Medicine and Health Sciences Commons^™

Promoting Sustainability In Quality Improvement: An Evaluation Of A Web-Based Continuing Education Program In Blood Pressure Measurement., L. Block, S. J. Flynn, L. A. Cooper, C. Lentz, T. Hull, K. B. Dietz, R. T. Boonyasai

Journal Articles

BACKGROUND: The accuracy of blood pressure measurement is variable in office-based settings. Even when staff training programs are effective, knowledge and skills decay over time, supporting the need for ongoing staff training. We evaluated whether a web-based continuing education program in blood pressure measurement reinforced knowledge and skills among clinical staff and promoted sustainability of an existing quality improvement program.

METHODS: Medical assistants and nurses at six primary care clinics within a health system enrolled in a 30-min online educational program designed to refresh their knowledge of blood pressure measurement. A 20-question pre- and post-intervention survey addressed learners' knowledge and …

Gene-Level Association Analysis Of Systemic Sclerosis: A Comparison Of African-Americans And White Populations, O. Y. Gorlova, Y. Li, I. Gorlov, J. Ying, W. V. Chen, S. Assassi, J. D. Reveille, P. K. Gregersen, A. T. Lee, D. Khanna, M. D. Mayes, +22 Additional Authors

Journal Articles

© 2018 Gorlova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma). The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies. The White …

Dynamic Hydrostatic Pressure Regulates Nucleus Pulposus Phenotypic Expression And Metabolism In A Cell Density-Dependent Manner, B. S. Shah, N. O. Chahine

Journal Articles

© 2018 by ASME. Dynamic hydrostatic pressure (HP) loading can modulate nucleus pulposus (NP) cell metabolism, extracellular matrix (ECM) composition, and induce transformation of notochordal NP cells into mature phenotype. However, the effects of varying cell density and dynamic HP magnitude on NP phenotype and metabolism are unknown. This study examined the effects of physiological magnitudes of HP loading applied to bovine NP cells encapsulated within three-dimensional (3D) alginate beads. Study 1: seeding density (1 M/mL versus 4 M/mL) was evaluated in unloaded and loaded (0.1 MPa, 0.1 Hz) conditions. Study 2: loading magnitude (0, 0.1, and 0.6 MPa) applied …

Smoking Is The Most Significant Modifiable Lung Cancer Risk Factor In Systemic Lupus Erythematosus, S. Bernatsky, R. Ramsey-Goldman, M. Petri, M. B. Urowitz, D. D. Gladman, P. R. Fortin, E. H. Yelin, E. Ginzler, C. Aranow, A. E. Clarke, +9 Additional Authors

Journal Articles

Copyright © 2018 The Journal of Rheumatology. All rights reserved. Objective. To assess lung cancer risk in systemic lupus erythematosus (SLE), relative to demographics, drug exposures, smoking, and disease activity. Methods.We analyzed data from 14 SLE cohorts. We calculated adjusted HR estimates for lung cancer in SLE, relative to demographics, smoking, time-dependent medication exposures, and cumulative disease activity [mean adjusted SLE Disease Activity Index (SLEDAI) scores]. This project was approved by the ethics boards of all participating institutions, including the Institutional Review Board of the McGill University Health Centre. The ethics approval number for the Cancer Risk study is GEN-06-031. …

New Insights Into The Function Of Rab Gtpases In The Context Of Exosomal Secretion, L. Blanc, M. Vidal

Journal Articles

© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group © 2017, © Lionel Blanc and Michel Vidal. In the last two decades, extracellular vesicle-mediated communication between cells has become a major field in cell biology. However, the function of extracellular vesicles is far from clear, especially due to the disparity of released vesicles by cells. Basically, one must consider vesicles budding from the cell plasma membrane (ectosomes) and vesicles released upon fusion of an endosomal multivesicular compartment (exosomes). Moreover, even for exosomes, we report and discuss here the possibility that different routes regulated by …

No Improvement In Long-Term Survival Over Time For Chronic Lymphocytic Leukemia Patients In Stereotyped Subsets #1 And #2 Treated With Chemo(Immuno)Therapy, P. Baliakas, M. Mattsson, A. Hadzidimitriou, E. Minga, A. Agathangelidis, L. A. Sutton, L. Scarfo, Z. Davis, N. Chiorazzi, K. Stamatopoulos, +30 Additional Authors

Journal Articles

No abstract provided.

