospital In South India, Leelavathi D. Acharya Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

IntroductionIron Deficiency Anemia (IDA) is a major nutritional problem globally which is especially true in developing countries like India. IDA is associated with worsened quality of life, impaired physical & cognitive performance. Even though treatment patterns are simple & effective, there is a high prevalence of IDA. The reason for this is partly due to non-compliance of the patients & partly due to ineffective/incomplete treatment by physicians.[4] Due to the risks associated with blood transfusions, alternative treatments of anemia in the critically ill are being explored.[5]ObjectivesTo assess the pattern, risk factors and treatment of IDA in adult and pediatric population …

The Study Of Prevalence Of Diabetes Mellitus And Its Complications In Hiv Patients In, Leelavathi D. Acharya Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background –Diabetes is a chronic, metabolic disorder that is characterized by resulting from defects in insulin secretion, insulin action or both which will affect the patient Quality of life. Pharmaceutical Care is the responsible provision of drug therapy for of achieving definite therapeutic outcomes that improve the patient‘s quality of life.It contributes to the resolution of medical conditions and can help avoid undesirable outcomes about patient‘s drug therapy problems, resulting in benefits to patients.Objectives –To study the impact of Pharmaceutical care in type 2 diabetic patients in a tertiarycare hospital.Methodology –A prospective interventional study was conducted for a period of …

Cardiovascular Safety Of Febuxostat And Allopurinol In Gout/Hyperuricemia Patients: A Retrospective Cohort Event Reporting In A Tertiary Healthcare Facility, Sonal M. Sekhar Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: On February 21st 2019, FDA added a boxed warning for increased risk of death with febuxostat compared to allopurinol. Purpose: To compare the incidence of cardiovascular events and efficacy between febuxostat and allopurinol use. Methods: A retrospective cohort study was conducted in hyperuricemic/gout patients admitted between 2013 to 2017. Study cohort (febuxostat/allopurinol/both) and control cohort (drugs other than febuxostat/allopurinol) were selected based on inclusion and exclusion criteria. The primary outcomes were various cardiovascular events which were compared and analysed using IBM SPSS version 20 and p<0.05 was considered statistically significant. Results: Mean reduction in level of serum urate after febuxostat and allopurinol use was 2.754 mg/dl [p=0.000; CI (95%) 2.209-3.299] and 1.137 mg/dl [p=0.000; CI (95%) 0.792-1.482], respectively. However, there was no statistically significant difference between the groups. The mean survival time for febuxostat was 37 months [CI (95%) 24-51], whereas for allopurinol was 107 months [CI (95%) 52-162] and for both users was 38 months [CI (95%) 20-56]. However, there was no significant difference among the groups (p=0.762). Cardiovascular events occurred in 4 (5.63%) patients in febuxostat group (n=71), 6 (6.45%) patients in allopurinol group (n=93) and 3 (30%) patients in group with both drugs (n=10). The number needed to harm (NNH) for febuxostat, allopurinol and with both drugs were 22, 19 and 3, respectively. Conclusion: Both febuxostat and allopurinol are significantly efficacious in reducing serum urate levels. Lesser mean survival time in febuxostat group indicates faster occurrence of cardiovascular events. On the other hand, incidence of cardiovascular events was more with allopurinol than febuxostat without statistical significance. We observed these cardiovascular adverse events of allopurinol and febuxostat are duration depended.

Development And Evaluation Of A Cancer Registry For Shirdi Sai Baba Cancer Hospital And Research Centre, Kanav Khera Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: There exists a National Cancer Registry Programme (NCRP) aimed at collecting cancer patient data at the hospital and population level. 33 population-based cancer registries (PBCRs) and 100+ hospital-based registries (HBCRs) are present. Continuous training of professionals and monitoring of data completeness are a requisite to ensure generation of reliable databases. Advances in information technology allow for proper planning and development in all active registries. However, due to lack of time and personnel, systematic filling in of data takes a back-seat in India. Objectives: To develop a cancer registry for Shirdi Sai Baba Cancer Hospital and Research Centre. Methods: After …