Somatic Cll Mutations Occur At Multiple Distinct Hematopoietic Maturation Stages: Documentation And Cautionary Note Regarding Cell Fraction Purity, S. Marsilio, H. Khiabanian, G. Fabbri, S. Vergani, C. Scuoppo, E. Montserrat, E. J. Shpall, M. Hadigol, K. R. Rai, N. Chiorazzi, +4 Additional Authors

Journal Articles

No abstract provided.

Genetic Background May Contribute To The Latitude-Dependent Prevalence Of Dermatomyositis And Anti-Tif1-Γ Autoantibodies In Adult Patients With Myositis, J. E. Parkes, S. Rothwell, A. Oldroyd, H. Chinoy, J. A. Lamb, I. E. Lundberg, F. W. Miller, P. K. Gregersen, G. Marder, Z. E. Betteridge, +25 Additional Authors

Journal Articles

© 2018 The Author(s). Background: The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultraviolet (UV) light towards the equator. In this study, we investigated whether differing genetic background in populations could contribute to this distribution of DM. Methods: Case data derived from the MYOGEN (Myositis Genetics Consortium) Immunochip study (n = 1769) were used to model the association of DM prevalence and DM-specific autoantibodies with latitude. Control data (n = 9911) were used to model the relationship of human …

Hydroxychloroquine Prescription Trends And Predictors For Excess Dosing Per Recent Ophthalmology Guidelines, A. M. Jorge, R. B. Melles, Y. Zhang, N. Lu, S. K. Rai, L. H. Young, K. H. Costenbader, R. Ramsey-Goldman, C. Aranow Md, H. Choi, +6 Additional Authors

Journal Articles

© 2018 The Author(s). Background: Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight (ABW)-based dosing. However, contemporary HCQ prescribing trends in the UK remain unknown. Methods: We examined a UK general population database to investigate HCQ dosing between 2007 and 2016. We studied trends of excess HCQ dosing per ophthalmology guidelines (defined by exceeding 6.5 mg/kg of IBW and 5.0 mg/kg of ABW) and determined their independent predictors using multivariable logistic regression analyses. Results: Among 20,933 new HCQ users (78% female), the …

Methods For High-Dimensonal Analysis Of Cells Dissociated From Cyropreserved Synovial Tissue, L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. Mcgeachy, J. D. Turner, P. K. Gregersen, R. Furie, B. Diamond, M. Mcmahon, +81 Additional Authors

Journal Articles

© 2018 The Author(s). Background: Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional assays. Robust standardized protocols need to be developed before cellular phenotypes at a single cell level can be effectively compared across patient samples. Methods: Multiple clinical sites collected cryopreserved synovial tissue fragments from arthroplasty and synovial biopsy in a 10% DMSO solution. Mechanical and enzymatic dissociation parameters were optimized for viable cell …

Sputum Detection Of Predisposing Genetic Mutations In Women With Pulmonary Nontuberculous Mycobacterial Disease, J. V. Philley, K. L. Hertweck, A. Kannan, B. A. Brown-Elliott, R. J. Wallace, A. Kurdowska, H. Ndetan, K. P. Singh, E. J. Miller, S. Dasgupta, +1 Additional Author

Journal Articles

© 2018, The Author(s). Nontuberculous mycobacterial lung disease (NTM), including Mycobacterium avium complex (MAC), is a growing health problem in North America and worldwide. Little is known about the molecular alterations occurring in the tissue microenvironment during NTM pathogenesis. Utilizing next generation sequencing, we sequenced sputum and matched lymphocyte DNA in 15 MAC patients for a panel of 19 genes known to harbor cancer susceptibility associated mutations. Thirteen of 15 NTM subjects had a diagnosis of breast cancer (BCa) before or after NTM infection. Thirty three percent (4/12) of these NTM-BCa cases exhibited at least 3 somatic mutations in sputa …

Preliminary Findings Of Altered Functional Connectivity Of The Default Mode Network Linked To Functional Outcomes One Year After Pediatric Traumatic Brain Injury, J. A. Stephens, C. F. Salorio, A. D. Barber, S. R. Risen, S. H. Mostofsky, S. J. Suskauer

Journal Articles

© 2018, © 2018 Taylor & Francis. Purpose and Method: This study examined functional connectivity of the default mode network (DMN) and examined brain–behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Results: Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks. Conclusion: Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 …

Investigation Of Superior Longitudinal Fasciculus Fiber Complexity In Recent Onset Psychosis, P. R. Szeszko, E. T. Tan, A. M. Ulug, P. B. Kingsley, J. A. Gallego, K. Rhindress, A. K. Malhotra, D. G. Robinson, L. Marinelli

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No abstract provided.

Latent Class Cluster Analysis Of Symptom Ratings Identifies Distinct Subgroups Within The Clinical High Risk For Psychosis Syndrome, A. T. Ryan, J. Addington, C. E. Bearden, K. S. Cadenhead, B. A. Cornblatt, D. H. Mathalon, T. H. Mcglashan, D. O. Perkins, L. J. Seidman, E. F. Walker, +3 Additional Authors

Journal Articles

© 2017 The clinical-high-risk for psychosis (CHR-P) syndrome is heterogeneous in terms of clinical presentation and outcomes. Identifying more homogenous subtypes of the syndrome may help clarify its etiology and improve the prediction of psychotic illness. This study applied latent class cluster analysis (LCCA) to symptom ratings from the North American Prodrome Longitudinal Studies 1 and 2 (NAPLS 1 and 2). These analyses produced evidence for three to five subgroups within the CHR-P syndrome. Differences in negative and disorganized symptoms distinguished among the subgroups. Subgroup membership was found to predict conversion to psychosis. The authors contrast the methods employed within …

A Collaborative, Network-Based Approach To Advance Women's Depression Research In The United States: Preliminary Findings, H. A. Flynn, C. Spino, C. Guille, K. M. Deligiannidis, P. Maki, J. Jahnke, K. L. Rosenblum, C. N. Epperson, S. J. Weiss

Journal Articles

No abstract provided.

Improved Estimation Of Subject-Level Functional Connectivity Using Full And Partial Correlation With Empirical Bayes Shrinkage, A. F. Mejia, M. B. Nebel, A. D. Barber, A. S. Choe, J. J. Pekar, B. S. Caffo, M. A. Lindquist

Journal Articles

© 2018 Reliability of subject-level resting-state functional connectivity (FC) is determined in part by the statistical techniques employed in its estimation. Methods that pool information across subjects to inform estimation of subject-level effects (e.g., Bayesian approaches) have been shown to enhance reliability of subject-level FC. However, fully Bayesian approaches are computationally demanding, while empirical Bayesian approaches typically rely on using repeated measures to estimate the variance components in the model. Here, we avoid the need for repeated measures by proposing a novel measurement error model for FC describing the different sources of variance and error, which we use to perform …

Smri Biomarkers Predict Electroconvulsive Treatment Outcomes: Accuracy With Independent Data Sets, R. Jiang, C. C. Abbott, T. Jiang, Y. Du, R. Espinoza, K. L. Narr, B. Wade, M. Argyelan, G. Petrides, V. D. Calhoun, +6 Additional Authors

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No abstract provided.

The Evolution Of Cultural Psychiatry, R. S. Shim

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No abstract provided.

Stress-Dependent Association Between Polygenic Risk For Schizophrenia And Schizotypal Traits In Young Army Recruits, A. Hatzimanolis, D. Avramopoulos, D. E. Arking, A. Moes, P. Bhatnagar, T. Lencz, A. K. Malhotra, S. G. Giakoumaki, P. Roussos, N. C. Stefanis, +2 Additional Authors

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No abstract provided.

Efficacy Of Guided Icbt For Depression And Mediation Of Change By Cognitive Skill Acquisition, N. R. Forand, J. G. Barnett, D. R. Strunk, M. U. Hindiyeh, J. E. Feinberg, J. R. Keefe

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No abstract provided.

Measuring Cognition And Function In The Preclinical Stage Of Alzheimer's Disease, S. Weintraub, M. C. Carrillo, S. T. Farias, T. E. Goldberg, J. A. Hendrix, J. Jaeger, D. S. Knopman, J. B. Langbaum, D. C. Park, C. Randolph, +9 Additional Authors

Journal Articles

© 2018 The Authors The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment …

Predictors Of Aggression In 3.322 Patients With Affective Disorders And Schizophrenia Spectrum Disorders Evaluated In An Emergency Department Setting, E. A. Blanco, L. M. Duque, V. Rachamallu, E. Yuen, J. M. Kane, J. A. Gallego

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No abstract provided.