Current Procedural Terminology Chapter, Module, Veronica Mcgowan

Faculty Articles & Research

Current Procedural Terminology (CPT ® ) is a medical code set used for describing and reporting medical, surgical, and diagnostic services and procedures. Copyrighted and published by the American Medical Association (https://www.ama-assn.org/practice-management/cpt)since 1966 and updated yearly by the Performance Measures Advisory Group (PMAG), these codes foster better data collection so that performance measurement is facilitated, and are often used for accreditation purposes to explain results and practices. Originally developed as a method of communication between physicians and third-party payers and intended to be used for reimbursement, current applications include usage in: benchmarking activities (Garber, Ledonio, & Polly, 2015), risk prediction …

Introduction To Medical Coding, Introductory Module, Veronica F. Mcgowan

Faculty Articles & Research

In our increasingly global economy, manufacturers and distributers sending and receiving goods are frustrated by the reality of multiple languages. As an example of corporate coding, proactive management in an automotive company have invented a coding system where each car type has its own identification code with associated words that describe the product. Therefore, they can be confident that anyone referring to ID 4523 is describing a four-door vehicle (4000 level), compact vehicle (500), black color (20) with leather interior (3). This example is analogous to clinical or medical coding.

Cortactin Phosphorylation By Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function And Tumor Cell Invasion, Steven M. Markwell, Amanda G. Ammer, Erik T. Interval, Jessica L. Allen, Brenen W. Papenberg, River A. Hames, Johnathan E. Castaño, Dorothy A. Schafer, Scott A. Weed

Clinical and Translational Science Institute

Malregulation of the actin cytoskeleton enhances tumor cell motility and invasion. The actin-binding protein cortactin facilitates branched actin network formation through activation of the actin-related protein (Arp) 2/3 complex. Increased cortactin expression due to gene amplification is observed in head and neck squamous cell carcinoma (HNSCC) and other cancers, corresponding with elevated tumor progression and poor patient outcome. Arp2/3 complex activation is responsible for driving increased migration and extracellular matrix (ECM) degradation by governing invadopodia formation and activity. Although cortactin-mediated activation of Arp2/3 complex and invadopodia regulation has been well established, signaling pathways responsible for governing cortactin binding to Arp2/3 …

Cyclin C: The Story Of A Non-Cycling Cyclin, Jan Jezek, Daniel G J Smethurst, David C Stieg, Z A C Kiss, Sara E Hanley, Vidyaramanan Ganesan, Kai-Ti Chang, Katrina F Cooper, Randy Strich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels. However, the role of class II cyclins, which primarily act as transcription factors and whose expression remains constant throughout the cell cycle, is less well understood. As a classic example of a transcriptional cyclin, cyclin C forms a regulatory sub-complex with its partner kinase Cdk8 and two accessory subunits Med12 and Med13 called the Cdk8-dependent kinase module (CKM). The CKM reversibly associates with the multi-subunit …

Exploring In Silence: Hearing And Deaf Infants Explore Objects Differently Before Cochlear Implantation, Mary K. Fagan

Communication Sciences and Disorders Faculty Articles and Research

Infant development has rarely been informed by the behavior of infants with sensory differences despite increasing recognition that infant behavior itself creates sensory learning opportunities. The purpose of this study of object exploration was to compare the behavior of hearing and deaf infants, with and without cochlear implants, in order to identify the effects of profound sensorineural hearing loss on infant exploration before cochlear implantation, the behavioral effects of access to auditory feedback after cochlear implantation, and the sensory motivation for exploration behaviors performed by hearing infants as well. The results showed that 9-month-old deaf infants explored objects as often …

Reward Improves Response Inhibition By Enhancing Attentional Capture, Yanqing Wang, Todd S Braver, Shouhang Yin, Xueping Hu, Xiangpeng Wang, Antao Chen

2010-2019 OA Pubs

Reward plays a crucial role in enhancing response inhibition. While it is generally assumed that the process of response inhibition involves attentional capture and the stopping of action, it is unclear whether this reflects a direct impact of reward on response inhibition or rather an indirect mediation via attentional capture. Here, we employed a revised stop-signal task (SST) that separated these two cognitive elements, by including a continue signal that required the same motor response as in go trials, but also attention to a cue, as in stop trials. We first confirmed the engagement of the right inferior frontal gyrus …