The Genetics Of Endophenotypes Of Neurofunction To Understand Schizophrenia (Genus) Consortium: A Collaborative Cognitive And Neuroimaging Genetics Project, G. A. Blokland, E. C. Del Re, R. I. Mesholam-Gately, J. Jovicich, J. Trampush, M. S. Keshavan, L. E. Delisi, A. K. Malhotra, T. Lencz, T. L. Petryshen, +64 Additional Authors

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No abstract provided.

Identifying Patients And Clinical Scenarios For Use Of Long-Acting Injectable Antipsychotics - Expert Consensus Survey Part I, M. Sajatovic, R. Ross, S. N. Legacy, C. U. Correll, J. M. Kane, F. Dibiasi, H. Fitzgerald, M. Byerly

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No abstract provided.

Networks Of Blood Proteins In The Neuroimmunology Of Schizophrenia, C. D. Jeffries, D. O. Perkins, M. Fournier, K. Q. Do, M. Cuenod, I. Khadimallah, E. Domenici, J. Addington, B. A. Cornblatt, S. W. Woods, +8 Additional Authors

Journal Articles

© 2018 The Author(s). Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks that could be prognostic. We analyzed baseline blood plasma samples with a Luminex platform from 72 subjects meeting criteria for a psychosis clinical high-risk syndrome; 32 subjects converted to a diagnosis of psychotic disorder within two years while 40 other subjects did not. Another comparison group included 35 unaffected subjects. Assays of 141 analytes passed early quality control. We then used an unweighted co-expression network analysis …

Erratum To: Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis, J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, R. K. Heinssen, L. J. Seidman, S. W. Woods, +4 Additional Authors

Journal Articles

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. An error in statistical syntax defining baseline disorder led to misidentification of baseline anxiety disorder in five cases in one of the two reported samples (PREDICT). NAPLS-1 data and previous publications of PREDICT data were not affected. The error affected rows in Table 1 labeled 'DSM-IV anxiety' and 'Any mood/anx disorder' and rows in Table 3 labeled 'Baseline Anxiety Excluded' and 'Any Baseline Mood/ Anxiety Excluded.' Corrected Tables are shown below with corrected numbers in bold. Tables S1-S5 in the …

A Longitudinal Human Phantom Reliability Study Of Multi-Center T1-Weighted, Dti, And Resting State Fmri Data, C. Hawco, J. D. Viviano, S. Chavez, E. W. Dickie, N. Calarco, P. Kochunov, M. Argyelan, J. A. Turner, A. K. Malhotra, A. N. Voineskos, +1 Additional Author

Journal Articles

© 2018 Multi-center MRI studies can enhance power, generalizability, and discovery for clinical neuroimaging research in brain disorders. Here, we sought to establish the utility of a clustering algorithm as an alternative to more traditional intra-class correlation coefficient approaches in a longitudinal multi-center human phantom study. We completed annual reliability scans on ‘travelling human phantoms’. Acquisitions across sites were harmonized prospectively. Twenty-seven MRI sessions were available across four participants, scanned on five scanners, across three years. For each scan, three metrics were extracted: cortical thickness (CT), white matter fractional anisotropy (FA), and resting state functional connectivity (FC). For each metric, …

The Early Psychosis Screener (Eps): Quantitative Validation Against The Sips Using Machine Learning, B. B. Brodey, R. R. Girgis, O. Favorov, J. Addington, D. O. Perkins, C. E. Bearden, S. W. Woods, E. F. Walker, B. A. Cornblatt, I. S. Brodey, +3 Additional Authors

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No abstract provided.

The Role Of Genetic Variation Of Human Metabolism For Bmi, Mental Traits And Mental Disorders, J. Hebebrand, T. Peters, D. Schijven, M. Hebebrand, C. Grasemann, T. W. Winkler, I. M. Heid, J. Antel, C. U. Correll, L. Libuda, +7 Additional Authors

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No abstract provided.

Use Of Machine Learning To Determine Deviance In Neuroanatomical Maturity Associated With Future Psychosis In Youths At Clinically High Risk, Y. Chung, J. Addington, C. E. Bearden, K. Cadenhead, B. Cornblatt, D. H. Mathalon, T. Mcglashan, D. Perkins, L. J. Seidman, T. D. Cannon, +5 Additional Authors

Journal Articles

No abstract provided.