01-08-2019 Hsc Committee Meeting Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Incidental Renal Cell Carcinoma In Pelvic Malignancies, Fatima Shaukat, Muhammad Atif Mansha, Nasir Ali, Agha Muhammad Hammad Khan, Ahmed Nadeem Abbasi

Department of Radiation Oncology

Simultaneous diagnosis of renal cell carcinoma with pelvic malignancies is rare but a well-documented phenomenon. It is not uncommon to have incidental renal masses on imaging done for investigating other tumors. There are no established guidelines for the treatment of patients with dual malignancies. The management of such patients is challenging and requires a multidisciplinary approach. We present a series of three cases with a diagnosed pelvic malignancy but further workup revealed a kidney tumor. Both the malignancies were evaluated individually and diagnosed as two different primary neoplastic lesions. This case series examines each distinct patient's presentation, discusses the diagnosis, …

Analysis For Science Librarians Of The 2018 Nobel Prize In Physiology Or Medicine: The Life And Work Of James P. Allison And Tasuku Honjo, Neyda V. Gilman

Library Scholarship

On October 1, 2018, James P. Allison and Tasuku Honjo were awarded the 2018 Physiology or Medicine Nobel for their work leading to Immune Checkpoint Inhibition (ICI). ICI is the fourth pillar of cancer treatment and has been used to treat previously un-treatable cancers. Allison discovered that the protein CTLA-4 acts as a T cell brake while Honjo discovered another T cell brake, PD-1. Releasing these brakes allows the immune system to attack tumors, sometimes leading to complete elimination. While there is still more research to be done, Allison’s and Honjo’s work is a breakthrough in cancer immunotherapy.

Assessing Risk Factors For Esophageal Cancer, Mahadev Rao Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Esophageal cancer (EC) stands the 6th most frequent cause of death due to cancer worldwide.It is mainly classified into mainly Esophageal squamous cell carcinoma (ESCC) and Esophageal adenocarcinoma (EAC). The incidence extends from Eastern to Central Asia. Although there are advances in the management and treatment of EC patients, the generaloutcome is very poor. It is mainly because of the diagnosis during its advanced stages and due to the absence of early clinical symptoms. Therefore, it is an important health challenge .A clear picture regarding the risk factors and other patient demographics may help to improve the management of …

Effects Of Prenatal Exercise On Fetal Heart Rate, Umbilical And Uterine Blood Flow: A Systematic Review And Meta-Analysis, Rachel J. Skow, Margie H. Davenport, Michelle Mottola, Gregory A. Davies, Veronica J. Poitras, Casey E. Gray, Alejandra Jaramillo Garcia, Nick Barrowman, Victoria L. Meah, Linda G. Slater, Kristi B. Adamo, Ruben Barakat, Stephanie-May Ruchat

Anatomy and Cell Biology Publications

Objective To perform a systematic review and meta-analysis examining the influence of acute and chronic prenatal exercise on fetal heart rate (FHR) and umbilical and uterine blood flow metrics.

Design Systematic review with random-effects meta-analysis and meta-regression.

Data sources Online databases were searched up to 6 January 2017.

Study eligibility criteria Studies of all designs were included (except case studies) if published in English, Spanish or French, and contained information on the population (pregnant women without contraindication to exercise), intervention (subjective or objective measures of frequency, intensity, duration, volume or type of exercise, alone [“exercise-only”] or in combination with other …

Cdk4 Inhibitors Thwart Immunity By Inhibiting Phospho-Rb-Nf-Kb Complexes, Seung J. Kim, Samuel Asfaha, Frederick A. Dick

Paediatrics Publications

PD-L1 plays a central role in immune recognition of cancer cells. In this issue of Molecular Cell, Jin et al. (2019) report that a phosphorylated retinoblastoma protein contacts the DNA-binding domain of p65 NF-kB, thereby blocking transcription of PD-L1.